Click here to switch to the map view.

The map label for this gene is mmgA [H]

Identifier: 118478864

GI number: 118478864

Start: 3459575

End: 3460744

Strand: Reverse

Name: mmgA [H]

Synonym: BALH_3262

Alternate gene names: 118478864

Gene position: 3460744-3459575 (Counterclockwise)

Preceding gene: 118478865

Following gene: 118478862

Centisome position: 65.83

GC content: 41.28

Gene sequence:

>1170_bases
ATGAAATACCGTATACAAATAGCGGGAAAATCGCTCGTATGGAAGCAAAAAGTATCATTGAAAATTAGGAGAAAATATAT
GAATAGAGCAGTTATTGTAGAAGCGAAAAGGACACCTATTGGTAAGAAGAATGGGATGTTAAAAGACTATGAAGTTCAGC
AATTAGCAGCGCCGCTTCTTACATTTTTAAGTAAAGGAATGGAGAGAGCAATAGACGATGTCATATTAGGGAATGTTGTT
GGGCCAGGGGGGAATGTTGCGAGATTATCTGCTTTAGAAGCAGGGCTTAGTCATCATATTCCGGGTGTAACGATTGACCG
GCAATGTGGTGCCGGATTGGAAGCGATTCGCACCGCATGTCATTTCATTCAAGGGGGGGCCGGTAAGTGCTATATCGCCG
GAGGGGTAGAGAGTACAAGTGCGTCACCTTTTCAAAATAGGGCGCGATTTTCACCAGAAACAATTGGCGATCCTAATATG
GGAGTAGCGGCTGAATATGTTGCAGAACGTTATAACATCACGAGAGAAATGCAAGATGAGTATGCATGCCTCAGTTATAA
ACGAACACTGCAAGCATTAGAAAAAGGATATATACATGATGAAATATTGTCTTTTCATGGATTATTAGATGAATCTATAA
AGCCAGAAATGAATTATGAACGAATTATTAAAAGAACAAAACCTGCATTTTTACACAATGGTACAGTAACGGCAGGTAAT
TCGTGCGGTGTCAATGATGGGGCATGTGCTGTTCTTGTAATGGAAGAGGGGCAAGCTCGAAAATTAGGATACAAGCCTGT
CCTTCGTTTCGTTCGTAGTGCTGTAGTTGGAGTAGATCCAAATCTTCCGGGGACTGGTCCGATATTTGCGGTGAACAAAT
TATTAAACGAAAGGAATATGAAAGTAGAGGACATCGATTATTTTGAAATAAATGAAGCATTCGCCTCAAAAGTTGTAGCT
TGTGCAAAGGAGTTACAAATTCCTTTCGGAAAATTAAATGTAAATGGTGGGGCAATTGCGCTTGGTCATCCGTACGGTGC
ATCTGGGGCTATGCTTGTAACGCGCTTGTTTTATCAGGCGAAACGAGAGCGTATGAAATATGGAATCGCAACGTTAGGAA
TAGGGGGCGGGATAGGTCTTGCACTATTATTTGAGAAAGTAGAAGACTAG

Upstream 100 bases:

>100_bases
GTCGCGATTGTAAAAGGAAGTGCTACGAGGCAACAATTAAAGAGTTTTTGCTTACAAAGATTATCCTCTTTTAAAATACC
GAAAGAATGGTATTTTGTAG

Downstream 100 bases:

>100_bases
AAAGGAACTAGTTTTCTACTTTTTGAGGAACATAAGCATTGCTACCAGGTTTTGCTTTTATTTCATTCCAAGCAGCGATA
GCATCAGCTTTTGATTTTCC

Product: acetyl-CoA acetyltransferase

Products: CoA; acetoacetyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MKYRIQIAGKSLVWKQKVSLKIRRKYMNRAVIVEAKRTPIGKKNGMLKDYEVQQLAAPLLTFLSKGMERAIDDVILGNVV
GPGGNVARLSALEAGLSHHIPGVTIDRQCGAGLEAIRTACHFIQGGAGKCYIAGGVESTSASPFQNRARFSPETIGDPNM
GVAAEYVAERYNITREMQDEYACLSYKRTLQALEKGYIHDEILSFHGLLDESIKPEMNYERIIKRTKPAFLHNGTVTAGN
SCGVNDGACAVLVMEEGQARKLGYKPVLRFVRSAVVGVDPNLPGTGPIFAVNKLLNERNMKVEDIDYFEINEAFASKVVA
CAKELQIPFGKLNVNGGAIALGHPYGASGAMLVTRLFYQAKRERMKYGIATLGIGGGIGLALLFEKVED

Sequences:

>Translated_389_residues
MKYRIQIAGKSLVWKQKVSLKIRRKYMNRAVIVEAKRTPIGKKNGMLKDYEVQQLAAPLLTFLSKGMERAIDDVILGNVV
GPGGNVARLSALEAGLSHHIPGVTIDRQCGAGLEAIRTACHFIQGGAGKCYIAGGVESTSASPFQNRARFSPETIGDPNM
GVAAEYVAERYNITREMQDEYACLSYKRTLQALEKGYIHDEILSFHGLLDESIKPEMNYERIIKRTKPAFLHNGTVTAGN
SCGVNDGACAVLVMEEGQARKLGYKPVLRFVRSAVVGVDPNLPGTGPIFAVNKLLNERNMKVEDIDYFEINEAFASKVVA
CAKELQIPFGKLNVNGGAIALGHPYGASGAMLVTRLFYQAKRERMKYGIATLGIGGGIGLALLFEKVED
>Mature_389_residues
MKYRIQIAGKSLVWKQKVSLKIRRKYMNRAVIVEAKRTPIGKKNGMLKDYEVQQLAAPLLTFLSKGMERAIDDVILGNVV
GPGGNVARLSALEAGLSHHIPGVTIDRQCGAGLEAIRTACHFIQGGAGKCYIAGGVESTSASPFQNRARFSPETIGDPNM
GVAAEYVAERYNITREMQDEYACLSYKRTLQALEKGYIHDEILSFHGLLDESIKPEMNYERIIKRTKPAFLHNGTVTAGN
SCGVNDGACAVLVMEEGQARKLGYKPVLRFVRSAVVGVDPNLPGTGPIFAVNKLLNERNMKVEDIDYFEINEAFASKVVA
CAKELQIPFGKLNVNGGAIALGHPYGASGAMLVTRLFYQAKRERMKYGIATLGIGGGIGLALLFEKVED

Specific function: May be involved in fatty acid metabolism [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=389, Percent_Identity=33.6760925449871, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI148539872, Length=392, Percent_Identity=35.969387755102, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI4501853, Length=384, Percent_Identity=35.6770833333333, Blast_Score=211, Evalue=7e-55,
Organism=Homo sapiens, GI4557237, Length=399, Percent_Identity=32.8320802005013, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI4504327, Length=435, Percent_Identity=29.1954022988506, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI194353979, Length=364, Percent_Identity=28.5714285714286, Blast_Score=127, Evalue=1e-29,
Organism=Escherichia coli, GI48994986, Length=388, Percent_Identity=37.6288659793814, Blast_Score=233, Evalue=1e-62,
Organism=Escherichia coli, GI1787663, Length=402, Percent_Identity=38.3084577114428, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI1788554, Length=397, Percent_Identity=39.0428211586902, Blast_Score=225, Evalue=3e-60,
Organism=Escherichia coli, GI87082165, Length=397, Percent_Identity=36.7758186397985, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1788683, Length=411, Percent_Identity=26.7639902676399, Blast_Score=125, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI133906874, Length=392, Percent_Identity=37.2448979591837, Blast_Score=225, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI17535921, Length=389, Percent_Identity=32.6478149100257, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17551802, Length=429, Percent_Identity=30.0699300699301, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI25147385, Length=389, Percent_Identity=31.1053984575836, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17535917, Length=387, Percent_Identity=26.3565891472868, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6322031, Length=403, Percent_Identity=34.7394540942928, Blast_Score=189, Evalue=7e-49,
Organism=Saccharomyces cerevisiae, GI6325229, Length=401, Percent_Identity=32.6683291770574, Blast_Score=168, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24655093, Length=397, Percent_Identity=38.2871536523929, Blast_Score=244, Evalue=7e-65,
Organism=Drosophila melanogaster, GI17648125, Length=390, Percent_Identity=37.1794871794872, Blast_Score=218, Evalue=5e-57,
Organism=Drosophila melanogaster, GI24640423, Length=403, Percent_Identity=32.258064516129, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI17137578, Length=428, Percent_Identity=28.9719626168224, Blast_Score=152, Evalue=4e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.9

Molecular weight: Translated: 42400; Mature: 42400

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: PS00737 THIOLASE_2 ; PS00139 THIOL_PROTEASE_CYS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYRIQIAGKSLVWKQKVSLKIRRKYMNRAVIVEAKRTPIGKKNGMLKDYEVQQLAAPLL
CCEEEEECCCCEEHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHH
TFLSKGMERAIDDVILGNVVGPGGNVARLSALEAGLSHHIPGVTIDRQCGAGLEAIRTAC
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHH
HFIQGGAGKCYIAGGVESTSASPFQNRARFSPETIGDPNMGVAAEYVAERYNITREMQDE
HHHCCCCCEEEEECCCCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
YACLSYKRTLQALEKGYIHDEILSFHGLLDESIKPEMNYERIIKRTKPAFLHNGTVTAGN
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCEEECCEEECCC
SCGVNDGACAVLVMEEGQARKLGYKPVLRFVRSAVVGVDPNLPGTGPIFAVNKLLNERNM
CCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCC
KVEDIDYFEINEAFASKVVACAKELQIPFGKLNVNGGAIALGHPYGASGAMLVTRLFYQA
CCCCCCCEEHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCCCCCHHHHHHHHHHHH
KRERMKYGIATLGIGGGIGLALLFEKVED
HHHHHHHCHHEEECCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKYRIQIAGKSLVWKQKVSLKIRRKYMNRAVIVEAKRTPIGKKNGMLKDYEVQQLAAPLL
CCEEEEECCCCEEHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHH
TFLSKGMERAIDDVILGNVVGPGGNVARLSALEAGLSHHIPGVTIDRQCGAGLEAIRTAC
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHH
HFIQGGAGKCYIAGGVESTSASPFQNRARFSPETIGDPNMGVAAEYVAERYNITREMQDE
HHHCCCCCEEEEECCCCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
YACLSYKRTLQALEKGYIHDEILSFHGLLDESIKPEMNYERIIKRTKPAFLHNGTVTAGN
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCEEECCEEECCC
SCGVNDGACAVLVMEEGQARKLGYKPVLRFVRSAVVGVDPNLPGTGPIFAVNKLLNERNM
CCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCC
KVEDIDYFEINEAFASKVVACAKELQIPFGKLNVNGGAIALGHPYGASGAMLVTRLFYQA
CCCCCCCEEHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCCCCCHHHHHHHHHHHH
KRERMKYGIATLGIGGGIGLALLFEKVED
HHHHHHHCHHEEECCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acetyl-CoA

Specific reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]