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The map label for this gene is dsbC [H]

Identifier: 118578703

GI number: 118578703

Start: 258019

End: 258771

Strand: Reverse

Name: dsbC [H]

Synonym: Ppro_0260

Alternate gene names: 118578703

Gene position: 258771-258019 (Counterclockwise)

Preceding gene: 118578704

Following gene: 118578702

Centisome position: 6.46

GC content: 51.79

Gene sequence:

>753_bases
GTGAAGACCGCAAACAACAAGAAACTTATGGTCGGCGGGCTGATGATGGTCATCATGACTGCGGCGGGTTTCTCTATGGC
TAACGAAAATCTGAGAACGGAGAAAGATGCCCTGATGAAGACCTTTCCAAATTTGAAAATGGACGGCTTCAGGGAATCGC
CGCTCAAAGGCCTATATGAGATCACCGCAGGCGACCAGGTGTTTTACTTCAGCCCTGAAGGATACCTGTTTTTTGGTGAA
TTATGGACCAAAGACGGCAAGAACCTGACAGCCGAGATGCGGGAGAAGGTTGCCACTGAACGAATCAACAGTCTCCCCCT
TGATAAGGCCCTGAAAGTCGGCAATGGCCCGAAAAAGGTCATCGAGTTCACCGACCCCGACTGTCCCTATTGCCGCAAGG
TGGACGGCTATCTTGCGAAGCGTACCGATGTGACGCGCTACATTTATTTCGTCCCGCTCCGCAGAATCCATCCTGACGCC
GAAAAGAAGGCCCGTTACATCTTGTCCCAATCTGATCGGAACAAGGCATTCCATGATGTTTTTACCGGTCAACTGGACGG
CAAACCGATTTCCATCGCCGAAGATGCGCAGCAACAGCAACTGGAGGAAATGGAGAAGATCGCTGCCGGGATTGGAATAC
GGGGAACACCGGCTCTCTGGATCGAAGGTGCTCACGTGAATGGTGCGGACATCCAACTGATATCCAGATTGCTTGACGAG
GGAAAGGAGGTAAGCAAGCCACAATCGCACTGA

Upstream 100 bases:

>100_bases
ACATCGGGACTATTGAAGGCAGAGGTAAATGCTGCCCTGCCTCGCAGGACAAACGACAGAACAGACGAGTGGAAATCATC
GGAATTCGAAAGGAGGGGAT

Downstream 100 bases:

>100_bases
TTCAGTACCAAAGTCACTTCACACCACCACGTAACCAGCACAAAGGAGAACTGAATGCACAAACGGAAACTGCTTCTGAT
GACCATTGTCGCAATAATCG

Product: protein-disulfide isomerase

Products: 3-oxo-D 4-steroid; protein with oxidized disulfide bonds [C]

Alternate protein names: NA

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MKTANNKKLMVGGLMMVIMTAAGFSMANENLRTEKDALMKTFPNLKMDGFRESPLKGLYEITAGDQVFYFSPEGYLFFGE
LWTKDGKNLTAEMREKVATERINSLPLDKALKVGNGPKKVIEFTDPDCPYCRKVDGYLAKRTDVTRYIYFVPLRRIHPDA
EKKARYILSQSDRNKAFHDVFTGQLDGKPISIAEDAQQQQLEEMEKIAAGIGIRGTPALWIEGAHVNGADIQLISRLLDE
GKEVSKPQSH

Sequences:

>Translated_250_residues
MKTANNKKLMVGGLMMVIMTAAGFSMANENLRTEKDALMKTFPNLKMDGFRESPLKGLYEITAGDQVFYFSPEGYLFFGE
LWTKDGKNLTAEMREKVATERINSLPLDKALKVGNGPKKVIEFTDPDCPYCRKVDGYLAKRTDVTRYIYFVPLRRIHPDA
EKKARYILSQSDRNKAFHDVFTGQLDGKPISIAEDAQQQQLEEMEKIAAGIGIRGTPALWIEGAHVNGADIQLISRLLDE
GKEVSKPQSH
>Mature_250_residues
MKTANNKKLMVGGLMMVIMTAAGFSMANENLRTEKDALMKTFPNLKMDGFRESPLKGLYEITAGDQVFYFSPEGYLFFGE
LWTKDGKNLTAEMREKVATERINSLPLDKALKVGNGPKKVIEFTDPDCPYCRKVDGYLAKRTDVTRYIYFVPLRRIHPDA
EKKARYILSQSDRNKAFHDVFTGQLDGKPISIAEDAQQQQLEEMEKIAAGIGIRGTPALWIEGAHVNGADIQLISRLLDE
GKEVSKPQSH

Specific function: Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process [H]

COG id: COG1651

COG function: function code O; Protein-disulfide isomerase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thioredoxin family. DsbC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789260, Length=222, Percent_Identity=25.2252252252252, Blast_Score=67, Evalue=9e-13,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018950
- InterPro:   IPR009094
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10411 DsbC_N [H]

EC number: NA

Molecular weight: Translated: 28110; Mature: 28110

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTANNKKLMVGGLMMVIMTAAGFSMANENLRTEKDALMKTFPNLKMDGFRESPLKGLYE
CCCCCCCEEHHHHHHHHHHHHHCHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHEE
ITAGDQVFYFSPEGYLFFGELWTKDGKNLTAEMREKVATERINSLPLDKALKVGNGPKKV
ECCCCEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHE
IEFTDPDCPYCRKVDGYLAKRTDVTRYIYFVPLRRIHPDAEKKARYILSQSDRNKAFHDV
EEECCCCCCHHHHHHHHHHHHCCCEEEEEEEEHHHHCCCHHHHHHHHHCCCCCCHHHHHH
FTGQLDGKPISIAEDAQQQQLEEMEKIAAGIGIRGTPALWIEGAHVNGADIQLISRLLDE
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHC
GKEVSKPQSH
CHHCCCCCCC
>Mature Secondary Structure
MKTANNKKLMVGGLMMVIMTAAGFSMANENLRTEKDALMKTFPNLKMDGFRESPLKGLYE
CCCCCCCEEHHHHHHHHHHHHHCHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHEE
ITAGDQVFYFSPEGYLFFGELWTKDGKNLTAEMREKVATERINSLPLDKALKVGNGPKKV
ECCCCEEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHE
IEFTDPDCPYCRKVDGYLAKRTDVTRYIYFVPLRRIHPDAEKKARYILSQSDRNKAFHDV
EEECCCCCCHHHHHHHHHHHHCCCEEEEEEEEHHHHCCCHHHHHHHHHCCCCCCHHHHHH
FTGQLDGKPISIAEDAQQQQLEEMEKIAAGIGIRGTPALWIEGAHVNGADIQLISRLLDE
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHC
GKEVSKPQSH
CHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-oxo-D 5-steroid; protein with reduced SH groups [C]

Specific reaction: 3-oxo-D 5-steroid = 3-oxo-D 4-steroid protein with reduced SH groups = protein with oxidized disulfide bonds [C]

General reaction: Isomerases; Intramolecular Oxidoreductases; Transposing S-S Bonds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA