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The map label for this gene is lpxC [H]

Identifier: 118579185

GI number: 118579185

Start: 787457

End: 788329

Strand: Reverse

Name: lpxC [H]

Synonym: Ppro_0747

Alternate gene names: 118579185

Gene position: 788329-787457 (Counterclockwise)

Preceding gene: 118579186

Following gene: 118579176

Centisome position: 19.67

GC content: 60.02

Gene sequence:

>873_bases
ATGTGGCCACTTGACGGCTCCTCCCAAACCTGCCATAGTCGCCCCATGATAAAGCGTCAGACGACTATAAACCGCATCTT
CAAGGTGACCGGCATCGGCCTGCACACCGGCCGCGAAGTCAACCTGGAATTCCTTCCCCGCCGGGAGTTCGGCATCGCCT
TCGTACATAACGGCAACCTGATCCCGGCCCGCTACGACATGGTTGCTGACACGCGACTCTCCACACTGATCGCCTCCGGC
GGCTCCTCCGTCTCCACCATCGAACACCTCATGGCCGCCTTTTATTTTTCCGGGATCACCAACTGCCTGGTCTACATCGA
CGGTCCCGAGGTGCCGATCCTGGACGGTTCGGCCTGGGAGTTCTACCAGGGGATGTGGAAGGCGGGGGTCTACGAATTCC
CCGAAAGCGGGGTCTACCTGAGGGTGCAGCGAACGGTGGAGGTTAGTCATAACGACTCCTGGGTGCGCATGAAACCGCTC
AACACCCTGGACATCACCATGACCATCGAGTTCCGCCAGCCGGTGGGCAAGCAGAAGAAGCGGGTCACCGACGTGGAAAA
CGCCTTCTCCATCATCAACTCGCGTACCTTCACCCTTGAGGAGGAGATCGAGGCCATCAAGAAGGCGGGGCTTGCCAAGG
GGGGCTCCCTGGACAACGCGGTGGTCATCGGCGCGGACGACGTGATCAATCCCCAGGGGCTGCGCTACAAGAAGGAGTTG
GTCAACCACAAGATCCTGGATCTGATCGGCGACCTGTACACCAGCGGCTACCGCATCCTGGGCAAGGTGGAGGCCAACAA
GACCGGCCACCACCTGAACAACCTGTTCCTCAGGGAGCTTTTCTCCGACCCGGCCAACTACGCCATCTACTGA

Upstream 100 bases:

>100_bases
TCCTGCCTGTTCGACCAGCTCCGGGAACTGGAGCGCAAGTACGCGCTCCTGGCCAGGGAACATGAAGAACTGAAGAACGT
CGTGGAGGCCTCCCGACGGG

Downstream 100 bases:

>100_bases
GCGTTTTCCCGTAGCGCCACAAAAATAGCCACCCTCGACCCGCTGTTGCGGGGAATCGGGGGTGGCTTTTTCCTGCCTCA
TGTTTATGCCGACTGTCAGA

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MWPLDGSSQTCHSRPMIKRQTTINRIFKVTGIGLHTGREVNLEFLPRREFGIAFVHNGNLIPARYDMVADTRLSTLIASG
GSSVSTIEHLMAAFYFSGITNCLVYIDGPEVPILDGSAWEFYQGMWKAGVYEFPESGVYLRVQRTVEVSHNDSWVRMKPL
NTLDITMTIEFRQPVGKQKKRVTDVENAFSIINSRTFTLEEEIEAIKKAGLAKGGSLDNAVVIGADDVINPQGLRYKKEL
VNHKILDLIGDLYTSGYRILGKVEANKTGHHLNNLFLRELFSDPANYAIY

Sequences:

>Translated_290_residues
MWPLDGSSQTCHSRPMIKRQTTINRIFKVTGIGLHTGREVNLEFLPRREFGIAFVHNGNLIPARYDMVADTRLSTLIASG
GSSVSTIEHLMAAFYFSGITNCLVYIDGPEVPILDGSAWEFYQGMWKAGVYEFPESGVYLRVQRTVEVSHNDSWVRMKPL
NTLDITMTIEFRQPVGKQKKRVTDVENAFSIINSRTFTLEEEIEAIKKAGLAKGGSLDNAVVIGADDVINPQGLRYKKEL
VNHKILDLIGDLYTSGYRILGKVEANKTGHHLNNLFLRELFSDPANYAIY
>Mature_290_residues
MWPLDGSSQTCHSRPMIKRQTTINRIFKVTGIGLHTGREVNLEFLPRREFGIAFVHNGNLIPARYDMVADTRLSTLIASG
GSSVSTIEHLMAAFYFSGITNCLVYIDGPEVPILDGSAWEFYQGMWKAGVYEFPESGVYLRVQRTVEVSHNDSWVRMKPL
NTLDITMTIEFRQPVGKQKKRVTDVENAFSIINSRTFTLEEEIEAIKKAGLAKGGSLDNAVVIGADDVINPQGLRYKKEL
VNHKILDLIGDLYTSGYRILGKVEANKTGHHLNNLFLRELFSDPANYAIY

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=278, Percent_Identity=37.410071942446, Blast_Score=176, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 32589; Mature: 32589

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWPLDGSSQTCHSRPMIKRQTTINRIFKVTGIGLHTGREVNLEFLPRREFGIAFVHNGNL
CCCCCCCCCCCCCCCCHHHHHHHHHHHHEEEEEEECCCEECEEEECCCCCCEEEEECCCC
IPARYDMVADTRLSTLIASGGSSVSTIEHLMAAFYFSGITNCLVYIDGPEVPILDGSAWE
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEECCCHHH
FYQGMWKAGVYEFPESGVYLRVQRTVEVSHNDSWVRMKPLNTLDITMTIEFRQPVGKQKK
HHHHHHHCCCEECCCCCEEEEEEEEEEECCCCCEEEEECCCEEEEEEEEEECCCCCHHHH
RVTDVENAFSIINSRTFTLEEEIEAIKKAGLAKGGSLDNAVVIGADDVINPQGLRYKKEL
HHHHHHHHHHHHCCCEEEHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCHHHHHH
VNHKILDLIGDLYTSGYRILGKVEANKTGHHLNNLFLRELFSDPANYAIY
HHHHHHHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHHHHCCCCCEECC
>Mature Secondary Structure
MWPLDGSSQTCHSRPMIKRQTTINRIFKVTGIGLHTGREVNLEFLPRREFGIAFVHNGNL
CCCCCCCCCCCCCCCCHHHHHHHHHHHHEEEEEEECCCEECEEEECCCCCCEEEEECCCC
IPARYDMVADTRLSTLIASGGSSVSTIEHLMAAFYFSGITNCLVYIDGPEVPILDGSAWE
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEECCCHHH
FYQGMWKAGVYEFPESGVYLRVQRTVEVSHNDSWVRMKPLNTLDITMTIEFRQPVGKQKK
HHHHHHHCCCEECCCCCEEEEEEEEEEECCCCCEEEEECCCEEEEEEEEEECCCCCHHHH
RVTDVENAFSIINSRTFTLEEEIEAIKKAGLAKGGSLDNAVVIGADDVINPQGLRYKKEL
HHHHHHHHHHHHCCCEEEHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCHHHHHH
VNHKILDLIGDLYTSGYRILGKVEANKTGHHLNNLFLRELFSDPANYAIY
HHHHHHHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHHHHCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA