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The map label for this gene is fmt

Identifier: 118578952

GI number: 118578952

Start: 539546

End: 540505

Strand: Reverse

Name: fmt

Synonym: Ppro_0513

Alternate gene names: 118578952

Gene position: 540505-539546 (Counterclockwise)

Preceding gene: 118578953

Following gene: 118578951

Centisome position: 13.49

GC content: 67.4

Gene sequence:

>960_bases
ATGAGCAGCAGGAGCATCGTCTTCATGGGAACGCCCGAGTTTGCCTGCCCCACCCTGCAGGCCCTGATCGACCGCGGAGA
ACGGCTGCTGGCAGTGGTCACCCAGCCCGACAGGCCCAAGGGGCGCGGCCACAAGCTGATGCCACCCCCGGTTAAGGAAC
TGGCCCTGGCCCACGACATTCCGGTGCTCCAACCCCACAGGGTCCGCGCTTCCGCCTTCGTCGAGAGCATCCGCCAGCTG
GCTCCCGAACTGATCGTGGTGGTTGCCTTCGGACAGATCCTGCCCAAGGCGCTGCTGGACATTCCTCCCCTGGGCTGCGT
CAACGTCCACGCCTCCCTGCTCCCCCGCTACCGAGGCGCCGCCCCGCTCAACTGGTGCATCATCAACGGAGAAACAGAGA
CCGGCGTCACCACCATGCTGATGGATACGGGGCTCGATACCGGTCCCATGCTGCTCAAGCGCTCGACCCCCATCGACGAG
AATGAGGACATCGTCTCGCTGCACGACCGCATGGCCTCCCTGGGCGCGGAGCTGCTGGCCGAGACCCTGGACGGCCTCCG
GGAGGGGCGCATCGAGCCGCAGCCCCAGAACGACAGCCTGAGCTGCTACGCTCCGCTGCTCAAGAAGGAGCACGGCCTAA
TCGACTGGCAGCGGCCTGCCCGCCAGATCCACAACCAGGTTCGCGGACTGGCTGCCTGGCCCGGCGCCCAGACCCTTCTC
AACGGCCATGCCCTGAAGCTGTTCCGCACCCGGGTAGCCGATGGCGCGGGAGCTCCGGGAACGGTGCTCTGCTCCACCGG
CGGCCAGCTCGAGGTGGCCTGCCTGGACGGCAGCCTGCTCATCCAGGAACTGCAGCTGGCGGGCAAAAAGCGCTTGGACA
GCGCCAGCTTCCTGGCCGGCTGCCCCATAGCCGAGGGAACCCTGCTGGGCGGAGCGGCAACGGAGAGACCGATACCGTGA

Upstream 100 bases:

>100_bases
TGGACGGCAGACTCTTCGTCGACCACCTCTCGCCCCTCAAGCGCGATCTGTTCCAGCGCAGGGCCCGCAAGGCGGCGGAA
GCGAAAGCAGCGGGGGAGCG

Downstream 100 bases:

>100_bases
CGGCACACAATCTCCAGCCCGAAGCGCCCCGCAAACGGCTGTTCATCTCCCTGATGGGGCTGACCTGCCTGCTGCTGGTG
GCCCTGATCTTCCTGGCCTG

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MSSRSIVFMGTPEFACPTLQALIDRGERLLAVVTQPDRPKGRGHKLMPPPVKELALAHDIPVLQPHRVRASAFVESIRQL
APELIVVVAFGQILPKALLDIPPLGCVNVHASLLPRYRGAAPLNWCIINGETETGVTTMLMDTGLDTGPMLLKRSTPIDE
NEDIVSLHDRMASLGAELLAETLDGLREGRIEPQPQNDSLSCYAPLLKKEHGLIDWQRPARQIHNQVRGLAAWPGAQTLL
NGHALKLFRTRVADGAGAPGTVLCSTGGQLEVACLDGSLLIQELQLAGKKRLDSASFLAGCPIAEGTLLGGAATERPIP

Sequences:

