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The map label for this gene is rpfC [H]

Identifier: 118579861

GI number: 118579861

Start: 1535458

End: 1537815

Strand: Reverse

Name: rpfC [H]

Synonym: Ppro_1437

Alternate gene names: 118579861

Gene position: 1537815-1535458 (Counterclockwise)

Preceding gene: 118579862

Following gene: 118579859

Centisome position: 38.37

GC content: 62.38

Gene sequence:

>2358_bases
ATGCAGGAAACACGGCAGACAGCGCTTACCGCACCAACCACAAGGAGACGGATCGGTCACTTCAAGCCGAAACGGATCGT
GCTGCGCCTAACGCTGACCTTTTCGGCCCTGATCGTGATCACCCTGGGACTGTTCATCCTGGTCAACATGCCCTTCCAGC
GCAGGGCGACCCTGGAGGCCATGGAGTCCGAGGCAAGGAGCACGGTCACCTCCATCGACCAGGTCACCGCCAGCGCCATC
ATCACCGAGGATTTCGGCACGGTGGTGGAGCACTGCCTGCGGGTGGTCAGGGAAAGCCCCTCCATCAGCTATGTGGTGGT
GACCCGCAACGACGGTTTTTCCCTGGTGATCACCAAGACCGGCTGGAGCCAGAACAGCCTCAAGGGAGTATGGTTACCCA
CCGGTGAGCGCGTCGCCGGCAGCCGTTTCCTGAAAAGCGACTTTGCCCCCCATGAGGTGTACCACTACTCGCACCCCTTC
CAGTACTCCGGCATCGACTGGGGATGGATCCACATCGGACTTTCCCTGAACAAGTTCCACAGCGACATCAGGGCACTGTA
CCTGCGCACCGGCCTTTTGACCCTGCTCTGCCTCTCGGTGGGCATCGTCGTGGCGCTCTATTTTGCCCGCAAGATCACCA
AACCGATCTCAAGCCTGGTGGACACCACGAGACAGGTTGCCCTGGGGAACCTGACCGCGCGCGCCGACATCGGAACCGGC
GACGAACTGGAGCACCTGGGGCGCTCCTTCAACATCATGACGGAACAGCTGCAGCAAACCCAGGGCGATATGAGTGCCGC
CCGCGAGTACACCGACAACATCATCAGATCCATGAACGACGCCATGATCGTGGTTTCCCCCGAAGGCATCATCGATCGGG
TCAACACGGCCACACTCAACCTGCTGGGCTATGACGAAAGGGAGCTGATCGGGTCCAACATCGACAAGATTCTGGCGTCA
GACGCGGCAACGGGCGAGGGGGCAGCGCCTGTCCCCGATCTGGCCGGGTTGATCCCCCGGGGGTTTATCAACAAGGTGGA
AACCTTCTACCGGGCCAGGGACGGCCGCCTGATCCCGGTGATTTTCTCCGCATCGGTCATGCATGGCGCGGGAAAAAGCG
CTCAGGGCATCGTCTGCGTCGCCCTGGACATCACCGAACGAAAGCAGGCCGAGGAGGCGCTGCGCATCGCCAAGGAAAAT
GCCGAGGCCGCCAACCGGGCCAAGTCCCAGTTCCTGGCCAACATGAGTCACGAGATCCGCACCCCCATGAACGGCGTGCT
GGGGATGCTGGACCTGCTGATGGACTCCCGCCTGGACGAAAACCAGCTCAGGCTGGCCAGCATGGCCCACGGCTCGGCCG
ACAAACTGCTGGAGATCATCAACGACATCCTGGATTTCTCCAAGATCGAGGCGGGCCGCTTCCAGCTGCACATGGCCGAT
TTCGCACTGCGTGAGACGGTGCGCGAGGTGGCCGACATGTTCTGGGTAAAGGCCCAGGACAAAAACATCAGGCTGATCTG
CCAGATCGATGACAGCGTACCCAACACCGTCAGGGGAGATGGGGTCCGCCTGCGACAGGTACTGATCAACCTGGTGGGCA
ATGCGGTAAAATTCACCGAAAACGGCCAGATATTCCTGGGGGTCAGCCTGATGGAGACGACGGCCGAAAACACGCAGCTG
CGCTTCGAGGTGCGGGACACCGGCACCGGCATACCGCTGGACGCCCAGCCGTATATCTTCGATGCCTTTTCCCAGGCGGA
CAACTCCATGGCGCGACGCCACGAGGGAACCGGCCTCGGCTTGGCCATCTCCCGGGAACTGGTGGAGGCCATGGGAGGAA
CGATCGGCGTGCGGAGCGAGCCGGGCACCGGTTCCCTGTTCTGGTTCACCCTCTGTTTGCGACACGCCCAATCCATCCCC
GCCCTGCTGCCGGCCGACGACGCCATGGAGGAGAATAGCGAGCGCCCGGCAACGCAGCGCACCCCCTTGGTGCTGCTGGC
CGAGGACAACCCGGTCAACCAGGAGCTGGGCAGGCTGGTTCTGGAATCCCTGGGATGCAAGGTGGATGTGGTGGGGAATG
GCCGTCAGGCGGTGGAGGCTGTTTCCGACAGGGAGTACGACCTGGTGTTCATGGACTGCCAGATGCCCGAGGTCGACGGA
TACGAGGCGACCAGGAGCATCAGGCAGCGTGAGGCTGAAACGGGCGAGCAAACGCGGCACATTCCCGTCATCGCTCTGAC
CGCCCACGCCATGGACGGGGACCGGGAAACCTGCCTGAGCGCCGGCATGGATGACTACGCCTCCAAGCCCTTCACCCCGA
TCCAGCTCCAGGCGCTGCTCAACCGCTGGTGCCGCTGA

Upstream 100 bases:

>100_bases
CTGATGAAAACCGGCAAGGGTGGGCGTGCCGGTTTCTTTCGCCAGGTCAAAGCGTCGCCCAAGATATCAGAAAAAAACAT
CCAAGAGGAAATAAGCGGAT

Downstream 100 bases:

>100_bases
GCAGGAAGGGCCGGCAGCCCTATCCCCCGGTCATGGGCGCCGTAAAGGGGCCGAGGATGGAATAGGCCTCCATGCGGGAG
TACCTTCCGTTGCCGTCCTG

Product: multi-sensor hybrid histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 785; Mature: 785

Protein sequence:

>785_residues
MQETRQTALTAPTTRRRIGHFKPKRIVLRLTLTFSALIVITLGLFILVNMPFQRRATLEAMESEARSTVTSIDQVTASAI
ITEDFGTVVEHCLRVVRESPSISYVVVTRNDGFSLVITKTGWSQNSLKGVWLPTGERVAGSRFLKSDFAPHEVYHYSHPF
QYSGIDWGWIHIGLSLNKFHSDIRALYLRTGLLTLLCLSVGIVVALYFARKITKPISSLVDTTRQVALGNLTARADIGTG
DELEHLGRSFNIMTEQLQQTQGDMSAAREYTDNIIRSMNDAMIVVSPEGIIDRVNTATLNLLGYDERELIGSNIDKILAS
DAATGEGAAPVPDLAGLIPRGFINKVETFYRARDGRLIPVIFSASVMHGAGKSAQGIVCVALDITERKQAEEALRIAKEN
AEAANRAKSQFLANMSHEIRTPMNGVLGMLDLLMDSRLDENQLRLASMAHGSADKLLEIINDILDFSKIEAGRFQLHMAD
FALRETVREVADMFWVKAQDKNIRLICQIDDSVPNTVRGDGVRLRQVLINLVGNAVKFTENGQIFLGVSLMETTAENTQL
RFEVRDTGTGIPLDAQPYIFDAFSQADNSMARRHEGTGLGLAISRELVEAMGGTIGVRSEPGTGSLFWFTLCLRHAQSIP
ALLPADDAMEENSERPATQRTPLVLLAEDNPVNQELGRLVLESLGCKVDVVGNGRQAVEAVSDREYDLVFMDCQMPEVDG
YEATRSIRQREAETGEQTRHIPVIALTAHAMDGDRETCLSAGMDDYASKPFTPIQLQALLNRWCR

Sequences:

>Translated_785_residues
MQETRQTALTAPTTRRRIGHFKPKRIVLRLTLTFSALIVITLGLFILVNMPFQRRATLEAMESEARSTVTSIDQVTASAI
ITEDFGTVVEHCLRVVRESPSISYVVVTRNDGFSLVITKTGWSQNSLKGVWLPTGERVAGSRFLKSDFAPHEVYHYSHPF
QYSGIDWGWIHIGLSLNKFHSDIRALYLRTGLLTLLCLSVGIVVALYFARKITKPISSLVDTTRQVALGNLTARADIGTG
DELEHLGRSFNIMTEQLQQTQGDMSAAREYTDNIIRSMNDAMIVVSPEGIIDRVNTATLNLLGYDERELIGSNIDKILAS
DAATGEGAAPVPDLAGLIPRGFINKVETFYRARDGRLIPVIFSASVMHGAGKSAQGIVCVALDITERKQAEEALRIAKEN
AEAANRAKSQFLANMSHEIRTPMNGVLGMLDLLMDSRLDENQLRLASMAHGSADKLLEIINDILDFSKIEAGRFQLHMAD
FALRETVREVADMFWVKAQDKNIRLICQIDDSVPNTVRGDGVRLRQVLINLVGNAVKFTENGQIFLGVSLMETTAENTQL
RFEVRDTGTGIPLDAQPYIFDAFSQADNSMARRHEGTGLGLAISRELVEAMGGTIGVRSEPGTGSLFWFTLCLRHAQSIP
ALLPADDAMEENSERPATQRTPLVLLAEDNPVNQELGRLVLESLGCKVDVVGNGRQAVEAVSDREYDLVFMDCQMPEVDG
YEATRSIRQREAETGEQTRHIPVIALTAHAMDGDRETCLSAGMDDYASKPFTPIQLQALLNRWCR
>Mature_785_residues
MQETRQTALTAPTTRRRIGHFKPKRIVLRLTLTFSALIVITLGLFILVNMPFQRRATLEAMESEARSTVTSIDQVTASAI
ITEDFGTVVEHCLRVVRESPSISYVVVTRNDGFSLVITKTGWSQNSLKGVWLPTGERVAGSRFLKSDFAPHEVYHYSHPF
QYSGIDWGWIHIGLSLNKFHSDIRALYLRTGLLTLLCLSVGIVVALYFARKITKPISSLVDTTRQVALGNLTARADIGTG
DELEHLGRSFNIMTEQLQQTQGDMSAAREYTDNIIRSMNDAMIVVSPEGIIDRVNTATLNLLGYDERELIGSNIDKILAS
DAATGEGAAPVPDLAGLIPRGFINKVETFYRARDGRLIPVIFSASVMHGAGKSAQGIVCVALDITERKQAEEALRIAKEN
AEAANRAKSQFLANMSHEIRTPMNGVLGMLDLLMDSRLDENQLRLASMAHGSADKLLEIINDILDFSKIEAGRFQLHMAD
FALRETVREVADMFWVKAQDKNIRLICQIDDSVPNTVRGDGVRLRQVLINLVGNAVKFTENGQIFLGVSLMETTAENTQL
RFEVRDTGTGIPLDAQPYIFDAFSQADNSMARRHEGTGLGLAISRELVEAMGGTIGVRSEPGTGSLFWFTLCLRHAQSIP
ALLPADDAMEENSERPATQRTPLVLLAEDNPVNQELGRLVLESLGCKVDVVGNGRQAVEAVSDREYDLVFMDCQMPEVDG
YEATRSIRQREAETGEQTRHIPVIALTAHAMDGDRETCLSAGMDDYASKPFTPIQLQALLNRWCR

Specific function: Involved in the positive regulation of synthesis of extracellular enzymes and polysaccharide, and hence in pathogenicity. Can restore function to the non-pathogenic mutant 8237 [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI48994928, Length=545, Percent_Identity=32.4770642201835, Blast_Score=242, Evalue=8e-65,
Organism=Escherichia coli, GI1788713, Length=397, Percent_Identity=36.0201511335013, Blast_Score=225, Evalue=1e-59,
Organism=Escherichia coli, GI1789149, Length=393, Percent_Identity=37.9134860050891, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI145693157, Length=273, Percent_Identity=40.2930402930403, Blast_Score=197, Evalue=3e-51,
Organism=Escherichia coli, GI87081816, Length=361, Percent_Identity=35.1800554016621, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI1788549, Length=481, Percent_Identity=24.1164241164241, Blast_Score=109, Evalue=8e-25,
Organism=Escherichia coli, GI1786912, Length=260, Percent_Identity=30.7692307692308, Blast_Score=98, Evalue=3e-21,
Organism=Escherichia coli, GI1786783, Length=242, Percent_Identity=29.7520661157025, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1786600, Length=399, Percent_Identity=26.0651629072682, Blast_Score=83, Evalue=7e-17,
Organism=Escherichia coli, GI1790436, Length=222, Percent_Identity=28.8288288288288, Blast_Score=79, Evalue=2e-15,
Organism=Escherichia coli, GI1788393, Length=223, Percent_Identity=26.457399103139, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1790300, Length=358, Percent_Identity=25.6983240223464, Blast_Score=74, Evalue=4e-14,
Organism=Escherichia coli, GI87082128, Length=224, Percent_Identity=27.6785714285714, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1786911, Length=117, Percent_Identity=35.042735042735, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1787894, Length=249, Percent_Identity=26.5060240963855, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI87082012, Length=115, Percent_Identity=34.7826086956522, Blast_Score=64, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=122, Percent_Identity=39.344262295082, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6322044, Length=198, Percent_Identity=29.2929292929293, Blast_Score=84, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 86751; Mature: 86751

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS50885 HAMP ; PS50112 PAS ; PS50113 PAC ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQETRQTALTAPTTRRRIGHFKPKRIVLRLTLTFSALIVITLGLFILVNMPFQRRATLEA
CCCHHHHHHCCCHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
MESEARSTVTSIDQVTASAIITEDFGTVVEHCLRVVRESPSISYVVVTRNDGFSLVITKT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEEEEC
GWSQNSLKGVWLPTGERVAGSRFLKSDFAPHEVYHYSHPFQYSGIDWGWIHIGLSLNKFH
CCCCCCCCEEECCCCCCHHHHHHHHCCCCCCHHEECCCCCEECCCCEEEEEEECCHHHHH
SDIRALYLRTGLLTLLCLSVGIVVALYFARKITKPISSLVDTTRQVALGNLTARADIGTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCC
DELEHLGRSFNIMTEQLQQTQGDMSAAREYTDNIIRSMNDAMIVVSPEGIIDRVNTATLN
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHCCCCEEEE
LLGYDERELIGSNIDKILASDAATGEGAAPVPDLAGLIPRGFINKVETFYRARDGRLIPV
EECCCHHHHHHCCHHHHHHCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHCCCCEEEE
IFSASVMHGAGKSAQGIVCVALDITERKQAEEALRIAKENAEAANRAKSQFLANMSHEIR
EEEHHHHHCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TPMNGVLGMLDLLMDSRLDENQLRLASMAHGSADKLLEIINDILDFSKIEAGRFQLHMAD
CCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEHHH
FALRETVREVADMFWVKAQDKNIRLICQIDDSVPNTVRGDGVRLRQVLINLVGNAVKFTE
HHHHHHHHHHHHHHEEEECCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCEEEEC
NGQIFLGVSLMETTAENTQLRFEVRDTGTGIPLDAQPYIFDAFSQADNSMARRHEGTGLG
CCCEEEEEEHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
LAISRELVEAMGGTIGVRSEPGTGSLFWFTLCLRHAQSIPALLPADDAMEENSERPATQR
HHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCC
TPLVLLAEDNPVNQELGRLVLESLGCKVDVVGNGRQAVEAVSDREYDLVFMDCQMPEVDG
CCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHCCCCEEEEEEECCCCCCCC
YEATRSIRQREAETGEQTRHIPVIALTAHAMDGDRETCLSAGMDDYASKPFTPIQLQALL
HHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCHHHHHHCCCHHHHCCCCCHHHHHHHH
NRWCR
HHHCC
>Mature Secondary Structure
MQETRQTALTAPTTRRRIGHFKPKRIVLRLTLTFSALIVITLGLFILVNMPFQRRATLEA
CCCHHHHHHCCCHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
MESEARSTVTSIDQVTASAIITEDFGTVVEHCLRVVRESPSISYVVVTRNDGFSLVITKT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEEEEC
GWSQNSLKGVWLPTGERVAGSRFLKSDFAPHEVYHYSHPFQYSGIDWGWIHIGLSLNKFH
CCCCCCCCEEECCCCCCHHHHHHHHCCCCCCHHEECCCCCEECCCCEEEEEEECCHHHHH
SDIRALYLRTGLLTLLCLSVGIVVALYFARKITKPISSLVDTTRQVALGNLTARADIGTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCC
DELEHLGRSFNIMTEQLQQTQGDMSAAREYTDNIIRSMNDAMIVVSPEGIIDRVNTATLN
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHCCCCEEEE
LLGYDERELIGSNIDKILASDAATGEGAAPVPDLAGLIPRGFINKVETFYRARDGRLIPV
EECCCHHHHHHCCHHHHHHCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHCCCCEEEE
IFSASVMHGAGKSAQGIVCVALDITERKQAEEALRIAKENAEAANRAKSQFLANMSHEIR
EEEHHHHHCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TPMNGVLGMLDLLMDSRLDENQLRLASMAHGSADKLLEIINDILDFSKIEAGRFQLHMAD
CCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEHHH
FALRETVREVADMFWVKAQDKNIRLICQIDDSVPNTVRGDGVRLRQVLINLVGNAVKFTE
HHHHHHHHHHHHHHEEEECCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCEEEEC
NGQIFLGVSLMETTAENTQLRFEVRDTGTGIPLDAQPYIFDAFSQADNSMARRHEGTGLG
CCCEEEEEEHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
LAISRELVEAMGGTIGVRSEPGTGSLFWFTLCLRHAQSIPALLPADDAMEENSERPATQR
HHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCC
TPLVLLAEDNPVNQELGRLVLESLGCKVDVVGNGRQAVEAVSDREYDLVFMDCQMPEVDG
CCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHCCCCEEEEEEECCCCCCCC
YEATRSIRQREAETGEQTRHIPVIALTAHAMDGDRETCLSAGMDDYASKPFTPIQLQALL
HHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCHHHHHHCCCHHHHCCCCCHHHHHHHH
NRWCR
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1645442 [H]