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The map label for this gene is tsaA [H]

Identifier: 118578922

GI number: 118578922

Start: 504831

End: 505427

Strand: Reverse

Name: tsaA [H]

Synonym: Ppro_0483

Alternate gene names: 118578922

Gene position: 505427-504831 (Counterclockwise)

Preceding gene: 118578928

Following gene: 118578921

Centisome position: 12.61

GC content: 59.46

Gene sequence:

>597_bases
ATGAGTTTGACAACCCTGGTCACCCAGCAGGCTCCCGACTTCACCGCCGAGGCGGTCATGGCCGACAATAGCTTCGCCTC
CATCACGCTCTCCAGCCTGAAGGGAAAATTTGTCCTGCTGCTCTTCTATCCCCTGGATTTCACCTTCGTCTGCCCGTCCG
AGATACTGGCCTTCAACCGACAGATTGCAGCCTTCAAGGCAAAGAACTGCGAGGTGATCGGCATCTCCGTTGACTCCAAG
TTCACCCATCTGGCATGGAAGAACACTCCCATCGAAAACGGCGGCATCGGCAACATCCAGTTCCCGCTGGTCCAGGATCT
GGACAGGGAGATCGCCAAATCATACGGTATCCTGCTGAACAATTCCGTGGCCCTGCGCGGCCTGTTCCTGATCGACCCGA
CGGGGACGGTCAGGCACTGCATCATCAACGACCTGCCCTTGGGGCGGAGCGTCACGGAGGCCATCAGGATGCTCGATGCG
ATCCAGTTTTCCGACACCCACGGCGAGGTCTGCCCCGCCAACTGGCAGGAGGGCGAGGAGGCGATGAAACCTACCACCGA
GGGGGTTGCCGACTACCTGACCAGATTCGCCCGCTGA

Upstream 100 bases:

>100_bases
AAAAAAACAAAGAAGATTGTTTTTATCCTATTGACAAGAGCGCGCGGGACTGATATGTATCGCTCATTCAGCGCAACTAT
TCGAAAAAGGAGGATATACC

Downstream 100 bases:

>100_bases
CTCGTGGGGCGCGGTCAAGGGACTGCACCCTGTGCGCCATTGCACGCCAAACCTGCGCAGCCACCGTGCCCGGAGCTCCC
GAACATCCCAAACTTACTGC

Product: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen

Products: NA

Alternate protein names: 26 kDa antigen; Thioredoxin reductase [H]

Number of amino acids: Translated: 198; Mature: 197

Protein sequence:

>198_residues
MSLTTLVTQQAPDFTAEAVMADNSFASITLSSLKGKFVLLLFYPLDFTFVCPSEILAFNRQIAAFKAKNCEVIGISVDSK
FTHLAWKNTPIENGGIGNIQFPLVQDLDREIAKSYGILLNNSVALRGLFLIDPTGTVRHCIINDLPLGRSVTEAIRMLDA
IQFSDTHGEVCPANWQEGEEAMKPTTEGVADYLTRFAR

Sequences:

>Translated_198_residues
MSLTTLVTQQAPDFTAEAVMADNSFASITLSSLKGKFVLLLFYPLDFTFVCPSEILAFNRQIAAFKAKNCEVIGISVDSK
FTHLAWKNTPIENGGIGNIQFPLVQDLDREIAKSYGILLNNSVALRGLFLIDPTGTVRHCIINDLPLGRSVTEAIRMLDA
IQFSDTHGEVCPANWQEGEEAMKPTTEGVADYLTRFAR
>Mature_197_residues
SLTTLVTQQAPDFTAEAVMADNSFASITLSSLKGKFVLLLFYPLDFTFVCPSEILAFNRQIAAFKAKNCEVIGISVDSKF
THLAWKNTPIENGGIGNIQFPLVQDLDREIAKSYGILLNNSVALRGLFLIDPTGTVRHCIINDLPLGRSVTEAIRMLDAI
QFSDTHGEVCPANWQEGEEAMKPTTEGVADYLTRFAR

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI4505591, Length=190, Percent_Identity=51.0526315789474, Blast_Score=219, Evalue=1e-57,
Organism=Homo sapiens, GI32455266, Length=190, Percent_Identity=51.0526315789474, Blast_Score=219, Evalue=1e-57,
Organism=Homo sapiens, GI32455264, Length=190, Percent_Identity=51.0526315789474, Blast_Score=219, Evalue=1e-57,
Organism=Homo sapiens, GI32189392, Length=190, Percent_Identity=49.4736842105263, Blast_Score=216, Evalue=1e-56,
Organism=Homo sapiens, GI5802974, Length=190, Percent_Identity=50, Blast_Score=215, Evalue=2e-56,
Organism=Homo sapiens, GI32483377, Length=198, Percent_Identity=48.989898989899, Blast_Score=213, Evalue=1e-55,
Organism=Homo sapiens, GI5453549, Length=191, Percent_Identity=47.1204188481675, Blast_Score=199, Evalue=1e-51,
Organism=Homo sapiens, GI33188454, Length=131, Percent_Identity=41.9847328244275, Blast_Score=103, Evalue=7e-23,
Organism=Homo sapiens, GI4758638, Length=192, Percent_Identity=25.5208333333333, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1786822, Length=183, Percent_Identity=28.4153005464481, Blast_Score=103, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17554494, Length=185, Percent_Identity=49.1891891891892, Blast_Score=199, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI193204376, Length=191, Percent_Identity=46.0732984293194, Blast_Score=197, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI32565831, Length=191, Percent_Identity=46.0732984293194, Blast_Score=197, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI25153706, Length=184, Percent_Identity=27.7173913043478, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6323613, Length=188, Percent_Identity=45.7446808510638, Blast_Score=185, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6320661, Length=188, Percent_Identity=42.5531914893617, Blast_Score=174, Evalue=7e-45,
Organism=Saccharomyces cerevisiae, GI6319407, Length=201, Percent_Identity=27.363184079602, Blast_Score=97, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24656348, Length=191, Percent_Identity=51.8324607329843, Blast_Score=214, Evalue=2e-56,
Organism=Drosophila melanogaster, GI17864676, Length=191, Percent_Identity=51.8324607329843, Blast_Score=214, Evalue=2e-56,
Organism=Drosophila melanogaster, GI17738015, Length=192, Percent_Identity=48.9583333333333, Blast_Score=204, Evalue=2e-53,
Organism=Drosophila melanogaster, GI17157991, Length=177, Percent_Identity=49.7175141242938, Blast_Score=196, Evalue=8e-51,
Organism=Drosophila melanogaster, GI24641739, Length=177, Percent_Identity=49.7175141242938, Blast_Score=196, Evalue=8e-51,
Organism=Drosophila melanogaster, GI21357347, Length=188, Percent_Identity=45.2127659574468, Blast_Score=189, Evalue=9e-49,
Organism=Drosophila melanogaster, GI24581278, Length=183, Percent_Identity=25.1366120218579, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17975518, Length=186, Percent_Identity=29.5698924731183, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24652434, Length=186, Percent_Identity=29.0322580645161, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24652436, Length=186, Percent_Identity=29.0322580645161, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 21804; Mature: 21673

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLTTLVTQQAPDFTAEAVMADNSFASITLSSLKGKFVLLLFYPLDFTFVCPSEILAFNR
CCCHHEEECCCCCCCHHEEEECCCCCEEEEECCCCCEEEEEEECCCEEEECHHHHHHHCC
QIAAFKAKNCEVIGISVDSKFTHLAWKNTPIENGGIGNIQFPLVQDLDREIAKSYGILLN
HHEEEECCCCEEEEEECCCCEEEEEECCCCCCCCCCCCEECHHHHHHHHHHHHHCCEEEE
NSVALRGLFLIDPTGTVRHCIINDLPLGRSVTEAIRMLDAIQFSDTHGEVCPANWQEGEE
CCEEEEEEEEECCCCCCHHHEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHH
AMKPTTEGVADYLTRFAR
HHCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SLTTLVTQQAPDFTAEAVMADNSFASITLSSLKGKFVLLLFYPLDFTFVCPSEILAFNR
CCHHEEECCCCCCCHHEEEECCCCCEEEEECCCCCEEEEEEECCCEEEECHHHHHHHCC
QIAAFKAKNCEVIGISVDSKFTHLAWKNTPIENGGIGNIQFPLVQDLDREIAKSYGILLN
HHEEEECCCCEEEEEECCCCEEEEEECCCCCCCCCCCCEECHHHHHHHHHHHHHCCEEEE
NSVALRGLFLIDPTGTVRHCIINDLPLGRSVTEAIRMLDAIQFSDTHGEVCPANWQEGEE
CCEEEEEEEEECCCCCCHHHEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHH
AMKPTTEGVADYLTRFAR
HHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682; 1987145 [H]