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The map label for this gene is lsrK [H]

Identifier: 118478303

GI number: 118478303

Start: 2829600

End: 2831168

Strand: Direct

Name: lsrK [H]

Synonym: BALH_2666

Alternate gene names: 118478303

Gene position: 2829600-2831168 (Clockwise)

Preceding gene: 118478302

Following gene: 118478304

Centisome position: 53.82

GC content: 40.41

Gene sequence:

>1569_bases
TTGTTAATGTCCAATTTATTAGCTTTCGATGCTGGTACAGGAAGTATTCGAGCAGTTCTTTTTGATTTACATGGTAATCA
AATTGCAGTAAGTCAAAAAGAATGGATTCACAAATCTGACCCACGTTACCCTGGTTCTATGAACTTTGATGTAATAGAAA
ATTGGAAGCTTGTACAAGTATGCACGAAAGAGGTTCTTCAAAAAAGCAATACTCTTGCCTCTTCCATTCTTGCTATTAGT
GCGACAAGTATGCGGGAAGGGTTTGTTTTATATGATCAAGATGGGCAAGAAATATGGGCGTGTGCAAATGTTGATGGGCG
CGCATCTGCTGAGGTTAGTGAACTAAAAGAAATTCGGTCACACCTTGAAAAAGATTTATATACAAAGTCTGGTCAAACTT
TTTCATTAGGTGCTTTACCCCGCCTACTTTGGATTAAAAAACATGAACCCGACGTCTATAATACTATTCACTCTTTTACA
ATGTTAAACGATTGGATCTTATATAAATTAAGCGGCGTGCTGCAAATCGATCCTTCAAACGGATGTACGTCAGGTATTTT
TGACTTACAAAATAGAGTGTGGGATAACGATGTTGCTAAGGAGTGCGGTCTATCTTTACCATTTTCACCAACAGTAAATG
AAGCTGGTACAGTAATTGGCAACGTTACAAAAGAGTGTGCAGCATTAACTGGATTATGTGAAGGAATTCCTGTCGTAGCC
GGGGGCGGAGATGCTCAAATGGCATCGCTCGGAACTGGAGTCGTGAAACCGAATCAAACATTAATATGCGGAGGTAGTTT
TTGGCAACAAGAAGTGAATATTACTGAGCCAATACCAGATCCACAAGCTGCGATTCGTATAAATTGTCACGTCGTACGTA
ACCTATGGCAATACGAAACGATTGCCTTTTTCCCAGGCCTCGTTATGCGCTGGTTTCGAGACGCTTTTTGTCAAGAGGAA
AAGAAACTTGCTGACAAACTCGGTGTAGATGCTTATGAATTACTAGAAGAACAAGCGAAAGACGTACCTGTCGGTTCACA
TGGCATTATCCCTACTTTTTCAAACGTTATGAACTACATTTCTTGGCGTCATGCCGCACCTTCTTTTTTAAATTTAAGTT
TAGACGCTGACAAATGCGGAAAAAAAGAACTGTTTCGTGCTATTGAAGAAAATGCCGCCTTCGTTACACTTGGAAACTTA
ATATTAATAGAAAATCTAACTGGTATATTCCCTTCTGAAGTTATTTTTGCTGGTGGTGCCGCTAAAGGAAAACTATGGCC
ACAAATTCTATCAGACGTCCTTGGTATTCCTGTAAAAATACCTGTTGTGAAAGAAGCAGCTGCTTTAGGAACTGCGATTG
CTGCAGGAGTTGGTGCTGGCATATATTCATCTATGGAAGAGACTGCCGAACAGTTTGTACAGTGGGAGCAAACATTCGAA
CCAGTTACTGAAAATCACGAACTATATAAAGAGTTCTATGAAACCTGGAAAACTGTGTATGACAGTCAGCTCGCTTTAGC
TGATAACGGGCTCACCTCACACATGTGGATTGCGCCTGGTGCACTGTAA

Upstream 100 bases:

>100_bases
AAAAGATAGATGCAATTTATGGTGCCTTAAAAGGAAAGTTTATTCATACATTAATTACCGATGAGGAAACTGCCCTTTCC
TTATTACGAAAGGATGGTGA

Downstream 100 bases:

