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The map label for this gene is ppx [H]

Identifier: 118479203

GI number: 118479203

Start: 3837674

End: 3839221

Strand: Reverse

Name: ppx [H]

Synonym: BALH_3614

Alternate gene names: 118479203

Gene position: 3839221-3837674 (Counterclockwise)

Preceding gene: 118479205

Following gene: 118479202

Centisome position: 73.03

GC content: 33.2

Gene sequence:

>1548_bases
GTGAGAAGTTTGAAAGAAATATTAAAACAGCAATATGCCATTATAGATATTGGATCTAATACAATGCGTTTAGTTATTTA
TGAAAAACAAAACGGGGGTTTTTATAAAGAGATTGAAAATACGAAAGTGGTTGCAAGGTTAAGGAATTACTTAGTCGATG
GCGTGTTGATTGAAGAAGGAATAGAGGTATTGTTACAAACATTATTTCAATTTCAAGAAAGTACACGATTCCATCAGTTG
CACCATGTACTTTGTGTTGCAACAGCAACAATTAGACAGGCTAAGAATCAAGAGGAAATTAAAAAACTTGTTGAAGGACA
AACAGACTTTACTCTTAGAGTATTATCAGAATATGAAGAAGTACGTTACGGCTATTTAGCAGTTATGAATTCAACTTCGT
TCTCTGAAGGGATTACAGTAGATATTGGTGGGGGGAGTACGGAGGTTACATACTTTCGAAATAGAGAGATTCTAGAGTAT
CATAGCTTTCCTTTTGGAGCACTTTCTTTAAAGCAACAATTTATTAAAGACGATATACCTACTGAAGAAGAGTTGGAAAA
GCTTCAAACGTATCTAGAATATCAATTTCGAACATTACCATGGTTAATTGATAAGAAATTGCCTCTTATTGCAATTGGTG
GTAGTGCGAGGAACTTAGTGAAAATCCATCAAAATTTAATTTGTTATCCTATAGCAGGAGTACATTTATACAAGATGAAA
GAAGAAGATATTAAAAATGTGAAAGAAGAATTGGAAGCATTGTCGTTCATAGAACTTCAAAAATTAGAAGGATTGGCAAA
AGATCGAGCAGATACAATTGTTCCAGCAGTCGAAGTATTTCATACGCTTGTTAATGTTATAGAGGCGCCAGCATTTGTAT
TAAGTAGAAAAGGATTACGAGAAGGTGTTTTCTATGAAGAGTTGACAAAAGATTTGGGGATTTCATATTATCCGAACGTA
GTCGAAGAAAGTTTGTATTTATTATCACATGAATATGAAATGGATATGGAATTTGTAATGCAGCTTATTAAACATGGGAG
ATTGATTTGTCAACAGCTTGAAGAAACAGGGCTGATTTCTATGTCAGTAGAAGACTGGGAAGTATTCCATCAAGCAGCGA
AAGTATTTAATATAGGCAAATATATAGACGAAGAAGCGAGCCGCTTACATACGTTTTATTTATTAGCGAATAAAACAATT
GATGGTATGATGCATAAAGAGCGAGTTAGATTAGCGCTTATTGCGTCTTATAAATCAAAAATGTTATTCAAACAACATTT
GTCTCCATTTGAAGGCTGGTTTGATAAAAACGAACAAAAAAAAATCCGCCTATTAGGGGCTGTTTTACAATTTTCAGCAG
CTCTAAATATAAGACAAAGATCGCTTGTTGAATCCATATCTATAACAGAAAGTAAAGAAGGATTAACATTTGAAATTGTA
TGTGAACAATCGGCGTTAGCGGAAAAAGTGCAAGCTGAAAAGCAGAAGAAACAGCTAGAAAGAGTATTGAAAACAAATAT
TATCTTGTTATTTAAATTAAAGAATTGA

Upstream 100 bases:

>100_bases
TGATTGTATATATTTTCAATATTAAAGCAATATTGTTACAAAAAACAACTATTTTGTATAATAGTAATAGAATGTGTTTT
AGAAATTTGATAATGAAAGA

Downstream 100 bases:

>100_bases
GTTGTACGGATGTCTTTACGAAAAATTTACACTTTATAATATTGTAATTTGCTAAAATGAAAGTAACTAAATTATAGTAA
AAAAGTTTCAAGGGGAAGTG

Product: exopolyphosphatase, Ppx/GppA phosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 515; Mature: 515

Protein sequence:

>515_residues
MRSLKEILKQQYAIIDIGSNTMRLVIYEKQNGGFYKEIENTKVVARLRNYLVDGVLIEEGIEVLLQTLFQFQESTRFHQL
HHVLCVATATIRQAKNQEEIKKLVEGQTDFTLRVLSEYEEVRYGYLAVMNSTSFSEGITVDIGGGSTEVTYFRNREILEY
HSFPFGALSLKQQFIKDDIPTEEELEKLQTYLEYQFRTLPWLIDKKLPLIAIGGSARNLVKIHQNLICYPIAGVHLYKMK
EEDIKNVKEELEALSFIELQKLEGLAKDRADTIVPAVEVFHTLVNVIEAPAFVLSRKGLREGVFYEELTKDLGISYYPNV
VEESLYLLSHEYEMDMEFVMQLIKHGRLICQQLEETGLISMSVEDWEVFHQAAKVFNIGKYIDEEASRLHTFYLLANKTI
DGMMHKERVRLALIASYKSKMLFKQHLSPFEGWFDKNEQKKIRLLGAVLQFSAALNIRQRSLVESISITESKEGLTFEIV
CEQSALAEKVQAEKQKKQLERVLKTNIILLFKLKN

Sequences:

>Translated_515_residues
MRSLKEILKQQYAIIDIGSNTMRLVIYEKQNGGFYKEIENTKVVARLRNYLVDGVLIEEGIEVLLQTLFQFQESTRFHQL
HHVLCVATATIRQAKNQEEIKKLVEGQTDFTLRVLSEYEEVRYGYLAVMNSTSFSEGITVDIGGGSTEVTYFRNREILEY
HSFPFGALSLKQQFIKDDIPTEEELEKLQTYLEYQFRTLPWLIDKKLPLIAIGGSARNLVKIHQNLICYPIAGVHLYKMK
EEDIKNVKEELEALSFIELQKLEGLAKDRADTIVPAVEVFHTLVNVIEAPAFVLSRKGLREGVFYEELTKDLGISYYPNV
VEESLYLLSHEYEMDMEFVMQLIKHGRLICQQLEETGLISMSVEDWEVFHQAAKVFNIGKYIDEEASRLHTFYLLANKTI
DGMMHKERVRLALIASYKSKMLFKQHLSPFEGWFDKNEQKKIRLLGAVLQFSAALNIRQRSLVESISITESKEGLTFEIV
CEQSALAEKVQAEKQKKQLERVLKTNIILLFKLKN
>Mature_515_residues
MRSLKEILKQQYAIIDIGSNTMRLVIYEKQNGGFYKEIENTKVVARLRNYLVDGVLIEEGIEVLLQTLFQFQESTRFHQL
HHVLCVATATIRQAKNQEEIKKLVEGQTDFTLRVLSEYEEVRYGYLAVMNSTSFSEGITVDIGGGSTEVTYFRNREILEY
HSFPFGALSLKQQFIKDDIPTEEELEKLQTYLEYQFRTLPWLIDKKLPLIAIGGSARNLVKIHQNLICYPIAGVHLYKMK
EEDIKNVKEELEALSFIELQKLEGLAKDRADTIVPAVEVFHTLVNVIEAPAFVLSRKGLREGVFYEELTKDLGISYYPNV
VEESLYLLSHEYEMDMEFVMQLIKHGRLICQQLEETGLISMSVEDWEVFHQAAKVFNIGKYIDEEASRLHTFYLLANKTI
DGMMHKERVRLALIASYKSKMLFKQHLSPFEGWFDKNEQKKIRLLGAVLQFSAALNIRQRSLVESISITESKEGLTFEIV
CEQSALAEKVQAEKQKKQLERVLKTNIILLFKLKN

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate of circa 500 residues long, while chains of circa 15 residues compete poorly with polyphosphate as substrate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=437, Percent_Identity=24.9427917620137, Blast_Score=106, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 59562; Mature: 59562

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSLKEILKQQYAIIDIGSNTMRLVIYEKQNGGFYKEIENTKVVARLRNYLVDGVLIEEG
CCHHHHHHHHCEEEEEECCCEEEEEEEEECCCCCHHHHCCHHHHHHHHHHHHHHHHHHHH
IEVLLQTLFQFQESTRFHQLHHVLCVATATIRQAKNQEEIKKLVEGQTDFTLRVLSEYEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHH
VRYGYLAVMNSTSFSEGITVDIGGGSTEVTYFRNREILEYHSFPFGALSLKQQFIKDDIP
HHHHEEEEEECCCCCCCEEEEECCCCEEEEEECCCCCHHHCCCCCHHHHHHHHHHHCCCC
TEEELEKLQTYLEYQFRTLPWLIDKKLPLIAIGGSARNLVKIHQNLICYPIAGVHLYKMK
CHHHHHHHHHHHHHHHHHCCHHHCCCCCEEEECCCHHHHHHHHHCEEEEEECCEEEEECC
EEDIKNVKEELEALSFIELQKLEGLAKDRADTIVPAVEVFHTLVNVIEAPAFVLSRKGLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCHH
EGVFYEELTKDLGISYYPNVVEESLYLLSHEYEMDMEFVMQLIKHGRLICQQLEETGLIS
CCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCEEE
MSVEDWEVFHQAAKVFNIGKYIDEEASRLHTFYLLANKTIDGMMHKERVRLALIASYKSK
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHH
MLFKQHLSPFEGWFDKNEQKKIRLLGAVLQFSAALNIRQRSLVESISITESKEGLTFEIV
HHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
CEQSALAEKVQAEKQKKQLERVLKTNIILLFKLKN
ECHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECC
>Mature Secondary Structure
MRSLKEILKQQYAIIDIGSNTMRLVIYEKQNGGFYKEIENTKVVARLRNYLVDGVLIEEG
CCHHHHHHHHCEEEEEECCCEEEEEEEEECCCCCHHHHCCHHHHHHHHHHHHHHHHHHHH
IEVLLQTLFQFQESTRFHQLHHVLCVATATIRQAKNQEEIKKLVEGQTDFTLRVLSEYEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHH
VRYGYLAVMNSTSFSEGITVDIGGGSTEVTYFRNREILEYHSFPFGALSLKQQFIKDDIP
HHHHEEEEEECCCCCCCEEEEECCCCEEEEEECCCCCHHHCCCCCHHHHHHHHHHHCCCC
TEEELEKLQTYLEYQFRTLPWLIDKKLPLIAIGGSARNLVKIHQNLICYPIAGVHLYKMK
CHHHHHHHHHHHHHHHHHCCHHHCCCCCEEEECCCHHHHHHHHHCEEEEEECCEEEEECC
EEDIKNVKEELEALSFIELQKLEGLAKDRADTIVPAVEVFHTLVNVIEAPAFVLSRKGLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCHH
EGVFYEELTKDLGISYYPNVVEESLYLLSHEYEMDMEFVMQLIKHGRLICQQLEETGLIS
CCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCEEE
MSVEDWEVFHQAAKVFNIGKYIDEEASRLHTFYLLANKTIDGMMHKERVRLALIASYKSK
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHH
MLFKQHLSPFEGWFDKNEQKKIRLLGAVLQFSAALNIRQRSLVESISITESKEGLTFEIV
HHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
CEQSALAEKVQAEKQKKQLERVLKTNIILLFKLKN
ECHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]