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The map label for this gene is atoC [H]

Identifier: 118580077

GI number: 118580077

Start: 1774055

End: 1775443

Strand: Direct

Name: atoC [H]

Synonym: Ppro_1655

Alternate gene names: 118580077

Gene position: 1774055-1775443 (Clockwise)

Preceding gene: 118580075

Following gene: 118580078

Centisome position: 44.26

GC content: 59.47

Gene sequence:

>1389_bases
ATGAAAACCAGAATCCTGATCGTCGATGATGAACTGAGCATGCGGGAGTTTCTCTCCATCCTGCTGGAGGGGGAGGGGTA
CGAGACGGTTGTTGCCGCCCATGCGGAACAGGCCCTGTCCCTTCTGGACAGCGGCCTGTTTGATCTGGTCATATCCGACG
TGCAGATGCCCGGGTTGGATGGCATCGAACTTCTGAGCCGCATCAAAACCGTTTCTCCCGGTACGGCCGTGCTGATGATG
ACCGCCTACTGCGCCGCCGAGCAGGCGGTGGAGGCCATGAAACTGGGCGCCTATGACTACATCTCCAAGCCGTTCAAGGT
GGAGGAGATCAAGGTGCTGATCCGCAACGCCCTGGAAAAATGCGACCTGAAGCGGGAGAACAGCGTACTCAAGGAGACGG
CCCAGCAGCGCGACAGTTTCTGTGGGATCATCGGCGCCAGCCCCAGGATGAAGGAGGTCTTTTCGCTGATCCAGAAGGTT
TCGCTGAGCAACAGTTCCGTAATGATCCAGGGGGAGAGCGGCACTGGCAAGGAACTGGTGGCCCGGGCCATCCACCACTG
CAGCTCGCGGGGGAAAAAGGCTTTCGTGGCGGTCAACTGCGGGGCCATTCCCGAGCAGCTCATGGAGAGCGAGCTGTTCG
GCCACAAGCGGGGCTCCTTCACCGGCGCCGTGGCGGACAGGGCCGGCCTGTTTGAACAGGCCGAGGGTGGTACGCTGTTT
CTGGATGAGATCGGCGAACTGCCGCTTCTGATGCAGACCAAGCTTTTGCGCGTGCTCCAGGAACGGGAATTCAGGCGGGT
GGGGGGCGCCCAGGTGCAGAAGTCGAATGTACGCATCCTGACGGCATCCAACCGCGACCTGCAGAGCCAGGTCAAGACGG
GCGGTTTCCGGGAGGATCTCTACTACCGCATCAACGTCATGCAGATCAGCATGCCGCCGCTTCGCGAGCGGATTGAAGAC
ATTCCGGTCCTGGTGGAGCATTTTTTTCGCAAATACGGTGATACGCGGCAGACCGGTGAGGTCATCACGCCGGGTGCGCT
CAAGGCGCTGATGAATTACCACTATCCGGGAAACATCCGCGAGTTGGAAAACATCGTCGAGCGCAGCCTGGTAATGGATG
CATCGAAAATCCAGGAGTGCAACCTGCCCAAGCAGGTCCGCACGGGGTTTTTGCCCTGTCCGGGAAGAGATGCGCTTATC
CCCGCGGAGGGGATGGACCTGGAGTCGTTCCTGTCCGGTCTGGAAAAACAGTACCTGGTGAAAGCGCTGGAGATGACCGG
TGGTGCCAAGAAAAAGGCCGGGGAACTCTTGGGGATGTCCTTTCGGTCATTCAGGTACCGTCTGGCCAAATTCGGGCTTG
ATTCCGGCGAGGGAGATCGGGATGAGTGA

Upstream 100 bases:

>100_bases
CGCGAAAGCGGTCAGCCATGCCATGATGCCTGTGCCAGGGGGATGTCGGCGGGCGAGCGGAGCGGAGAACACAGCTGGCA
AGAAATCCGCGGGAGTATCA

Downstream 100 bases:

