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The map label for this gene is nprB [H]

Identifier: 118480127

GI number: 118480127

Start: 4815729

End: 4817393

Strand: Reverse

Name: nprB [H]

Synonym: BALH_4578

Alternate gene names: 118480127

Gene position: 4817393-4815729 (Counterclockwise)

Preceding gene: 118480128

Following gene: 118480122

Centisome position: 91.64

GC content: 37.06

Gene sequence:

>1665_bases
ATGGGGAATGTTATAGTGAAAAAGCAAGTCATTTCATCAGCATTAGCGTTAACTGTTATCGCCGGGGGATTTGGAACATT
TGGAGCAACGACAACGAAAGCGGAAGAACAAAAAATTCAATATCATCAAGAATTTAAAACGCCTGCATACATAGGTGAAG
AATGGAAAGCACCGGAAGGACTAGATAAAAAAGAGACAGTCTTTCAATATTTAGAGAGTAAGAAAGACATGTTTAAATTA
GCAGGAAATATTGATAAACATTTCAATGTCGTTGGGGAAGAAAAAGATGCTGAATCTGGCACAACACACGTGAAGCTAGT
TGAGAAACATAATAACATTCCTGTATATGGTTCAGACCAAACTGTTACAATAGATAAAGAAAATAATGTAAAAGCATTCT
TCGGACAAGTTATTCCGAATTTAGAGGATAAAAATATTCCTGAGTTTGCAAGCATTAGTGCGGAACAAGCAGAAACGATT
GCAAAGGCAGATATTGAAAAAGAAGTGGGGAAAGTAAAGAATTATGATGGTGTGAAAAAAGATTTATTTGTGTATGAAAA
AGATGGAAATTACTATCTTGCATATTTAGTGAAAGCGTCGATTTCAAAGCCAGCTCCAGGATATTGGCATTATTTTGTTG
ATGCAACGAATGGAAATGTGATTGAGAAATATAATGCTGTAGATCACATTACAGGATTTGGTTACGGAGTACTAGGAGCT
AGACAATCATTTGAAATTGCTCAAGATGAGAAAACAGGAGCATTCCATTTATTTGATGGTAAACGTGGACAAGGTGTTCA
TACATTTGATGCAGAGAATATGGATGAAAACTTGTTTAATATATTCTCACAATGGTTCGGACATACAGGTGTTGAAGTAG
AAAGTAAGAATAAGTTCTTTGATGATAAAGCAGCGGTTGATGCACATGTAAATGCAGGAAAAGTATATGATTACTACAAA
AAGACATTTAATCGTAACTCGTTCGATGATAAAGGTGCAAAGCTTATTTCCTCTGTTCACGTAGGTGAAAGCTGGAATAA
CGCAGCTTGGAATGGTGTGCAAATGATGTATGGTGATGGCGATGGTACGACATTTATTCCATTATCTGCTGGATTAGATG
TTATCGGTCACGAATTAACGCATGCTGTAACGGAACATACAGCAAATCTTGTTTATAAAAATGAGTCAGGTGCGTTAAAT
GAATCGTTATCTGATATTATGGGTGTCATGGTTGAGAAGAAGAGCTGGGATTTAGGTGCTGACATTTATACACCTGGAAA
ACCTGGTGATGCACTTCGTTCTCTGAAAGATCCAGCGTCTATTCCAAATCCATTAAAACCAGGTGAAGGCTACCCAGATC
ATTACAATAAACGCTACACTGGAACAGCTGATAACGGCGGCGTTCATATTAACAGTAGTATTAACAATAAAGCTGCCTAT
TTAGTATCTGATGGCGGAGAGCATTACGGTGTGAAAGTAACTGGAGTAGGACGTGAAGCGACAGAGAAAATTTATTACCG
TGCTCTTACGAAATATTTAACTGCAAACTCTGACTTTAAGATGATGCGTCAAGCGGCACTTCAGTCAGCTGAAGATTTAT
ATGGTAAAGATTCTAAAGCTGTACAAGCTGTAACGAAAGCTTATGATGCAGTAGGCGTAAAATAA

Upstream 100 bases:

>100_bases
TTTTTGCGTGGAATTGTCAGAAAAAACTTTCTCAAATTTTAGGTAAAGGTATCCACTTGAAAAACAAGAACTGTATAAAA
GTGTCAAAAATCTTTAGGGA

Downstream 100 bases:

>100_bases
TAAGAGAAAAAGACCTGACTAGGATGTCAGGTCTTTCTGTATTTAGTCGCGAATACCTAATGCAATTTTCGCCATACGTG
ACATACGTTCTTTCGACCAT

Product: neutral peptidase B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 554; Mature: 553

Protein sequence:

>554_residues
MGNVIVKKQVISSALALTVIAGGFGTFGATTTKAEEQKIQYHQEFKTPAYIGEEWKAPEGLDKKETVFQYLESKKDMFKL
AGNIDKHFNVVGEEKDAESGTTHVKLVEKHNNIPVYGSDQTVTIDKENNVKAFFGQVIPNLEDKNIPEFASISAEQAETI
AKADIEKEVGKVKNYDGVKKDLFVYEKDGNYYLAYLVKASISKPAPGYWHYFVDATNGNVIEKYNAVDHITGFGYGVLGA
RQSFEIAQDEKTGAFHLFDGKRGQGVHTFDAENMDENLFNIFSQWFGHTGVEVESKNKFFDDKAAVDAHVNAGKVYDYYK
KTFNRNSFDDKGAKLISSVHVGESWNNAAWNGVQMMYGDGDGTTFIPLSAGLDVIGHELTHAVTEHTANLVYKNESGALN
ESLSDIMGVMVEKKSWDLGADIYTPGKPGDALRSLKDPASIPNPLKPGEGYPDHYNKRYTGTADNGGVHINSSINNKAAY
LVSDGGEHYGVKVTGVGREATEKIYYRALTKYLTANSDFKMMRQAALQSAEDLYGKDSKAVQAVTKAYDAVGVK

Sequences:

>Translated_554_residues
MGNVIVKKQVISSALALTVIAGGFGTFGATTTKAEEQKIQYHQEFKTPAYIGEEWKAPEGLDKKETVFQYLESKKDMFKL
AGNIDKHFNVVGEEKDAESGTTHVKLVEKHNNIPVYGSDQTVTIDKENNVKAFFGQVIPNLEDKNIPEFASISAEQAETI
AKADIEKEVGKVKNYDGVKKDLFVYEKDGNYYLAYLVKASISKPAPGYWHYFVDATNGNVIEKYNAVDHITGFGYGVLGA
RQSFEIAQDEKTGAFHLFDGKRGQGVHTFDAENMDENLFNIFSQWFGHTGVEVESKNKFFDDKAAVDAHVNAGKVYDYYK
KTFNRNSFDDKGAKLISSVHVGESWNNAAWNGVQMMYGDGDGTTFIPLSAGLDVIGHELTHAVTEHTANLVYKNESGALN
ESLSDIMGVMVEKKSWDLGADIYTPGKPGDALRSLKDPASIPNPLKPGEGYPDHYNKRYTGTADNGGVHINSSINNKAAY
LVSDGGEHYGVKVTGVGREATEKIYYRALTKYLTANSDFKMMRQAALQSAEDLYGKDSKAVQAVTKAYDAVGVK
>Mature_553_residues
GNVIVKKQVISSALALTVIAGGFGTFGATTTKAEEQKIQYHQEFKTPAYIGEEWKAPEGLDKKETVFQYLESKKDMFKLA
GNIDKHFNVVGEEKDAESGTTHVKLVEKHNNIPVYGSDQTVTIDKENNVKAFFGQVIPNLEDKNIPEFASISAEQAETIA
KADIEKEVGKVKNYDGVKKDLFVYEKDGNYYLAYLVKASISKPAPGYWHYFVDATNGNVIEKYNAVDHITGFGYGVLGAR
QSFEIAQDEKTGAFHLFDGKRGQGVHTFDAENMDENLFNIFSQWFGHTGVEVESKNKFFDDKAAVDAHVNAGKVYDYYKK
TFNRNSFDDKGAKLISSVHVGESWNNAAWNGVQMMYGDGDGTTFIPLSAGLDVIGHELTHAVTEHTANLVYKNESGALNE
SLSDIMGVMVEKKSWDLGADIYTPGKPGDALRSLKDPASIPNPLKPGEGYPDHYNKRYTGTADNGGVHINSSINNKAAYL
VSDGGEHYGVKVTGVGREATEKIYYRALTKYLTANSDFKMMRQAALQSAEDLYGKDSKAVQAVTKAYDAVGVK

Specific function: Unknown

COG id: COG3227

COG function: function code E; Zinc metalloprotease (elastase)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005075
- InterPro:   IPR013856
- InterPro:   IPR001570
- InterPro:   IPR011096 [H]

Pfam domain/function: PF07504 FTP; PF03413 PepSY; PF01447 Peptidase_M4; PF02868 Peptidase_M4_C [H]

EC number: NA

Molecular weight: Translated: 61003; Mature: 60871

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNVIVKKQVISSALALTVIAGGFGTFGATTTKAEEQKIQYHQEFKTPAYIGEEWKAPEG
CCCEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
LDKKETVFQYLESKKDMFKLAGNIDKHFNVVGEEKDAESGTTHVKLVEKHNNIPVYGSDQ
CCHHHHHHHHHHHHHHHHHHHCCCCHHHEECCCCCCCCCCCEEEEEEEECCCCCEECCCC
TVTIDKENNVKAFFGQVIPNLEDKNIPEFASISAEQAETIAKADIEKEVGKVKNYDGVKK
EEEEECCCCHHHHHHHHCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
DLFVYEKDGNYYLAYLVKASISKPAPGYWHYFVDATNGNVIEKYNAVDHITGFGYGVLGA
CEEEEEECCCEEEEEEEEHHCCCCCCCEEEEEEECCCCCEEEHHCCHHHHCCCCCHHHCC
RQSFEIAQDEKTGAFHLFDGKRGQGVHTFDAENMDENLFNIFSQWFGHTGVEVESKNKFF
CCCCCCCCCCCCCEEEEECCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCEECCCCCCC
DDKAAVDAHVNAGKVYDYYKKTFNRNSFDDKGAKLISSVHVGESWNNAAWNGVQMMYGDG
CCHHHEECCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEECC
DGTTFIPLSAGLDVIGHELTHAVTEHTANLVYKNESGALNESLSDIMGVMVEKKSWDLGA
CCCEEEEECCCHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHCCCCCCCCC
DIYTPGKPGDALRSLKDPASIPNPLKPGEGYPDHYNKRYTGTADNGGVHINSSINNKAAY
CCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCEEE
LVSDGGEHYGVKVTGVGREATEKIYYRALTKYLTANSDFKMMRQAALQSAEDLYGKDSKA
EEECCCCEEEEEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHH
VQAVTKAYDAVGVK
HHHHHHHHHHCCCC
>Mature Secondary Structure 
GNVIVKKQVISSALALTVIAGGFGTFGATTTKAEEQKIQYHQEFKTPAYIGEEWKAPEG
CCEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
LDKKETVFQYLESKKDMFKLAGNIDKHFNVVGEEKDAESGTTHVKLVEKHNNIPVYGSDQ
CCHHHHHHHHHHHHHHHHHHHCCCCHHHEECCCCCCCCCCCEEEEEEEECCCCCEECCCC
TVTIDKENNVKAFFGQVIPNLEDKNIPEFASISAEQAETIAKADIEKEVGKVKNYDGVKK
EEEEECCCCHHHHHHHHCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
DLFVYEKDGNYYLAYLVKASISKPAPGYWHYFVDATNGNVIEKYNAVDHITGFGYGVLGA
CEEEEEECCCEEEEEEEEHHCCCCCCCEEEEEEECCCCCEEEHHCCHHHHCCCCCHHHCC
RQSFEIAQDEKTGAFHLFDGKRGQGVHTFDAENMDENLFNIFSQWFGHTGVEVESKNKFF
CCCCCCCCCCCCCEEEEECCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCEECCCCCCC
DDKAAVDAHVNAGKVYDYYKKTFNRNSFDDKGAKLISSVHVGESWNNAAWNGVQMMYGDG
CCHHHEECCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEECC
DGTTFIPLSAGLDVIGHELTHAVTEHTANLVYKNESGALNESLSDIMGVMVEKKSWDLGA
CCCEEEEECCCHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHCCCCCCCCC
DIYTPGKPGDALRSLKDPASIPNPLKPGEGYPDHYNKRYTGTADNGGVHINSSINNKAAY
CCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCEEE
LVSDGGEHYGVKVTGVGREATEKIYYRALTKYLTANSDFKMMRQAALQSAEDLYGKDSKA
EEECCCCEEEEEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHH
VQAVTKAYDAVGVK
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1917867; 9025291; 9353931; 9384377 [H]