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The map label for this gene is pqqL [C]

Identifier: 118578485

GI number: 118578485

Start: 42754

End: 44028

Strand: Direct

Name: pqqL [C]

Synonym: Ppro_0037

Alternate gene names: 118578485

Gene position: 42754-44028 (Clockwise)

Preceding gene: 118578483

Following gene: 118578486

Centisome position: 1.07

GC content: 64.86

Gene sequence:

>1275_bases
ATGCCGCACAGTATAGAACTACCCAGGCCACGCATGACCACCCTCGACAACGGCATCCGCGTGGTCACCCAGAGCATTGC
CGGCATGCAGAGCGCCGCCATCGGCATACGCATCGACAGCAGCACCAGGAACGAGCCGGCTGACATGGGGGGGGCGTCCC
ACTTCATCGAGCACCTGCTCTTCAAGGGGACCGATCGGCGCAGCGCGGACCGGATCATGGAGGAGTTCGACGCCCTGGGC
GCCGGCGCCAACGCCTACACCAGCCAGGAAGAGGTCTTCTACTACGCCACCTGCCTCTGCTCCGCCCTCCCGGCCACCTT
CGACATCCTGGCCGACCTGTTCGTGAACTCCACCCTGCCGCAGGAGGAGGTGGAAAAGGAGCGGGGCGTGGTGCTGCAGG
AGATCTCCATGATCCAGGACAACCCGGGGCGCTACCTGTATCAGCGCTTTCACCAGGGGTTCTGGAAGGATCACCCCATC
GGCCAGAGCGTGCTGGGAACGACGGAGTCCATCGCTTCCGTGGGGCGCGACCGCCTGATGGGACACAAGCTTTCCCAGTA
CGTCGCCAACGCCACCATCGTCTCCGCTGCCGGCAATGTGGAGCATGACCGTATCGTGGAGCTGGTCCAGCGGTTGCTGT
GTGAACTGCCTGGCGGCAGTGTACCACGGATCGCGCCCGAGCCGGGATGGCAGCCGTCCATCGGCGTGTATGTCCACAAC
CCGCGCCCCATGGAGCAGACCCAGTTCTACATGGGCTACCCCATCCCGCCGGCGGGAAACGAGCATCGTCACACCTTGGC
CGTGTTCAACCAGATTCTGGGCGGCGGCATGAGCTCGCGCCTGTTCCGGGAGGTCAGGGAGCGCCGTGGCCTGGCCTATG
CCGTCTACTCCACCATGGTCTCCTACAGCGACAGCGCCAGCCTGCTGGTTTTTGCCGGCACCGGACCGGAGCGGGCCCAG
GAGGCCATCGATGTCTGTCATGGCGAGTTGCTGCGCTTCTGCGGTGAGACGGTCAGTAGTGAGACCTTGGATTCCGCCAG
GGAGCAACTGCGCTGCAAACGGCTGATGTCCCTTGATGACTGCGAAACCCAGGTGCGCAGGATCTCCAACTCCCTATCCG
TACTGGGGACGCCAGAGCCTATGGAGGATGTACTGCGGGGAATCGCCGCGGTCAGCGCCGAGGATGTGCGCTCCCTGGCG
CAGTCGCTGTTTGGAGAGGTCACCCCGAGGGTCGAGTCTGTTGGCCCGGGAGACGGCCCCGGCCTGCCGCGCTGA

Upstream 100 bases:

>100_bases
TCCACATAAAAGTTGCTATTGTACCTCCTTTGTTGAATCGACCCTCACCCCTGCCCACCTCGATTCGGTGCTGTTTGGGG
GGAAAGCAAAAGGAGCAGTA

Downstream 100 bases:

>100_bases
ATTAGCTTTCCTGATTCATTACCGGCTGTTTTGCCAGCGCTGAGGCACCGGAGCCTCCCCCGCTGCAAAAGGAACCCTGG
GGCGATTCCCTCTGTTGCCA

Product: processing peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MPHSIELPRPRMTTLDNGIRVVTQSIAGMQSAAIGIRIDSSTRNEPADMGGASHFIEHLLFKGTDRRSADRIMEEFDALG
AGANAYTSQEEVFYYATCLCSALPATFDILADLFVNSTLPQEEVEKERGVVLQEISMIQDNPGRYLYQRFHQGFWKDHPI
GQSVLGTTESIASVGRDRLMGHKLSQYVANATIVSAAGNVEHDRIVELVQRLLCELPGGSVPRIAPEPGWQPSIGVYVHN
PRPMEQTQFYMGYPIPPAGNEHRHTLAVFNQILGGGMSSRLFREVRERRGLAYAVYSTMVSYSDSASLLVFAGTGPERAQ
EAIDVCHGELLRFCGETVSSETLDSAREQLRCKRLMSLDDCETQVRRISNSLSVLGTPEPMEDVLRGIAAVSAEDVRSLA
QSLFGEVTPRVESVGPGDGPGLPR

Sequences:

>Translated_424_residues
MPHSIELPRPRMTTLDNGIRVVTQSIAGMQSAAIGIRIDSSTRNEPADMGGASHFIEHLLFKGTDRRSADRIMEEFDALG
AGANAYTSQEEVFYYATCLCSALPATFDILADLFVNSTLPQEEVEKERGVVLQEISMIQDNPGRYLYQRFHQGFWKDHPI
GQSVLGTTESIASVGRDRLMGHKLSQYVANATIVSAAGNVEHDRIVELVQRLLCELPGGSVPRIAPEPGWQPSIGVYVHN
PRPMEQTQFYMGYPIPPAGNEHRHTLAVFNQILGGGMSSRLFREVRERRGLAYAVYSTMVSYSDSASLLVFAGTGPERAQ
EAIDVCHGELLRFCGETVSSETLDSAREQLRCKRLMSLDDCETQVRRISNSLSVLGTPEPMEDVLRGIAAVSAEDVRSLA
QSLFGEVTPRVESVGPGDGPGLPR
>Mature_423_residues
PHSIELPRPRMTTLDNGIRVVTQSIAGMQSAAIGIRIDSSTRNEPADMGGASHFIEHLLFKGTDRRSADRIMEEFDALGA
GANAYTSQEEVFYYATCLCSALPATFDILADLFVNSTLPQEEVEKERGVVLQEISMIQDNPGRYLYQRFHQGFWKDHPIG
QSVLGTTESIASVGRDRLMGHKLSQYVANATIVSAAGNVEHDRIVELVQRLLCELPGGSVPRIAPEPGWQPSIGVYVHNP
RPMEQTQFYMGYPIPPAGNEHRHTLAVFNQILGGGMSSRLFREVRERRGLAYAVYSTMVSYSDSASLLVFAGTGPERAQE
AIDVCHGELLRFCGETVSSETLDSAREQLRCKRLMSLDDCETQVRRISNSLSVLGTPEPMEDVLRGIAAVSAEDVRSLAQ
SLFGEVTPRVESVGPGDGPGLPR

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=426, Percent_Identity=27.6995305164319, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI46593007, Length=424, Percent_Identity=26.1792452830189, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI24308013, Length=439, Percent_Identity=25.5125284738041, Blast_Score=119, Evalue=7e-27,
Organism=Escherichia coli, GI1787770, Length=222, Percent_Identity=24.3243243243243, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI71999683, Length=424, Percent_Identity=26.6509433962264, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17553678, Length=272, Percent_Identity=27.9411764705882, Blast_Score=109, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6323192, Length=409, Percent_Identity=25.6723716381418, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6321813, Length=429, Percent_Identity=20.979020979021, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI21357875, Length=428, Percent_Identity=28.0373831775701, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24646943, Length=428, Percent_Identity=28.0373831775701, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI19921772, Length=425, Percent_Identity=24.9411764705882, Blast_Score=106, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 46540; Mature: 46409

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHSIELPRPRMTTLDNGIRVVTQSIAGMQSAAIGIRIDSSTRNEPADMGGASHFIEHLL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCHHCCCHHHHHHHHH
FKGTDRRSADRIMEEFDALGAGANAYTSQEEVFYYATCLCSALPATFDILADLFVNSTLP
HCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
QEEVEKERGVVLQEISMIQDNPGRYLYQRFHQGFWKDHPIGQSVLGTTESIASVGRDRLM
HHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHHHH
GHKLSQYVANATIVSAAGNVEHDRIVELVQRLLCELPGGSVPRIAPEPGWQPSIGVYVHN
HHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECC
PRPMEQTQFYMGYPIPPAGNEHRHTLAVFNQILGGGMSSRLFREVRERRGLAYAVYSTMV
CCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHH
SYSDSASLLVFAGTGPERAQEAIDVCHGELLRFCGETVSSETLDSAREQLRCKRLMSLDD
HCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
CETQVRRISNSLSVLGTPEPMEDVLRGIAAVSAEDVRSLAQSLFGEVTPRVESVGPGDGP
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHCCCCCCCC
GLPR
CCCC
>Mature Secondary Structure 
PHSIELPRPRMTTLDNGIRVVTQSIAGMQSAAIGIRIDSSTRNEPADMGGASHFIEHLL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCHHCCCHHHHHHHHH
FKGTDRRSADRIMEEFDALGAGANAYTSQEEVFYYATCLCSALPATFDILADLFVNSTLP
HCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
QEEVEKERGVVLQEISMIQDNPGRYLYQRFHQGFWKDHPIGQSVLGTTESIASVGRDRLM
HHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHHHHHHH
GHKLSQYVANATIVSAAGNVEHDRIVELVQRLLCELPGGSVPRIAPEPGWQPSIGVYVHN
HHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECC
PRPMEQTQFYMGYPIPPAGNEHRHTLAVFNQILGGGMSSRLFREVRERRGLAYAVYSTMV
CCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHH
SYSDSASLLVFAGTGPERAQEAIDVCHGELLRFCGETVSSETLDSAREQLRCKRLMSLDD
HCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
CETQVRRISNSLSVLGTPEPMEDVLRGIAAVSAEDVRSLAQSLFGEVTPRVESVGPGDGP
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHCCCCCCCC
GLPR
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]