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The map label for this gene is gloB [H]

Identifier: 118478537

GI number: 118478537

Start: 3086149

End: 3087600

Strand: Reverse

Name: gloB [H]

Synonym: BALH_2913

Alternate gene names: 118478537

Gene position: 3087600-3086149 (Counterclockwise)

Preceding gene: 118478538

Following gene: 118478536

Centisome position: 58.73

GC content: 34.44

Gene sequence:

>1452_bases
TTGGAGGGAATAGCTATGCTTTTAAAATATTTTTATGATGAAAAATTAGCACATGCTTCTTATTTAGTTGGTTGTCAGAA
GGAAGGCGTAGCAATTGTGATTGATCCAGGTCGCTATATAGAACAATATATAGACTTTGCTAAGAAAGAGGGGATGGAAG
TAATTGCTGCGGCTGAAACTCACATTCATGCAGATTTTCTTTCTGGGTCTAGAGAACTTTCTACTCTTTATCATACCAAT
TTATATGTATCTGATGAAGGTGATTGTGATTGGAAATATCAATATCTTAACGAAGGTCGATATAATTTGGTTAGAGAGGG
GACAGAGTTTAAAGTAGGTCATATAAAATTTAATGTAATTCACACACCAGGGCATACACCTGAAAGCATTTCTTTTTTAG
TAACTGATACAAGTCAAAATAACTATACGAATGATAAGCCAATAGGAATATTCACAGGTGATTTTATATTTGTAGGAGAT
ATAGGAAGACCCGATTTACTAGAAACCGCTGTAGGTATGAAAGATACCGCAAAAATAGGAGCAAAACAATTATTTGATTC
GATACAAAAAATAAAAACACTCCCTGATTATTTGCAAATATGGCCATCACATGGTGCAGGAAGCGCATGTGGAAAAGCAT
TAGGAGCAATTCCAACTTCTACTTTAGGTTATGAAAAGATGTTCAATTGGGCATTTCAGTGTAATGAAGAAAGTGATTTT
GTATCGACTTTATTGACGGGGCAGCCAGAGCCTCCAAGGTATTTTTCTTTAATGAAGAATTTAAATAAGTATGGTCCTCC
AATTCGTAAGAAAAGAGAAGTTACTACTATTAATACAATAGAAAAACTTCAAGAAGCTATGAGAAACGTTCAGCAAATAG
TTGATATAAGGGATGTAGAGAGTTTTGCTTCTGGTCACATCGAGAAATCAATTAACATACCGTATAACAATTCCTTCACA
ACCTGGTGTGGATGGTTACTAGATTATAAAACAGAAACTTTAATCATTCTAGATGAGGAAAAGGTTAGAGTGGAGGAAGT
TATTAGAGACTTTGAATCTATTGGGTTAGATAATAGTATTGCTTTTGCACCCTTACAAGTTATACAAAGACTTGATAGAT
TTGAAAGTTATAAAGAAAAAACATCAATTGAATTATATCCGCATATAAAAGATGGAAGTGTTAAGGTAATCGACGTGCGT
AGTAAAAAAGAGTGGGAGGAAGGACATCTTTATGATGCAATACATATCCCTTTAGGAAATCTATTTAAGCAGCTAGATTG
TATACCAAAAGATTACCCAATCATTTTACAATGTCGAACCGGATTGCGCTCTGCTATAGCAGCTAGTATTTTACAAAGAG
CTGGTATAAAGGAAGTGGTGAATCTAAAGGGAGGATTTCTTGCATGGAAAAAAGAAGAGCTTCCTTATACAACTTGTAGT
CTCAATGTGTAG

Upstream 100 bases:

>100_bases
TATGTTGCCATATATGTATTGGAACTTTATGTTGAAAGGAATCCTATAAGGGAAGAGAGAAAGCGGTTATAAAAATTGAA
AAGCATTTTGAATTAACTAT

Downstream 100 bases:

>100_bases
GGAAATGATCCTTACTAATTTAAAATGGATCATGATACATTTTACAGTTGAAATAGAAGAATTTTAAAGAGCTGAAATAT
AAAAAACACCTTATAGCTAT

Product: hydroxyacylglutathione hydrolase

Products: glutathione; 2-hydroxy carboxylate

Alternate protein names: NA

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MEGIAMLLKYFYDEKLAHASYLVGCQKEGVAIVIDPGRYIEQYIDFAKKEGMEVIAAAETHIHADFLSGSRELSTLYHTN
LYVSDEGDCDWKYQYLNEGRYNLVREGTEFKVGHIKFNVIHTPGHTPESISFLVTDTSQNNYTNDKPIGIFTGDFIFVGD
IGRPDLLETAVGMKDTAKIGAKQLFDSIQKIKTLPDYLQIWPSHGAGSACGKALGAIPTSTLGYEKMFNWAFQCNEESDF
VSTLLTGQPEPPRYFSLMKNLNKYGPPIRKKREVTTINTIEKLQEAMRNVQQIVDIRDVESFASGHIEKSINIPYNNSFT
TWCGWLLDYKTETLIILDEEKVRVEEVIRDFESIGLDNSIAFAPLQVIQRLDRFESYKEKTSIELYPHIKDGSVKVIDVR
SKKEWEEGHLYDAIHIPLGNLFKQLDCIPKDYPIILQCRTGLRSAIAASILQRAGIKEVVNLKGGFLAWKKEELPYTTCS
LNV

Sequences:

>Translated_483_residues
MEGIAMLLKYFYDEKLAHASYLVGCQKEGVAIVIDPGRYIEQYIDFAKKEGMEVIAAAETHIHADFLSGSRELSTLYHTN
LYVSDEGDCDWKYQYLNEGRYNLVREGTEFKVGHIKFNVIHTPGHTPESISFLVTDTSQNNYTNDKPIGIFTGDFIFVGD
IGRPDLLETAVGMKDTAKIGAKQLFDSIQKIKTLPDYLQIWPSHGAGSACGKALGAIPTSTLGYEKMFNWAFQCNEESDF
VSTLLTGQPEPPRYFSLMKNLNKYGPPIRKKREVTTINTIEKLQEAMRNVQQIVDIRDVESFASGHIEKSINIPYNNSFT
TWCGWLLDYKTETLIILDEEKVRVEEVIRDFESIGLDNSIAFAPLQVIQRLDRFESYKEKTSIELYPHIKDGSVKVIDVR
SKKEWEEGHLYDAIHIPLGNLFKQLDCIPKDYPIILQCRTGLRSAIAASILQRAGIKEVVNLKGGFLAWKKEELPYTTCS
LNV
>Mature_483_residues
MEGIAMLLKYFYDEKLAHASYLVGCQKEGVAIVIDPGRYIEQYIDFAKKEGMEVIAAAETHIHADFLSGSRELSTLYHTN
LYVSDEGDCDWKYQYLNEGRYNLVREGTEFKVGHIKFNVIHTPGHTPESISFLVTDTSQNNYTNDKPIGIFTGDFIFVGD
IGRPDLLETAVGMKDTAKIGAKQLFDSIQKIKTLPDYLQIWPSHGAGSACGKALGAIPTSTLGYEKMFNWAFQCNEESDF
VSTLLTGQPEPPRYFSLMKNLNKYGPPIRKKREVTTINTIEKLQEAMRNVQQIVDIRDVESFASGHIEKSINIPYNNSFT
TWCGWLLDYKTETLIILDEEKVRVEEVIRDFESIGLDNSIAFAPLQVIQRLDRFESYKEKTSIELYPHIKDGSVKVIDVR
SKKEWEEGHLYDAIHIPLGNLFKQLDCIPKDYPIILQCRTGLRSAIAASILQRAGIKEVVNLKGGFLAWKKEELPYTTCS
LNV

Specific function: Unknown

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 rhodanese domain [H]

Homologues:

Organism=Homo sapiens, GI41327741, Length=205, Percent_Identity=26.3414634146341, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1787158, Length=227, Percent_Identity=25.9911894273128, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17538952, Length=204, Percent_Identity=26.4705882352941, Blast_Score=68, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR001763 [H]

Pfam domain/function: PF00753 Lactamase_B; PF00581 Rhodanese [H]

EC number: 3.1.2.6

Molecular weight: Translated: 54786; Mature: 54786

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGIAMLLKYFYDEKLAHASYLVGCQKEGVAIVIDPGRYIEQYIDFAKKEGMEVIAAAET
CCHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEECCHHHHHHHHHHHHHCCCEEEEEHHH
HIHADFLSGSRELSTLYHTNLYVSDEGDCDWKYQYLNEGRYNLVREGTEFKVGHIKFNVI
HHHHHHHCCCHHHHEEEEEEEEEECCCCCCEEEHHHCCCCEEEEECCCCEEEEEEEEEEE
HTPGHTPESISFLVTDTSQNNYTNDKPIGIFTGDFIFVGDIGRPDLLETAVGMKDTAKIG
ECCCCCCCCEEEEEEECCCCCCCCCCCEEEEECCEEEEECCCCCHHHHHHCCCCHHHHHH
AKQLFDSIQKIKTLPDYLQIWPSHGAGSACGKALGAIPTSTLGYEKMFNWAFQCNEESDF
HHHHHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHEECCCCHHH
VSTLLTGQPEPPRYFSLMKNLNKYGPPIRKKREVTTINTIEKLQEAMRNVQQIVDIRDVE
HHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SFASGHIEKSINIPYNNSFTTWCGWLLDYKTETLIILDEEKVRVEEVIRDFESIGLDNSI
HHHCCCCCEEECCCCCCCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCC
AFAPLQVIQRLDRFESYKEKTSIELYPHIKDGSVKVIDVRSKKEWEEGHLYDAIHIPLGN
HHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCCCCCCCCCEEEEEECCHHH
LFKQLDCIPKDYPIILQCRTGLRSAIAASILQRAGIKEVVNLKGGFLAWKKEELPYTTCS
HHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEEECCCCCEEEEE
LNV
CCC
>Mature Secondary Structure
MEGIAMLLKYFYDEKLAHASYLVGCQKEGVAIVIDPGRYIEQYIDFAKKEGMEVIAAAET
CCHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEECCHHHHHHHHHHHHHCCCEEEEEHHH
HIHADFLSGSRELSTLYHTNLYVSDEGDCDWKYQYLNEGRYNLVREGTEFKVGHIKFNVI
HHHHHHHCCCHHHHEEEEEEEEEECCCCCCEEEHHHCCCCEEEEECCCCEEEEEEEEEEE
HTPGHTPESISFLVTDTSQNNYTNDKPIGIFTGDFIFVGDIGRPDLLETAVGMKDTAKIG
ECCCCCCCCEEEEEEECCCCCCCCCCCEEEEECCEEEEECCCCCHHHHHHCCCCHHHHHH
AKQLFDSIQKIKTLPDYLQIWPSHGAGSACGKALGAIPTSTLGYEKMFNWAFQCNEESDF
HHHHHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHEECCCCHHH
VSTLLTGQPEPPRYFSLMKNLNKYGPPIRKKREVTTINTIEKLQEAMRNVQQIVDIRDVE
HHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SFASGHIEKSINIPYNNSFTTWCGWLLDYKTETLIILDEEKVRVEEVIRDFESIGLDNSI
HHHCCCCCEEECCCCCCCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCC
AFAPLQVIQRLDRFESYKEKTSIELYPHIKDGSVKVIDVRSKKEWEEGHLYDAIHIPLGN
HHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCCCCCCCCCEEEEEECCHHH
LFKQLDCIPKDYPIILQCRTGLRSAIAASILQRAGIKEVVNLKGGFLAWKKEELPYTTCS
HHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEEECCCCCEEEEE
LNV
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-(2-hydroxyacyl)glutathione; H2O

Specific reaction: S-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]