Click here to switch to the map view.

The map label for this gene is asd [H]

Identifier: 118578494

GI number: 118578494

Start: 53943

End: 55040

Strand: Direct

Name: asd [H]

Synonym: Ppro_0046

Alternate gene names: 118578494

Gene position: 53943-55040 (Clockwise)

Preceding gene: 118578493

Following gene: 118578495

Centisome position: 1.35

GC content: 63.57

Gene sequence:

>1098_bases
ATGAAAGTCGGACTGGTCGGTTGGCGTGGCATGGTTGGCTCGGTACTCCTTCAGCGCATGCGGGAGGAAAACGATTTTGA
CGGTATTGAACCGCTGTTCTTTACCACCTCCCAGCAGGGTCAGCCGGCCCCCATGGACAGGGGCGTGCTGATCGACGCCC
TGAATTTCGAGGAACTGAAGAAACAGGACATCATCGTCACCTGCCAGGGCGGAGGCTATACCACCAAGGCCCACGCCGAA
CTGCGCCGCCAGGGATGGGATGGCTACTGGATCGATGCCGCCAGCACCCTGCGCATGGAGAGGGATTCGGTGATCGTGCT
GGATCCGGTCAATCGCGACGTGATCGACGCCGCCCTGGCCAACGGCCAGAAGGACTTCATCGGCGGCAACTGCACCGTCA
GTCTGATGCTGATGGCCCTGGGCGGCCTGTTCCGCGCCGGGCTGGTGGAGTGGGTCTCCTCCATGACCTATCAGGCCGCC
TCCGGCGCCGGCGCCCCCAACATGCGTGAGCTCCTGAACCAGATGGGTATGCTCAGGGACTGTGTCGCCGACCAGCTGGC
AACCCCCTCCTCGGCCATCCTGGACATCGATTGCCAGGTCACCGCAACCATGCGCGGCGACAGCCTGCCCACCAAGGCAT
TCGGCTATCCCCTGGCCGGCAACGTGCTTCCCTGGATCGACAGCGAGGTGGAGGACGGCCAGAGCCGCGAGGAGTGGAAG
GGATTCGTGGAGACCAACAAGATCCTGGGAACCACCACTCCCATCCCGGTGGACGGCCTCTGCGTGCGGGTCGGTTCCAT
GCGTTGCCACAGCCAGGCCCTGACCATCAAGCTGAACAGGGACCTGCCCATTGCCGACATTGAAAGCCTGATCGCCCATG
ACAACCAGTGGGTCGATCTGGTGCCCAACACCAAGGCGGAAAGCCTGTCCCGCCTGACCCCGGCCGCCATTGCCGGTACC
CTGACGGTGCCCATCGGCCGGGTACGCAAGATGAAGCAGGGGCCGGAGTACATCTCGGCCTTTACCTGCGGCGATCAGCT
CCTCTGGGGAGCCGCCGAGCCTTTGCGCCGCATGCTGCGCATACTGATGGAACGATAG

Upstream 100 bases:

>100_bases
CCGGGGGAGAAGCTGGTCAACACGAAAGAGATGGGCGACGCGATTATCGCTGTGCTCTGAGCGCGGCAGAAAAATTCACT
TCAGAAAAGGAAGACAAGCA

Downstream 100 bases:

>100_bases
GGAGAACAGAGTATCGTGCCTAAAAAACGTTGGAATATCGCAGTTGTGGGAGTCAGTGGCGTCATTGGCGAACAGCTGCT
GGAGTGCCTGGAGGAAGGGG

Product: aspartate-semialdehyde dehydrogenase

Products: NA

Alternate protein names: ASA dehydrogenase; ASADH [H]

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MKVGLVGWRGMVGSVLLQRMREENDFDGIEPLFFTTSQQGQPAPMDRGVLIDALNFEELKKQDIIVTCQGGGYTTKAHAE
LRRQGWDGYWIDAASTLRMERDSVIVLDPVNRDVIDAALANGQKDFIGGNCTVSLMLMALGGLFRAGLVEWVSSMTYQAA
SGAGAPNMRELLNQMGMLRDCVADQLATPSSAILDIDCQVTATMRGDSLPTKAFGYPLAGNVLPWIDSEVEDGQSREEWK
GFVETNKILGTTTPIPVDGLCVRVGSMRCHSQALTIKLNRDLPIADIESLIAHDNQWVDLVPNTKAESLSRLTPAAIAGT
LTVPIGRVRKMKQGPEYISAFTCGDQLLWGAAEPLRRMLRILMER

Sequences:

>Translated_365_residues
MKVGLVGWRGMVGSVLLQRMREENDFDGIEPLFFTTSQQGQPAPMDRGVLIDALNFEELKKQDIIVTCQGGGYTTKAHAE
LRRQGWDGYWIDAASTLRMERDSVIVLDPVNRDVIDAALANGQKDFIGGNCTVSLMLMALGGLFRAGLVEWVSSMTYQAA
SGAGAPNMRELLNQMGMLRDCVADQLATPSSAILDIDCQVTATMRGDSLPTKAFGYPLAGNVLPWIDSEVEDGQSREEWK
GFVETNKILGTTTPIPVDGLCVRVGSMRCHSQALTIKLNRDLPIADIESLIAHDNQWVDLVPNTKAESLSRLTPAAIAGT
LTVPIGRVRKMKQGPEYISAFTCGDQLLWGAAEPLRRMLRILMER
>Mature_365_residues
MKVGLVGWRGMVGSVLLQRMREENDFDGIEPLFFTTSQQGQPAPMDRGVLIDALNFEELKKQDIIVTCQGGGYTTKAHAE
LRRQGWDGYWIDAASTLRMERDSVIVLDPVNRDVIDAALANGQKDFIGGNCTVSLMLMALGGLFRAGLVEWVSSMTYQAA
SGAGAPNMRELLNQMGMLRDCVADQLATPSSAILDIDCQVTATMRGDSLPTKAFGYPLAGNVLPWIDSEVEDGQSREEWK
GFVETNKILGTTTPIPVDGLCVRVGSMRCHSQALTIKLNRDLPIADIESLIAHDNQWVDLVPNTKAESLSRLTPAAIAGT
LTVPIGRVRKMKQGPEYISAFTCGDQLLWGAAEPLRRMLRILMER

Specific function: Second step in the common biosynthetic pathway leading from Asp to the cell wall precursor meso-diaminopimelate, to Lys, to Met, to Ile and to Thr. [C]

COG id: COG0136

COG function: function code E; Aspartate-semialdehyde dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aspartate-semialdehyde dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1789841, Length=364, Percent_Identity=63.7362637362637, Blast_Score=481, Evalue=1e-137,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000319
- InterPro:   IPR011534
- InterPro:   IPR012080
- InterPro:   IPR016040
- InterPro:   IPR000534
- InterPro:   IPR012280 [H]

Pfam domain/function: PF01118 Semialdhyde_dh; PF02774 Semialdhyde_dhC [H]

EC number: =1.2.1.11 [H]

Molecular weight: Translated: 39987; Mature: 39987

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS01103 ASD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVGLVGWRGMVGSVLLQRMREENDFDGIEPLFFTTSQQGQPAPMDRGVLIDALNFEELK
CCEECCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCEEEEECCHHHHC
KQDIIVTCQGGGYTTKAHAELRRQGWDGYWIDAASTLRMERDSVIVLDPVNRDVIDAALA
CCCEEEEECCCCCCCHHHHHHHHCCCCCEEECCHHHEEECCCCEEEECCCCHHHHHHHHH
NGQKDFIGGNCTVSLMLMALGGLFRAGLVEWVSSMTYQAASGAGAPNMRELLNQMGMLRD
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
CVADQLATPSSAILDIDCQVTATMRGDSLPTKAFGYPLAGNVLPWIDSEVEDGQSREEWK
HHHHHHCCCCCCEEEEEEEEEEEECCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCHHHHH
GFVETNKILGTTTPIPVDGLCVRVGSMRCHSQALTIKLNRDLPIADIESLIAHDNQWVDL
HHHHCCCEECCCCCCCCCHHHEEECCCEECCEEEEEEECCCCCHHHHHHHHHCCCCEEEE
VPNTKAESLSRLTPAAIAGTLTVPIGRVRKMKQGPEYISAFTCGDQLLWGAAEPLRRMLR
CCCCCHHHHHHCCHHHHHCEEECCHHHHHHHHCCHHHHHHHHCCCHHHHCCHHHHHHHHH
ILMER
HHHCC
>Mature Secondary Structure
MKVGLVGWRGMVGSVLLQRMREENDFDGIEPLFFTTSQQGQPAPMDRGVLIDALNFEELK
CCEECCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCEEEEECCHHHHC
KQDIIVTCQGGGYTTKAHAELRRQGWDGYWIDAASTLRMERDSVIVLDPVNRDVIDAALA
CCCEEEEECCCCCCCHHHHHHHHCCCCCEEECCHHHEEECCCCEEEECCCCHHHHHHHHH
NGQKDFIGGNCTVSLMLMALGGLFRAGLVEWVSSMTYQAASGAGAPNMRELLNQMGMLRD
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
CVADQLATPSSAILDIDCQVTATMRGDSLPTKAFGYPLAGNVLPWIDSEVEDGQSREEWK
HHHHHHCCCCCCEEEEEEEEEEEECCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCHHHHH
GFVETNKILGTTTPIPVDGLCVRVGSMRCHSQALTIKLNRDLPIADIESLIAHDNQWVDL
HHHHCCCEECCCCCCCCCHHHEEECCCEECCEEEEEEECCCCCHHHHHHHHHCCCCEEEE
VPNTKAESLSRLTPAAIAGTLTVPIGRVRKMKQGPEYISAFTCGDQLLWGAAEPLRRMLR
CCCCCHHHHHHCCHHHHHCEEECCHHHHHHHHCCHHHHHHHHCCCHHHHCCHHHHHHHHH
ILMER
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9084174; 10984043 [H]