>100_bases
CATAAATTGTCATAGGTAGTGACAATGCTTGGTAAGTGGAAAGGGCTTCGCTTCGGTGGGATACAAAAAATTCCTTGAAA
ATAAAGTGTTATAACTTTGC

Product: two component sigma54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MKTRILIVDDELSMREFLSILLEGEGYETVVAAHAEQALSLLDSGLFDLVISDVQMPGLDGIELLSRIKTVSPGTAVLMM
TAYCAAEQAVEAMKLGAYDYISKPFKVEEIKVLIRNALEKCDLKRENSVLKETAQQRDSFCGIIGASPRMKEVFSLIQKV
SLSNSSVMIQGESGTGKELVARAIHHCSSRGKKAFVAVNCGAIPEQLMESELFGHKRGSFTGAVADRAGLFEQAEGGTLF
LDEIGELPLLMQTKLLRVLQEREFRRVGGAQVQKSNVRILTASNRDLQSQVKTGGFREDLYYRINVMQISMPPLRERIED
IPVLVEHFFRKYGDTRQTGEVITPGALKALMNYHYPGNIRELENIVERSLVMDASKIQECNLPKQVRTGFLPCPGRDALI
PAEGMDLESFLSGLEKQYLVKALEMTGGAKKKAGELLGMSFRSFRYRLAKFGLDSGEGDRDE

Sequences:

>Translated_462_residues
MKTRILIVDDELSMREFLSILLEGEGYETVVAAHAEQALSLLDSGLFDLVISDVQMPGLDGIELLSRIKTVSPGTAVLMM
TAYCAAEQAVEAMKLGAYDYISKPFKVEEIKVLIRNALEKCDLKRENSVLKETAQQRDSFCGIIGASPRMKEVFSLIQKV
SLSNSSVMIQGESGTGKELVARAIHHCSSRGKKAFVAVNCGAIPEQLMESELFGHKRGSFTGAVADRAGLFEQAEGGTLF
LDEIGELPLLMQTKLLRVLQEREFRRVGGAQVQKSNVRILTASNRDLQSQVKTGGFREDLYYRINVMQISMPPLRERIED
IPVLVEHFFRKYGDTRQTGEVITPGALKALMNYHYPGNIRELENIVERSLVMDASKIQECNLPKQVRTGFLPCPGRDALI
PAEGMDLESFLSGLEKQYLVKALEMTGGAKKKAGELLGMSFRSFRYRLAKFGLDSGEGDRDE
>Mature_462_residues
MKTRILIVDDELSMREFLSILLEGEGYETVVAAHAEQALSLLDSGLFDLVISDVQMPGLDGIELLSRIKTVSPGTAVLMM
TAYCAAEQAVEAMKLGAYDYISKPFKVEEIKVLIRNALEKCDLKRENSVLKETAQQRDSFCGIIGASPRMKEVFSLIQKV
SLSNSSVMIQGESGTGKELVARAIHHCSSRGKKAFVAVNCGAIPEQLMESELFGHKRGSFTGAVADRAGLFEQAEGGTLF
LDEIGELPLLMQTKLLRVLQEREFRRVGGAQVQKSNVRILTASNRDLQSQVKTGGFREDLYYRINVMQISMPPLRERIED
IPVLVEHFFRKYGDTRQTGEVITPGALKALMNYHYPGNIRELENIVERSLVMDASKIQECNLPKQVRTGFLPCPGRDALI
PAEGMDLESFLSGLEKQYLVKALEMTGGAKKKAGELLGMSFRSFRYRLAKFGLDSGEGDRDE

