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The map label for this gene is atoC [H]

Identifier: 118579149

GI number: 118579149

Start: 740261

End: 741631

Strand: Direct

Name: atoC [H]

Synonym: Ppro_0710

Alternate gene names: 118579149

Gene position: 740261-741631 (Clockwise)

Preceding gene: 118579148

Following gene: 118579155

Centisome position: 18.47

GC content: 57.84

Gene sequence:

>1371_bases
ATGTCGAAATTAATACTTGTGGTGGATGATGAGAATGATATCCGGACCTCGCTGACAGGAATTCTGGAGGATGAGGGCTT
TCTGGTGTCCTGCGCTGCCAGTGGCGTTGAGGCGTTGGAGAACGTGTGCCATGAAATCCCTGATATCGTTCTGCTGGATA
TCTGGATGCCCGGGCTGGACGGTCTGGAAACGCTGGAAAAGCTGAAGCAATTGTTTCCGCACCTGACGGTCATCATGATC
TCCGGTCATGGAACGATCGAGACTGCGGTCAGGGCAACCAAGCTGGGGGCTTTCGACTTCATCGAGAAGCCGCTTTCCCT
GGACAAGGTGCTGATCACCGTAAACAATGCCCTGCGCATGGGGGAGTTGCGGGTTGAAAACGAAGAGCTCAGGCGCGTGG
CTGGCTATGAATACGAGCTGATCGGCGAGAGCCCGGCCATGGTCTGCTTGCGGGATCAGGTCATGCGTGTTGCTCCGACA
TCGTTATGCGTCCTGGTAAACGGCGAGAATGGCAGCGGCAAGGAACGGGTTGCCCGCTCAATCCACTACTACAGCAAACG
TTGTGCTCGGCCGTTTGTTGCCATCAACTGCGCTGCCATCCCCGAAGAGCTGATCCAGAATGAGTTGTTCGGTCATGAGA
AAGGTGCCCTCGGGGGGGCGCCGTCCCAGAAGAAGGGGAAGATCGATCTTGCCGATGGCGGCACACTGTTTCTGGACGAG
ATCGGTGATATGTCGCTGGCGACACAGTCACGAATCCTGGGCGTCATTCAAGAGCACTGCTTCCAGCGGGTAGGCGGAAA
CCGGTCAGTGCCGGCGGATGTGCGGGTGATCGCCGCCAGCAGCAGGGACATTGCCGATGAGGTGCGCAACAGTCGCTTCC
GCGAGGACCTCTTCTACCTCCTCAACGTCATTCCGTTGGTTGTTCCTCCCCTGCGGGAGAGGAGAGAGGACATCGCGCTT
CTGGTGCCGCACTTCGTCGAGCAGTTCAATCGCCGCGAGGGGCGCGAGCAGAAGACGTTTTCTCCGCAAGCCATGGCGCT
GCTTGCCCGATTGGACTGGCCCGGAAACGTACGCGAGCTCCAGAACATCGTCGAGCGCGTCCTGATCATGGTCCCCGGCA
GGATGATAGCGGCGGAGGATCTCTCCGGGCTGTTTGGTGATCAGGCGCGAATTTTGGCGAATGAGGAGATGCTCCAGGCT
GCTGCGCCCGGCACGTTGCGGGAGGCGCGCGAGGAGTTCGAACGGGATTTCATTGTCAGGAAGCTGGAGGAGAACGACTG
GAATATCTCGCGCACCGCCGAGACCATCGAATTGAAGCGGAGCAACCTGCACAGGAAAATAAAGAGCTACGGAATAGATG
TCAAAAAGTAG

Upstream 100 bases:

>100_bases
GCCTGCTTCGTCGTTGAACTTCCCGCTGCCTGAGTGAGCTGCGCTGACCAGGGTAAGAGTGGGACGGGCCGGTCTCTGGC
CGTGCAAAAGAGAGGAGCAT

Downstream 100 bases:

>100_bases
CTCTCCTGCCTGATGGTCATTGGCTAACGGTTGCCCAGCAGTATGCGCAACTGGGAGCCGATGTCCGTCTCGCGCATCAG
TGACTCGCCGATCAGGAAGG

Product: two component sigma54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MSKLILVVDDENDIRTSLTGILEDEGFLVSCAASGVEALENVCHEIPDIVLLDIWMPGLDGLETLEKLKQLFPHLTVIMI
SGHGTIETAVRATKLGAFDFIEKPLSLDKVLITVNNALRMGELRVENEELRRVAGYEYELIGESPAMVCLRDQVMRVAPT
SLCVLVNGENGSGKERVARSIHYYSKRCARPFVAINCAAIPEELIQNELFGHEKGALGGAPSQKKGKIDLADGGTLFLDE
IGDMSLATQSRILGVIQEHCFQRVGGNRSVPADVRVIAASSRDIADEVRNSRFREDLFYLLNVIPLVVPPLRERREDIAL
LVPHFVEQFNRREGREQKTFSPQAMALLARLDWPGNVRELQNIVERVLIMVPGRMIAAEDLSGLFGDQARILANEEMLQA
AAPGTLREAREEFERDFIVRKLEENDWNISRTAETIELKRSNLHRKIKSYGIDVKK

Sequences:

>Translated_456_residues
MSKLILVVDDENDIRTSLTGILEDEGFLVSCAASGVEALENVCHEIPDIVLLDIWMPGLDGLETLEKLKQLFPHLTVIMI
SGHGTIETAVRATKLGAFDFIEKPLSLDKVLITVNNALRMGELRVENEELRRVAGYEYELIGESPAMVCLRDQVMRVAPT
SLCVLVNGENGSGKERVARSIHYYSKRCARPFVAINCAAIPEELIQNELFGHEKGALGGAPSQKKGKIDLADGGTLFLDE
IGDMSLATQSRILGVIQEHCFQRVGGNRSVPADVRVIAASSRDIADEVRNSRFREDLFYLLNVIPLVVPPLRERREDIAL
LVPHFVEQFNRREGREQKTFSPQAMALLARLDWPGNVRELQNIVERVLIMVPGRMIAAEDLSGLFGDQARILANEEMLQA
AAPGTLREAREEFERDFIVRKLEENDWNISRTAETIELKRSNLHRKIKSYGIDVKK
>Mature_455_residues
SKLILVVDDENDIRTSLTGILEDEGFLVSCAASGVEALENVCHEIPDIVLLDIWMPGLDGLETLEKLKQLFPHLTVIMIS
GHGTIETAVRATKLGAFDFIEKPLSLDKVLITVNNALRMGELRVENEELRRVAGYEYELIGESPAMVCLRDQVMRVAPTS
LCVLVNGENGSGKERVARSIHYYSKRCARPFVAINCAAIPEELIQNELFGHEKGALGGAPSQKKGKIDLADGGTLFLDEI
GDMSLATQSRILGVIQEHCFQRVGGNRSVPADVRVIAASSRDIADEVRNSRFREDLFYLLNVIPLVVPPLRERREDIALL
VPHFVEQFNRREGREQKTFSPQAMALLARLDWPGNVRELQNIVERVLIMVPGRMIAAEDLSGLFGDQARILANEEMLQAA
APGTLREAREEFERDFIVRKLEENDWNISRTAETIELKRSNLHRKIKSYGIDVKK

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=452, Percent_Identity=40.2654867256637, Blast_Score=359, Evalue=1e-100,
Organism=Escherichia coli, GI1790437, Length=444, Percent_Identity=42.1171171171171, Blast_Score=347, Evalue=9e-97,
Organism=Escherichia coli, GI1790299, Length=468, Percent_Identity=40.3846153846154, Blast_Score=338, Evalue=3e-94,
Organism=Escherichia coli, GI1788905, Length=449, Percent_Identity=36.0801781737194, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI87082152, Length=321, Percent_Identity=43.613707165109, Blast_Score=249, Evalue=3e-67,
Organism=Escherichia coli, GI87082117, Length=329, Percent_Identity=43.4650455927052, Blast_Score=248, Evalue=8e-67,
Organism=Escherichia coli, GI1789087, Length=360, Percent_Identity=39.7222222222222, Blast_Score=241, Evalue=7e-65,
Organism=Escherichia coli, GI1789233, Length=321, Percent_Identity=39.8753894080997, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1787583, Length=350, Percent_Identity=32.8571428571429, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1786524, Length=318, Percent_Identity=38.0503144654088, Blast_Score=191, Evalue=8e-50,
Organism=Escherichia coli, GI87081872, Length=338, Percent_Identity=34.3195266272189, Blast_Score=185, Evalue=5e-48,
Organism=Escherichia coli, GI87081858, Length=307, Percent_Identity=31.9218241042345, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1789828, Length=244, Percent_Identity=35.2459016393443, Blast_Score=128, Evalue=8e-31,
Organism=Escherichia coli, GI1786599, Length=121, Percent_Identity=32.2314049586777, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1790860, Length=175, Percent_Identity=26.8571428571429, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786784, Length=117, Percent_Identity=29.9145299145299, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51018; Mature: 50886

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLILVVDDENDIRTSLTGILEDEGFLVSCAASGVEALENVCHEIPDIVLLDIWMPGLD
CCEEEEEEECCCCHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCCEEEEEECCCCCC
GLETLEKLKQLFPHLTVIMISGHGTIETAVRATKLGAFDFIEKPLSLDKVLITVNNALRM
HHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHCCHHHHHHCCCCCCEEEEEECCCCEE
GELRVENEELRRVAGYEYELIGESPAMVCLRDQVMRVAPTSLCVLVNGENGSGKERVARS
CCEEECHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHH
IHYYSKRCARPFVAINCAAIPEELIQNELFGHEKGALGGAPSQKKGKIDLADGGTLFLDE
HHHHHHHHCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCEEEEEC
IGDMSLATQSRILGVIQEHCFQRVGGNRSVPADVRVIAASSRDIADEVRNSRFREDLFYL
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHH
LNVIPLVVPPLRERREDIALLVPHFVEQFNRREGREQKTFSPQAMALLARLDWPGNVREL
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCHHHH
QNIVERVLIMVPGRMIAAEDLSGLFGDQARILANEEMLQAAAPGTLREAREEFERDFIVR
HHHHHHHHHHCCCCEEEHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
KLEENDWNISRTAETIELKRSNLHRKIKSYGIDVKK
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SKLILVVDDENDIRTSLTGILEDEGFLVSCAASGVEALENVCHEIPDIVLLDIWMPGLD
CEEEEEEECCCCHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCCEEEEEECCCCCC
GLETLEKLKQLFPHLTVIMISGHGTIETAVRATKLGAFDFIEKPLSLDKVLITVNNALRM
HHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHCCHHHHHHCCCCCCEEEEEECCCCEE
GELRVENEELRRVAGYEYELIGESPAMVCLRDQVMRVAPTSLCVLVNGENGSGKERVARS
CCEEECHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHH
IHYYSKRCARPFVAINCAAIPEELIQNELFGHEKGALGGAPSQKKGKIDLADGGTLFLDE
HHHHHHHHCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCEEEEEC
IGDMSLATQSRILGVIQEHCFQRVGGNRSVPADVRVIAASSRDIADEVRNSRFREDLFYL
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHH
LNVIPLVVPPLRERREDIALLVPHFVEQFNRREGREQKTFSPQAMALLARLDWPGNVREL
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCHHHH
QNIVERVLIMVPGRMIAAEDLSGLFGDQARILANEEMLQAAAPGTLREAREEFERDFIVR
HHHHHHHHHHCCCCEEEHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
KLEENDWNISRTAETIELKRSNLHRKIKSYGIDVKK
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]