>100_bases
CACATTACATAAAGGAGTGGAATGTATGTTAAAAGCGAATGAAAATGACTTCTCCTATCGCTTCGGTGATAACGGGCCGA
AATATTTAATACAAGGTCCG

Product: autoinducer-2 (AI-2) kinase

Products: NA

Alternate protein names: AI-2 kinase [H]

Number of amino acids: Translated: 522; Mature: 522

Protein sequence:

>522_residues
MLMSNLLAFDAGTGSIRAVLFDLHGNQIAVSQKEWIHKSDPRYPGSMNFDVIENWKLVQVCTKEVLQKSNTLASSILAIS
ATSMREGFVLYDQDGQEIWACANVDGRASAEVSELKEIRSHLEKDLYTKSGQTFSLGALPRLLWIKKHEPDVYNTIHSFT
MLNDWILYKLSGVLQIDPSNGCTSGIFDLQNRVWDNDVAKECGLSLPFSPTVNEAGTVIGNVTKECAALTGLCEGIPVVA
GGGDAQMASLGTGVVKPNQTLICGGSFWQQEVNITEPIPDPQAAIRINCHVVRNLWQYETIAFFPGLVMRWFRDAFCQEE
KKLADKLGVDAYELLEEQAKDVPVGSHGIIPTFSNVMNYISWRHAAPSFLNLSLDADKCGKKELFRAIEENAAFVTLGNL
ILIENLTGIFPSEVIFAGGAAKGKLWPQILSDVLGIPVKIPVVKEAAALGTAIAAGVGAGIYSSMEETAEQFVQWEQTFE
PVTENHELYKEFYETWKTVYDSQLALADNGLTSHMWIAPGAL

Sequences:

>Translated_522_residues
MLMSNLLAFDAGTGSIRAVLFDLHGNQIAVSQKEWIHKSDPRYPGSMNFDVIENWKLVQVCTKEVLQKSNTLASSILAIS
ATSMREGFVLYDQDGQEIWACANVDGRASAEVSELKEIRSHLEKDLYTKSGQTFSLGALPRLLWIKKHEPDVYNTIHSFT
MLNDWILYKLSGVLQIDPSNGCTSGIFDLQNRVWDNDVAKECGLSLPFSPTVNEAGTVIGNVTKECAALTGLCEGIPVVA
GGGDAQMASLGTGVVKPNQTLICGGSFWQQEVNITEPIPDPQAAIRINCHVVRNLWQYETIAFFPGLVMRWFRDAFCQEE
KKLADKLGVDAYELLEEQAKDVPVGSHGIIPTFSNVMNYISWRHAAPSFLNLSLDADKCGKKELFRAIEENAAFVTLGNL
ILIENLTGIFPSEVIFAGGAAKGKLWPQILSDVLGIPVKIPVVKEAAALGTAIAAGVGAGIYSSMEETAEQFVQWEQTFE
PVTENHELYKEFYETWKTVYDSQLALADNGLTSHMWIAPGAL
>Mature_522_residues
MLMSNLLAFDAGTGSIRAVLFDLHGNQIAVSQKEWIHKSDPRYPGSMNFDVIENWKLVQVCTKEVLQKSNTLASSILAIS
ATSMREGFVLYDQDGQEIWACANVDGRASAEVSELKEIRSHLEKDLYTKSGQTFSLGALPRLLWIKKHEPDVYNTIHSFT
MLNDWILYKLSGVLQIDPSNGCTSGIFDLQNRVWDNDVAKECGLSLPFSPTVNEAGTVIGNVTKECAALTGLCEGIPVVA
GGGDAQMASLGTGVVKPNQTLICGGSFWQQEVNITEPIPDPQAAIRINCHVVRNLWQYETIAFFPGLVMRWFRDAFCQEE
KKLADKLGVDAYELLEEQAKDVPVGSHGIIPTFSNVMNYISWRHAAPSFLNLSLDADKCGKKELFRAIEENAAFVTLGNL
ILIENLTGIFPSEVIFAGGAAKGKLWPQILSDVLGIPVKIPVVKEAAALGTAIAAGVGAGIYSSMEETAEQFVQWEQTFE
PVTENHELYKEFYETWKTVYDSQLALADNGLTSHMWIAPGAL

Specific function: Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione

COG id: COG1070

COG function: function code G; Sugar (pentulose and hexulose) kinases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI88196792, Length=529, Percent_Identity=22.4952741020794, Blast_Score=83, Evalue=6e-16,
Organism=Escherichia coli, GI1787789, Length=516, Percent_Identity=54.4573643410853, Blast_Score=593, Evalue=1e-170,
Organism=Escherichia coli, GI1789168, Length=498, Percent_Identity=23.2931726907631, Blast_Score=118, Evalue=8e-28,
Organism=Escherichia coli, GI1790361, Length=517, Percent_Identity=24.9516441005803, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1789987, Length=510, Percent_Identity=24.9019607843137, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1789138, Length=334, Percent_Identity=24.251497005988, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1790005, Length=284, Percent_Identity=28.169014084507, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17535599, Length=466, Percent_Identity=23.175965665236, Blast_Score=75, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018484 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: NA

Molecular weight: Translated: 57359; Mature: 57359

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMSNLLAFDAGTGSIRAVLFDLHGNQIAVSQKEWIHKSDPRYPGSMNFDVIENWKLVQV
CCHHHCEEECCCCCCEEEEEEEECCCEEEECHHHHCCCCCCCCCCCCCCHHHCCCHHHHH
CTKEVLQKSNTLASSILAISATSMREGFVLYDQDGQEIWACANVDGRASAEVSELKEIRS
HHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHH
HLEKDLYTKSGQTFSLGALPRLLWIKKHEPDVYNTIHSFTMLNDWILYKLSGVLQIDPSN
HHHHHHHHCCCCEEECCCCCHHHEEECCCCHHHHHHHHHHHHHHHHHEEECCEEEECCCC
GCTSGIFDLQNRVWDNDVAKECGLSLPFSPTVNEAGTVIGNVTKECAALTGLCEGIPVVA
CCCHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEE
GGGDAQMASLGTGVVKPNQTLICGGSFWQQEVNITEPIPDPQAAIRINCHVVRNLWQYET
CCCCCHHHHCCCCCCCCCCEEEECCHHHHCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHH
IAFFPGLVMRWFRDAFCQEEKKLADKLGVDAYELLEEQAKDVPVGSHGIIPTFSNVMNYI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
SWRHAAPSFLNLSLDADKCGKKELFRAIEENAAFVTLGNLILIENLTGIFPSEVIFAGGA
HHHCCCCCEEEEECCHHHCCHHHHHHHHHCCCCEEEECCEEEEECCCCCCCCHHEEECCC
AKGKLWPQILSDVLGIPVKIPVVKEAAALGTAIAAGVGAGIYSSMEETAEQFVQWEQTFE
CCCCHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PVTENHELYKEFYETWKTVYDSQLALADNGLTSHMWIAPGAL
CCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEECCCCC
>Mature Secondary Structure
MLMSNLLAFDAGTGSIRAVLFDLHGNQIAVSQKEWIHKSDPRYPGSMNFDVIENWKLVQV
CCHHHCEEECCCCCCEEEEEEEECCCEEEECHHHHCCCCCCCCCCCCCCHHHCCCHHHHH
CTKEVLQKSNTLASSILAISATSMREGFVLYDQDGQEIWACANVDGRASAEVSELKEIRS
HHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHH
HLEKDLYTKSGQTFSLGALPRLLWIKKHEPDVYNTIHSFTMLNDWILYKLSGVLQIDPSN
HHHHHHHHCCCCEEECCCCCHHHEEECCCCHHHHHHHHHHHHHHHHHEEECCEEEECCCC
GCTSGIFDLQNRVWDNDVAKECGLSLPFSPTVNEAGTVIGNVTKECAALTGLCEGIPVVA
CCCHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEE
GGGDAQMASLGTGVVKPNQTLICGGSFWQQEVNITEPIPDPQAAIRINCHVVRNLWQYET
CCCCCHHHHCCCCCCCCCCEEEECCHHHHCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHH
IAFFPGLVMRWFRDAFCQEEKKLADKLGVDAYELLEEQAKDVPVGSHGIIPTFSNVMNYI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHH
SWRHAAPSFLNLSLDADKCGKKELFRAIEENAAFVTLGNLILIENLTGIFPSEVIFAGGA
HHHCCCCCEEEEECCHHHCCHHHHHHHHHCCCCEEEECCEEEEECCCCCCCCHHEEECCC
AKGKLWPQILSDVLGIPVKIPVVKEAAALGTAIAAGVGAGIYSSMEETAEQFVQWEQTFE
CCCCHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PVTENHELYKEFYETWKTVYDSQLALADNGLTSHMWIAPGAL
CCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA