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The map label for this gene is moaA [H]

Identifier: 118578746

GI number: 118578746

Start: 302576

End: 303556

Strand: Reverse

Name: moaA [H]

Synonym: Ppro_0304

Alternate gene names: 118578746

Gene position: 303556-302576 (Counterclockwise)

Preceding gene: 118578747

Following gene: 118578745

Centisome position: 7.57

GC content: 62.59

Gene sequence:

>981_bases
ATGAACCTGACCGATTCTCTAGGTAGAAAAATCAACTATCTGCGTCTGTCCATAACCGACCGCTGCAACATGCGCTGCTT
CTACTGCATGCCCAGCGTGGGTGTGGTGGACAAGGGGCACAAGTCGGTGCTCAGCTACGAGGAGCTACTCCTGATAGCCG
AGACTGCGGTGAAGTTGGGCATCGAGAAGATCCGTATCACCGGCGGCGAGCCGCTGGTGCGCATCGGCGTGGTCGGCTTT
CTGGAGCGCCTGGCCGCCATCCCCGGTCTGCAGCATCTGGCGGTGACAACCAACGGACTGCTGCTGGAAGAGATGGCCAG
CGACCTGTACCGGGCCGGCGTGCAGCGCCTGAACGTCAGCTTGGACTCCCTCAACCCTGAGACCTTCGGGAAGATCACCC
GCGGCGGCGACCTGAAGAAGGTTCTGGCCGGCCTGGATGCCGCGGAACGGGCGGGATTCCCTCCGCCCAAGATCAACGTG
GTGACCATGCGCGGGGTGAACGACGGCGAGATCCTGGATTTTGCCGCCCTGACCCTGACGCGGGGCAACCCGGTGCGCTT
CATCGAATACATGCCGGCCATCAAGGAGAACGGCTGGCAGCGCTACTGCATCTCCGGCAGCGAAATCCTGGAGCGGATCT
CCACCAGGTACCCTCTGGAGGAGGTGGACCGGGGCATATTCTCCGGGCCATCGCGGGACTACCGCATTCCGGGTGCCCAG
GGCCACATCGGCATCATCACCGCCGTGTCCGGCCACTTCTGCAGCGAGTGCAACCGCATCCGGGTAACCTCAACCGGAAA
GGCCAAGGGATGCCTGTTCGCCGACGAAGCGACCGACCTGATCCCCTGGCTGCGGCCGCCGGACCGGGAGGGGCTGGAGA
AAGTACTGAAGGAGGTGGTCATGAGCAAGCCGGAACGCCACGGCATCACCCAGGACGGCTACCACCACAAGAATTTCAAT
ATGTCACAGATAGGAGGCTGA

Upstream 100 bases:

>100_bases
ACCGCGCATTTTCGAAGATCAATGGCTGCATTCACCGTTGTCCATCGGTTCCTGTAGGTTTCCGTGACAATAAATCCAAC
TGATTGCGTGATGGGTAGAC

Downstream 100 bases:

>100_bases
CATGGCACAGGTCGTGGCCACCTGTATCAGCGAAAAGAAGGGTGAACGCAAGACGCCGCTGGAGGCGGTGACCCTGCGAG
AAAATCACGGCATCGTCGGC

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MNLTDSLGRKINYLRLSITDRCNMRCFYCMPSVGVVDKGHKSVLSYEELLLIAETAVKLGIEKIRITGGEPLVRIGVVGF
LERLAAIPGLQHLAVTTNGLLLEEMASDLYRAGVQRLNVSLDSLNPETFGKITRGGDLKKVLAGLDAAERAGFPPPKINV
VTMRGVNDGEILDFAALTLTRGNPVRFIEYMPAIKENGWQRYCISGSEILERISTRYPLEEVDRGIFSGPSRDYRIPGAQ
GHIGIITAVSGHFCSECNRIRVTSTGKAKGCLFADEATDLIPWLRPPDREGLEKVLKEVVMSKPERHGITQDGYHHKNFN
MSQIGG

Sequences:

>Translated_326_residues
MNLTDSLGRKINYLRLSITDRCNMRCFYCMPSVGVVDKGHKSVLSYEELLLIAETAVKLGIEKIRITGGEPLVRIGVVGF
LERLAAIPGLQHLAVTTNGLLLEEMASDLYRAGVQRLNVSLDSLNPETFGKITRGGDLKKVLAGLDAAERAGFPPPKINV
VTMRGVNDGEILDFAALTLTRGNPVRFIEYMPAIKENGWQRYCISGSEILERISTRYPLEEVDRGIFSGPSRDYRIPGAQ
GHIGIITAVSGHFCSECNRIRVTSTGKAKGCLFADEATDLIPWLRPPDREGLEKVLKEVVMSKPERHGITQDGYHHKNFN
MSQIGG
>Mature_326_residues
MNLTDSLGRKINYLRLSITDRCNMRCFYCMPSVGVVDKGHKSVLSYEELLLIAETAVKLGIEKIRITGGEPLVRIGVVGF
LERLAAIPGLQHLAVTTNGLLLEEMASDLYRAGVQRLNVSLDSLNPETFGKITRGGDLKKVLAGLDAAERAGFPPPKINV
VTMRGVNDGEILDFAALTLTRGNPVRFIEYMPAIKENGWQRYCISGSEILERISTRYPLEEVDRGIFSGPSRDYRIPGAQ
GHIGIITAVSGHFCSECNRIRVTSTGKAKGCLFADEATDLIPWLRPPDREGLEKVLKEVVMSKPERHGITQDGYHHKNFN
MSQIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=327, Percent_Identity=41.8960244648318, Blast_Score=238, Evalue=4e-63,
Organism=Homo sapiens, GI22027536, Length=327, Percent_Identity=41.8960244648318, Blast_Score=238, Evalue=5e-63,
Organism=Escherichia coli, GI1786999, Length=338, Percent_Identity=35.207100591716, Blast_Score=182, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI32566331, Length=313, Percent_Identity=37.3801916932907, Blast_Score=214, Evalue=7e-56,
Organism=Caenorhabditis elegans, GI32566329, Length=326, Percent_Identity=37.1165644171779, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17561210, Length=325, Percent_Identity=36.6153846153846, Blast_Score=208, Evalue=3e-54,
Organism=Drosophila melanogaster, GI28574490, Length=320, Percent_Identity=40.9375, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI28574488, Length=330, Percent_Identity=40.6060606060606, Blast_Score=228, Evalue=4e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 35954; Mature: 35954

Theoretical pI: Translated: 8.28; Mature: 8.28

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLTDSLGRKINYLRLSITDRCNMRCFYCMPSVGVVDKGHKSVLSYEELLLIAETAVKLG
CCCCHHHCCCEEEEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
IEKIRITGGEPLVRIGVVGFLERLAAIPGLQHLAVTTNGLLLEEMASDLYRAGVQRLNVS
CEEEEEECCCCEEHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCC
LDSLNPETFGKITRGGDLKKVLAGLDAAERAGFPPPKINVVTMRGVNDGEILDFAALTLT
HHCCCHHHHHCCCCCCCHHHHHHCCCHHHHCCCCCCCEEEEEEECCCCCCEEEEEEEEEE
RGNPVRFIEYMPAIKENGWQRYCISGSEILERISTRYPLEEVDRGIFSGPSRDYRIPGAQ
CCCCEEHHHHHHHHHCCCCEEEECCHHHHHHHHHHCCCHHHHHCHHHCCCCCCEECCCCC
GHIGIITAVSGHFCSECNRIRVTSTGKAKGCLFADEATDLIPWLRPPDREGLEKVLKEVV
CCEEEEEEECCHHHHCCCEEEEEECCCCCCEEEECCHHHHCCCCCCCCHHHHHHHHHHHH
MSKPERHGITQDGYHHKNFNMSQIGG
HCCCCCCCCCCCCCCCCCCCHHHCCC
>Mature Secondary Structure
MNLTDSLGRKINYLRLSITDRCNMRCFYCMPSVGVVDKGHKSVLSYEELLLIAETAVKLG
CCCCHHHCCCEEEEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
IEKIRITGGEPLVRIGVVGFLERLAAIPGLQHLAVTTNGLLLEEMASDLYRAGVQRLNVS
CEEEEEECCCCEEHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCC
LDSLNPETFGKITRGGDLKKVLAGLDAAERAGFPPPKINVVTMRGVNDGEILDFAALTLT
HHCCCHHHHHCCCCCCCHHHHHHCCCHHHHCCCCCCCEEEEEEECCCCCCEEEEEEEEEE
RGNPVRFIEYMPAIKENGWQRYCISGSEILERISTRYPLEEVDRGIFSGPSRDYRIPGAQ
CCCCEEHHHHHHHHHCCCCEEEECCHHHHHHHHHHCCCHHHHHCHHHCCCCCCEECCCCC
GHIGIITAVSGHFCSECNRIRVTSTGKAKGCLFADEATDLIPWLRPPDREGLEKVLKEVV
CCEEEEEEECCHHHHCCCEEEEEECCCCCCEEEECCHHHHCCCCCCCCHHHHHHHHHHHH
MSKPERHGITQDGYHHKNFNMSQIGG
HCCCCCCCCCCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA