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The map label for this gene is fabB [H]

Identifier: 118579344

GI number: 118579344

Start: 958233

End: 959459

Strand: Direct

Name: fabB [H]

Synonym: Ppro_0907

Alternate gene names: 118579344

Gene position: 958233-959459 (Clockwise)

Preceding gene: 118579343

Following gene: 118579345

Centisome position: 23.91

GC content: 64.38

Gene sequence:

>1227_bases
ATGTCATTGAAACGAGTCGTCATAACGGGAATCGGTGTTGTTTCGCCCTTCGGAAACGGGGTGGCGGAACTGGTCAGGGG
GATGGAAGAGGGGCGCAGCGCCGTGCGCTTCATGGAGGGGTGGGACCGCTACAACGGCCTGCAGAGCCTGGTGGCCGCTC
CGGTGGAGATGCGCGGCGAGAAGGACATCCCCCGCCAGAAGCGCCGCTCCATGGGACGCATGAGCATCTTCGCGGCCCAG
GCTGCCGACGAGGCCCTGGCTGACGCCGGCATCTGCCTGGCGGACGAGAACCTGTGGAGAGTCGGCTGCGTCATCGGCTC
CACCATGGGGAGCGCCAAGAGCATCAACGACACCTTCGAGACCATGCTGCCGGACCGGGACTTGAGCAGGCTCAACTCCA
CCATGTTCTTCCAGTGCATGTCCCACACCGTGACGGCCAACGTGGCCCAGTACCTGGGACTGAACGGCACGGTCATGGCC
ACCTCGGCCGCCTGCGCCTCGGCCCTGCACGCCCTGGGTGTGGGATACGACCTGATCCGCCTGGGGAGGCAGGAGGTTCT
GCTGTGCGGCGGGGCGGAAGAGCTGCATCCCACGGTGACCGGCTCCTTCGACATCCTCTTCGCCACCTCCACAAAATACA
ACGAAAACCCTCAGAAGACTCCGCGTCCCTTTGACCGGGACCGGGACGGCCTGGTCTGCGGCGAGGGGAGCGGCATCCTG
GTGCTGGAGGAGTACGAGCGGGCTGTTGCCCGCAACGCCAGGATCTATGCCGAACTGACCGGTTTCTGTACCACTGCCAA
CGGCCTGCACGTCAGCCAGTCCAACCGGGACTCCATGGTCACTTGCATGCGCCAGGCCATCGAGGAGGCCGGGCTTGCGC
CCGAGGGGATCGACTACATCAACGCCCATGCCACGGCTACCATTCAGGGGGATCAGGAGGAGGCGGAGGCGATCCGCGAG
CTGTTCGGTCCGGCGGTGCCGGTCAGTTGCATCAAGGGGTACATCGGCCACACCCTGGGCGCGGCCGGATCCATAGAGCT
GGCCGCGGCCCTGAAGATGATGGAGCAGGGAGTGATCTACCCGACTCACAACCTGGAGACGGTCAGCCAGGAGTGCGCGG
GGATCGGGCATGTGATGCAACCGCTCAAAAAGCAGATCCGCAGCATACTGAAGAACGGGTTCGCCTTCGGCGGCATCAAT
GCCGCGCTGGTGTGCACAAAAATCTGA

Upstream 100 bases:

>100_bases
CGCTCTTGCCCGGCGTGATCGGCGCCATGATGTCGTCACTGATCGTCGGTCGCAACCTGCTGGGAAAAGAACAGTACGGA
CAACTGCTGGACAGGAACCT

Downstream 100 bases:

>100_bases
GCCGAGAGGGCGCCAAATCCGGAGGAGAGCATGACCGAGCAGGAAATTATCGACAAAACCAACAGGGTCTTCGAGGAGGC
CTTTGAAATAGAGCCGGAGC

Product: beta-ketoacyl synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MSLKRVVITGIGVVSPFGNGVAELVRGMEEGRSAVRFMEGWDRYNGLQSLVAAPVEMRGEKDIPRQKRRSMGRMSIFAAQ
AADEALADAGICLADENLWRVGCVIGSTMGSAKSINDTFETMLPDRDLSRLNSTMFFQCMSHTVTANVAQYLGLNGTVMA
TSAACASALHALGVGYDLIRLGRQEVLLCGGAEELHPTVTGSFDILFATSTKYNENPQKTPRPFDRDRDGLVCGEGSGIL
VLEEYERAVARNARIYAELTGFCTTANGLHVSQSNRDSMVTCMRQAIEEAGLAPEGIDYINAHATATIQGDQEEAEAIRE
LFGPAVPVSCIKGYIGHTLGAAGSIELAAALKMMEQGVIYPTHNLETVSQECAGIGHVMQPLKKQIRSILKNGFAFGGIN
AALVCTKI

Sequences:

>Translated_408_residues
MSLKRVVITGIGVVSPFGNGVAELVRGMEEGRSAVRFMEGWDRYNGLQSLVAAPVEMRGEKDIPRQKRRSMGRMSIFAAQ
AADEALADAGICLADENLWRVGCVIGSTMGSAKSINDTFETMLPDRDLSRLNSTMFFQCMSHTVTANVAQYLGLNGTVMA
TSAACASALHALGVGYDLIRLGRQEVLLCGGAEELHPTVTGSFDILFATSTKYNENPQKTPRPFDRDRDGLVCGEGSGIL
VLEEYERAVARNARIYAELTGFCTTANGLHVSQSNRDSMVTCMRQAIEEAGLAPEGIDYINAHATATIQGDQEEAEAIRE
LFGPAVPVSCIKGYIGHTLGAAGSIELAAALKMMEQGVIYPTHNLETVSQECAGIGHVMQPLKKQIRSILKNGFAFGGIN
AALVCTKI
>Mature_407_residues
SLKRVVITGIGVVSPFGNGVAELVRGMEEGRSAVRFMEGWDRYNGLQSLVAAPVEMRGEKDIPRQKRRSMGRMSIFAAQA
ADEALADAGICLADENLWRVGCVIGSTMGSAKSINDTFETMLPDRDLSRLNSTMFFQCMSHTVTANVAQYLGLNGTVMAT
SAACASALHALGVGYDLIRLGRQEVLLCGGAEELHPTVTGSFDILFATSTKYNENPQKTPRPFDRDRDGLVCGEGSGILV
LEEYERAVARNARIYAELTGFCTTANGLHVSQSNRDSMVTCMRQAIEEAGLAPEGIDYINAHATATIQGDQEEAEAIREL
FGPAVPVSCIKGYIGHTLGAAGSIELAAALKMMEQGVIYPTHNLETVSQECAGIGHVMQPLKKQIRSILKNGFAFGGINA
ALVCTKI

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=422, Percent_Identity=34.3601895734597, Blast_Score=186, Evalue=5e-47,
Organism=Homo sapiens, GI223972627, Length=129, Percent_Identity=43.4108527131783, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI41872631, Length=292, Percent_Identity=26.3698630136986, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1788663, Length=408, Percent_Identity=36.7647058823529, Blast_Score=255, Evalue=5e-69,
Organism=Escherichia coli, GI1787337, Length=420, Percent_Identity=32.8571428571429, Blast_Score=199, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI71983541, Length=417, Percent_Identity=35.0119904076739, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI71983535, Length=265, Percent_Identity=36.9811320754717, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI212642053, Length=338, Percent_Identity=25.4437869822485, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17550940, Length=284, Percent_Identity=26.4084507042254, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6320904, Length=445, Percent_Identity=29.438202247191, Blast_Score=166, Evalue=6e-42,
Organism=Drosophila melanogaster, GI24644341, Length=413, Percent_Identity=33.1719128329298, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI221330659, Length=336, Percent_Identity=27.0833333333333, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19920632, Length=336, Percent_Identity=27.0833333333333, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24581345, Length=335, Percent_Identity=24.7761194029851, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 43777; Mature: 43645

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKRVVITGIGVVSPFGNGVAELVRGMEEGRSAVRFMEGWDRYNGLQSLVAAPVEMRGE
CCCCEEEEECCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCC
KDIPRQKRRSMGRMSIFAAQAADEALADAGICLADENLWRVGCVIGSTMGSAKSINDTFE
CCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCEEECCCCEEEHHHHHCCCCCCHHHHHHHH
TMLPDRDLSRLNSTMFFQCMSHTVTANVAQYLGLNGTVMATSAACASALHALGVGYDLIR
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHCCHHHHH
LGRQEVLLCGGAEELHPTVTGSFDILFATSTKYNENPQKTPRPFDRDRDGLVCGEGSGIL
CCCCCEEEECCHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCEE
VLEEYERAVARNARIYAELTGFCTTANGLHVSQSNRDSMVTCMRQAIEEAGLAPEGIDYI
EEHHHHHHHHHCCEEEEEEHHHEECCCCEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCC
NAHATATIQGDQEEAEAIRELFGPAVPVSCIKGYIGHTLGAAGSIELAAALKMMEQGVIY
CCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCC
PTHNLETVSQECAGIGHVMQPLKKQIRSILKNGFAFGGINAALVCTKI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCEEEEEECC
>Mature Secondary Structure 
SLKRVVITGIGVVSPFGNGVAELVRGMEEGRSAVRFMEGWDRYNGLQSLVAAPVEMRGE
CCCEEEEECCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCC
KDIPRQKRRSMGRMSIFAAQAADEALADAGICLADENLWRVGCVIGSTMGSAKSINDTFE
CCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCEEECCCCEEEHHHHHCCCCCCHHHHHHHH
TMLPDRDLSRLNSTMFFQCMSHTVTANVAQYLGLNGTVMATSAACASALHALGVGYDLIR
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHCCHHHHH
LGRQEVLLCGGAEELHPTVTGSFDILFATSTKYNENPQKTPRPFDRDRDGLVCGEGSGIL
CCCCCEEEECCHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCEE
VLEEYERAVARNARIYAELTGFCTTANGLHVSQSNRDSMVTCMRQAIEEAGLAPEGIDYI
EEHHHHHHHHHCCEEEEEEHHHEECCCCEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCC
NAHATATIQGDQEEAEAIRELFGPAVPVSCIKGYIGHTLGAAGSIELAAALKMMEQGVIY
CCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCC
PTHNLETVSQECAGIGHVMQPLKKQIRSILKNGFAFGGINAALVCTKI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]