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The map label for this gene is shc [H]

Identifier: 118579203

GI number: 118579203

Start: 810315

End: 812474

Strand: Direct

Name: shc [H]

Synonym: Ppro_0765

Alternate gene names: 118579203

Gene position: 810315-812474 (Clockwise)

Preceding gene: 118579202

Following gene: 118579204

Centisome position: 20.22

GC content: 62.31

Gene sequence:

>2160_bases
ATGAAGAAAGCAACCAGGTCGGTATTCAGTCTGCTGGATGGCGGCAAAATCAGCGACTCGGGCAGCAGGGGCGACAGCCG
TCATGCAGGCTCCAGGCTGGACAGCGTGACAAAGAGCGCGGCAGCCCTGCTCGCATCCCGCCAGAATCCCGATGGGCACT
GGGTTTTCGATCTGGAGGCGGACGTTACCATCCCGGCGGAATATGTGATGATGCGGTGCTTCATCGGCGAGCCCCTGGAT
TCCGATATGGCTTCACGGTTGTCCGCCTACTTGCTGGAACGGCAGTTGCCCGATGGAGGCTGGCCGCTGTATGCCGTTGA
CGGCAATGCCAATATAAGCGCCACTGTCAAGGCCTATTTCGCCCTCAAACTGCTGGGGCACGACAAGTATGCGCCGCATA
TGGTCAGCGCGCGCCGAATGATACTGGCGCAGGGGGGGGCGGAACGGAGTAATGTGTTCACCAGGATCACCCTGGCGCTC
TTCGGCCAGGTGCCGTGGCATACGACTCCCGCCATGCCGATCGAGATCATGCTGCTGCCGAAATGGTTCTTCTTTCATCT
GAGCAAGGTCGCGTACTGGTCGAGAACGGTGATCGTGCCGCTGCTGATCCTGTACAACAAACAACCGGTCTGCCGGTTGG
GCTACAGCGAAGGGATTGCCGAACTGTTTTCGACGTCGCCGGACATGCTTGTCCATCTGGATCACTTCCGCTACCGCGCC
TGGCGCAAGAACGCCTTCATCGTGCTGGACCGCCTGCTCAAACGCACGATGCATCTGGTTCCCGGTCGCATCAAACGACG
TGCCCTGGAGGAGGCTGAACGCTGGACGCGGGAACGGATGAAGGGGGATGGCAGTATCGGCGCCATTTATCCCGCCATGG
CAAATGCCGTCATGGCGCTGAAAACACTGGGGTGCGGTGATAGTGATCCCGATTACCTGCGCGGTCTGCGGGCCATCGAC
AGACTGCTGATCCACGGGAAGCCAGAGGCCGGGGCTCTGCCGGCCGACGGCGCGGGGACATTGTTCCCGGTTCTTGACGG
AGCGTCCTCCGCCGCTGTCGACCTGTATCCCGCATCCCTCAGTGATACCGCGAAAAGCCACGCATTCAGCTTCTGCCAGC
CCTGCAACTCGCCTGTCTGGGACACTGCCCTGAGCCTCACGGCCCTCTCCGAAGCAGGTGGTGGCGGGTACTCGCCGGAG
AGGGCCATGGAATGGCTCTTCAACCGGCAGATCGCCACGCAGGGCGACTGGACCGAGAGATGCCCCGGCCTGGAGTGCGG
CGGCTGGGCATTCCAGTACGAGAATGCGCTCTATCCCGATGTGGACGATACCGCCAAGGTACTGATGAGTCTGTTCCGCG
CCGGAGCGCTGGAGAGGGGGGAGTACCCGGAGAAGATCGCAAAGGCGGTGCGGTGGGTGCTGGGCATGCAGGGGGCGGAC
GGCGGCTGGGGCGCTTTTGATGTGGACAACAATCACTTCTACCTCAACGACATCCCCTTTGCCGACCATGGGGCTTTGCT
CGACCCGAGCACGGCCGACCTGACCGGCAGATGCATAGAAATGCTGGGGATGCTCGGCCACGGCCCGGACTACCCGCCCA
TCACCCGGGGGATCGAGTTTCTCAGGGAGGAACAGGAACCCTTCGGGGGGTGGTTCGGACGCTGGGGGGTGAACTACATC
TACGGCACCTGGTCGGTCCTCTCGGGGCTGAGTCAGGCCGGGGAGGATATGGGCCGGCCCTATGTCAGGAAGGCGGTTGA
ATGGCTGGTTTCATGCCAGAACGACGATGGCGGGTGGGGTGAGACCTGTGCCAGCTATGACGACCCCTCCCTTGCGGGAA
GCGGAGCCAGCACCGCATCCCAGACCGCCTGGGCGCTCCTGGGGTTGATGGCGGCCGGCGAGGCGGATCATGCCGCCGTC
AGGGCGGGCATTGCCTACCTGGCGGACAGTTTCGCCGATGGCTGGGATGAGCGCCATTTCACCGGCACCGGTTTTCCGCG
GGTATTTTATCTGCGCTACCATGGCTACAGCCTTTTCTTCCCCGTCTGGGCCCTGGGGGTGTACGCACGACACAGGGAAG
GGGGAAAGACTGTTCAGGAACAGGTTCGCGAACGCGGTGTCAACGGGGTCTTTGATTTCGTTATGGGCGGCTCTGCATGA