>Translated_319_residues
MSSRSIVFMGTPEFACPTLQALIDRGERLLAVVTQPDRPKGRGHKLMPPPVKELALAHDIPVLQPHRVRASAFVESIRQL
APELIVVVAFGQILPKALLDIPPLGCVNVHASLLPRYRGAAPLNWCIINGETETGVTTMLMDTGLDTGPMLLKRSTPIDE
NEDIVSLHDRMASLGAELLAETLDGLREGRIEPQPQNDSLSCYAPLLKKEHGLIDWQRPARQIHNQVRGLAAWPGAQTLL
NGHALKLFRTRVADGAGAPGTVLCSTGGQLEVACLDGSLLIQELQLAGKKRLDSASFLAGCPIAEGTLLGGAATERPIP
>Mature_318_residues
SSRSIVFMGTPEFACPTLQALIDRGERLLAVVTQPDRPKGRGHKLMPPPVKELALAHDIPVLQPHRVRASAFVESIRQLA
PELIVVVAFGQILPKALLDIPPLGCVNVHASLLPRYRGAAPLNWCIINGETETGVTTMLMDTGLDTGPMLLKRSTPIDEN
EDIVSLHDRMASLGAELLAETLDGLREGRIEPQPQNDSLSCYAPLLKKEHGLIDWQRPARQIHNQVRGLAAWPGAQTLLN
GHALKLFRTRVADGAGAPGTVLCSTGGQLEVACLDGSLLIQELQLAGKKRLDSASFLAGCPIAEGTLLGGAATERPIP

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI238814322, Length=306, Percent_Identity=27.1241830065359, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI21614513, Length=315, Percent_Identity=27.9365079365079, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI164663775, Length=317, Percent_Identity=29.9684542586751, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1789683, Length=298, Percent_Identity=44.6308724832215, Blast_Score=245, Evalue=2e-66,
Organism=Escherichia coli, GI1788589, Length=282, Percent_Identity=32.6241134751773, Blast_Score=152, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI133930964, Length=261, Percent_Identity=29.1187739463602, Blast_Score=124, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6319458, Length=361, Percent_Identity=26.5927977839335, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI45550868, Length=302, Percent_Identity=31.1258278145695, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI28571984, Length=225, Percent_Identity=32.4444444444444, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24585660, Length=247, Percent_Identity=29.9595141700405, Blast_Score=105, Evalue=5e-23,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_PELPD (A1ALC4)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_900202.1
- ProteinModelPortal:   A1ALC4
- SMR:   A1ALC4
- STRING:   A1ALC4
- GeneID:   4572884
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_0513
- eggNOG:   COG0223
- HOGENOM:   HBG571560
- OMA:   VVAYGAI
- PhylomeDB:   A1ALC4
- ProtClustDB:   CLSK827657
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 34234; Mature: 34103

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSRSIVFMGTPEFACPTLQALIDRGERLLAVVTQPDRPKGRGHKLMPPPVKELALAHDI
CCCCCEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHCC
PVLQPHRVRASAFVESIRQLAPELIVVVAFGQILPKALLDIPPLGCVNVHASLLPRYRGA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
APLNWCIINGETETGVTTMLMDTGLDTGPMLLKRSTPIDENEDIVSLHDRMASLGAELLA
CCCEEEEECCCCCCCCEEEEECCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHH
ETLDGLREGRIEPQPQNDSLSCYAPLLKKEHGLIDWQRPARQIHNQVRGLAAWPGAQTLL
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCEECCCCHHHHH
NGHALKLFRTRVADGAGAPGTVLCSTGGQLEVACLDGSLLIQELQLAGKKRLDSASFLAG
CCHHHHHHHHHHCCCCCCCCEEEECCCCEEEEEEECHHHHHHHHHHHHHHCCCCCHHHHC
CPIAEGTLLGGAATERPIP
CCCCCCCEECCCCCCCCCC
>Mature Secondary Structure 
SSRSIVFMGTPEFACPTLQALIDRGERLLAVVTQPDRPKGRGHKLMPPPVKELALAHDI
CCCCEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHCC
PVLQPHRVRASAFVESIRQLAPELIVVVAFGQILPKALLDIPPLGCVNVHASLLPRYRGA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
APLNWCIINGETETGVTTMLMDTGLDTGPMLLKRSTPIDENEDIVSLHDRMASLGAELLA
CCCEEEEECCCCCCCCEEEEECCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHH
ETLDGLREGRIEPQPQNDSLSCYAPLLKKEHGLIDWQRPARQIHNQVRGLAAWPGAQTLL
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCEECCCCHHHHH
NGHALKLFRTRVADGAGAPGTVLCSTGGQLEVACLDGSLLIQELQLAGKKRLDSASFLAG
CCHHHHHHHHHHCCCCCCCCEEEECCCCEEEEEEECHHHHHHHHHHHHHHCCCCCHHHHC
CPIAEGTLLGGAATERPIP
CCCCCCCEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA