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The map label for this gene is dxs [H]

Identifier: 118479368

GI number: 118479368

Start: 4001291

End: 4003192

Strand: Reverse

Name: dxs [H]

Synonym: BALH_3785

Alternate gene names: 118479368

Gene position: 4003192-4001291 (Counterclockwise)

Preceding gene: 118479369

Following gene: 118479367

Centisome position: 76.15

GC content: 39.22

Gene sequence:

>1902_bases
GTGATCCATGTGGATCTAACGCAAATTCAAAACCCTAGTTTTTTGAAAGATATGTCTATCAGTGAACTAGAGGGATTGAG
TGAGGATATTCGTAAGTTTTTAATTGAAGAGCTCTCTCAAACAGGTGGACATATTGCACCTAATTTAGGTGTAGTAGAAC
TCACAATTGCTCTGCATAAATTATTTGATAGTCCGAAAGATAAATTTTTATGGGACGTAGGACATCAATCCTATGTACAT
AAAATTTTAACTGGACGTGCAAAAGAATTCGGCACATTAAGGCAATATCAAGGTCTATGTGGTTTCCCAAAACGTTGCGA
GAGTGAGCACGATGTATGGGAAACTGGCCATAGCTCGACATCATTATCTGCTGCAATGGGAATGGCTCTAGCACGTGATT
TAAAGAAAACGAAAGAATATGTTATACCAATCATTGGTGATGGTGCTTTAACAGGCGGAATGGCTTTAGAGGCATTGAAC
CATATTGGACATGAAAAAACAGACATGATTGTTATTTTGAATGATAATGAAATGTCAATTGCGCCAAACGTTGGTGCGCT
TCATAATGTGCTTGGGCGTCTACGTACCGCAGGAAAATACCATTGGGTAAAAGACGAACTAGAGTATATATTGAAGAAAA
TCCCAGCAGTTGGCGGGAAAGTTGCTGCGACAGCAGAGAAAATAAAAGATAGTCTTAAATATTTATTAGTATCCGGTGTC
TTTTTCGAAGAGTTAGGCTTTACATATTTAGGTCCAGTTGATGGGCATGACTATGAAAAGTTATTCGAAACGTTGCAATA
TGCAAAGAAAACAAAAGGCCCAGTGCTTGTTCATGTTATTACGAAAAAAGGAAAAGGTTACAAACCAGCCGAGAGTGATG
TTATTGGTACTTGGCATGGGACAGGACCTTATAAAATTGAATCAGGTGACTTCGTTAAACCGAAAGAAGTTGCACCAGCA
TGGAGTGCTGTCGTTAGTGAAACAGTACTTAAGCTGGCGAGAACGGACGAGCGTATCGTAGCAATTACACCTGCAATGCC
TGTTGGATCAAAACTTGAGAAATTCCAAAAAGAATTCCCAGATCGTATGATTGATGTAGGTATTGCAGAACAGCATGCTA
CAACAATGGCAGCGGGTATGGCAACGCAAGGTATGAAGCCATTCTTAGCAATTTATTCAACATTTTTACAAAGAGCATAT
GACCAAGTTGTTCATGATATATGCCGCCAAAATTTAAATGTTTTCATTGGAATCGATCGCTCTGGTTTAGTAGGAGCAGA
TGGTGAAACGCATCAAGGTGTATTTGACATCTCATTCTTACGCCACTTGCCGAATATGGTAATTATGATGCCAAAAGATG
AAAATGAAGGGCAACATTTAGTATATACGGCGATGCAATATGAAGATGGACCAATCGCATTACGATATGCGCGCGGTAAT
GGACTTGGCGTTCATATGGATGAAGAATTAAAGGCGATTCCAATTGGTTCATGGGAAACGTTAAAAGAAGGTACACAAGC
AGCTATTTTAACATTTGGTACGACAATACCAATGGCAATGGAAGCGGCTGAGCGTCTTGAAAAGGCTGGAGTTTCAGTGA
AAGTAGTGAACGCTCGTTTTATTAAACCGATGGATGAAGCATATTTACATGATCTCTTAGGAAAGAATATACCGATTTTA
ACGATTGAAGAAGCTTGTTTAATCGGTGGTTTTGGAACAGGAGTAGTTGAATTTGCGTCTGAGAACGGGTACCATAGTGC
GTTAGTTGAACGAATGGGTATTCCAGATCGTTTCATAGAGCACGGTAGTGTAACAAAATTATTAGAAGAAATTGGTTTAA
CGACAGATGCTGTTGTAGACCGTATTCATACAATGATTCCATCAAAACAAAAAAGGGCGTAA

Upstream 100 bases:

>100_bases
AATAGCAGGACAAGGTGAAAAATAAAAAAGAGAATTTCTTGTTTTGTGTAAATGTTTTTTATAATATTTGACATGTTGAC
AGATTATGAAATGAAAGTGA

Downstream 100 bases:

>100_bases
CAAATGAGTGCAAAAAAAGAAAGAGTAGATGTACTATTAGTAGAGCGAGGACTTATAGAAACACGTGAGAAAGCAAAACG
CGCCATTATGGCGGGACTTG

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 633; Mature: 633

Protein sequence:

>633_residues
MIHVDLTQIQNPSFLKDMSISELEGLSEDIRKFLIEELSQTGGHIAPNLGVVELTIALHKLFDSPKDKFLWDVGHQSYVH
KILTGRAKEFGTLRQYQGLCGFPKRCESEHDVWETGHSSTSLSAAMGMALARDLKKTKEYVIPIIGDGALTGGMALEALN
HIGHEKTDMIVILNDNEMSIAPNVGALHNVLGRLRTAGKYHWVKDELEYILKKIPAVGGKVAATAEKIKDSLKYLLVSGV
FFEELGFTYLGPVDGHDYEKLFETLQYAKKTKGPVLVHVITKKGKGYKPAESDVIGTWHGTGPYKIESGDFVKPKEVAPA
WSAVVSETVLKLARTDERIVAITPAMPVGSKLEKFQKEFPDRMIDVGIAEQHATTMAAGMATQGMKPFLAIYSTFLQRAY
DQVVHDICRQNLNVFIGIDRSGLVGADGETHQGVFDISFLRHLPNMVIMMPKDENEGQHLVYTAMQYEDGPIALRYARGN
GLGVHMDEELKAIPIGSWETLKEGTQAAILTFGTTIPMAMEAAERLEKAGVSVKVVNARFIKPMDEAYLHDLLGKNIPIL
TIEEACLIGGFGTGVVEFASENGYHSALVERMGIPDRFIEHGSVTKLLEEIGLTTDAVVDRIHTMIPSKQKRA

Sequences:

>Translated_633_residues
MIHVDLTQIQNPSFLKDMSISELEGLSEDIRKFLIEELSQTGGHIAPNLGVVELTIALHKLFDSPKDKFLWDVGHQSYVH
KILTGRAKEFGTLRQYQGLCGFPKRCESEHDVWETGHSSTSLSAAMGMALARDLKKTKEYVIPIIGDGALTGGMALEALN
HIGHEKTDMIVILNDNEMSIAPNVGALHNVLGRLRTAGKYHWVKDELEYILKKIPAVGGKVAATAEKIKDSLKYLLVSGV
FFEELGFTYLGPVDGHDYEKLFETLQYAKKTKGPVLVHVITKKGKGYKPAESDVIGTWHGTGPYKIESGDFVKPKEVAPA
WSAVVSETVLKLARTDERIVAITPAMPVGSKLEKFQKEFPDRMIDVGIAEQHATTMAAGMATQGMKPFLAIYSTFLQRAY
DQVVHDICRQNLNVFIGIDRSGLVGADGETHQGVFDISFLRHLPNMVIMMPKDENEGQHLVYTAMQYEDGPIALRYARGN
GLGVHMDEELKAIPIGSWETLKEGTQAAILTFGTTIPMAMEAAERLEKAGVSVKVVNARFIKPMDEAYLHDLLGKNIPIL
TIEEACLIGGFGTGVVEFASENGYHSALVERMGIPDRFIEHGSVTKLLEEIGLTTDAVVDRIHTMIPSKQKRA
>Mature_633_residues
MIHVDLTQIQNPSFLKDMSISELEGLSEDIRKFLIEELSQTGGHIAPNLGVVELTIALHKLFDSPKDKFLWDVGHQSYVH
KILTGRAKEFGTLRQYQGLCGFPKRCESEHDVWETGHSSTSLSAAMGMALARDLKKTKEYVIPIIGDGALTGGMALEALN
HIGHEKTDMIVILNDNEMSIAPNVGALHNVLGRLRTAGKYHWVKDELEYILKKIPAVGGKVAATAEKIKDSLKYLLVSGV
FFEELGFTYLGPVDGHDYEKLFETLQYAKKTKGPVLVHVITKKGKGYKPAESDVIGTWHGTGPYKIESGDFVKPKEVAPA
WSAVVSETVLKLARTDERIVAITPAMPVGSKLEKFQKEFPDRMIDVGIAEQHATTMAAGMATQGMKPFLAIYSTFLQRAY
DQVVHDICRQNLNVFIGIDRSGLVGADGETHQGVFDISFLRHLPNMVIMMPKDENEGQHLVYTAMQYEDGPIALRYARGN
GLGVHMDEELKAIPIGSWETLKEGTQAAILTFGTTIPMAMEAAERLEKAGVSVKVVNARFIKPMDEAYLHDLLGKNIPIL
TIEEACLIGGFGTGVVEFASENGYHSALVERMGIPDRFIEHGSVTKLLEEIGLTTDAVVDRIHTMIPSKQKRA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=614, Percent_Identity=23.9413680781759, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI4507521, Length=614, Percent_Identity=23.9413680781759, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI133778974, Length=425, Percent_Identity=26.5882352941176, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI225637463, Length=432, Percent_Identity=25.2314814814815, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI225637461, Length=432, Percent_Identity=25.2314814814815, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI225637459, Length=432, Percent_Identity=25.2314814814815, Blast_Score=98, Evalue=3e-20,
Organism=Escherichia coli, GI1786622, Length=608, Percent_Identity=45.3947368421053, Blast_Score=539, Evalue=1e-154,
Organism=Escherichia coli, GI48994911, Length=272, Percent_Identity=26.8382352941176, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1788808, Length=271, Percent_Identity=25.0922509225092, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17539652, Length=418, Percent_Identity=24.1626794258373, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17538422, Length=233, Percent_Identity=23.175965665236, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24666278, Length=533, Percent_Identity=24.953095684803, Blast_Score=108, Evalue=2e-23,
Organism=Drosophila melanogaster, GI45551847, Length=670, Percent_Identity=22.8358208955224, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI45550715, Length=670, Percent_Identity=22.8358208955224, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24645119, Length=626, Percent_Identity=23.0031948881789, Blast_Score=107, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 69777; Mature: 69777

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHVDLTQIQNPSFLKDMSISELEGLSEDIRKFLIEELSQTGGHIAPNLGVVELTIALHK
CEEEEHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
LFDSPKDKFLWDVGHQSYVHKILTGRAKEFGTLRQYQGLCGFPKRCESEHDVWETGHSST
HHCCCCHHHEEECCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHCCCCCCHHHCCCCCC
SLSAAMGMALARDLKKTKEYVIPIIGDGALTGGMALEALNHIGHEKTDMIVILNDNEMSI
HHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCEEE
APNVGALHNVLGRLRTAGKYHWVKDELEYILKKIPAVGGKVAATAEKIKDSLKYLLVSGV
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
FFEELGFTYLGPVDGHDYEKLFETLQYAKKTKGPVLVHVITKKGKGYKPAESDVIGTWHG
HHHHCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCEEEEECC
TGPYKIESGDFVKPKEVAPAWSAVVSETVLKLARTDERIVAITPAMPVGSKLEKFQKEFP
CCCEEECCCCCCCCHHCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCC
DRMIDVGIAEQHATTMAAGMATQGMKPFLAIYSTFLQRAYDQVVHDICRQNLNVFIGIDR
HHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
SGLVGADGETHQGVFDISFLRHLPNMVIMMPKDENEGQHLVYTAMQYEDGPIALRYARGN
CCCCCCCCCCCCCEEHHHHHHHCCCEEEEECCCCCCCCEEEEEEEEECCCCEEEEEECCC
GLGVHMDEELKAIPIGSWETLKEGTQAAILTFGTTIPMAMEAAERLEKAGVSVKVVNARF
CCEEEECCCCCEECCCCHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEECHHH
IKPMDEAYLHDLLGKNIPILTIEEACLIGGFGTGVVEFASENGYHSALVERMGIPDRFIE
CCCHHHHHHHHHHCCCCCEEEECCHHEECCCCCCHHHHCCCCCHHHHHHHHHCCCHHHHC
HGSVTKLLEEIGLTTDAVVDRIHTMIPSKQKRA
CCHHHHHHHHHCCCHHHHHHHHHHHCCCHHCCC
>Mature Secondary Structure
MIHVDLTQIQNPSFLKDMSISELEGLSEDIRKFLIEELSQTGGHIAPNLGVVELTIALHK
CEEEEHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
LFDSPKDKFLWDVGHQSYVHKILTGRAKEFGTLRQYQGLCGFPKRCESEHDVWETGHSST
HHCCCCHHHEEECCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHCCCCCCHHHCCCCCC
SLSAAMGMALARDLKKTKEYVIPIIGDGALTGGMALEALNHIGHEKTDMIVILNDNEMSI
HHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCEEE
APNVGALHNVLGRLRTAGKYHWVKDELEYILKKIPAVGGKVAATAEKIKDSLKYLLVSGV
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
FFEELGFTYLGPVDGHDYEKLFETLQYAKKTKGPVLVHVITKKGKGYKPAESDVIGTWHG
HHHHCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCEEEEECC
TGPYKIESGDFVKPKEVAPAWSAVVSETVLKLARTDERIVAITPAMPVGSKLEKFQKEFP
CCCEEECCCCCCCCHHCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCC
DRMIDVGIAEQHATTMAAGMATQGMKPFLAIYSTFLQRAYDQVVHDICRQNLNVFIGIDR
HHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
SGLVGADGETHQGVFDISFLRHLPNMVIMMPKDENEGQHLVYTAMQYEDGPIALRYARGN
CCCCCCCCCCCCCEEHHHHHHHCCCEEEEECCCCCCCCEEEEEEEEECCCCEEEEEECCC
GLGVHMDEELKAIPIGSWETLKEGTQAAILTFGTTIPMAMEAAERLEKAGVSVKVVNARF
CCEEEECCCCCEECCCCHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEECHHH
IKPMDEAYLHDLLGKNIPILTIEEACLIGGFGTGVVEFASENGYHSALVERMGIPDRFIE
CCCHHHHHHHHHHCCCCCEEEECCHHEECCCCCCHHHHCCCCCHHHHHHHHHCCCHHHHC
HGSVTKLLEEIGLTTDAVVDRIHTMIPSKQKRA
CCHHHHHHHHHCCCHHHHHHHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA