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The map label for this gene is yrhP [H]

Identifier: 118580408

GI number: 118580408

Start: 2137889

End: 2138509

Strand: Direct

Name: yrhP [H]

Synonym: Ppro_1992

Alternate gene names: 118580408

Gene position: 2137889-2138509 (Clockwise)

Preceding gene: 118580407

Following gene: 118580409

Centisome position: 53.34

GC content: 65.54

Gene sequence:

>621_bases
ATGACCGCATCAACCCTGCTCTACTTCCTGGGGGTCTCCATGGCCCTGACCATCGCCCCCGGGCCGGACAACATCTTCGT
CATGGCCCAGGGGATCACCCGCGGCAGGAAGCAGGCCATCGTCACAGCCCTGGGGATGTGCAGCGGCGTCAGCGTGCACA
CCACGGCGGCGGCCTTCGGCATCTCGGCCCTGTTCTACTCCTCGGTGCTGGCCTTCAACATCGTCAAGTACGCCGGCGCG
GCCTACCTGCTCTACCTGGCCTGCATGACCATGAAAGAGCGTTCCTCGGTGCGCCTGGCCGCCGACGACGACCGCCCCCT
GTCAGCCCTGTTCAAGCGCGGCTTCATCATGAACGTGCTCAACCCCAAGGTGGCCCTGTTCTTCCTGGCCTTCCTGCCCC
AGTTCGTCTCCCCCGCCGCCGGCTCCGTGCCGCTGCAGATGCTGCTTCTGGGACTGATCTTCATGCTGCAGGCAGTAGTC
ATCTTCTGCGTCATCGGCTATTTCTCCGGCGGCATCGGCGGCTATCTCCTGGCCAGGCCGAGGATCGCCCGCTCCTTCGA
CTGGCTGACCGCCGGCGTCTTCGCCTCCCTGGGGATCAGGCTGGCCCTGGCGGAACGTTGA

Upstream 100 bases:

>100_bases
GACGCTGCGGCGAATCGCCTGCGGCACCAGGCACGACAATACGGGTGACCCCGGCAGCCTCTGAACACGACATCCCGGCA
CCACCTTGAAAGGCAACCCC

Downstream 100 bases:

>100_bases
GAAAATACGCAAACGAAAAACGCCGTGTCCCCCTCTCCTGGGGGGCACGGCGTTTTTCTGTTCCGTTCCCTGGTGTACTT
GTATCCGTTCCGTTCCGCTC

Product: lysine exporter protein LysE/YggA

Products: homoserine lactone [Periplasm]; Proton [Cytoplasm]; homoserine [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MTASTLLYFLGVSMALTIAPGPDNIFVMAQGITRGRKQAIVTALGMCSGVSVHTTAAAFGISALFYSSVLAFNIVKYAGA
AYLLYLACMTMKERSSVRLAADDDRPLSALFKRGFIMNVLNPKVALFFLAFLPQFVSPAAGSVPLQMLLLGLIFMLQAVV
IFCVIGYFSGGIGGYLLARPRIARSFDWLTAGVFASLGIRLALAER

Sequences:

>Translated_206_residues
MTASTLLYFLGVSMALTIAPGPDNIFVMAQGITRGRKQAIVTALGMCSGVSVHTTAAAFGISALFYSSVLAFNIVKYAGA
AYLLYLACMTMKERSSVRLAADDDRPLSALFKRGFIMNVLNPKVALFFLAFLPQFVSPAAGSVPLQMLLLGLIFMLQAVV
IFCVIGYFSGGIGGYLLARPRIARSFDWLTAGVFASLGIRLALAER
>Mature_205_residues
TASTLLYFLGVSMALTIAPGPDNIFVMAQGITRGRKQAIVTALGMCSGVSVHTTAAAFGISALFYSSVLAFNIVKYAGAA
YLLYLACMTMKERSSVRLAADDDRPLSALFKRGFIMNVLNPKVALFFLAFLPQFVSPAAGSVPLQMLLLGLIFMLQAVVI
FCVIGYFSGGIGGYLLARPRIARSFDWLTAGVFASLGIRLALAER

Specific function: Conducts The Efflux Of Homoserine And Homoserine Lactone. [C]

COG id: COG1280

COG function: function code E; Putative threonine efflux protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the rht family [H]

Homologues:

Organism=Escherichia coli, GI48994979, Length=168, Percent_Identity=30.3571428571429, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI1788099, Length=194, Percent_Identity=30.4123711340206, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1786522, Length=116, Percent_Identity=31.0344827586207, Blast_Score=64, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004778
- InterPro:   IPR001123 [H]

Pfam domain/function: PF01810 LysE [H]

EC number: NA

Molecular weight: Translated: 22039; Mature: 21907

Theoretical pI: Translated: 10.22; Mature: 10.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASTLLYFLGVSMALTIAPGPDNIFVMAQGITRGRKQAIVTALGMCSGVSVHTTAAAFG
CCHHHHHHHHHHHHEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHH
ISALFYSSVLAFNIVKYAGAAYLLYLACMTMKERSSVRLAADDDRPLSALFKRGFIMNVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHCCHHHHHH
NPKVALFFLAFLPQFVSPAAGSVPLQMLLLGLIFMLQAVVIFCVIGYFSGGIGGYLLARP
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCC
RIARSFDWLTAGVFASLGIRLALAER
HHHHHHHHHHHHHHHHHCHHEEECCC
>Mature Secondary Structure 
TASTLLYFLGVSMALTIAPGPDNIFVMAQGITRGRKQAIVTALGMCSGVSVHTTAAAFG
CHHHHHHHHHHHHEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHH
ISALFYSSVLAFNIVKYAGAAYLLYLACMTMKERSSVRLAADDDRPLSALFKRGFIMNVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHCCHHHHHH
NPKVALFFLAFLPQFVSPAAGSVPLQMLLLGLIFMLQAVVIFCVIGYFSGGIGGYLLARP
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCC
RIARSFDWLTAGVFASLGIRLALAER
HHHHHHHHHHHHHHHHHCHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; homoserine [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + homoserine lactone [Cytoplasm] = Proton [Cytoplasm] + homoserine lactone [Periplasm] Proton [Periplasm] + homoserine [Cytoplasm] = Proton [Cytoplasm] + homoserine [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377; 9308178 [H]