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The map label for this gene is atoC [H]

Identifier: 118579609

GI number: 118579609

Start: 1231237

End: 1232610

Strand: Direct

Name: atoC [H]

Synonym: Ppro_1179

Alternate gene names: 118579609

Gene position: 1231237-1232610 (Clockwise)

Preceding gene: 118579608

Following gene: 118579619

Centisome position: 30.72

GC content: 61.28

Gene sequence:

>1374_bases
ATGACGGATGAAACACGCATACTGGTGGTTGACGACGATGATTCGGGACGCGAGGCGCTGGAGCTTTTGCTCAGGTCCGG
CGGCTATACCGTCATGGGTGCCGCCACCGGTGAGGAGGCCCTGGCCGCCCTGGAACGTGAGAGCTTCCACCTGTTGGTGC
TGGACCTGTTCCTACCGGACACGAGCGGTATCGAAATCCTTCAGGTTACGCGCCGCAAGTACCCAACCACGGAGGTGATC
GTGGTGACCGGCTACGCCTCGGCCGAGACCGCGGTGAGCGCCATGAAAGAGGGGGCCTTCGACTATATCACCAAGCCGGT
CAACTTCGAGGAGTTGCGGATCGTCGTCAGGAAGGCCCTGGAGAAGCAGCAGCTGTTGTCGGAGAACGTGTATCTGCGCC
GGCAGTTGGAGGAACGTTTCGAGTTCAGCAACATCATCGGCTCGTCACCGGCAATGAAGATTGTCTTCGAGCGCATGGCG
CGCATCGTGAAGACCGACTCCACGGTGCTGATAACCGGAGAATCCGGGACAGGCAAGGAACTGGTGGCCAGGGCGCTGCA
CTTCAACGGTCCGCGCAAGCAGAAGGCGTTCATCGCCGTCAACTGCAGTGCCATTCCGGAAACGCTGATGGAGAGCGAAC
TGTTCGGCCATGTGCGCGGCTCGTTTACCGGCGCGGTCAAGGACAAACCCGGAAAGTTCGAGGCGGCCAACCACGGCACC
ATCTTCCTGGACGAGATCGGCACCATGCCCCAGCACCTGCAGACAAAGTTGCTGCGGGTGCTCCAGGAGCAGGAACTGCA
GCGGGTCGGCTCCAACAGCTCCATAAAACTGGATGTGCGGGTCATATCGGCCACCAACCTGGACCTGGAGCAGCAGGTGC
GCCAGGGGCTCTTCCGCGATGACCTGTTCTATCGCCTGAACGTGATTCCTCTGCACCTCCCGCCGCTGCGCGAGCGCAAG
CAGGACATCCGGGCGCTGGTGGGGGCGTTTCTGGAGAAGTACTGTCGGCTCATGGGGCGGCCGTTGATGACCATCAGCAG
GAAGGCGCTGGAGGCGCTGGAGCAGCACTCCTGGCCCGGGAACGTGCGTGAACTGGAGAATCTGGTGGAACGTCTGGTGG
CTCTGACTGAAGGTGAGGTGATCCGGCTGGAGGACCTGCCGCCTGGAGTCTGTGGACAGGGGGCGCTGCCGGGTGCATTC
TCCCTGGAGCTGACAGCCAGCGGCATGGATATGGTCGAAACCATCGCGCTGATCGAGCGCAAGTTGATTGGTCAGGCTTT
GGAACTCTCCGGCGGGGTCAAGGCCAAGGCATCGCACTTGTTGGGGATCAACCGGACAACGCTGGTGGAGAAGATGAAAC
GGCTGAAGATGTGA

Upstream 100 bases:

>100_bases
TCGATACGCTGTCCGCCAGGGAGGACGTGCATTTTGCGGTTGCATTTGGCGGCGATTGGAGATTATATGACTTTTATAAT
GTGCTGAACGGGATGACGAT

Downstream 100 bases:

>100_bases
ACCGGAACCGGTTCAGGATCAGCTCTTCTGCTGTCGCTTGATGCGGAATGTGGCCCTGAAGGTGGCGACTCTGATTCCCT
CCTCGGTGCTGAGCTCCACC

Product: two component sigma54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MTDETRILVVDDDDSGREALELLLRSGGYTVMGAATGEEALAALERESFHLLVLDLFLPDTSGIEILQVTRRKYPTTEVI
VVTGYASAETAVSAMKEGAFDYITKPVNFEELRIVVRKALEKQQLLSENVYLRRQLEERFEFSNIIGSSPAMKIVFERMA
RIVKTDSTVLITGESGTGKELVARALHFNGPRKQKAFIAVNCSAIPETLMESELFGHVRGSFTGAVKDKPGKFEAANHGT
IFLDEIGTMPQHLQTKLLRVLQEQELQRVGSNSSIKLDVRVISATNLDLEQQVRQGLFRDDLFYRLNVIPLHLPPLRERK
QDIRALVGAFLEKYCRLMGRPLMTISRKALEALEQHSWPGNVRELENLVERLVALTEGEVIRLEDLPPGVCGQGALPGAF
SLELTASGMDMVETIALIERKLIGQALELSGGVKAKASHLLGINRTTLVEKMKRLKM

Sequences:

>Translated_457_residues
MTDETRILVVDDDDSGREALELLLRSGGYTVMGAATGEEALAALERESFHLLVLDLFLPDTSGIEILQVTRRKYPTTEVI
VVTGYASAETAVSAMKEGAFDYITKPVNFEELRIVVRKALEKQQLLSENVYLRRQLEERFEFSNIIGSSPAMKIVFERMA
RIVKTDSTVLITGESGTGKELVARALHFNGPRKQKAFIAVNCSAIPETLMESELFGHVRGSFTGAVKDKPGKFEAANHGT
IFLDEIGTMPQHLQTKLLRVLQEQELQRVGSNSSIKLDVRVISATNLDLEQQVRQGLFRDDLFYRLNVIPLHLPPLRERK
QDIRALVGAFLEKYCRLMGRPLMTISRKALEALEQHSWPGNVRELENLVERLVALTEGEVIRLEDLPPGVCGQGALPGAF
SLELTASGMDMVETIALIERKLIGQALELSGGVKAKASHLLGINRTTLVEKMKRLKM
>Mature_456_residues
TDETRILVVDDDDSGREALELLLRSGGYTVMGAATGEEALAALERESFHLLVLDLFLPDTSGIEILQVTRRKYPTTEVIV
VTGYASAETAVSAMKEGAFDYITKPVNFEELRIVVRKALEKQQLLSENVYLRRQLEERFEFSNIIGSSPAMKIVFERMAR
IVKTDSTVLITGESGTGKELVARALHFNGPRKQKAFIAVNCSAIPETLMESELFGHVRGSFTGAVKDKPGKFEAANHGTI
FLDEIGTMPQHLQTKLLRVLQEQELQRVGSNSSIKLDVRVISATNLDLEQQVRQGLFRDDLFYRLNVIPLHLPPLRERKQ
DIRALVGAFLEKYCRLMGRPLMTISRKALEALEQHSWPGNVRELENLVERLVALTEGEVIRLEDLPPGVCGQGALPGAFS
LELTASGMDMVETIALIERKLIGQALELSGGVKAKASHLLGINRTTLVEKMKRLKM

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=457, Percent_Identity=43.1072210065646, Blast_Score=382, Evalue=1e-107,
Organism=Escherichia coli, GI1790437, Length=452, Percent_Identity=41.3716814159292, Blast_Score=345, Evalue=4e-96,
Organism=Escherichia coli, GI1790299, Length=469, Percent_Identity=40.724946695096, Blast_Score=335, Evalue=3e-93,
Organism=Escherichia coli, GI1788905, Length=449, Percent_Identity=39.4209354120267, Blast_Score=301, Evalue=6e-83,
Organism=Escherichia coli, GI1789087, Length=338, Percent_Identity=48.2248520710059, Blast_Score=291, Evalue=8e-80,
Organism=Escherichia coli, GI87082117, Length=343, Percent_Identity=46.064139941691, Blast_Score=281, Evalue=5e-77,
Organism=Escherichia coli, GI1789233, Length=319, Percent_Identity=45.7680250783699, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI87082152, Length=235, Percent_Identity=50.2127659574468, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1786524, Length=458, Percent_Identity=37.9912663755458, Blast_Score=235, Evalue=4e-63,
Organism=Escherichia coli, GI87081872, Length=310, Percent_Identity=39.6774193548387, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI1787583, Length=317, Percent_Identity=37.5394321766561, Blast_Score=209, Evalue=4e-55,
Organism=Escherichia coli, GI87081858, Length=318, Percent_Identity=32.7044025157233, Blast_Score=141, Evalue=9e-35,
Organism=Escherichia coli, GI1789828, Length=280, Percent_Identity=33.5714285714286, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1789809, Length=123, Percent_Identity=39.0243902439024, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI87082012, Length=125, Percent_Identity=31.2, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790552, Length=119, Percent_Identity=32.7731092436975, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50851; Mature: 50720

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDETRILVVDDDDSGREALELLLRSGGYTVMGAATGEEALAALERESFHLLVLDLFLPD
CCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCCEEEEEEEEECCC
TSGIEILQVTRRKYPTTEVIVVTGYASAETAVSAMKEGAFDYITKPVNFEELRIVVRKAL
CCCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHH
EKQQLLSENVYLRRQLEERFEFSNIIGSSPAMKIVFERMARIVKTDSTVLITGESGTGKE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHH
LVARALHFNGPRKQKAFIAVNCSAIPETLMESELFGHVRGSFTGAVKDKPGKFEAANHGT
HHHHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCEEECCCCCCCCEECCCCCE
IFLDEIGTMPQHLQTKLLRVLQEQELQRVGSNSSIKLDVRVISATNLDLEQQVRQGLFRD
EEEHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCHHHHHHHCHHHC
DLFYRLNVIPLHLPPLRERKQDIRALVGAFLEKYCRLMGRPLMTISRKALEALEQHSWPG
CCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCC
NVRELENLVERLVALTEGEVIRLEDLPPGVCGQGALPGAFSLELTASGMDMVETIALIER
CHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHH
KLIGQALELSGGVKAKASHLLGINRTTLVEKMKRLKM
HHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TDETRILVVDDDDSGREALELLLRSGGYTVMGAATGEEALAALERESFHLLVLDLFLPD
CCCCEEEEEECCCCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCCEEEEEEEEECCC
TSGIEILQVTRRKYPTTEVIVVTGYASAETAVSAMKEGAFDYITKPVNFEELRIVVRKAL
CCCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHH
EKQQLLSENVYLRRQLEERFEFSNIIGSSPAMKIVFERMARIVKTDSTVLITGESGTGKE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHH
LVARALHFNGPRKQKAFIAVNCSAIPETLMESELFGHVRGSFTGAVKDKPGKFEAANHGT
HHHHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCEEECCCCCCCCEECCCCCE
IFLDEIGTMPQHLQTKLLRVLQEQELQRVGSNSSIKLDVRVISATNLDLEQQVRQGLFRD
EEEHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCHHHHHHHCHHHC
DLFYRLNVIPLHLPPLRERKQDIRALVGAFLEKYCRLMGRPLMTISRKALEALEQHSWPG
CCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCC
NVRELENLVERLVALTEGEVIRLEDLPPGVCGQGALPGAFSLELTASGMDMVETIALIER
CHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHH
KLIGQALELSGGVKAKASHLLGINRTTLVEKMKRLKM
HHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]