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The map label for this gene is acdA [H]

Identifier: 118480375

GI number: 118480375

Start: 5097488

End: 5098627

Strand: Reverse

Name: acdA [H]

Synonym: BALH_4840

Alternate gene names: 118480375

Gene position: 5098627-5097488 (Counterclockwise)

Preceding gene: 118480376

Following gene: 118480374

Centisome position: 96.99

GC content: 43.77

Gene sequence:

>1140_bases
ATGCATTTTAAACTATCAGAAGAACATGAAATGATAAGAAAAATGGTTCGAGACTTTGCTAAGAACGAAGTAGCACCAAC
AGCAGCCGAGCGTGATGAAGAAGAGAGATTTGATCGTGAACTATTTGATCAAATGGCAGAGCTTGGTTTAACCGGAATTC
CGTGGCCTGAAGAATACGGCGGAATTGGAAGCGATTACTTAGCGTATGTAATTGCTATTGAAGAATTATCGCGTGTATGT
GCTTCTACAGGTGTAACATTGTCTGCACATACTTCGCTTGCTGGTTGGCCAATTTTTAAATTTGGAACAGAAGAGCAAAA
GCAAACATTTTTACGACCGATGGCTGAAGGGAAGAAAATTGGTGCGTACGGCTTAACGGAGCCAGGATCTGGATCGGATG
CTGGTGGAATGAAGACAATCGCCAAAAGAGATGGAGACCATTACGTTTTAAATGGATCGAAAATATTTATTACAAATGGC
GGTATTGCCGACATTTATGTTGTTTTCGCGTTAACTGATCCTGAATCGAAGCAGCGTGGCACGAGCGCATTTATAGTGGA
AAGTGATGCACCAGGATTCTCAGTTGGGAAGAAGGAAAGTAAGTTAGGGATTCGCTCTTCACCAACAACTGAAATTATGT
TTGAAGATTGCCGCATTCCTGTAGAGAATTTACTAGGGGAAGAAGGACAAGGGTTTAAGATAGCGATGCAAACATTAGAT
GGGGGTCGTAACGGTATTGCAGCGCAAGCTGTTGGTATTGCACAAGGGGCTTTAGATGCTTCCGTAGCATATGCAAGAGA
GCGCCATCAGTTTGGGAAGCCAATTGCGGCGCAACAAGGAATTGGCTTTAAACTTGCAGATATGGCAACGGATGTGGAGG
CGGCGCGCCTTCTAACATACCAAGCAGCTTGGCTTGAATCGGAAGGGCTTCCGTATGGGAAAGAGTCAGCGATGTCAAAA
GTATTTGCAGGCGATGCAGCGATGAAGGTGACGACGGAAGCGGTACAAGTATTTGGTGGTTACGGTTATACGAAAGATTA
TCCAGTAGAGCGTTATATGCGGGATGCAAAGATTACACAGATATATGAAGGAACACAAGAGATTCAAAGGCTCGTAATTT
CTCGTATGTTAACGAAGTAG

Upstream 100 bases:

>100_bases
TTTCCGTGATGCGAAAATCACGCAAATATATGAAGGAACGAGTGAAATACAGAAACTTGTTATTAGCCGAGCTTTATAAA
AGCACAAGGGGGAGACGGAC

Downstream 100 bases:

>100_bases
GATCGAAGGCGTAGGTATTTTCCTACGCTTTTTCCTTCCAAAAAATAATAGAGGGGTGAAGGGGATGGTTAAACATAATG
TGCACGCATCAGTGAAAGAT

Product: butyryl-CoA dehydrogenase

Products: 2-butenoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MHFKLSEEHEMIRKMVRDFAKNEVAPTAAERDEEERFDRELFDQMAELGLTGIPWPEEYGGIGSDYLAYVIAIEELSRVC
ASTGVTLSAHTSLAGWPIFKFGTEEQKQTFLRPMAEGKKIGAYGLTEPGSGSDAGGMKTIAKRDGDHYVLNGSKIFITNG
GIADIYVVFALTDPESKQRGTSAFIVESDAPGFSVGKKESKLGIRSSPTTEIMFEDCRIPVENLLGEEGQGFKIAMQTLD
GGRNGIAAQAVGIAQGALDASVAYARERHQFGKPIAAQQGIGFKLADMATDVEAARLLTYQAAWLESEGLPYGKESAMSK
VFAGDAAMKVTTEAVQVFGGYGYTKDYPVERYMRDAKITQIYEGTQEIQRLVISRMLTK

Sequences:

>Translated_379_residues
MHFKLSEEHEMIRKMVRDFAKNEVAPTAAERDEEERFDRELFDQMAELGLTGIPWPEEYGGIGSDYLAYVIAIEELSRVC
ASTGVTLSAHTSLAGWPIFKFGTEEQKQTFLRPMAEGKKIGAYGLTEPGSGSDAGGMKTIAKRDGDHYVLNGSKIFITNG
GIADIYVVFALTDPESKQRGTSAFIVESDAPGFSVGKKESKLGIRSSPTTEIMFEDCRIPVENLLGEEGQGFKIAMQTLD
GGRNGIAAQAVGIAQGALDASVAYARERHQFGKPIAAQQGIGFKLADMATDVEAARLLTYQAAWLESEGLPYGKESAMSK
VFAGDAAMKVTTEAVQVFGGYGYTKDYPVERYMRDAKITQIYEGTQEIQRLVISRMLTK
>Mature_379_residues
MHFKLSEEHEMIRKMVRDFAKNEVAPTAAERDEEERFDRELFDQMAELGLTGIPWPEEYGGIGSDYLAYVIAIEELSRVC
ASTGVTLSAHTSLAGWPIFKFGTEEQKQTFLRPMAEGKKIGAYGLTEPGSGSDAGGMKTIAKRDGDHYVLNGSKIFITNG
GIADIYVVFALTDPESKQRGTSAFIVESDAPGFSVGKKESKLGIRSSPTTEIMFEDCRIPVENLLGEEGQGFKIAMQTLD
GGRNGIAAQAVGIAQGALDASVAYARERHQFGKPIAAQQGIGFKLADMATDVEAARLLTYQAAWLESEGLPYGKESAMSK
VFAGDAAMKVTTEAVQVFGGYGYTKDYPVERYMRDAKITQIYEGTQEIQRLVISRMLTK

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=376, Percent_Identity=53.4574468085106, Blast_Score=400, Evalue=1e-112,
Organism=Homo sapiens, GI4501859, Length=381, Percent_Identity=42.7821522309711, Blast_Score=322, Evalue=3e-88,
Organism=Homo sapiens, GI7656849, Length=377, Percent_Identity=43.5013262599469, Blast_Score=309, Evalue=3e-84,
Organism=Homo sapiens, GI187960098, Length=377, Percent_Identity=43.5013262599469, Blast_Score=301, Evalue=5e-82,
Organism=Homo sapiens, GI4557231, Length=377, Percent_Identity=43.5013262599469, Blast_Score=301, Evalue=5e-82,
Organism=Homo sapiens, GI226958412, Length=377, Percent_Identity=40.8488063660477, Blast_Score=291, Evalue=8e-79,
Organism=Homo sapiens, GI226958414, Length=345, Percent_Identity=41.1594202898551, Blast_Score=273, Evalue=3e-73,
Organism=Homo sapiens, GI21361497, Length=351, Percent_Identity=43.019943019943, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI4501857, Length=374, Percent_Identity=36.6310160427808, Blast_Score=243, Evalue=1e-64,
Organism=Homo sapiens, GI76496475, Length=377, Percent_Identity=37.4005305039788, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI4557235, Length=377, Percent_Identity=37.4005305039788, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI4503943, Length=378, Percent_Identity=32.2751322751323, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI7669494, Length=366, Percent_Identity=31.9672131147541, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI211971008, Length=295, Percent_Identity=31.1864406779661, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI48976061, Length=295, Percent_Identity=31.1864406779661, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI38505218, Length=288, Percent_Identity=30.9027777777778, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI218563752, Length=228, Percent_Identity=28.0701754385965, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786223, Length=381, Percent_Identity=30.9711286089239, Blast_Score=183, Evalue=1e-47,
Organism=Escherichia coli, GI87081958, Length=384, Percent_Identity=30.46875, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI87081702, Length=315, Percent_Identity=27.3015873015873, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87082384, Length=271, Percent_Identity=28.7822878228782, Blast_Score=88, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=45.4068241469816, Blast_Score=317, Evalue=8e-87,
Organism=Caenorhabditis elegans, GI17508101, Length=374, Percent_Identity=42.7807486631016, Blast_Score=316, Evalue=2e-86,
Organism=Caenorhabditis elegans, GI17534899, Length=383, Percent_Identity=45.6919060052219, Blast_Score=313, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI17506239, Length=373, Percent_Identity=41.2868632707775, Blast_Score=311, Evalue=5e-85,
Organism=Caenorhabditis elegans, GI17570075, Length=380, Percent_Identity=41.5789473684211, Blast_Score=305, Evalue=4e-83,
Organism=Caenorhabditis elegans, GI17538396, Length=379, Percent_Identity=39.0501319261214, Blast_Score=283, Evalue=9e-77,
Organism=Caenorhabditis elegans, GI17533517, Length=378, Percent_Identity=39.6825396825397, Blast_Score=275, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI71990804, Length=277, Percent_Identity=44.7653429602888, Blast_Score=249, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI71985184, Length=367, Percent_Identity=39.2370572207085, Blast_Score=237, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17534353, Length=377, Percent_Identity=32.8912466843501, Blast_Score=214, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI71982178, Length=268, Percent_Identity=37.3134328358209, Blast_Score=207, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI32563615, Length=230, Percent_Identity=43.4782608695652, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17505929, Length=379, Percent_Identity=31.6622691292876, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17551932, Length=383, Percent_Identity=30.5483028720627, Blast_Score=195, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI71985192, Length=314, Percent_Identity=39.171974522293, Blast_Score=194, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI17531909, Length=241, Percent_Identity=34.8547717842324, Blast_Score=171, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI17562446, Length=288, Percent_Identity=28.8194444444444, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17531913, Length=179, Percent_Identity=29.608938547486, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI86563383, Length=310, Percent_Identity=26.4516129032258, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI86563381, Length=310, Percent_Identity=26.4516129032258, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21356377, Length=375, Percent_Identity=52.5333333333333, Blast_Score=405, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24646207, Length=375, Percent_Identity=47.4666666666667, Blast_Score=354, Evalue=7e-98,
Organism=Drosophila melanogaster, GI24666513, Length=375, Percent_Identity=41.6, Blast_Score=322, Evalue=3e-88,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=43.3862433862434, Blast_Score=310, Evalue=1e-84,
Organism=Drosophila melanogaster, GI21355753, Length=381, Percent_Identity=38.5826771653543, Blast_Score=265, Evalue=5e-71,
Organism=Drosophila melanogaster, GI281363737, Length=386, Percent_Identity=38.60103626943, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI19920834, Length=382, Percent_Identity=34.2931937172775, Blast_Score=204, Evalue=6e-53,
Organism=Drosophila melanogaster, GI24652780, Length=324, Percent_Identity=24.6913580246914, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.2

Molecular weight: Translated: 41400; Mature: 41400

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHFKLSEEHEMIRKMVRDFAKNEVAPTAAERDEEERFDRELFDQMAELGLTGIPWPEEYG
CCCCCCHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHC
GIGSDYLAYVIAIEELSRVCASTGVTLSAHTSLAGWPIFKFGTEEQKQTFLRPMAEGKKI
CCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCEEECCCHHHHHHHHHHHHCCCEE
GAYGLTEPGSGSDAGGMKTIAKRDGDHYVLNGSKIFITNGGIADIYVVFALTDPESKQRG
CCCCCCCCCCCCCCCCHHHHHHCCCCEEEEECCEEEEECCCCEEEEEEEEECCCCHHHCC
TSAFIVESDAPGFSVGKKESKLGIRSSPTTEIMFEDCRIPVENLLGEEGQGFKIAMQTLD
CEEEEEECCCCCCCCCCCHHCCCCCCCCCHHEEHHCCCCCHHHHCCCCCCCEEEEEEECC
GGRNGIAAQAVGIAQGALDASVAYARERHQFGKPIAAQQGIGFKLADMATDVEAARLLTY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCEEHHHHHHHHHHHHHHHH
QAAWLESEGLPYGKESAMSKVFAGDAAMKVTTEAVQVFGGYGYTKDYPVERYMRDAKITQ
HHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
IYEGTQEIQRLVISRMLTK
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHFKLSEEHEMIRKMVRDFAKNEVAPTAAERDEEERFDRELFDQMAELGLTGIPWPEEYG
CCCCCCHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHC
GIGSDYLAYVIAIEELSRVCASTGVTLSAHTSLAGWPIFKFGTEEQKQTFLRPMAEGKKI
CCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCEEECCCHHHHHHHHHHHHCCCEE
GAYGLTEPGSGSDAGGMKTIAKRDGDHYVLNGSKIFITNGGIADIYVVFALTDPESKQRG
CCCCCCCCCCCCCCCCHHHHHHCCCCEEEEECCEEEEECCCCEEEEEEEEECCCCHHHCC
TSAFIVESDAPGFSVGKKESKLGIRSSPTTEIMFEDCRIPVENLLGEEGQGFKIAMQTLD
CEEEEEECCCCCCCCCCCHHCCCCCCCCCHHEEHHCCCCCHHHHCCCCCCCEEEEEEECC
GGRNGIAAQAVGIAQGALDASVAYARERHQFGKPIAAQQGIGFKLADMATDVEAARLLTY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCEEHHHHHHHHHHHHHHHH
QAAWLESEGLPYGKESAMSKVFAGDAAMKVTTEAVQVFGGYGYTKDYPVERYMRDAKITQ
HHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
IYEGTQEIQRLVISRMLTK
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: butanoyl-CoA; acceptor

Specific reaction: butanoyl-CoA + acceptor = 2-butenoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]