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The map label for this gene is hmuU [H]

Identifier: 118579643

GI number: 118579643

Start: 1267351

End: 1268379

Strand: Direct

Name: hmuU [H]

Synonym: Ppro_1214

Alternate gene names: 118579643

Gene position: 1267351-1268379 (Clockwise)

Preceding gene: 118579642

Following gene: 118579644

Centisome position: 31.62

GC content: 58.11

Gene sequence:

>1029_bases
ATGGTGAAAAAGGACTATTTCATAATCGCACTCCTGATGGCCCTGGTTGTTGCCGGTGGTCTGCTCTCCCTCTCGTCGGG
CTCATGGTCGATTCCTGCCTCCCATGTGGTCATGATCGTTTTGTCAAAATTGGGGCTGTACGCCGGCGCCATCAGTGACG
TGGAGGCTTCCATTGTCTGGGACGGCCGGCTTCCGCGCTTTCTGGTCGCCTTTCTGGTGGGCTTTTCCCTTGGCGGAGCA
GGTACGATCATGCAGGGGATATTCAAGAATCCCATGGCCAGTCCCGGAGTCATGGGCATCGACGCAGGTGCGGCGCTGGG
CGCCGTGCTGGCCATTTACCTGGGGCTTGCATCGTACTCGCTGGTGGCGCTCCCCTGCGCGGCGATCGTTTTTTCCCTGC
TCACCCTGGTCATGGTCTTCGCCATCGCCACATCAGGAGGGCGGACGTCGGTTTCAACGCTGCTGCTGGCGGGCATTGCC
CTCAGCCTGGTGTTCGGCGCCCTCACATCATTTGTCATTACCCTGAGCACCGCGGAGTTCGACGTTGGGCGGGTGATCGT
GAACTGGCTCATGGGTGACCTTAACAACCGCTCCTGGGAGCACGTTGCCATCGTCATTCCGACCACTCTTGTCGCACTCC
TGGGAACCCTCTTTTTTGCCCGGGACCTTAACCTTCTCATGCTCGGAGAAGAAACCGCGGCAAACCTGGGAGTCAACATA
CGACGCGCCCGCAATGGTCTTTTGCTCTTTTCCTCCATCGAAACCGGCGGAGCCATCGCGGTGTCGGGGGTCATCGGCTT
TGTCGGGCTGGTGGCGCCGCATATCATGCGTAGCCTCACCGGACCGGACAACCGGAAGCTGATATTCTCTTCCGGGCTGC
TGGCGGCGGTTTTCATTATCTACGCCGATCTTTTTGTGCGGCTGATCGTAACGGTGGACCTGAAGGTGGGGATCATCACC
TCCATGCTCGGCGGCCCGTTTTTTCTCTATCTGATCGTAAAGCACAGAAAACAGTTTGAATACATGTGA

Upstream 100 bases:

>100_bases
TGACGTCCCCGGCGTGTATCTGCGGGCTTCATCCCAATACATGCTTCTCAGCGCCGATCTGATCGCGGGGATCATCTACC
GGCAGCCCCGCTAATCCGTC

Downstream 100 bases:

>100_bases
ATAAGCCAGCCTGGGGCCAGGCCATGGATTCCACTACCTATCGTTGCAGTACATGGGAACGCACATGCAGGAACCAATCG
CAGACGGCGCAAGCACGGCG

Product: transport system permease

Products: ADP; phosphate; iron dicitrate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MVKKDYFIIALLMALVVAGGLLSLSSGSWSIPASHVVMIVLSKLGLYAGAISDVEASIVWDGRLPRFLVAFLVGFSLGGA
GTIMQGIFKNPMASPGVMGIDAGAALGAVLAIYLGLASYSLVALPCAAIVFSLLTLVMVFAIATSGGRTSVSTLLLAGIA
LSLVFGALTSFVITLSTAEFDVGRVIVNWLMGDLNNRSWEHVAIVIPTTLVALLGTLFFARDLNLLMLGEETAANLGVNI
RRARNGLLLFSSIETGGAIAVSGVIGFVGLVAPHIMRSLTGPDNRKLIFSSGLLAAVFIIYADLFVRLIVTVDLKVGIIT
SMLGGPFFLYLIVKHRKQFEYM

Sequences:

>Translated_342_residues
MVKKDYFIIALLMALVVAGGLLSLSSGSWSIPASHVVMIVLSKLGLYAGAISDVEASIVWDGRLPRFLVAFLVGFSLGGA
GTIMQGIFKNPMASPGVMGIDAGAALGAVLAIYLGLASYSLVALPCAAIVFSLLTLVMVFAIATSGGRTSVSTLLLAGIA
LSLVFGALTSFVITLSTAEFDVGRVIVNWLMGDLNNRSWEHVAIVIPTTLVALLGTLFFARDLNLLMLGEETAANLGVNI
RRARNGLLLFSSIETGGAIAVSGVIGFVGLVAPHIMRSLTGPDNRKLIFSSGLLAAVFIIYADLFVRLIVTVDLKVGIIT
SMLGGPFFLYLIVKHRKQFEYM
>Mature_342_residues
MVKKDYFIIALLMALVVAGGLLSLSSGSWSIPASHVVMIVLSKLGLYAGAISDVEASIVWDGRLPRFLVAFLVGFSLGGA
GTIMQGIFKNPMASPGVMGIDAGAALGAVLAIYLGLASYSLVALPCAAIVFSLLTLVMVFAIATSGGRTSVSTLLLAGIA
LSLVFGALTSFVITLSTAEFDVGRVIVNWLMGDLNNRSWEHVAIVIPTTLVALLGTLFFARDLNLLMLGEETAANLGVNI
RRARNGLLLFSSIETGGAIAVSGVIGFVGLVAPHIMRSLTGPDNRKLIFSSGLLAAVFIIYADLFVRLIVTVDLKVGIIT
SMLGGPFFLYLIVKHRKQFEYM

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790740, Length=277, Percent_Identity=37.5451263537906, Blast_Score=156, Evalue=1e-39,
Organism=Escherichia coli, GI1788004, Length=277, Percent_Identity=35.0180505415162, Blast_Score=134, Evalue=6e-33,
Organism=Escherichia coli, GI1786805, Length=315, Percent_Identity=33.6507936507937, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1790741, Length=298, Percent_Identity=36.5771812080537, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1786804, Length=331, Percent_Identity=29.0030211480363, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1786347, Length=276, Percent_Identity=31.1594202898551, Blast_Score=97, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 36044; Mature: 36044

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKKDYFIIALLMALVVAGGLLSLSSGSWSIPASHVVMIVLSKLGLYAGAISDVEASIVW
CCCCHHHHHHHHHHHHHHCCHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEE
DGRLPRFLVAFLVGFSLGGAGTIMQGIFKNPMASPGVMGIDAGAALGAVLAIYLGLASYS
CCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHH
LVALPCAAIVFSLLTLVMVFAIATSGGRTSVSTLLLAGIALSLVFGALTSFVITLSTAEF
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
DVGRVIVNWLMGDLNNRSWEHVAIVIPTTLVALLGTLFFARDLNLLMLGEETAANLGVNI
HHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCEEEECCHHHHHCCCEE
RRARNGLLLFSSIETGGAIAVSGVIGFVGLVAPHIMRSLTGPDNRKLIFSSGLLAAVFII
EECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHH
YADLFVRLIVTVDLKVGIITSMLGGPFFLYLIVKHRKQFEYM
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVKKDYFIIALLMALVVAGGLLSLSSGSWSIPASHVVMIVLSKLGLYAGAISDVEASIVW
CCCCHHHHHHHHHHHHHHCCHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEE
DGRLPRFLVAFLVGFSLGGAGTIMQGIFKNPMASPGVMGIDAGAALGAVLAIYLGLASYS
CCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHH
LVALPCAAIVFSLLTLVMVFAIATSGGRTSVSTLLLAGIALSLVFGALTSFVITLSTAEF
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
DVGRVIVNWLMGDLNNRSWEHVAIVIPTTLVALLGTLFFARDLNLLMLGEETAANLGVNI
HHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCEEEECCHHHHHCCCEE
RRARNGLLLFSSIETGGAIAVSGVIGFVGLVAPHIMRSLTGPDNRKLIFSSGLLAAVFII
EECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHH
YADLFVRLIVTVDLKVGIITSMLGGPFFLYLIVKHRKQFEYM
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron dicitrate [Periplasm]; H2O [C]

Specific reaction: ATP + iron dicitrate [Periplasm] + H2O = ADP + phosphate + iron dicitrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]