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The map label for this gene is hisS1 [H]

Identifier: 118478621

GI number: 118478621

Start: 3193941

End: 3195275

Strand: Direct

Name: hisS1 [H]

Synonym: BALH_3000

Alternate gene names: 118478621

Gene position: 3193941-3195275 (Clockwise)

Preceding gene: 118478620

Following gene: 118478622

Centisome position: 60.75

GC content: 37.68

Gene sequence:

>1335_bases
ATGTGGGTATTTTTATACCTGCATAGCTTTTTTTCATTTAAAAAAGGAGTGATTATGATGGAAATGAAAAATGTAAAAGG
AACGAAAGACTATTTACCAGAAGAGCAAGTGCTACGAAATAAAATTAAAAGAGCTTGTGAAGATACGTTTGAACGATATG
GCTGTAAACCGTTAGAAACACCAATGTTAAACATGTATGAGCTTATGTCATACAAGTACGGCGGTGGCGATGAAATATTA
AAAGAAATATATACGCTCAGGGATCAAGGAAAACGCGACCTTGCCTTACGCTACGATTTAACAATTCCATTCGCAAAAGT
CGTAGCAATGAACCCGAACATCCGCCTCCCTTTTAAACGGTATGAAATTGGAAAAGTCTTTCGAGATGGGCCAATTAAAC
AAGGAAGATTTCGTGAGTTCATTCAATGTGACGTTGATATAGTCGGTGTAGAATCTGTCATGGCAGAAGCGGAACTTATG
AGTATGGCGTTTGAACTGTTCCGAACGTTAAACTTAGAAGTAACGATCCAATATAATAACCGAAAATTGTTAAACGGTAT
TCTCGAGTCAATAAACATTCCTACTGAACGAACGAGTGACGTCATTTTATCATTAGACAAAATCGAAAAAATTGGGATTG
ATGGTGTACGAAAAGATGTACTTGAGCGCGGAATTTCTGAAGAAATGGCTGATACGATATGTAATACCGTTTTATCTTGT
CTACAGCTTTCGATTGATGACTTTAAAGACGCTTTCAATACTCCACTCGTTGCCGAAGGAGTAAACGAACTACAACAATT
ACAGCAATATTTAATTGCTCTCGGAATAAATGAAAATGCTATATTCAATCCATTTTTAGCACGAGGACTCACAATGTACA
CAGGTACCGTATATGAAATCTTTCTAAAAGATGGCTCGATTACATCCAGCATCGGTAGCGGTGGTCGATACGATAATATT
ATTGGGGCATTCCGTGGCGATAATATGAGCTATCCAACAGTCGGTATTTCATTCGGTTTAGACGTTATTTACACAGCACT
GTCGCAGAAAGAAACGATATCATCTACAGCGGATGTATTTATCATCCCGCTCGGGACAGAATTACACTGTTTACAAATTG
CCCAGCAATTACGTTCTACCACTACCTTAAAAGTCGAACTCGAACTAGCGGGACGCAAATTAAAACGTGCCCTGAATTAT
GCCAATAAAGAAAATATCCCTTATGTGCTTATTATTGGGGAAGAAGAAATATGTACAGAAACCGTTATGCTACGGAATAT
GAAGGAAGGTAGTGAAGTGAAGGTTCCCCTTTCTTCTTTAAGTAATTATTTATAA

Upstream 100 bases:

>100_bases
TCCAACTTCATCATCATACGTAACGCCGTGTATCCGAAGAAAAATTTTTCTTCGTGGGTACAGGGCTTTTCCTGTTGACC
CACGAAGCGTTCATAAAGCT

Downstream 100 bases:

>100_bases
TACAAACCACCCTCGTTTGGGTGGTTTTTCTATTTTATACATATCCCACAATTAGTTAACATAAAAAAATTACATTCTAC
TAAATTCTACTAAATTCTAC

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase 1; HisRS 1 [H]

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MWVFLYLHSFFSFKKGVIMMEMKNVKGTKDYLPEEQVLRNKIKRACEDTFERYGCKPLETPMLNMYELMSYKYGGGDEIL
KEIYTLRDQGKRDLALRYDLTIPFAKVVAMNPNIRLPFKRYEIGKVFRDGPIKQGRFREFIQCDVDIVGVESVMAEAELM
SMAFELFRTLNLEVTIQYNNRKLLNGILESINIPTERTSDVILSLDKIEKIGIDGVRKDVLERGISEEMADTICNTVLSC
LQLSIDDFKDAFNTPLVAEGVNELQQLQQYLIALGINENAIFNPFLARGLTMYTGTVYEIFLKDGSITSSIGSGGRYDNI
IGAFRGDNMSYPTVGISFGLDVIYTALSQKETISSTADVFIIPLGTELHCLQIAQQLRSTTTLKVELELAGRKLKRALNY
ANKENIPYVLIIGEEEICTETVMLRNMKEGSEVKVPLSSLSNYL

Sequences:

>Translated_444_residues
MWVFLYLHSFFSFKKGVIMMEMKNVKGTKDYLPEEQVLRNKIKRACEDTFERYGCKPLETPMLNMYELMSYKYGGGDEIL
KEIYTLRDQGKRDLALRYDLTIPFAKVVAMNPNIRLPFKRYEIGKVFRDGPIKQGRFREFIQCDVDIVGVESVMAEAELM
SMAFELFRTLNLEVTIQYNNRKLLNGILESINIPTERTSDVILSLDKIEKIGIDGVRKDVLERGISEEMADTICNTVLSC
LQLSIDDFKDAFNTPLVAEGVNELQQLQQYLIALGINENAIFNPFLARGLTMYTGTVYEIFLKDGSITSSIGSGGRYDNI
IGAFRGDNMSYPTVGISFGLDVIYTALSQKETISSTADVFIIPLGTELHCLQIAQQLRSTTTLKVELELAGRKLKRALNY
ANKENIPYVLIIGEEEICTETVMLRNMKEGSEVKVPLSSLSNYL
>Mature_444_residues
MWVFLYLHSFFSFKKGVIMMEMKNVKGTKDYLPEEQVLRNKIKRACEDTFERYGCKPLETPMLNMYELMSYKYGGGDEIL
KEIYTLRDQGKRDLALRYDLTIPFAKVVAMNPNIRLPFKRYEIGKVFRDGPIKQGRFREFIQCDVDIVGVESVMAEAELM
SMAFELFRTLNLEVTIQYNNRKLLNGILESINIPTERTSDVILSLDKIEKIGIDGVRKDVLERGISEEMADTICNTVLSC
LQLSIDDFKDAFNTPLVAEGVNELQQLQQYLIALGINENAIFNPFLARGLTMYTGTVYEIFLKDGSITSSIGSGGRYDNI
IGAFRGDNMSYPTVGISFGLDVIYTALSQKETISSTADVFIIPLGTELHCLQIAQQLRSTTTLKVELELAGRKLKRALNY
ANKENIPYVLIIGEEEICTETVMLRNMKEGSEVKVPLSSLSNYL

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI15029520, Length=440, Percent_Identity=32.7272727272727, Blast_Score=213, Evalue=4e-55,
Organism=Homo sapiens, GI6996014, Length=440, Percent_Identity=32.5, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI65287717, Length=428, Percent_Identity=26.6355140186916, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1788861, Length=437, Percent_Identity=22.883295194508, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71993693, Length=456, Percent_Identity=31.359649122807, Blast_Score=195, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI71993686, Length=456, Percent_Identity=31.359649122807, Blast_Score=195, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6325290, Length=451, Percent_Identity=31.7073170731707, Blast_Score=193, Evalue=4e-50,
Organism=Drosophila melanogaster, GI24643061, Length=464, Percent_Identity=32.1120689655172, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24643059, Length=483, Percent_Identity=30.8488612836439, Blast_Score=199, Evalue=4e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.21 [H]

Molecular weight: Translated: 50356; Mature: 50356

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWVFLYLHSFFSFKKGVIMMEMKNVKGTKDYLPEEQVLRNKIKRACEDTFERYGCKPLET
CEEEEEHHHHHHHHCCEEEEEECCCCCCHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
PMLNMYELMSYKYGGGDEILKEIYTLRDQGKRDLALRYDLTIPFAKVVAMNPNIRLPFKR
HHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCHHHEEEECCCEECCHHH
YEIGKVFRDGPIKQGRFREFIQCDVDIVGVESVMAEAELMSMAFELFRTLNLEVTIQYNN
HHHHHHHCCCCCCCHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHCCEEEEEEECC
RKLLNGILESINIPTERTSDVILSLDKIEKIGIDGVRKDVLERGISEEMADTICNTVLSC
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHH
LQLSIDDFKDAFNTPLVAEGVNELQQLQQYLIALGINENAIFNPFLARGLTMYTGTVYEI
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEECHHHHCCHHHHCCEEEEE
FLKDGSITSSIGSGGRYDNIIGAFRGDNMSYPTVGISFGLDVIYTALSQKETISSTADVF
EEECCCEECCCCCCCCCCCCEEEECCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCEE
IIPLGTELHCLQIAQQLRSTTTLKVELELAGRKLKRALNYANKENIPYVLIIGEEEICTE
EEECCCCHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHH
TVMLRNMKEGSEVKVPLSSLSNYL
HHHHHCCCCCCEEEEEHHHHCCCC
>Mature Secondary Structure
MWVFLYLHSFFSFKKGVIMMEMKNVKGTKDYLPEEQVLRNKIKRACEDTFERYGCKPLET
CEEEEEHHHHHHHHCCEEEEEECCCCCCHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
PMLNMYELMSYKYGGGDEILKEIYTLRDQGKRDLALRYDLTIPFAKVVAMNPNIRLPFKR
HHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCHHHEEEECCCEECCHHH
YEIGKVFRDGPIKQGRFREFIQCDVDIVGVESVMAEAELMSMAFELFRTLNLEVTIQYNN
HHHHHHHCCCCCCCHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHCCEEEEEEECC
RKLLNGILESINIPTERTSDVILSLDKIEKIGIDGVRKDVLERGISEEMADTICNTVLSC
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHH
LQLSIDDFKDAFNTPLVAEGVNELQQLQQYLIALGINENAIFNPFLARGLTMYTGTVYEI
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEECHHHHCCHHHHCCEEEEE
FLKDGSITSSIGSGGRYDNIIGAFRGDNMSYPTVGISFGLDVIYTALSQKETISSTADVF
EEECCCEECCCCCCCCCCCCEEEECCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCEE
IIPLGTELHCLQIAQQLRSTTTLKVELELAGRKLKRALNYANKENIPYVLIIGEEEICTE
EEECCCCHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHH
TVMLRNMKEGSEVKVPLSSLSNYL
HHHHHCCCCCCEEEEEHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA