Click here to switch to the map view.

The map label for this gene is tipA [H]

Identifier: 118480051

GI number: 118480051

Start: 4739499

End: 4740185

Strand: Reverse

Name: tipA [H]

Synonym: BALH_4499

Alternate gene names: 118480051

Gene position: 4740185-4739499 (Counterclockwise)

Preceding gene: 118480053

Following gene: 118480046

Centisome position: 90.17

GC content: 38.86

Gene sequence:

>687_bases
GTGCGCACACTGCATCATTATGATGAAATCGGGTTGTTAACCCCAGACGAGACGACAGAGTCTGGATATCGTCTGTATTC
CAATGAAAATTTAGAGACGTTACAGCAAATTTTATTTTTTAAAGAACTAGGCTTCCCTTTGAAGAAAATTAAAGAAATTA
TCATGAGTCCATCATTTGACCGGGAAGAGGCACTAAAGCTTCATAAGAAAATGCTTCTTGAAAAGCGCGCTAGGTTAGAT
AAAGTGATTGCGACGATTGATAAAACAATTCAGTATACAAAAGGAGAGATTGAAATGACGAACAAAGAGAAATTTGAAGG
ATTCGATTTCAGCCATAACCCATATGAAGAAGAAGCACGTGAAAGATGGGGAGACGCAGCTGTAGATAAAGCGAATGAAT
ATGCGAAAGGTATGTCAAAAGAGAAGCAAGAAGAGTTTAATGCTATTTACAGAAATTTAGCGGCACTTAGACACGGTGCT
CCAGATTCCAAAGAGGCGCAAGAAGCTATCAAAGTATGGTACGATTACTTGCAAAACTTCAGTCACTATTCATTAGATGC
TTTTAAAGGGCTCGGCCAAATGTACGTCGCTGATGAGCGCTTTACGAAAAATATCGATAAGTTTGGCGAAGGTTTAGCGC
AATTTATGTGTGATGCGATGGAAGTTTATGCGGATCGTAATAAATAG

Upstream 100 bases:

>100_bases
TATTGACTCTAACGTTGCGTCATACTTTATCGTATGTATTAAGGGGGAGATACACATGGCAATGAAGGTAAAAGAAGTAG
CTAATTTAGTTGGAATTAGT

Downstream 100 bases:

>100_bases
TAAAAAATAAAGAAGGTGGAGGTTGTCTCCGCCTTCTTTATTTTTTTATCATATCATTTAAAGTCTGATCCCCTGTATTG
TTCAAATGAGGATTTTTACT

Product: transcriptional activator TipA

Products: NA

Alternate protein names: Multidrug transporter activation protein [H]

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MRTLHHYDEIGLLTPDETTESGYRLYSNENLETLQQILFFKELGFPLKKIKEIIMSPSFDREEALKLHKKMLLEKRARLD
KVIATIDKTIQYTKGEIEMTNKEKFEGFDFSHNPYEEEARERWGDAAVDKANEYAKGMSKEKQEEFNAIYRNLAALRHGA
PDSKEAQEAIKVWYDYLQNFSHYSLDAFKGLGQMYVADERFTKNIDKFGEGLAQFMCDAMEVYADRNK

Sequences:

>Translated_228_residues
MRTLHHYDEIGLLTPDETTESGYRLYSNENLETLQQILFFKELGFPLKKIKEIIMSPSFDREEALKLHKKMLLEKRARLD
KVIATIDKTIQYTKGEIEMTNKEKFEGFDFSHNPYEEEARERWGDAAVDKANEYAKGMSKEKQEEFNAIYRNLAALRHGA
PDSKEAQEAIKVWYDYLQNFSHYSLDAFKGLGQMYVADERFTKNIDKFGEGLAQFMCDAMEVYADRNK
>Mature_228_residues
MRTLHHYDEIGLLTPDETTESGYRLYSNENLETLQQILFFKELGFPLKKIKEIIMSPSFDREEALKLHKKMLLEKRARLD
KVIATIDKTIQYTKGEIEMTNKEKFEGFDFSHNPYEEEARERWGDAAVDKANEYAKGMSKEKQEEFNAIYRNLAALRHGA
PDSKEAQEAIKVWYDYLQNFSHYSLDAFKGLGQMYVADERFTKNIDKFGEGLAQFMCDAMEVYADRNK

Specific function: Global transcriptional regulator that activates transcription of bmr and blt by binding directly to their promoter. Stimulates also the expression of the mta gene itself, ydfK and ymfE [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR012925
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind; PF07739 TipAS [H]

EC number: NA

Molecular weight: Translated: 26714; Mature: 26714

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTLHHYDEIGLLTPDETTESGYRLYSNENLETLQQILFFKELGFPLKKIKEIIMSPSFD
CCCCHHHHCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCC
REEALKLHKKMLLEKRARLDKVIATIDKTIQYTKGEIEMTNKEKFEGFDFSHNPYEEEAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHCCCCCCCCCCHHHHHH
ERWGDAAVDKANEYAKGMSKEKQEEFNAIYRNLAALRHGAPDSKEAQEAIKVWYDYLQNF
HHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
SHYSLDAFKGLGQMYVADERFTKNIDKFGEGLAQFMCDAMEVYADRNK
CCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRTLHHYDEIGLLTPDETTESGYRLYSNENLETLQQILFFKELGFPLKKIKEIIMSPSFD
CCCCHHHHCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCCC
REEALKLHKKMLLEKRARLDKVIATIDKTIQYTKGEIEMTNKEKFEGFDFSHNPYEEEAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHCCCCCCCCCCHHHHHH
ERWGDAAVDKANEYAKGMSKEKQEEFNAIYRNLAALRHGAPDSKEAQEAIKVWYDYLQNF
HHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
SHYSLDAFKGLGQMYVADERFTKNIDKFGEGLAQFMCDAMEVYADRNK
CCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9150240; 9384377 [H]