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The map label for this gene is yyxA [H]

Identifier: 118478843

GI number: 118478843

Start: 3439034

End: 3440401

Strand: Reverse

Name: yyxA [H]

Synonym: BALH_3241

Alternate gene names: 118478843

Gene position: 3440401-3439034 (Counterclockwise)

Preceding gene: 118478844

Following gene: 118478842

Centisome position: 65.44

GC content: 36.77

Gene sequence:

>1368_bases
ATGCTTTTTTTGTCTACAATGTTAAATAAGCGTATTTTTTTAATTGGATTTCACGATGAGTTCACAAGAAGGACACAAAA
CGTGACTATACTGAAAATACGAATTCACCAGAGAGGGGAAGTAAACATGGGATATTACGACGGACCAAATTTAAATGAAG
AGCATAGTGAAACGAGAGAAGTGAGAAAATCGGGCAGTAAAAAAGGCTATTTTTTCACAGGTTTAGTCGGAGCTGTAGTT
GGGGCTGTTTCAATTAGTTTTGCGGCACCATATATGCCATGGGCTCAAAATAATGGAGCGACTGTATCATCTTTTAGTTC
AGATTCAAAAGTTGAAGGTACTGTAGTTCCTGTTGTCAATAAAGCAAAAAATGAAACGGATTTACCTGGTATGATTGAAG
GCGCGAAAGATGTTGTTGTAGGTGTTATTAACATGCAACAAAGCATTGATCCATTTGCAATGCAACCGACAGGTCAAGAG
CAACAAGCTGGTTCAGGATCAGGTGTTATTTATAAAAAGGCAGGAAATAAAGCATATATTGTAACGAACAATCATGTAGT
AGATGGTGCAAATAAACTTGCTGTAAAACTGAGCGATGGCAAGAAGGTAGATGCAAAGCTTGTAGGGAAAGACCCTTGGT
TAGATTTAGCTGTTGTTGAAATTGATGGTGCTAATGTTAATAAAGTTGCCACTTTAGGTGATTCAAGTAAACTTCGTGCG
GGTGAAAAAGCAATTGCAATCGGTAACCCATTAGGATTTGACGGAAGTGTAACGGAAGGTATTATTAGTAGTAAAGAACG
TGAAATTCCAGTAGATATCGATGGCGATAAGCGTGCAGATTGGAATGCTCAAGTTATTCAAACAGATGCAGCAATTAACC
CTGGTAACAGTGGTGGTGCGTTATTTAACCAAAACGGAGAAATAATTGGGATTAATTCAAGTAAAATTGCACAACAAGAA
GTTGAAGGAATTGGATTTGCTATTCCAATTAATATCGCAAAACCAGTTATTGAATCACTTGAAAAAGACGGAGTAGTGAA
ACGTCCAGCTCTTGGAGTAGGTGTCGTTTCATTAGAAGATGTGCAAGCTTATGCAGTAAATCAATTGAAAGTGCCAAAAG
AAGTAACAAACGGCGTTGTATTAGGTAAAATTTACCCAATATCACCTGCAGAAAAAGCTGGTTTAGAGCAATATGATATT
GTAGTAGCATTAGATAATCAAAAAGTAGAAAACTCACTTCAATTCCGTAAATATTTATATGAGAAGAAAAAAGTAGGCGA
GAAAGTGGAAGTTACATTCTACCGTAACGGTCAAAAAATGACGAAAACAGCTACTTTAGCAGATAACTCAGCTACAAAGA
ATCAATAA

Upstream 100 bases:

>100_bases
GTTGGTTATAAATTTGAAGAATAACTCGGAACGTATTGTGTGCTTCACTCTAGGAAAATAACAATTTTATATCCTCTTTT
GCAGGTAGAATGTACAAAAA

Downstream 100 bases:

>100_bases
TCGGAATAAAAGAAAGTCTCTTTCATATTGAAAGAGACTTTCTTTATCGGCTATACTAAAGGAATAGGAGGGATTAATTA
TGACAATTGAAAACCCAACT

Product: serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MLFLSTMLNKRIFLIGFHDEFTRRTQNVTILKIRIHQRGEVNMGYYDGPNLNEEHSETREVRKSGSKKGYFFTGLVGAVV
GAVSISFAAPYMPWAQNNGATVSSFSSDSKVEGTVVPVVNKAKNETDLPGMIEGAKDVVVGVINMQQSIDPFAMQPTGQE
QQAGSGSGVIYKKAGNKAYIVTNNHVVDGANKLAVKLSDGKKVDAKLVGKDPWLDLAVVEIDGANVNKVATLGDSSKLRA
GEKAIAIGNPLGFDGSVTEGIISSKEREIPVDIDGDKRADWNAQVIQTDAAINPGNSGGALFNQNGEIIGINSSKIAQQE
VEGIGFAIPINIAKPVIESLEKDGVVKRPALGVGVVSLEDVQAYAVNQLKVPKEVTNGVVLGKIYPISPAEKAGLEQYDI
VVALDNQKVENSLQFRKYLYEKKKVGEKVEVTFYRNGQKMTKTATLADNSATKNQ

Sequences:

>Translated_455_residues
MLFLSTMLNKRIFLIGFHDEFTRRTQNVTILKIRIHQRGEVNMGYYDGPNLNEEHSETREVRKSGSKKGYFFTGLVGAVV
GAVSISFAAPYMPWAQNNGATVSSFSSDSKVEGTVVPVVNKAKNETDLPGMIEGAKDVVVGVINMQQSIDPFAMQPTGQE
QQAGSGSGVIYKKAGNKAYIVTNNHVVDGANKLAVKLSDGKKVDAKLVGKDPWLDLAVVEIDGANVNKVATLGDSSKLRA
GEKAIAIGNPLGFDGSVTEGIISSKEREIPVDIDGDKRADWNAQVIQTDAAINPGNSGGALFNQNGEIIGINSSKIAQQE
VEGIGFAIPINIAKPVIESLEKDGVVKRPALGVGVVSLEDVQAYAVNQLKVPKEVTNGVVLGKIYPISPAEKAGLEQYDI
VVALDNQKVENSLQFRKYLYEKKKVGEKVEVTFYRNGQKMTKTATLADNSATKNQ
>Mature_455_residues
MLFLSTMLNKRIFLIGFHDEFTRRTQNVTILKIRIHQRGEVNMGYYDGPNLNEEHSETREVRKSGSKKGYFFTGLVGAVV
GAVSISFAAPYMPWAQNNGATVSSFSSDSKVEGTVVPVVNKAKNETDLPGMIEGAKDVVVGVINMQQSIDPFAMQPTGQE
QQAGSGSGVIYKKAGNKAYIVTNNHVVDGANKLAVKLSDGKKVDAKLVGKDPWLDLAVVEIDGANVNKVATLGDSSKLRA
GEKAIAIGNPLGFDGSVTEGIISSKEREIPVDIDGDKRADWNAQVIQTDAAINPGNSGGALFNQNGEIIGINSSKIAQQE
VEGIGFAIPINIAKPVIESLEKDGVVKRPALGVGVVSLEDVQAYAVNQLKVPKEVTNGVVLGKIYPISPAEKAGLEQYDI
VVALDNQKVENSLQFRKYLYEKKKVGEKVEVTFYRNGQKMTKTATLADNSATKNQ

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=283, Percent_Identity=34.982332155477, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI7019477, Length=296, Percent_Identity=33.1081081081081, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI22129776, Length=291, Percent_Identity=30.9278350515464, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI24308541, Length=265, Percent_Identity=32.0754716981132, Blast_Score=112, Evalue=9e-25,
Organism=Escherichia coli, GI1786356, Length=286, Percent_Identity=39.1608391608392, Blast_Score=169, Evalue=5e-43,
Organism=Escherichia coli, GI1789629, Length=284, Percent_Identity=36.9718309859155, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1789630, Length=293, Percent_Identity=33.1058020477816, Blast_Score=148, Evalue=8e-37,
Organism=Drosophila melanogaster, GI24646839, Length=335, Percent_Identity=33.7313432835821, Blast_Score=134, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 48969; Mature: 48969

Theoretical pI: Translated: 8.56; Mature: 8.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFLSTMLNKRIFLIGFHDEFTRRTQNVTILKIRIHQRGEVNMGYYDGPNLNEEHSETRE
CEEHEEHHCCEEEEEEECHHHHHHHCCEEEEEEEEECCCCEECCCCCCCCCCHHHHHHHH
VRKSGSKKGYFFTGLVGAVVGAVSISFAAPYMPWAQNNGATVSSFSSDSKVEGTVVPVVN
HHHCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCEEEEEEEC
KAKNETDLPGMIEGAKDVVVGVINMQQSIDPFAMQPTGQEQQAGSGSGVIYKKAGNKAYI
CCCCCCCCCHHHCCCCEEEEEEEEHHCCCCCEEECCCCCHHCCCCCCCEEEEECCCEEEE
VTNNHVVDGANKLAVKLSDGKKVDAKLVGKDPWLDLAVVEIDGANVNKVATLGDSSKLRA
EECCEEECCCCEEEEEECCCCEEEEEEECCCCCCEEEEEEECCCCCCEEEECCCCCCCCC
GEKAIAIGNPLGFDGSVTEGIISSKEREIPVDIDGDKRADWNAQVIQTDAAINPGNSGGA
CCEEEEECCCCCCCCCHHHHHHCCCCCCCCEECCCCCCCCCCCEEEEECCCCCCCCCCCE
LFNQNGEIIGINSSKIAQQEVEGIGFAIPINIAKPVIESLEKDGVVKRPALGVGVVSLED
EECCCCCEEEECCHHHHHHHHCCCCEEEEECHHHHHHHHHHHCCCEECCCCCEEEEEECH
VQAYAVNQLKVPKEVTNGVVLGKIYPISPAEKAGLEQYDIVVALDNQKVENSLQFRKYLY
HHHHHHHHEECCHHHHCCEEEEEEEECCCHHHCCCCEEEEEEEECCCHHHHHHHHHHHHH
EKKKVGEKVEVTFYRNGQKMTKTATLADNSATKNQ
HHHHCCCEEEEEEEECCCEEEEEEEECCCCCCCCC
>Mature Secondary Structure
MLFLSTMLNKRIFLIGFHDEFTRRTQNVTILKIRIHQRGEVNMGYYDGPNLNEEHSETRE
CEEHEEHHCCEEEEEEECHHHHHHHCCEEEEEEEEECCCCEECCCCCCCCCCHHHHHHHH
VRKSGSKKGYFFTGLVGAVVGAVSISFAAPYMPWAQNNGATVSSFSSDSKVEGTVVPVVN
HHHCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCEEEEEEEC
KAKNETDLPGMIEGAKDVVVGVINMQQSIDPFAMQPTGQEQQAGSGSGVIYKKAGNKAYI
CCCCCCCCCHHHCCCCEEEEEEEEHHCCCCCEEECCCCCHHCCCCCCCEEEEECCCEEEE
VTNNHVVDGANKLAVKLSDGKKVDAKLVGKDPWLDLAVVEIDGANVNKVATLGDSSKLRA
EECCEEECCCCEEEEEECCCCEEEEEEECCCCCCEEEEEEECCCCCCEEEECCCCCCCCC
GEKAIAIGNPLGFDGSVTEGIISSKEREIPVDIDGDKRADWNAQVIQTDAAINPGNSGGA
CCEEEEECCCCCCCCCHHHHHHCCCCCCCCEECCCCCCCCCCCEEEEECCCCCCCCCCCE
LFNQNGEIIGINSSKIAQQEVEGIGFAIPINIAKPVIESLEKDGVVKRPALGVGVVSLED
EECCCCCEEEECCHHHHHHHHCCCCEEEEECHHHHHHHHHHHCCCEECCCCCEEEEEECH
VQAYAVNQLKVPKEVTNGVVLGKIYPISPAEKAGLEQYDIVVALDNQKVENSLQFRKYLY
HHHHHHHHEECCHHHHCCEEEEEEEECCCHHHCCCCEEEEEEEECCCHHHHHHHHHHHHH
EKKKVGEKVEVTFYRNGQKMTKTATLADNSATKNQ
HHHHCCCEEEEEEEECCCEEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8113162 [H]