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The map label for this gene is atoC [H]

Identifier: 118579419

GI number: 118579419

Start: 1026298

End: 1027665

Strand: Direct

Name: atoC [H]

Synonym: Ppro_0984

Alternate gene names: 118579419

Gene position: 1026298-1027665 (Clockwise)

Preceding gene: 118579418

Following gene: 118579420

Centisome position: 25.61

GC content: 60.82

Gene sequence:

>1368_bases
ATGACCGCGCAGAAACACATTCTGATTATCGACGACGAGGAGAACCTGCGCCACATGCTGTCGGTCATGCTCTCCCGCCA
GGGGTATCGGGCTGACTGCGCGGCGAACGGTGTCGAGGGGCTGGCAGCCCTGCGCGGCACGGTCTATGACTTTATCCTCT
GTGACATCCGCATGCCGGAGATGGATGGCAAGGCATTCCTTCAAGCGGCGCTGCGCGACCAGGTCGGGTCGCCCATCATC
ATGATGTCGGCCTATGGGACGGTGGATACGGCGGTGGAGTGCATGAAACTGGGCGCCTATGACTATATCTCCAAGCCGTT
CAAGAAGGATGAGATCGTCATGGTGCTGAGGAAGGCCGAAGAGAGGGAACGCTTGAAGGATGAGAACAGCCGTCTGCGGG
CCGCTGCCGCCGGACGATTCAATCATGGCGGCATTATCAGCCGCACTGCCAGGATGGAGGAGATATTCGGCAAGATACGC
AAGGTTGCCGGCCTGAAAACGACCGTTCTGATTCTGGGGGAGTCCGGCACCGGCAAGGAACTGGTGGCCCGGGCCGTGCA
TTGCAATGGCGGGCGCGCTTCCAAGTCCTTCGTGGCGGTGAATTGCGGGGCAATCCCGGAGAACCTGCTGGAGAGCGAGC
TGTTCGGCCACGTACGGGGAGCCTTCACCAATGCTACTGGCGACAAGGCCGGTCTCTTTGAGCAGGCGGATGGTGGAACG
CTCTTTTTGGACGAAATCGGCGAGATGTCACTGGCGCTTCAGGTGAAACTCCTGCGGGTGCTGCAGGAGGAGGAGATCCG
CAGGGTGGGGGCCACCGTCTCCAGCAAGATAGACGTGCGCATCGTGTCGGCCACCTCCCGAGACCTGGAGGCGGACATTC
AGACGGGACGCTTCCGTGAGGATCTCTACTTCCGCTTGAACGTCTTCTGTCTTCGTCTTCCCCCGCTGCGGGAGCGCGTG
GAGGATATTCCGCTGCTGGTGGAGCATTTCCTGAGATCCGCGCTGCGCGATCGCGACCCCGGGCAAATGCGCATCGAACC
GGACGCCATGCGCAGCCTCATGTCCTATGTCTGGCCGGGCAACATCCGCGAATTGGAGAATGCCATCGAACATGCCGCCA
TCGTCTGCGAGGACGGCAGCATTACCAACGCCTGTCTCCCGCCGGCAGTCAGATCTGTGGGAGCGCCGTGGCCGCTGATG
GAGCATGATGAGGAGCTCTCTATAAAGAAGGCCGAAGCGGCCATGGAGCGCGAGTTAATCAGGAAGGCCCTGGCCAGGAC
CGGCGGTAACCGCACCCATGCTGCGAAGATTCTCGAGATCAGCCATCGCTCCCTGCTCTACAAGCTCAAGGAATACGGCA
TCGACTAG

Upstream 100 bases:

>100_bases
TCGAGGGCTTTGGTGGCAGTATCGACGTGCGGAGCACCCTCGGCAGAGGGAGCTGCTTTACCCTCCGGCTGCCGGCCATC
TCGAAAAAAGGAGCGCGATA

Downstream 100 bases:

>100_bases
GCAAAAGTTGCGCCTCTTTGGGGGCTATTTTTCTGTTGATTGTGCAAAGTTTGCGTAGTGTGCTGTGGGGCTGTTGCGCA
TAAGCCTCTAAAACAGCGTG

Product: two component sigma54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MTAQKHILIIDDEENLRHMLSVMLSRQGYRADCAANGVEGLAALRGTVYDFILCDIRMPEMDGKAFLQAALRDQVGSPII
MMSAYGTVDTAVECMKLGAYDYISKPFKKDEIVMVLRKAEERERLKDENSRLRAAAAGRFNHGGIISRTARMEEIFGKIR
KVAGLKTTVLILGESGTGKELVARAVHCNGGRASKSFVAVNCGAIPENLLESELFGHVRGAFTNATGDKAGLFEQADGGT
LFLDEIGEMSLALQVKLLRVLQEEEIRRVGATVSSKIDVRIVSATSRDLEADIQTGRFREDLYFRLNVFCLRLPPLRERV
EDIPLLVEHFLRSALRDRDPGQMRIEPDAMRSLMSYVWPGNIRELENAIEHAAIVCEDGSITNACLPPAVRSVGAPWPLM
EHDEELSIKKAEAAMERELIRKALARTGGNRTHAAKILEISHRSLLYKLKEYGID

Sequences:

>Translated_455_residues
MTAQKHILIIDDEENLRHMLSVMLSRQGYRADCAANGVEGLAALRGTVYDFILCDIRMPEMDGKAFLQAALRDQVGSPII
MMSAYGTVDTAVECMKLGAYDYISKPFKKDEIVMVLRKAEERERLKDENSRLRAAAAGRFNHGGIISRTARMEEIFGKIR
KVAGLKTTVLILGESGTGKELVARAVHCNGGRASKSFVAVNCGAIPENLLESELFGHVRGAFTNATGDKAGLFEQADGGT
LFLDEIGEMSLALQVKLLRVLQEEEIRRVGATVSSKIDVRIVSATSRDLEADIQTGRFREDLYFRLNVFCLRLPPLRERV
EDIPLLVEHFLRSALRDRDPGQMRIEPDAMRSLMSYVWPGNIRELENAIEHAAIVCEDGSITNACLPPAVRSVGAPWPLM
EHDEELSIKKAEAAMERELIRKALARTGGNRTHAAKILEISHRSLLYKLKEYGID
>Mature_454_residues
TAQKHILIIDDEENLRHMLSVMLSRQGYRADCAANGVEGLAALRGTVYDFILCDIRMPEMDGKAFLQAALRDQVGSPIIM
MSAYGTVDTAVECMKLGAYDYISKPFKKDEIVMVLRKAEERERLKDENSRLRAAAAGRFNHGGIISRTARMEEIFGKIRK
VAGLKTTVLILGESGTGKELVARAVHCNGGRASKSFVAVNCGAIPENLLESELFGHVRGAFTNATGDKAGLFEQADGGTL
FLDEIGEMSLALQVKLLRVLQEEEIRRVGATVSSKIDVRIVSATSRDLEADIQTGRFREDLYFRLNVFCLRLPPLRERVE
DIPLLVEHFLRSALRDRDPGQMRIEPDAMRSLMSYVWPGNIRELENAIEHAAIVCEDGSITNACLPPAVRSVGAPWPLME
HDEELSIKKAEAAMERELIRKALARTGGNRTHAAKILEISHRSLLYKLKEYGID

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=462, Percent_Identity=46.1038961038961, Blast_Score=405, Evalue=1e-114,
Organism=Escherichia coli, GI1790437, Length=444, Percent_Identity=44.8198198198198, Blast_Score=358, Evalue=1e-100,
Organism=Escherichia coli, GI1788905, Length=445, Percent_Identity=42.0224719101124, Blast_Score=332, Evalue=3e-92,
Organism=Escherichia coli, GI1790299, Length=470, Percent_Identity=38.7234042553192, Blast_Score=320, Evalue=1e-88,
Organism=Escherichia coli, GI87082117, Length=261, Percent_Identity=49.8084291187739, Blast_Score=258, Evalue=6e-70,
Organism=Escherichia coli, GI1789087, Length=342, Percent_Identity=43.859649122807, Blast_Score=252, Evalue=4e-68,
Organism=Escherichia coli, GI1789233, Length=307, Percent_Identity=43.9739413680782, Blast_Score=244, Evalue=9e-66,
Organism=Escherichia coli, GI87082152, Length=324, Percent_Identity=41.9753086419753, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI1786524, Length=332, Percent_Identity=43.9759036144578, Blast_Score=230, Evalue=2e-61,
Organism=Escherichia coli, GI1787583, Length=316, Percent_Identity=39.5569620253165, Blast_Score=205, Evalue=6e-54,
Organism=Escherichia coli, GI87081872, Length=313, Percent_Identity=37.6996805111821, Blast_Score=196, Evalue=4e-51,
Organism=Escherichia coli, GI87081858, Length=300, Percent_Identity=35, Blast_Score=153, Evalue=3e-38,
Organism=Escherichia coli, GI1789828, Length=277, Percent_Identity=35.0180505415162, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI1786784, Length=116, Percent_Identity=31.8965517241379, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87082012, Length=111, Percent_Identity=35.1351351351351, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789402, Length=140, Percent_Identity=27.8571428571429, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1787487, Length=146, Percent_Identity=31.5068493150685, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1787375, Length=107, Percent_Identity=28.9719626168224, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50581; Mature: 50450

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAQKHILIIDDEENLRHMLSVMLSRQGYRADCAANGVEGLAALRGTVYDFILCDIRMPE
CCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCHHCCCHHHHHHHHHHHHHHHEEEEECCC
MDGKAFLQAALRDQVGSPIIMMSAYGTVDTAVECMKLGAYDYISKPFKKDEIVMVLRKAE
CCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHH
ERERLKDENSRLRAAAAGRFNHGGIISRTARMEEIFGKIRKVAGLKTTVLILGESGTGKE
HHHHHHCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHH
LVARAVHCNGGRASKSFVAVNCGAIPENLLESELFGHVRGAFTNATGDKAGLFEQADGGT
HHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCE
LFLDEIGEMSLALQVKLLRVLQEEEIRRVGATVSSKIDVRIVSATSRDLEADIQTGRFRE
EEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHCCCHHH
DLYFRLNVFCLRLPPLRERVEDIPLLVEHFLRSALRDRDPGQMRIEPDAMRSLMSYVWPG
HHHEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHHCCC
NIRELENAIEHAAIVCEDGSITNACLPPAVRSVGAPWPLMEHDEELSIKKAEAAMERELI
CHHHHHHHHHHHEEEECCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
RKALARTGGNRTHAAKILEISHRSLLYKLKEYGID
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TAQKHILIIDDEENLRHMLSVMLSRQGYRADCAANGVEGLAALRGTVYDFILCDIRMPE
CCCCEEEEEECCHHHHHHHHHHHHCCCCCCCHHCCCHHHHHHHHHHHHHHHEEEEECCC
MDGKAFLQAALRDQVGSPIIMMSAYGTVDTAVECMKLGAYDYISKPFKKDEIVMVLRKAE
CCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHH
ERERLKDENSRLRAAAAGRFNHGGIISRTARMEEIFGKIRKVAGLKTTVLILGESGTGKE
HHHHHHCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHH
LVARAVHCNGGRASKSFVAVNCGAIPENLLESELFGHVRGAFTNATGDKAGLFEQADGGT
HHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCE
LFLDEIGEMSLALQVKLLRVLQEEEIRRVGATVSSKIDVRIVSATSRDLEADIQTGRFRE
EEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHCCCHHH
DLYFRLNVFCLRLPPLRERVEDIPLLVEHFLRSALRDRDPGQMRIEPDAMRSLMSYVWPG
HHHEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHHCCC
NIRELENAIEHAAIVCEDGSITNACLPPAVRSVGAPWPLMEHDEELSIKKAEAAMERELI
CHHHHHHHHHHHEEEECCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
RKALARTGGNRTHAAKILEISHRSLLYKLKEYGID
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]