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The map label for this gene is ahcY [H]

Identifier: 118578489

GI number: 118578489

Start: 47363

End: 48760

Strand: Direct

Name: ahcY [H]

Synonym: Ppro_0041

Alternate gene names: 118578489

Gene position: 47363-48760 (Clockwise)

Preceding gene: 118578488

Following gene: 118578491

Centisome position: 1.18

GC content: 62.23

Gene sequence:

>1398_bases
ATGTCAGAATATGATTACGTCGTCAAGGATATGTCCCTGGCCCAGTGGGGCCGCAAGGAAATGATCATCGCCGAGACCGA
GATGCCGGGACTCATGGCCATCCGCCAGGAGTTTGCCAAGACGCAGCCGCTGAAAGGGGCGCGCATCGCCGGCTCCCTGC
ACATGACCATCCAGACCGCCATGCTGATCGAGACGCTGACCGCGCTGGGGGCCGAGGTGCGCTGGGCATCCTGCAACATC
TTCTCCACCCAGGACCATGCCGCAGCCGCCATCGCGGCGGCAGGCATCCCGGTCTTCGCCCACAAGGGGGAGACCCTGGA
GGAGTACTGGGAGTACACCCACAAGATCTTTGAATGGCACGACGGCGGCAGCCCGAACATGATCCTGGATGACGGCGGCG
ATGCCACCCTGCTCTTGCACCTGGGGAGCGATGCCGAGAGCAACCCGGCTGTTATCGACAATCCCAGCTGCGAAGAGGAG
CAGGCCCTGTTCGGCGCCATCAAGAAACGTCTGGCCGAGCAGCCGGGCTGGTACTCCCGAACCGCCGCAACCATCAGGGG
GGTCACCGAGGAGACCACCACCGGCGTGCACCGGCTGTACGAGATGCACCGGAAGGGGACGCTCAAGTTCCCGGCCATAA
ACGTCAACGACTCGGTCACCAAGTCCAAGTTCGACAACATCTACGGCTGCCGCGAATCGCTCATGGACGGCATCAAGCGC
GCAACCGACGTGATGGTGGCCGGCAAGGTGGCCGTGATCTGCGGCTACGGCGACGTGGGCAAGGGGTGCGCCCAAGCTAT
GCGCGGACTCCAGGCCCAGGTCTGGGTGACCGAGATCGACCCGATCTGCGCCCTCCAGGCGGCAATGGAAGGGTACAAGG
TAGTCACCATGGAGTATGCCTGCGACAAGGCCGACATCTTCGTCACCACCACCGGCAACATCGACGTGATCACCCACGAC
CACATGAAGGCCATGAAGCACAACGCCATCGTCTGCAACATCGGCCACTTCGACAACGAGATCGAGGTTGCCAAGCTGAA
AGCGTACCACTGGGAGAATATCAAGCCCCAGGTGGACCACATCATCTTCCCGGACGGCAAGCGCATCATATTGCTGGCCG
AGGGGCGCCTGGTCAACCTGGGCTGCGCCACCGGCCATCCCTCCTTTGTCATGTCCTCCTCCTTTGCCAACCAGACCCTG
GCCCAGATCGAGCTGTTCTGCAACCCGGGCAAATACCCGCTCGGCGTCCATACCCTGCCCAAGGAGCTGGACGAGAAGGT
AGCCCGCCTGCAGCTCAAGAACCTGGGCGCCATGCTGACCGAACTGAACGATGCCCAGGCCGCCTACATCGGCGTCAAAA
AGGAAGGTCCGTACAAGAGCGACCACTACCGCTACTGA

Upstream 100 bases:

>100_bases
CAGGGGGTTTGTAAAAGGTAGAAAAACAAAGTCCTCGTATTGATTGCAGATACGTTAGTCGCTACGAAAAACCATATAAT
GTAAAAGGAGAAATACTGAA

Downstream 100 bases:

>100_bases
GTGGCTTTATCCGAGGCTAATGAAAAAAGGGGGGCGGCATCATGAGATGCCGCCCCCCTTTTTGTTCATACCGATTCCAG
CCAGATCGAGTCTGGCTATA

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MSEYDYVVKDMSLAQWGRKEMIIAETEMPGLMAIRQEFAKTQPLKGARIAGSLHMTIQTAMLIETLTALGAEVRWASCNI
FSTQDHAAAAIAAAGIPVFAHKGETLEEYWEYTHKIFEWHDGGSPNMILDDGGDATLLLHLGSDAESNPAVIDNPSCEEE
QALFGAIKKRLAEQPGWYSRTAATIRGVTEETTTGVHRLYEMHRKGTLKFPAINVNDSVTKSKFDNIYGCRESLMDGIKR
ATDVMVAGKVAVICGYGDVGKGCAQAMRGLQAQVWVTEIDPICALQAAMEGYKVVTMEYACDKADIFVTTTGNIDVITHD
HMKAMKHNAIVCNIGHFDNEIEVAKLKAYHWENIKPQVDHIIFPDGKRIILLAEGRLVNLGCATGHPSFVMSSSFANQTL
AQIELFCNPGKYPLGVHTLPKELDEKVARLQLKNLGAMLTELNDAQAAYIGVKKEGPYKSDHYRY

Sequences:

>Translated_465_residues
MSEYDYVVKDMSLAQWGRKEMIIAETEMPGLMAIRQEFAKTQPLKGARIAGSLHMTIQTAMLIETLTALGAEVRWASCNI
FSTQDHAAAAIAAAGIPVFAHKGETLEEYWEYTHKIFEWHDGGSPNMILDDGGDATLLLHLGSDAESNPAVIDNPSCEEE
QALFGAIKKRLAEQPGWYSRTAATIRGVTEETTTGVHRLYEMHRKGTLKFPAINVNDSVTKSKFDNIYGCRESLMDGIKR
ATDVMVAGKVAVICGYGDVGKGCAQAMRGLQAQVWVTEIDPICALQAAMEGYKVVTMEYACDKADIFVTTTGNIDVITHD
HMKAMKHNAIVCNIGHFDNEIEVAKLKAYHWENIKPQVDHIIFPDGKRIILLAEGRLVNLGCATGHPSFVMSSSFANQTL
AQIELFCNPGKYPLGVHTLPKELDEKVARLQLKNLGAMLTELNDAQAAYIGVKKEGPYKSDHYRY
>Mature_464_residues
SEYDYVVKDMSLAQWGRKEMIIAETEMPGLMAIRQEFAKTQPLKGARIAGSLHMTIQTAMLIETLTALGAEVRWASCNIF
STQDHAAAAIAAAGIPVFAHKGETLEEYWEYTHKIFEWHDGGSPNMILDDGGDATLLLHLGSDAESNPAVIDNPSCEEEQ
ALFGAIKKRLAEQPGWYSRTAATIRGVTEETTTGVHRLYEMHRKGTLKFPAINVNDSVTKSKFDNIYGCRESLMDGIKRA
TDVMVAGKVAVICGYGDVGKGCAQAMRGLQAQVWVTEIDPICALQAAMEGYKVVTMEYACDKADIFVTTTGNIDVITHDH
MKAMKHNAIVCNIGHFDNEIEVAKLKAYHWENIKPQVDHIIFPDGKRIILLAEGRLVNLGCATGHPSFVMSSSFANQTLA
QIELFCNPGKYPLGVHTLPKELDEKVARLQLKNLGAMLTELNDAQAAYIGVKKEGPYKSDHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=462, Percent_Identity=61.038961038961, Blast_Score=536, Evalue=1e-152,
Organism=Homo sapiens, GI239937451, Length=440, Percent_Identity=61.1363636363636, Blast_Score=512, Evalue=1e-145,
Organism=Homo sapiens, GI298286489, Length=464, Percent_Identity=48.7068965517241, Blast_Score=454, Evalue=1e-128,
Organism=Homo sapiens, GI24308043, Length=464, Percent_Identity=48.7068965517241, Blast_Score=454, Evalue=1e-128,
Organism=Homo sapiens, GI195539337, Length=464, Percent_Identity=48.7068965517241, Blast_Score=454, Evalue=1e-127,
Organism=Homo sapiens, GI195539349, Length=464, Percent_Identity=48.7068965517241, Blast_Score=454, Evalue=1e-127,
Organism=Homo sapiens, GI21361647, Length=464, Percent_Identity=48.0603448275862, Blast_Score=433, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17506425, Length=469, Percent_Identity=59.4882729211087, Blast_Score=533, Evalue=1e-152,
Organism=Saccharomyces cerevisiae, GI6320882, Length=478, Percent_Identity=59.2050209205021, Blast_Score=528, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24642172, Length=467, Percent_Identity=60.3854389721627, Blast_Score=534, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24656245, Length=465, Percent_Identity=49.4623655913978, Blast_Score=454, Evalue=1e-128,
Organism=Drosophila melanogaster, GI45553387, Length=463, Percent_Identity=50.5399568034557, Blast_Score=447, Evalue=1e-126,
Organism=Drosophila melanogaster, GI45553385, Length=462, Percent_Identity=50.4329004329004, Blast_Score=443, Evalue=1e-124,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 51302; Mature: 51171

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEYDYVVKDMSLAQWGRKEMIIAETEMPGLMAIRQEFAKTQPLKGARIAGSLHMTIQTA
CCCCHHHHHCCHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCEEECEEEHHHHHH
MLIETLTALGAEVRWASCNIFSTQDHAAAAIAAAGIPVFAHKGETLEEYWEYTHKIFEWH
HHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHEEEC
DGGSPNMILDDGGDATLLLHLGSDAESNPAVIDNPSCEEEQALFGAIKKRLAEQPGWYSR
CCCCCCEEEECCCCEEEEEEECCCCCCCCCEECCCCCCHHHHHHHHHHHHHHCCCCCCCH
TAATIRGVTEETTTGVHRLYEMHRKGTLKFPAINVNDSVTKSKFDNIYGCRESLMDGIKR
HHHHHCCCCHHHHHHHHHHHHHHCCCCEECCEECCCCCHHHHHHHHHHHHHHHHHHHHHH
ATDVMVAGKVAVICGYGDVGKGCAQAMRGLQAQVWVTEIDPICALQAAMEGYKVVTMEYA
HHHEEEECCEEEEECCCCCCHHHHHHHHCCEEEEEEEECCHHHHHHHHHCCCEEEEEEEC
CDKADIFVTTTGNIDVITHDHMKAMKHNAIVCNIGHFDNEIEVAKLKAYHWENIKPQVDH
CCCCCEEEEECCCEEEEECHHHHHHHCCEEEEEECCCCCCEEEEEEEEECCCCCCCCCCE
IIFPDGKRIILLAEGRLVNLGCATGHPSFVMSSSFANQTLAQIELFCNPGKYPLGVHTLP
EECCCCCEEEEEECCEEEEEEECCCCCCCEEECHHHHCCEEEEEEEECCCCCCCCCCHHH
KELDEKVARLQLKNLGAMLTELNDAQAAYIGVKKEGPYKSDHYRY
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
SEYDYVVKDMSLAQWGRKEMIIAETEMPGLMAIRQEFAKTQPLKGARIAGSLHMTIQTA
CCCHHHHHCCHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCEEECEEEHHHHHH
MLIETLTALGAEVRWASCNIFSTQDHAAAAIAAAGIPVFAHKGETLEEYWEYTHKIFEWH
HHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHEEEC
DGGSPNMILDDGGDATLLLHLGSDAESNPAVIDNPSCEEEQALFGAIKKRLAEQPGWYSR
CCCCCCEEEECCCCEEEEEEECCCCCCCCCEECCCCCCHHHHHHHHHHHHHHCCCCCCCH
TAATIRGVTEETTTGVHRLYEMHRKGTLKFPAINVNDSVTKSKFDNIYGCRESLMDGIKR
HHHHHCCCCHHHHHHHHHHHHHHCCCCEECCEECCCCCHHHHHHHHHHHHHHHHHHHHHH
ATDVMVAGKVAVICGYGDVGKGCAQAMRGLQAQVWVTEIDPICALQAAMEGYKVVTMEYA
HHHEEEECCEEEEECCCCCCHHHHHHHHCCEEEEEEEECCHHHHHHHHHCCCEEEEEEEC
CDKADIFVTTTGNIDVITHDHMKAMKHNAIVCNIGHFDNEIEVAKLKAYHWENIKPQVDH
CCCCCEEEEECCCEEEEECHHHHHHHCCEEEEEECCCCCCEEEEEEEEECCCCCCCCCCE
IIFPDGKRIILLAEGRLVNLGCATGHPSFVMSSSFANQTLAQIELFCNPGKYPLGVHTLP
EECCCCCEEEEEECCEEEEEEECCCCCCCEEECHHHHCCEEEEEEEECCCCCCCCCCHHH
KELDEKVARLQLKNLGAMLTELNDAQAAYIGVKKEGPYKSDHYRY
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA