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The map label for this gene is lysP [H]

Identifier: 118478382

GI number: 118478382

Start: 2910405

End: 2911976

Strand: Direct

Name: lysP [H]

Synonym: BALH_2747

Alternate gene names: 118478382

Gene position: 2910405-2911976 (Clockwise)

Preceding gene: 118478380

Following gene: 118478383

Centisome position: 55.36

GC content: 40.01

Gene sequence:

>1572_bases
ATGATGGGGTGGTTATTTGTGAAACGTTCCGCCAAATTCCTTTGGCGGTTTTTTGTATTTTTCTCCCCCGCTCCTTCCTA
TCTTACAAGAAAAGGAGTGTTGAACATGAATAGCGCAACGAATCAAACTACCTCTCAAACAGAAACTACAAAAGGAAAAG
GTGAATTAAGACGCGGTCTAAAATCAAGGCACCTTACGATGATTTCTCTCGGCGGTACAATTGGTACCGGACTATTTCTT
GCCAGCGGTGGTGTCATTCATTCAGCTGGACCTGGCGGCGCATTAATTGCATACGCCGCAATTGGAATTATGGTTTACTT
TTTAATGACAAGCTTAGCCGAACTCGCAGCTTACATGCCTGTTACTGGATCTTTTAGCACGTACGCAACAAAATTTGTTG
ATCCATCACTTGGCTTTGCACTTGGATGGAACTATTGGTATAACTGGGCAATTACTATCGCTGCTGAACTAGCGGCTGTA
ACATTAATTATGAAATTTTGGTTTCCAGATACTCCTTCCCTCATTTGGAGCGGATTATGTTTAGCTATTATTTTCCTTTT
AAACTACTTATCTGTTAAAGGATTTGGTGAATCTGAATATTGGTTCGCACTTATTAAAGTAGCTACGATTATTATCTTTT
TAATTGTCGGGTTTATGATGATTTTCGGAATTATGGGCGGCGAAACTGTTGGATTTAAAAACTTCACTGTTGCAGATGCA
CCATTTAATGGCGGCATCATGGCAATTATCGGTGTATTTATGGCAGCTGGTTTCTCATTCCAAGGTACTGAATTATTAGG
TGTAGCTGCTGGTGAAACATCTGATCCAGAGCGTAATATTCCGAAAGCAATTCGTTCGATCTTTTGGCGTATCCTTTTAT
TCTATATCCTTGCGATTCTCGTTATCGGTTTATTAATTCCTTATACAACCGAAAGTCTTGCCGCAAGTGATGTAACAGTA
AGTCCATTTACACTTATTTTTGAAAAAGCGGGCGTTGCCTTCGCTGCTTCTGTTATGAACGCTGTTATTTTAACGGCAGT
ACTATCTGCTGGTAACTCTGGTATGTATGCATCAACTCGTATGCTTTGGGACTTAGCTCGCCAAGGGAAAGCACCAAAGT
TTCTTGGTAAATTAGATAGCCGCGGCGTACCTGTTAACGCATTAATCGTAACATCGATTGTCGGTAGTATCGCTTTCATT
GCTTCTTTATTCGGTGACGGTGTTGTATACATTTGGTTACTAAATGCATCAGGAATGTCTGGCTTTATCGCATGGGTTGG
AATCGCAATTAGTCATTACCGTTTCCGCAAAGCATATATCGCACAAGGAAAAGATTTAAATGACTTACCTTATAGAGCAA
AATGGTTCCCATTCGGACCAATCTTCGCTTTTGCACTTTGCGTCATCGTAATTTTAGGTCAAAACTACGGCGCATTTATG
GGCGAATCAATCGATTGGAACGGCGTACTCGTTTCTTACATCGGTTTACCACTCTTCTTAGTACTTTGGTTAGGATACAA
ATTTACGAAAAAAACAAAAGTCATTCCACTTGATAAATGTGAACTAAAATAA

Upstream 100 bases:

>100_bases
TTCTCTGGAAATATGAGCTGGGGCTGTCACCGAAAGGAACAGAACTGTCACGTTTACAAAATTACCGTGTAAACGTGGGG
TGCTATCTTAACGGAAGGGT

Downstream 100 bases:

>100_bases
AGTGAAACGAGCAAACAAATTTGTTTGCTCGTTTTTTATTGCAAACCTCTTTGCTTCCCTATTGCCCCTGTTTTTGCAAT
AATAAAGGAAATATAAATAA

Product: lysine specific permease

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 523; Mature: 523

Protein sequence:

>523_residues
MMGWLFVKRSAKFLWRFFVFFSPAPSYLTRKGVLNMNSATNQTTSQTETTKGKGELRRGLKSRHLTMISLGGTIGTGLFL
ASGGVIHSAGPGGALIAYAAIGIMVYFLMTSLAELAAYMPVTGSFSTYATKFVDPSLGFALGWNYWYNWAITIAAELAAV
TLIMKFWFPDTPSLIWSGLCLAIIFLLNYLSVKGFGESEYWFALIKVATIIIFLIVGFMMIFGIMGGETVGFKNFTVADA
PFNGGIMAIIGVFMAAGFSFQGTELLGVAAGETSDPERNIPKAIRSIFWRILLFYILAILVIGLLIPYTTESLAASDVTV
SPFTLIFEKAGVAFAASVMNAVILTAVLSAGNSGMYASTRMLWDLARQGKAPKFLGKLDSRGVPVNALIVTSIVGSIAFI
ASLFGDGVVYIWLLNASGMSGFIAWVGIAISHYRFRKAYIAQGKDLNDLPYRAKWFPFGPIFAFALCVIVILGQNYGAFM
GESIDWNGVLVSYIGLPLFLVLWLGYKFTKKTKVIPLDKCELK

Sequences:

>Translated_523_residues
MMGWLFVKRSAKFLWRFFVFFSPAPSYLTRKGVLNMNSATNQTTSQTETTKGKGELRRGLKSRHLTMISLGGTIGTGLFL
ASGGVIHSAGPGGALIAYAAIGIMVYFLMTSLAELAAYMPVTGSFSTYATKFVDPSLGFALGWNYWYNWAITIAAELAAV
TLIMKFWFPDTPSLIWSGLCLAIIFLLNYLSVKGFGESEYWFALIKVATIIIFLIVGFMMIFGIMGGETVGFKNFTVADA
PFNGGIMAIIGVFMAAGFSFQGTELLGVAAGETSDPERNIPKAIRSIFWRILLFYILAILVIGLLIPYTTESLAASDVTV
SPFTLIFEKAGVAFAASVMNAVILTAVLSAGNSGMYASTRMLWDLARQGKAPKFLGKLDSRGVPVNALIVTSIVGSIAFI
ASLFGDGVVYIWLLNASGMSGFIAWVGIAISHYRFRKAYIAQGKDLNDLPYRAKWFPFGPIFAFALCVIVILGQNYGAFM
GESIDWNGVLVSYIGLPLFLVLWLGYKFTKKTKVIPLDKCELK
>Mature_523_residues
MMGWLFVKRSAKFLWRFFVFFSPAPSYLTRKGVLNMNSATNQTTSQTETTKGKGELRRGLKSRHLTMISLGGTIGTGLFL
ASGGVIHSAGPGGALIAYAAIGIMVYFLMTSLAELAAYMPVTGSFSTYATKFVDPSLGFALGWNYWYNWAITIAAELAAV
TLIMKFWFPDTPSLIWSGLCLAIIFLLNYLSVKGFGESEYWFALIKVATIIIFLIVGFMMIFGIMGGETVGFKNFTVADA
PFNGGIMAIIGVFMAAGFSFQGTELLGVAAGETSDPERNIPKAIRSIFWRILLFYILAILVIGLLIPYTTESLAASDVTV
SPFTLIFEKAGVAFAASVMNAVILTAVLSAGNSGMYASTRMLWDLARQGKAPKFLGKLDSRGVPVNALIVTSIVGSIAFI
ASLFGDGVVYIWLLNASGMSGFIAWVGIAISHYRFRKAYIAQGKDLNDLPYRAKWFPFGPIFAFALCVIVILGQNYGAFM
GESIDWNGVLVSYIGLPLFLVLWLGYKFTKKTKVIPLDKCELK

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788480, Length=481, Percent_Identity=62.993762993763, Blast_Score=632, Evalue=0.0,
Organism=Escherichia coli, GI87081708, Length=470, Percent_Identity=39.1489361702128, Blast_Score=345, Evalue=6e-96,
Organism=Escherichia coli, GI1786789, Length=438, Percent_Identity=37.4429223744292, Blast_Score=284, Evalue=1e-77,
Organism=Escherichia coli, GI1786302, Length=470, Percent_Identity=36.3829787234043, Blast_Score=280, Evalue=2e-76,
Organism=Escherichia coli, GI48994972, Length=433, Percent_Identity=36.4896073903002, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI87081915, Length=427, Percent_Identity=34.192037470726, Blast_Score=242, Evalue=5e-65,
Organism=Escherichia coli, GI1790653, Length=349, Percent_Identity=37.8223495702006, Blast_Score=236, Evalue=3e-63,
Organism=Escherichia coli, GI1789017, Length=394, Percent_Identity=34.7715736040609, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI1786602, Length=390, Percent_Identity=36.4102564102564, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI87081869, Length=406, Percent_Identity=24.8768472906404, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87082023, Length=411, Percent_Identity=25.7907542579075, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87082250, Length=275, Percent_Identity=29.8181818181818, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17540018, Length=414, Percent_Identity=24.3961352657005, Blast_Score=66, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=360, Percent_Identity=23.6111111111111, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=506, Percent_Identity=37.7470355731225, Blast_Score=333, Evalue=4e-92,
Organism=Saccharomyces cerevisiae, GI6324061, Length=499, Percent_Identity=34.6693386773547, Blast_Score=320, Evalue=2e-88,
Organism=Saccharomyces cerevisiae, GI6322892, Length=498, Percent_Identity=37.3493975903614, Blast_Score=310, Evalue=4e-85,
Organism=Saccharomyces cerevisiae, GI6324990, Length=495, Percent_Identity=33.3333333333333, Blast_Score=296, Evalue=5e-81,
Organism=Saccharomyces cerevisiae, GI6324059, Length=500, Percent_Identity=34.8, Blast_Score=293, Evalue=7e-80,
Organism=Saccharomyces cerevisiae, GI6324924, Length=509, Percent_Identity=33.2023575638507, Blast_Score=285, Evalue=9e-78,
Organism=Saccharomyces cerevisiae, GI6320717, Length=513, Percent_Identity=31.7738791423002, Blast_Score=276, Evalue=8e-75,
Organism=Saccharomyces cerevisiae, GI6321629, Length=519, Percent_Identity=31.0211946050096, Blast_Score=273, Evalue=5e-74,
Organism=Saccharomyces cerevisiae, GI6319542, Length=531, Percent_Identity=31.0734463276836, Blast_Score=265, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6324553, Length=425, Percent_Identity=35.0588235294118, Blast_Score=261, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6320251, Length=509, Percent_Identity=30.2554027504912, Blast_Score=254, Evalue=3e-68,
Organism=Saccharomyces cerevisiae, GI6322967, Length=466, Percent_Identity=31.5450643776824, Blast_Score=246, Evalue=8e-66,
Organism=Saccharomyces cerevisiae, GI6319543, Length=519, Percent_Identity=30.8285163776493, Blast_Score=244, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6319824, Length=504, Percent_Identity=28.968253968254, Blast_Score=243, Evalue=6e-65,
Organism=Saccharomyces cerevisiae, GI6321053, Length=468, Percent_Identity=32.0512820512821, Blast_Score=235, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6324981, Length=487, Percent_Identity=30.5954825462012, Blast_Score=216, Evalue=6e-57,
Organism=Saccharomyces cerevisiae, GI6319608, Length=474, Percent_Identity=27.6371308016878, Blast_Score=214, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6320364, Length=553, Percent_Identity=27.3056057866184, Blast_Score=171, Evalue=3e-43,
Organism=Drosophila melanogaster, GI281366235, Length=390, Percent_Identity=23.5897435897436, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI116007820, Length=390, Percent_Identity=23.5897435897436, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI116007818, Length=391, Percent_Identity=23.5294117647059, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI85725152, Length=391, Percent_Identity=23.5294117647059, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 56962; Mature: 56962

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMGWLFVKRSAKFLWRFFVFFSPAPSYLTRKGVLNMNSATNQTTSQTETTKGKGELRRGL
CCCEEEHHHHHHHHHHHHHHHCCCHHHHHHCCCEECCCCCCCCCCCCCCCCCHHHHHHHH
KSRHLTMISLGGTIGTGLFLASGGVIHSAGPGGALIAYAAIGIMVYFLMTSLAELAAYMP
HHCCEEEEEECCHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VTGSFSTYATKFVDPSLGFALGWNYWYNWAITIAAELAAVTLIMKFWFPDTPSLIWSGLC
CCCCCHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
LAIIFLLNYLSVKGFGESEYWFALIKVATIIIFLIVGFMMIFGIMGGETVGFKNFTVADA
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEECC
PFNGGIMAIIGVFMAAGFSFQGTELLGVAAGETSDPERNIPKAIRSIFWRILLFYILAIL
CCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VIGLLIPYTTESLAASDVTVSPFTLIFEKAGVAFAASVMNAVILTAVLSAGNSGMYASTR
HHHHHHCCCCHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
MLWDLARQGKAPKFLGKLDSRGVPVNALIVTSIVGSIAFIASLFGDGVVYIWLLNASGMS
HHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCH
GFIAWVGIAISHYRFRKAYIAQGKDLNDLPYRAKWFPFGPIFAFALCVIVILGQNYGAFM
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHC
GESIDWNGVLVSYIGLPLFLVLWLGYKFTKKTKVIPLDKCELK
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCC
>Mature Secondary Structure
MMGWLFVKRSAKFLWRFFVFFSPAPSYLTRKGVLNMNSATNQTTSQTETTKGKGELRRGL
CCCEEEHHHHHHHHHHHHHHHCCCHHHHHHCCCEECCCCCCCCCCCCCCCCCHHHHHHHH
KSRHLTMISLGGTIGTGLFLASGGVIHSAGPGGALIAYAAIGIMVYFLMTSLAELAAYMP
HHCCEEEEEECCHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VTGSFSTYATKFVDPSLGFALGWNYWYNWAITIAAELAAVTLIMKFWFPDTPSLIWSGLC
CCCCCHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
LAIIFLLNYLSVKGFGESEYWFALIKVATIIIFLIVGFMMIFGIMGGETVGFKNFTVADA
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEECC
PFNGGIMAIIGVFMAAGFSFQGTELLGVAAGETSDPERNIPKAIRSIFWRILLFYILAIL
CCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VIGLLIPYTTESLAASDVTVSPFTLIFEKAGVAFAASVMNAVILTAVLSAGNSGMYASTR
HHHHHHCCCCHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
MLWDLARQGKAPKFLGKLDSRGVPVNALIVTSIVGSIAFIASLFGDGVVYIWLLNASGMS
HHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCH
GFIAWVGIAISHYRFRKAYIAQGKDLNDLPYRAKWFPFGPIFAFALCVIVILGQNYGAFM
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHC
GESIDWNGVLVSYIGLPLFLVLWLGYKFTKKTKVIPLDKCELK
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]