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The map label for this gene is rpfC [H]

Identifier: 118580297

GI number: 118580297

Start: 2029150

End: 2030964

Strand: Direct

Name: rpfC [H]

Synonym: Ppro_1879

Alternate gene names: 118580297

Gene position: 2029150-2030964 (Clockwise)

Preceding gene: 118580296

Following gene: 118580299

Centisome position: 50.63

GC content: 54.27

Gene sequence:

>1815_bases
ATGATATTACGCCAAAAGGCTGAAGAACGGCTGTTGGACAAAACAATTGAAGCTGACCCTTCTCATACAGAGATGGACTC
ACAACGCCTGATCCACGAATTGCAGGTGTACCAAATCGAACTAGAGATGCAGGTAGAGGAACTTCGCCAGGCTAGGGATG
AGGAAGCTATGGCGCGAGAGATGTACGCCGACCTCTACGATTTCGCCCCGGTGGGATACGTTACCCTCGACCGCGACGGG
ATCATCCGAAATGCAAACCTGACCGGCTCTGTTCTCTTGGGAGTCGTGCGCTCCCAGCTGATCGGCCAGCGCCTTGGGGT
TTTCGTCGCCGTTGTATCCCGTCCCGCTTTCGCCGACTTCCTCGAAAAGGTTTTTACGAGCCCGACCAAAGTGGCCTGCG
AGGTGTCGCTCATGAAAGAGGGCGTTCCCGAGCTTTTCGTGCAGATCGAGGGGGTGGCCGTCGCATCGGGAGAGGAATGC
CGGATTGGGTTGATTGACATCACCGAACATAAGCGGGCAGAAGAGGTGCTTTGGATGGCCAAGGAGGCTACCGAAGCGGC
AATTTTAGCCAAGGAGACAGCCAAGGCACTTCGCCTGGAGAAGGAGATAAGCGAGTCGCTTCGAAGGGAAAAAGAGGCAG
CAGAGTCAGCTACTAGAGCAAAGGACCAGTTTCTTGCCAACATGAGCCACGAGCTGCGCACCCCGATGACAGGCGTTCTC
GGCATGCTCCAACTCGCTCTAGAAGAAGAACTCGCCCCGACGCTACGTAATTACCTGGGAACAGCGCATAGTTCGGCCAA
CTCTCTGCTCCAGATTCTTAATGATATCCTCGACATGACCAAAATTGAAGCCGGAAAGATCATCATCGAGGAAATGCCTT
TCTCTCCACGGAGGTGCGTAACTGGGGCAGTCGATATCATTACTCCCGAAGTGCGGCGCAAGGGACTTGACATCGCCATT
TCGGTGGCGGAGGAAGTGCCAGATAAGCTTGTCGGGGACCAGATGCGACTACGGCAAGTCCTCATCAACCTCATCGCCAA
CGCCGTCAAGTTCACTAACGAGGGTAAGGTAGCCGTGCAAGTCACAGCAGGTGGGACGAACTCCGACGGGAAGCGAGAGT
ACACTTTCGCCGTTACGGACACCGGCATCGGCATCCCCGAAGACAAGAAAGACCTTCTCTTCCACGTATTCAGCCAGGTT
GATGCATCTCACACTCGCACTTACGGCGGCACGGGCCTTGGTCTTGCCATCTGCAAGGAACTTGTGGAACTGATGGGGGG
AATGATTGATTTCGATAGCAAAGAGGGGGTGGGAAGCACCTTCTACTTCACCATCTCACTAAGAGAAGCCAAATCAGAGA
GAAATGCTCCGACCGCAGCCGAACCCCTGTCACCCGAAACTTTTACTGCTCCGAAGGGGGAAAGGATTCCGCATCTCCTT
CTTGCCGAAGACGATCCGACCATCCAACAAATCCTCGAAATGATGCTCACGAAGTCGAACTACAGTCTTGATATCGCTAA
GGATGGCAAGCAGGCGGTCGAAATGTGGGAACAGGGAGAATATGACCTCGTGCTGATGGATGTCCAGATGCCTCTTCTCA
GCGGCTTCGATGTGACCCTAGCCATTCGGGAGAGAGAGAGAGAACGTGGCGGTCACACCCCCATCGTCGCCATGACGGCC
CACACCGGCAAGGAAGCCGAGAAGAAGTGCATCGCCGCAGGCATGGACCACTATATTTCCAAGCCGATTGACTTTAATGA
GTGTTTGAAGTTGATAGGGCAGATCATCGGGCAGAAGTCCAGCGGCAATAACTGA

Upstream 100 bases:

>100_bases
GTTGAGACTTAGGCACATACTGGGATTACTGGAGCATATTGATGAGGAAGCTCTATGATAAAAATTCTACCCCCCCCCCC
CCCCCCCCGAAAAACCCCCA

Downstream 100 bases:

>100_bases
CTTCTTTAATAATTTTGAAGGTTTTCTGCTTCACGCGGGCGCGCTGCTTTTACCGCCTCCGCTCCCGCCGTGGAGGCAAT
CATGTTGAACCTGATCTCCG

Product: PAS/PAC sensor hybrid histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 604; Mature: 604

Protein sequence:

>604_residues
MILRQKAEERLLDKTIEADPSHTEMDSQRLIHELQVYQIELEMQVEELRQARDEEAMAREMYADLYDFAPVGYVTLDRDG
IIRNANLTGSVLLGVVRSQLIGQRLGVFVAVVSRPAFADFLEKVFTSPTKVACEVSLMKEGVPELFVQIEGVAVASGEEC
RIGLIDITEHKRAEEVLWMAKEATEAAILAKETAKALRLEKEISESLRREKEAAESATRAKDQFLANMSHELRTPMTGVL
GMLQLALEEELAPTLRNYLGTAHSSANSLLQILNDILDMTKIEAGKIIIEEMPFSPRRCVTGAVDIITPEVRRKGLDIAI
SVAEEVPDKLVGDQMRLRQVLINLIANAVKFTNEGKVAVQVTAGGTNSDGKREYTFAVTDTGIGIPEDKKDLLFHVFSQV
DASHTRTYGGTGLGLAICKELVELMGGMIDFDSKEGVGSTFYFTISLREAKSERNAPTAAEPLSPETFTAPKGERIPHLL
LAEDDPTIQQILEMMLTKSNYSLDIAKDGKQAVEMWEQGEYDLVLMDVQMPLLSGFDVTLAIRERERERGGHTPIVAMTA
HTGKEAEKKCIAAGMDHYISKPIDFNECLKLIGQIIGQKSSGNN

Sequences:

>Translated_604_residues
MILRQKAEERLLDKTIEADPSHTEMDSQRLIHELQVYQIELEMQVEELRQARDEEAMAREMYADLYDFAPVGYVTLDRDG
IIRNANLTGSVLLGVVRSQLIGQRLGVFVAVVSRPAFADFLEKVFTSPTKVACEVSLMKEGVPELFVQIEGVAVASGEEC
RIGLIDITEHKRAEEVLWMAKEATEAAILAKETAKALRLEKEISESLRREKEAAESATRAKDQFLANMSHELRTPMTGVL
GMLQLALEEELAPTLRNYLGTAHSSANSLLQILNDILDMTKIEAGKIIIEEMPFSPRRCVTGAVDIITPEVRRKGLDIAI
SVAEEVPDKLVGDQMRLRQVLINLIANAVKFTNEGKVAVQVTAGGTNSDGKREYTFAVTDTGIGIPEDKKDLLFHVFSQV
DASHTRTYGGTGLGLAICKELVELMGGMIDFDSKEGVGSTFYFTISLREAKSERNAPTAAEPLSPETFTAPKGERIPHLL
LAEDDPTIQQILEMMLTKSNYSLDIAKDGKQAVEMWEQGEYDLVLMDVQMPLLSGFDVTLAIRERERERGGHTPIVAMTA
HTGKEAEKKCIAAGMDHYISKPIDFNECLKLIGQIIGQKSSGNN
>Mature_604_residues
MILRQKAEERLLDKTIEADPSHTEMDSQRLIHELQVYQIELEMQVEELRQARDEEAMAREMYADLYDFAPVGYVTLDRDG
IIRNANLTGSVLLGVVRSQLIGQRLGVFVAVVSRPAFADFLEKVFTSPTKVACEVSLMKEGVPELFVQIEGVAVASGEEC
RIGLIDITEHKRAEEVLWMAKEATEAAILAKETAKALRLEKEISESLRREKEAAESATRAKDQFLANMSHELRTPMTGVL
GMLQLALEEELAPTLRNYLGTAHSSANSLLQILNDILDMTKIEAGKIIIEEMPFSPRRCVTGAVDIITPEVRRKGLDIAI
SVAEEVPDKLVGDQMRLRQVLINLIANAVKFTNEGKVAVQVTAGGTNSDGKREYTFAVTDTGIGIPEDKKDLLFHVFSQV
DASHTRTYGGTGLGLAICKELVELMGGMIDFDSKEGVGSTFYFTISLREAKSERNAPTAAEPLSPETFTAPKGERIPHLL
LAEDDPTIQQILEMMLTKSNYSLDIAKDGKQAVEMWEQGEYDLVLMDVQMPLLSGFDVTLAIRERERERGGHTPIVAMTA
HTGKEAEKKCIAAGMDHYISKPIDFNECLKLIGQIIGQKSSGNN

Specific function: Involved in the positive regulation of synthesis of extracellular enzymes and polysaccharide, and hence in pathogenicity. Can restore function to the non-pathogenic mutant 8237 [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI48994928, Length=388, Percent_Identity=37.1134020618557, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI1789149, Length=237, Percent_Identity=46.8354430379747, Blast_Score=228, Evalue=1e-60,
Organism=Escherichia coli, GI1788713, Length=386, Percent_Identity=32.3834196891192, Blast_Score=181, Evalue=2e-46,
Organism=Escherichia coli, GI87081816, Length=382, Percent_Identity=33.5078534031414, Blast_Score=181, Evalue=2e-46,
Organism=Escherichia coli, GI145693157, Length=251, Percent_Identity=41.0358565737052, Blast_Score=179, Evalue=5e-46,
Organism=Escherichia coli, GI1788393, Length=215, Percent_Identity=27.4418604651163, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1786912, Length=236, Percent_Identity=29.2372881355932, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1786600, Length=240, Percent_Identity=30.4166666666667, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI1790436, Length=248, Percent_Identity=25, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788549, Length=412, Percent_Identity=23.0582524271845, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1787894, Length=248, Percent_Identity=28.6290322580645, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1790346, Length=223, Percent_Identity=26.0089686098655, Blast_Score=67, Evalue=5e-12,
Organism=Escherichia coli, GI87082128, Length=228, Percent_Identity=25.8771929824561, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1786783, Length=243, Percent_Identity=25.1028806584362, Blast_Score=63, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=74, Percent_Identity=48.6486486486487, Blast_Score=78, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6323034, Length=179, Percent_Identity=29.0502793296089, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322000, Length=106, Percent_Identity=34.9056603773585, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 66798; Mature: 66798

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILRQKAEERLLDKTIEADPSHTEMDSQRLIHELQVYQIELEMQVEELRQARDEEAMARE
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHH
MYADLYDFAPVGYVTLDRDGIIRNANLTGSVLLGVVRSQLIGQRLGVFVAVVSRPAFADF
HHHHHHHCCCCCEEEECCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LEKVFTSPTKVACEVSLMKEGVPELFVQIEGVAVASGEECRIGLIDITEHKRAEEVLWMA
HHHHHCCCCHHHHHHHHHHCCHHHHHEEECCEEEECCCCCEEEEEECCCHHHHHHHHHHH
KEATEAAILAKETAKALRLEKEISESLRREKEAAESATRAKDQFLANMSHELRTPMTGVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
GMLQLALEEELAPTLRNYLGTAHSSANSLLQILNDILDMTKIEAGKIIIEEMPFSPRRCV
HHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHH
TGAVDIITPEVRRKGLDIAISVAEEVPDKLVGDQMRLRQVLINLIANAVKFTNEGKVAVQ
CCHHHHCCHHHHHCCCCEEEEEHHHCCHHHHCHHHHHHHHHHHHHHHHHHCCCCCCEEEE
VTAGGTNSDGKREYTFAVTDTGIGIPEDKKDLLFHVFSQVDASHTRTYGGTGLGLAICKE
EEECCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
LVELMGGMIDFDSKEGVGSTFYFTISLREAKSERNAPTAAEPLSPETFTAPKGERIPHLL
HHHHHCCCCCCCCCCCCCCEEEEEEEEHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEE
LAEDDPTIQQILEMMLTKSNYSLDIAKDGKQAVEMWEQGEYDLVLMDVQMPLLSGFDVTL
EECCCHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHCCCCCEEEEEECCHHHCCCCEEE
AIRERERERGGHTPIVAMTAHTGKEAEKKCIAAGMDHYISKPIDFNECLKLIGQIIGQKS
EEHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCC
SGNN
CCCC
>Mature Secondary Structure
MILRQKAEERLLDKTIEADPSHTEMDSQRLIHELQVYQIELEMQVEELRQARDEEAMARE
CCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHH
MYADLYDFAPVGYVTLDRDGIIRNANLTGSVLLGVVRSQLIGQRLGVFVAVVSRPAFADF
HHHHHHHCCCCCEEEECCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
LEKVFTSPTKVACEVSLMKEGVPELFVQIEGVAVASGEECRIGLIDITEHKRAEEVLWMA
HHHHHCCCCHHHHHHHHHHCCHHHHHEEECCEEEECCCCCEEEEEECCCHHHHHHHHHHH
KEATEAAILAKETAKALRLEKEISESLRREKEAAESATRAKDQFLANMSHELRTPMTGVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
GMLQLALEEELAPTLRNYLGTAHSSANSLLQILNDILDMTKIEAGKIIIEEMPFSPRRCV
HHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHH
TGAVDIITPEVRRKGLDIAISVAEEVPDKLVGDQMRLRQVLINLIANAVKFTNEGKVAVQ
CCHHHHCCHHHHHCCCCEEEEEHHHCCHHHHCHHHHHHHHHHHHHHHHHHCCCCCCEEEE
VTAGGTNSDGKREYTFAVTDTGIGIPEDKKDLLFHVFSQVDASHTRTYGGTGLGLAICKE
EEECCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
LVELMGGMIDFDSKEGVGSTFYFTISLREAKSERNAPTAAEPLSPETFTAPKGERIPHLL
HHHHHCCCCCCCCCCCCCCEEEEEEEEHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEE
LAEDDPTIQQILEMMLTKSNYSLDIAKDGKQAVEMWEQGEYDLVLMDVQMPLLSGFDVTL
EECCCHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHCCCCCEEEEEECCHHHCCCCEEE
AIRERERERGGHTPIVAMTAHTGKEAEKKCIAAGMDHYISKPIDFNECLKLIGQIIGQKS
EEHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCC
SGNN
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1645442 [H]