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The map label for this gene is folK [H]

Identifier: 118578738

GI number: 118578738

Start: 292345

End: 292833

Strand: Reverse

Name: folK [H]

Synonym: Ppro_0296

Alternate gene names: 118578738

Gene position: 292833-292345 (Counterclockwise)

Preceding gene: 118578739

Following gene: 118578737

Centisome position: 7.31

GC content: 62.58

Gene sequence:

>489_bases
GTGGAAACGGATGCCTACATCGGCCTTGGCTCCAATCAGGGAGACAGGGAGCTCAACCTGCTGCGCGCGGTGGCTGAACT
GGGCAAACTGCCCGAGAGCAGGGTCCGCGGATTGTCATCCTTTTACGAGACCTCGCCGGTGGGCGTCAACGAACAGCCTG
ACTTTTACAACGCAGTCCTGCGGCTCTCCACCCGCCTTTCCCCCCTGGAATTGCTGCGTCGACTCCTTAAGATCGAACAT
AACATCTTCCACCGCAAGCGAACCCTGCGCTGGGGGCCACGCGCCATGGACCTGGATCTTTTGCTCTACGGTGACCTGGT
GATCACCAGCGATGAGTTGACCGTACCCCATCCCGCCATGGCAGAGCGGCGCTTCGTACTCCAGCCGCTGCATGACCTGG
CGCCCGACCTCACTCACCCCACCCTGGGACGCACCGTGGCCGAGCTGCTTCAGGCACTCCCCCCGACGGAGCGCGTGAAG
CCACTCTGA

Upstream 100 bases:

>100_bases
TTTTCCCTCCTAGTTGCCAGGGTGTTTTTTTGTCTGATCGCCCCCGCCATCCAGCAGAGTGCGGTTGACGTGAGAATCCG
GTTGTGTTTTAATCCCCTGC

Downstream 100 bases:

>100_bases
GCGAACAAGAGAGACACCATGATTCGACTACTGCTCTGGGGGCTGCTCGTGTACTGCGGCTTCCGGATCGTTTCCTCGTT
GAAACGGACAGCGAAACACC

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 162; Mature: 162

Protein sequence:

>162_residues
METDAYIGLGSNQGDRELNLLRAVAELGKLPESRVRGLSSFYETSPVGVNEQPDFYNAVLRLSTRLSPLELLRRLLKIEH
NIFHRKRTLRWGPRAMDLDLLLYGDLVITSDELTVPHPAMAERRFVLQPLHDLAPDLTHPTLGRTVAELLQALPPTERVK
PL

Sequences:

>Translated_162_residues
METDAYIGLGSNQGDRELNLLRAVAELGKLPESRVRGLSSFYETSPVGVNEQPDFYNAVLRLSTRLSPLELLRRLLKIEH
NIFHRKRTLRWGPRAMDLDLLLYGDLVITSDELTVPHPAMAERRFVLQPLHDLAPDLTHPTLGRTVAELLQALPPTERVK
PL
>Mature_162_residues
METDAYIGLGSNQGDRELNLLRAVAELGKLPESRVRGLSSFYETSPVGVNEQPDFYNAVLRLSTRLSPLELLRRLLKIEH
NIFHRKRTLRWGPRAMDLDLLLYGDLVITSDELTVPHPAMAERRFVLQPLHDLAPDLTHPTLGRTVAELLQALPPTERVK
PL

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=138, Percent_Identity=44.2028985507246, Blast_Score=119, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6324073, Length=155, Percent_Identity=33.5483870967742, Blast_Score=99, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18352; Mature: 18352

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METDAYIGLGSNQGDRELNLLRAVAELGKLPESRVRGLSSFYETSPVGVNEQPDFYNAVL
CCCCCEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
RLSTRLSPLELLRRLLKIEHNIFHRKRTLRWGPRAMDLDLLLYGDLVITSDELTVPHPAM
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCEEEECCCCCCCCCHH
AERRFVLQPLHDLAPDLTHPTLGRTVAELLQALPPTERVKPL
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
METDAYIGLGSNQGDRELNLLRAVAELGKLPESRVRGLSSFYETSPVGVNEQPDFYNAVL
CCCCCEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
RLSTRLSPLELLRRLLKIEHNIFHRKRTLRWGPRAMDLDLLLYGDLVITSDELTVPHPAM
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCEEEECCCCCCCCCHH
AERRFVLQPLHDLAPDLTHPTLGRTVAELLQALPPTERVKPL
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1325970; 8202364; 9278503; 1657875; 2537812; 10378268; 10452528 [H]