Upstream 100 bases:

>100_bases
TATGCTCATCAGCGGGTTGCTCAGGGGCTACAGGCCGTAGTTTTTTTGTGATAAATGTTAACGGTGTTATTTTTAGTGAC
TGGTGTTTTGAGGAGTGGGT

Downstream 100 bases:

>100_bases
GACACGCCAGGTAATGTTTGCACTAGCCGCTGTACATGGGGTAGACTTTGCCCCTCCCGTACCCTGACCTCCGGCTCAAT
ACTCTGGGGACTCATGTACG

Product: squalene-hopene cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 719; Mature: 719

Protein sequence:

>719_residues
MKKATRSVFSLLDGGKISDSGSRGDSRHAGSRLDSVTKSAAALLASRQNPDGHWVFDLEADVTIPAEYVMMRCFIGEPLD
SDMASRLSAYLLERQLPDGGWPLYAVDGNANISATVKAYFALKLLGHDKYAPHMVSARRMILAQGGAERSNVFTRITLAL
FGQVPWHTTPAMPIEIMLLPKWFFFHLSKVAYWSRTVIVPLLILYNKQPVCRLGYSEGIAELFSTSPDMLVHLDHFRYRA
WRKNAFIVLDRLLKRTMHLVPGRIKRRALEEAERWTRERMKGDGSIGAIYPAMANAVMALKTLGCGDSDPDYLRGLRAID
RLLIHGKPEAGALPADGAGTLFPVLDGASSAAVDLYPASLSDTAKSHAFSFCQPCNSPVWDTALSLTALSEAGGGGYSPE
RAMEWLFNRQIATQGDWTERCPGLECGGWAFQYENALYPDVDDTAKVLMSLFRAGALERGEYPEKIAKAVRWVLGMQGAD
GGWGAFDVDNNHFYLNDIPFADHGALLDPSTADLTGRCIEMLGMLGHGPDYPPITRGIEFLREEQEPFGGWFGRWGVNYI
YGTWSVLSGLSQAGEDMGRPYVRKAVEWLVSCQNDDGGWGETCASYDDPSLAGSGASTASQTAWALLGLMAAGEADHAAV
RAGIAYLADSFADGWDERHFTGTGFPRVFYLRYHGYSLFFPVWALGVYARHREGGKTVQEQVRERGVNGVFDFVMGGSA

Sequences:

>Translated_719_residues
MKKATRSVFSLLDGGKISDSGSRGDSRHAGSRLDSVTKSAAALLASRQNPDGHWVFDLEADVTIPAEYVMMRCFIGEPLD
SDMASRLSAYLLERQLPDGGWPLYAVDGNANISATVKAYFALKLLGHDKYAPHMVSARRMILAQGGAERSNVFTRITLAL
FGQVPWHTTPAMPIEIMLLPKWFFFHLSKVAYWSRTVIVPLLILYNKQPVCRLGYSEGIAELFSTSPDMLVHLDHFRYRA
WRKNAFIVLDRLLKRTMHLVPGRIKRRALEEAERWTRERMKGDGSIGAIYPAMANAVMALKTLGCGDSDPDYLRGLRAID
RLLIHGKPEAGALPADGAGTLFPVLDGASSAAVDLYPASLSDTAKSHAFSFCQPCNSPVWDTALSLTALSEAGGGGYSPE
RAMEWLFNRQIATQGDWTERCPGLECGGWAFQYENALYPDVDDTAKVLMSLFRAGALERGEYPEKIAKAVRWVLGMQGAD
GGWGAFDVDNNHFYLNDIPFADHGALLDPSTADLTGRCIEMLGMLGHGPDYPPITRGIEFLREEQEPFGGWFGRWGVNYI
YGTWSVLSGLSQAGEDMGRPYVRKAVEWLVSCQNDDGGWGETCASYDDPSLAGSGASTASQTAWALLGLMAAGEADHAAV
RAGIAYLADSFADGWDERHFTGTGFPRVFYLRYHGYSLFFPVWALGVYARHREGGKTVQEQVRERGVNGVFDFVMGGSA
>Mature_719_residues
MKKATRSVFSLLDGGKISDSGSRGDSRHAGSRLDSVTKSAAALLASRQNPDGHWVFDLEADVTIPAEYVMMRCFIGEPLD
SDMASRLSAYLLERQLPDGGWPLYAVDGNANISATVKAYFALKLLGHDKYAPHMVSARRMILAQGGAERSNVFTRITLAL
FGQVPWHTTPAMPIEIMLLPKWFFFHLSKVAYWSRTVIVPLLILYNKQPVCRLGYSEGIAELFSTSPDMLVHLDHFRYRA
WRKNAFIVLDRLLKRTMHLVPGRIKRRALEEAERWTRERMKGDGSIGAIYPAMANAVMALKTLGCGDSDPDYLRGLRAID
RLLIHGKPEAGALPADGAGTLFPVLDGASSAAVDLYPASLSDTAKSHAFSFCQPCNSPVWDTALSLTALSEAGGGGYSPE
RAMEWLFNRQIATQGDWTERCPGLECGGWAFQYENALYPDVDDTAKVLMSLFRAGALERGEYPEKIAKAVRWVLGMQGAD
GGWGAFDVDNNHFYLNDIPFADHGALLDPSTADLTGRCIEMLGMLGHGPDYPPITRGIEFLREEQEPFGGWFGRWGVNYI
YGTWSVLSGLSQAGEDMGRPYVRKAVEWLVSCQNDDGGWGETCASYDDPSLAGSGASTASQTAWALLGLMAAGEADHAAV
RAGIAYLADSFADGWDERHFTGTGFPRVFYLRYHGYSLFFPVWALGVYARHREGGKTVQEQVRERGVNGVFDFVMGGSA

Specific function: Catalyzes the cyclization of squalene into hopene [H]

COG id: COG1657

COG function: function code I; Squalene cyclase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 4 PFTB repeats [H]

Homologues:

Organism=Homo sapiens, GI224177558, Length=342, Percent_Identity=28.3625730994152, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI224177556, Length=342, Percent_Identity=28.3625730994152, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI47933395, Length=342, Percent_Identity=28.3625730994152, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI47933397, Length=342, Percent_Identity=28.3625730994152, Blast_Score=112, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6321863, Length=163, Percent_Identity=34.9693251533742, Blast_Score=92, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006400
- InterPro:   IPR001330
- InterPro:   IPR018333
- InterPro:   IPR002365
- InterPro:   IPR008930 [H]

Pfam domain/function: PF00432 Prenyltrans [H]

EC number: =5.4.99.17 [H]

Molecular weight: Translated: 79006; Mature: 79006

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKATRSVFSLLDGGKISDSGSRGDSRHAGSRLDSVTKSAAALLASRQNPDGHWVFDLEA
CCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECC
DVTIPAEYVMMRCFIGEPLDSDMASRLSAYLLERQLPDGGWPLYAVDGNANISATVKAYF
CCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEHHHHHHH
ALKLLGHDKYAPHMVSARRMILAQGGAERSNVFTRITLALFGQVPWHTTPAMPIEIMLLP
HHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEC
KWFFFHLSKVAYWSRTVIVPLLILYNKQPVCRLGYSEGIAELFSTSPDMLVHLDHFRYRA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHCCCCCCEEEHHHHHHHH
WRKNAFIVLDRLLKRTMHLVPGRIKRRALEEAERWTRERMKGDGSIGAIYPAMANAVMAL
HHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHH
KTLGCGDSDPDYLRGLRAIDRLLIHGKPEAGALPADGAGTLFPVLDGASSAAVDLYPASL
HHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHEECCCCCCEEEEECCCH
SDTAKSHAFSFCQPCNSPVWDTALSLTALSEAGGGGYSPERAMEWLFNRQIATQGDWTER
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCHHHC
CPGLECGGWAFQYENALYPDVDDTAKVLMSLFRAGALERGEYPEKIAKAVRWVLGMQGAD
CCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCC
GGWGAFDVDNNHFYLNDIPFADHGALLDPSTADLTGRCIEMLGMLGHGPDYPPITRGIEF
CCCCEEECCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LREEQEPFGGWFGRWGVNYIYGTWSVLSGLSQAGEDMGRPYVRKAVEWLVSCQNDDGGWG
HHHHCCCCCCCHHHCCCHHEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCC
ETCASYDDPSLAGSGASTASQTAWALLGLMAAGEADHAAVRAGIAYLADSFADGWDERHF
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
TGTGFPRVFYLRYHGYSLFFPVWALGVYARHREGGKTVQEQVRERGVNGVFDFVMGGSA
CCCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHCCCCC
>Mature Secondary Structure
MKKATRSVFSLLDGGKISDSGSRGDSRHAGSRLDSVTKSAAALLASRQNPDGHWVFDLEA
CCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECC
DVTIPAEYVMMRCFIGEPLDSDMASRLSAYLLERQLPDGGWPLYAVDGNANISATVKAYF
CCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEHHHHHHH
ALKLLGHDKYAPHMVSARRMILAQGGAERSNVFTRITLALFGQVPWHTTPAMPIEIMLLP
HHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEC
KWFFFHLSKVAYWSRTVIVPLLILYNKQPVCRLGYSEGIAELFSTSPDMLVHLDHFRYRA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHCCCCCCEEEHHHHHHHH
WRKNAFIVLDRLLKRTMHLVPGRIKRRALEEAERWTRERMKGDGSIGAIYPAMANAVMAL
HHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHH
KTLGCGDSDPDYLRGLRAIDRLLIHGKPEAGALPADGAGTLFPVLDGASSAAVDLYPASL
HHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHEECCCCCCEEEEECCCH
SDTAKSHAFSFCQPCNSPVWDTALSLTALSEAGGGGYSPERAMEWLFNRQIATQGDWTER
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCHHHC
CPGLECGGWAFQYENALYPDVDDTAKVLMSLFRAGALERGEYPEKIAKAVRWVLGMQGAD
CCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCC
GGWGAFDVDNNHFYLNDIPFADHGALLDPSTADLTGRCIEMLGMLGHGPDYPPITRGIEF
CCCCEEECCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LREEQEPFGGWFGRWGVNYIYGTWSVLSGLSQAGEDMGRPYVRKAVEWLVSCQNDDGGWG
HHHHCCCCCCCHHHCCCHHEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCC
ETCASYDDPSLAGSGASTASQTAWALLGLMAAGEADHAAVRAGIAYLADSFADGWDERHF
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
TGTGFPRVFYLRYHGYSLFFPVWALGVYARHREGGKTVQEQVRERGVNGVFDFVMGGSA
CCCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7894707 [H]