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The map label for this gene is patB [H]

Identifier: 118580414

GI number: 118580414

Start: 2144794

End: 2145945

Strand: Direct

Name: patB [H]

Synonym: Ppro_1998

Alternate gene names: 118580414

Gene position: 2144794-2145945 (Clockwise)

Preceding gene: 118580413

Following gene: 118580434

Centisome position: 53.51

GC content: 67.62

Gene sequence:

>1152_bases
ATGGCCGATTCCCCATTCGATTTCGACAGCATCGTCGACCGGAGCAACAGCGGCAGCGAGAAGTGGGACAGGTACAAGGG
GCGCGACATCATCCCGCTCTGGGTGGCGGATATGGACTTCCGCTCCCCCCCGGCAATCATCCGGGCCCTGCACGAGCGGG
TGGACCACGGTCTCTTCGGCTACACCCGCCCCTGGCAGGGGGTGACCGATGCGGTCATGGAGCACCTGGAGCGCGACTTC
CACTGGAGGATCGAGGCGGAGTGGATTGTTTGGCTCCCCGGCTTGGTCTGCGGCCTGAACGTGCTCTGCCGGGCCGTGGG
AGAGATTGGTGACGACGTGGTCACCCTCACCCCGGTCTACCCCCCCTTCCTGTCGGCCCCATCCCTCTCCCGCCGCAACC
TGGTCACGGTTCCGCTGGTTCTCCGGGGCACGCGCTGGGAGGCTGACAGGGATGAGCTGGAGCGGGCCATCACCCCCCGC
AGCCGACTGCTGCTGCTCTGCTCCCCCCACAACCCGGTGGGGCGCTGCTGGACGAGGGAGGAGCTGCTCGGCTTCGCGGA
TCTGGCCAAACGCCACAATCTGGTCATCGGCTCCGACGAGATCCACGCCGGCCTGGTCCTTGATCAAGAGAAATGCCACC
TCCCCCTGGCCACCCTCTCCCCGGACGCGGCCAGACGCACCATCACCCTGATGGCCCCCAGCAAGACCTTCAACATCCCC
GGCCTGGGCTGTTCCTTCGCCATCATCCCGGACCAGGGGTTGCGCGACAGCTTCAGGAAGGCCAAAGCGGGGATCGTTCC
CCACGTGAACAGCCTCGGCTACACCGCAACCGAGGCTGCCTACCGCCATGGTGGGGAATGGCGCCTGGCGCTGATCGACT
ACCTGCGGGACAACCGGGACCTGGTGATCCGGGCGGTGGGGCGCATGCCCGGCCTGTCAGTCACGCCGGTGGAGGCCACC
TACCTGGCCTGGATCGATGCCCGCAAAAGCGGGATCGACCATCCGGCACGCTTCTTCGAGCAGGCCGGGGTGGGGCTCTC
CGACGGAGCCCCCTTTGGAGCCCCCGGCTTCGTGCGCCTGAACTTCGGCTGCCCCCGCCCCCTGCTGGAGGAGGCGCTGG
GGCGTATGGAGCGTGCTTTGGCGCGTCCCTGA

Upstream 100 bases:

>100_bases
AAACCGCTGGGGGCGGACGAACTCCCCTGCCACAAGGTCAGGCACAACCGCTACGACGAGCCGTGGCAGCCGTCGGGCAG
GCCCTGACGGGGGAGCGGCA

Downstream 100 bases:

>100_bases
CAGCCTCACCCCCCTGCAACAATCAGAAACAGTGCAATTTAAGTATGATACAAACTGTTTTTTACAGCAGTGACAGAAGG
GATACCGGGGATAATCTACA

Product: class I and II aminotransferase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 383; Mature: 382

Protein sequence:

>383_residues
MADSPFDFDSIVDRSNSGSEKWDRYKGRDIIPLWVADMDFRSPPAIIRALHERVDHGLFGYTRPWQGVTDAVMEHLERDF
HWRIEAEWIVWLPGLVCGLNVLCRAVGEIGDDVVTLTPVYPPFLSAPSLSRRNLVTVPLVLRGTRWEADRDELERAITPR
SRLLLLCSPHNPVGRCWTREELLGFADLAKRHNLVIGSDEIHAGLVLDQEKCHLPLATLSPDAARRTITLMAPSKTFNIP
GLGCSFAIIPDQGLRDSFRKAKAGIVPHVNSLGYTATEAAYRHGGEWRLALIDYLRDNRDLVIRAVGRMPGLSVTPVEAT
YLAWIDARKSGIDHPARFFEQAGVGLSDGAPFGAPGFVRLNFGCPRPLLEEALGRMERALARP

Sequences:

>Translated_383_residues
MADSPFDFDSIVDRSNSGSEKWDRYKGRDIIPLWVADMDFRSPPAIIRALHERVDHGLFGYTRPWQGVTDAVMEHLERDF
HWRIEAEWIVWLPGLVCGLNVLCRAVGEIGDDVVTLTPVYPPFLSAPSLSRRNLVTVPLVLRGTRWEADRDELERAITPR
SRLLLLCSPHNPVGRCWTREELLGFADLAKRHNLVIGSDEIHAGLVLDQEKCHLPLATLSPDAARRTITLMAPSKTFNIP
GLGCSFAIIPDQGLRDSFRKAKAGIVPHVNSLGYTATEAAYRHGGEWRLALIDYLRDNRDLVIRAVGRMPGLSVTPVEAT
YLAWIDARKSGIDHPARFFEQAGVGLSDGAPFGAPGFVRLNFGCPRPLLEEALGRMERALARP
>Mature_382_residues
ADSPFDFDSIVDRSNSGSEKWDRYKGRDIIPLWVADMDFRSPPAIIRALHERVDHGLFGYTRPWQGVTDAVMEHLERDFH
WRIEAEWIVWLPGLVCGLNVLCRAVGEIGDDVVTLTPVYPPFLSAPSLSRRNLVTVPLVLRGTRWEADRDELERAITPRS
RLLLLCSPHNPVGRCWTREELLGFADLAKRHNLVIGSDEIHAGLVLDQEKCHLPLATLSPDAARRTITLMAPSKTFNIPG
LGCSFAIIPDQGLRDSFRKAKAGIVPHVNSLGYTATEAAYRHGGEWRLALIDYLRDNRDLVIRAVGRMPGLSVTPVEATY
LAWIDARKSGIDHPARFFEQAGVGLSDGAPFGAPGFVRLNFGCPRPLLEEALGRMERALARP

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713254, Length=227, Percent_Identity=27.7533039647577, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI56713256, Length=227, Percent_Identity=27.7533039647577, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI4507369, Length=353, Percent_Identity=23.7960339943343, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI95147551, Length=235, Percent_Identity=23.8297872340426, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI169881279, Length=235, Percent_Identity=23.8297872340426, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI169881281, Length=187, Percent_Identity=25.668449197861, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1787909, Length=390, Percent_Identity=35.3846153846154, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1786816, Length=292, Percent_Identity=24.3150684931507, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788627, Length=305, Percent_Identity=26.5573770491803, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788722, Length=353, Percent_Identity=23.7960339943343, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71994476, Length=153, Percent_Identity=29.4117647058824, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71994472, Length=153, Percent_Identity=29.4117647058824, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17567369, Length=150, Percent_Identity=28, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322401, Length=327, Percent_Identity=23.2415902140673, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI28573069, Length=156, Percent_Identity=30.7692307692308, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24646114, Length=156, Percent_Identity=30.7692307692308, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28573067, Length=156, Percent_Identity=30.7692307692308, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28573065, Length=156, Percent_Identity=30.7692307692308, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42721; Mature: 42590

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADSPFDFDSIVDRSNSGSEKWDRYKGRDIIPLWVADMDFRSPPAIIRALHERVDHGLFG
CCCCCCCHHHHHCCCCCCCHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCC
YTRPWQGVTDAVMEHLERDFHWRIEAEWIVWLPGLVCGLNVLCRAVGEIGDDVVTLTPVY
CCCCCCCHHHHHHHHHCCCCEEEEEEEEEEEHHHHHHHHHHHHHHHHHCCCCEEEECCCC
PPFLSAPSLSRRNLVTVPLVLRGTRWEADRDELERAITPRSRLLLLCSPHNPVGRCWTRE
CCCCCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHCCCCCCEEEEECCCCCHHHCCCHH
ELLGFADLAKRHNLVIGSDEIHAGLVLDQEKCHLPLATLSPDAARRTITLMAPSKTFNIP
HHHHHHHHHHHCCEEECCCCCEEEEEECCHHCCCCCCCCCCCHHHCEEEEEECCCCCCCC
GLGCSFAIIPDQGLRDSFRKAKAGIVPHVNSLGYTATEAAYRHGGEWRLALIDYLRDNRD
CCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCEEEEEHHHHHCCCC
LVIRAVGRMPGLSVTPVEATYLAWIDARKSGIDHPARFFEQAGVGLSDGAPFGAPGFVRL
EEEEEECCCCCCEECCCCCEEEEEEHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEE
NFGCPRPLLEEALGRMERALARP
ECCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ADSPFDFDSIVDRSNSGSEKWDRYKGRDIIPLWVADMDFRSPPAIIRALHERVDHGLFG
CCCCCCHHHHHCCCCCCCHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCC
YTRPWQGVTDAVMEHLERDFHWRIEAEWIVWLPGLVCGLNVLCRAVGEIGDDVVTLTPVY
CCCCCCCHHHHHHHHHCCCCEEEEEEEEEEEHHHHHHHHHHHHHHHHHCCCCEEEECCCC
PPFLSAPSLSRRNLVTVPLVLRGTRWEADRDELERAITPRSRLLLLCSPHNPVGRCWTRE
CCCCCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHCCCCCCEEEEECCCCCHHHCCCHH
ELLGFADLAKRHNLVIGSDEIHAGLVLDQEKCHLPLATLSPDAARRTITLMAPSKTFNIP
HHHHHHHHHHHCCEEECCCCCEEEEEECCHHCCCCCCCCCCCHHHCEEEEEECCCCCCCC
GLGCSFAIIPDQGLRDSFRKAKAGIVPHVNSLGYTATEAAYRHGGEWRLALIDYLRDNRD
CCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCEEEEEHHHHHCCCC
LVIRAVGRMPGLSVTPVEATYLAWIDARKSGIDHPARFFEQAGVGLSDGAPFGAPGFVRL
EEEEEECCCCCCEECCCCCEEEEEEHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEE
NFGCPRPLLEEALGRMERALARP
ECCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]