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=457, Percent_Identity=43.9824945295405, Blast_Score=398, Evalue=1e-112,
Organism=Escherichia coli, GI1790437, Length=448, Percent_Identity=43.3035714285714, Blast_Score=368, Evalue=1e-103,
Organism=Escherichia coli, GI1790299, Length=473, Percent_Identity=39.9577167019027, Blast_Score=326, Evalue=2e-90,
Organism=Escherichia coli, GI1788905, Length=457, Percent_Identity=39.1684901531729, Blast_Score=318, Evalue=3e-88,
Organism=Escherichia coli, GI1789087, Length=364, Percent_Identity=41.7582417582418, Blast_Score=265, Evalue=5e-72,
Organism=Escherichia coli, GI87082117, Length=344, Percent_Identity=42.1511627906977, Blast_Score=261, Evalue=6e-71,
Organism=Escherichia coli, GI1789233, Length=321, Percent_Identity=40.809968847352, Blast_Score=233, Evalue=1e-62,
Organism=Escherichia coli, GI87082152, Length=232, Percent_Identity=48.7068965517241, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI1786524, Length=332, Percent_Identity=42.1686746987952, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI87081872, Length=320, Percent_Identity=39.375, Blast_Score=221, Evalue=1e-58,
Organism=Escherichia coli, GI1787583, Length=327, Percent_Identity=36.3914373088685, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI1789828, Length=262, Percent_Identity=33.587786259542, Blast_Score=139, Evalue=6e-34,
Organism=Escherichia coli, GI87081858, Length=323, Percent_Identity=27.8637770897833, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1786599, Length=123, Percent_Identity=32.520325203252, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789809, Length=117, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1787375, Length=107, Percent_Identity=30.8411214953271, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788394, Length=123, Percent_Identity=30.8943089430894, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1786784, Length=117, Percent_Identity=29.9145299145299, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1790863, Length=117, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1786911, Length=118, Percent_Identity=33.8983050847458, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790552, Length=127, Percent_Identity=30.7086614173228, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1788191, Length=121, Percent_Identity=35.5371900826446, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1787487, Length=103, Percent_Identity=36.8932038834951, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1789402, Length=126, Percent_Identity=27.7777777777778, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51260; Mature: 51260

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTRILIVDDELSMREFLSILLEGEGYETVVAAHAEQALSLLDSGLFDLVISDVQMPGLD
CCEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCC
GIELLSRIKTVSPGTAVLMMTAYCAAEQAVEAMKLGAYDYISKPFKVEEIKVLIRNALEK
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHH
CDLKRENSVLKETAQQRDSFCGIIGASPRMKEVFSLIQKVSLSNSSVMIQGESGTGKELV
CCCHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHH
ARAIHHCSSRGKKAFVAVNCGAIPEQLMESELFGHKRGSFTGAVADRAGLFEQAEGGTLF
HHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHCCHHCCCCCEEE
LDEIGELPLLMQTKLLRVLQEREFRRVGGAQVQKSNVRILTASNRDLQSQVKTGGFREDL
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCEEEEEECCCHHHHHHHCCCCCCCE
YYRINVMQISMPPLRERIEDIPVLVEHFFRKYGDTRQTGEVITPGALKALMNYHYPGNIR
EEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCHH
ELENIVERSLVMDASKIQECNLPKQVRTGFLPCPGRDALIPAEGMDLESFLSGLEKQYLV
HHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
KALEMTGGAKKKAGELLGMSFRSFRYRLAKFGLDSGEGDRDE
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKTRILIVDDELSMREFLSILLEGEGYETVVAAHAEQALSLLDSGLFDLVISDVQMPGLD
CCEEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCC
GIELLSRIKTVSPGTAVLMMTAYCAAEQAVEAMKLGAYDYISKPFKVEEIKVLIRNALEK
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHH
CDLKRENSVLKETAQQRDSFCGIIGASPRMKEVFSLIQKVSLSNSSVMIQGESGTGKELV
CCCHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCHHHH
ARAIHHCSSRGKKAFVAVNCGAIPEQLMESELFGHKRGSFTGAVADRAGLFEQAEGGTLF
HHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCHHHHHHHCCHHCCCCCEEE
LDEIGELPLLMQTKLLRVLQEREFRRVGGAQVQKSNVRILTASNRDLQSQVKTGGFREDL
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCEEEEEECCCHHHHHHHCCCCCCCE
YYRINVMQISMPPLRERIEDIPVLVEHFFRKYGDTRQTGEVITPGALKALMNYHYPGNIR
EEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCHH
ELENIVERSLVMDASKIQECNLPKQVRTGFLPCPGRDALIPAEGMDLESFLSGLEKQYLV
HHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
KALEMTGGAKKKAGELLGMSFRSFRYRLAKFGLDSGEGDRDE
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]