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The map label for this gene is relA [H]

Identifier: 118477842

GI number: 118477842

Start: 2337867

End: 2339255

Strand: Reverse

Name: relA [H]

Synonym: BALH_2184

Alternate gene names: 118477842

Gene position: 2339255-2337867 (Counterclockwise)

Preceding gene: 118477849

Following gene: 118477841

Centisome position: 44.5

GC content: 28.94

Gene sequence:

>1389_bases
ATGAGTGAGGTATTATTACAAAAGGCAAATTATTTACAATCTAATGAATTAAAACTTTTGAAAAAAGCTATACAATTTGC
AGAGCGAGCACATGATGGACAATACCGTCAAACCGGAGAACCATATATTATTCACCCTTTCGCAATTGCAGAAATACTGA
TAAATTATAAAGCTGACATCACTACATTGATTGCTGCATTATTACACGATGTTGTAGAAGATACTGAACATTCTTTAGAA
GAAATTGAATCGCATTTTGGTACAACTATTAGATATATTGTAAATGGATTAACAAAAAGAAAAAAACAACAAAATCAAAA
CAAAATAATATACGAGGCAATTAATTTTAAAAAACTACTATTATCCTCTCAACATGATATACGTGTTGGCATTATTAAAG
TTATAGATCGCCTTCACAATATAAAAACATTGAATGTTAAAAAACCGGCGAAACAAGTAGCATATGCGAATGAAACTTTA
ACACTTTTTGCGCCACTTGCAAAGCGACTAGGATTATATACAATCCAGTATGAATTAGAAAATCTTGCTTTTCAATATTT
ACATAAAGAAAGATATAACAAGGTACTTGAATTTTTAACTGGATATGTGCCACATCTCCAAAAAAATATAACTGATTTGA
GAAGAGGAATTCATTCTTTTTATGATACTAACCTTTCATTTGAAATAAGCTATGAGTTTCCTCCAATTTATACTGCCTAC
TCACAACTACAAGAAGTACAAAACGTATCAGGTATTTCACAAATCTGTATTACAACTACAAGTGTACTAGATTGCTATAA
AATTCTTGGAATAATACATCAATTATACAAACCAACTATCAACTATTTCGAAGACAACATAGCACTTGAAAACAGCCCTT
TTAATAGCAATTTAAAAACTAAAATCAAGATGAATGATACTGAACAAACAATTATCATCCAAACAAAATTTGCAAAAAGA
TTAAAAAATAATGGTATTTTTTCTTTATTGAATAATGAAACTGTGGATATTCAATCCCTATCTTATAAAATAATGAATGA
TACAATTTTGAATAACAATTTATTAACTACAGATCCAATCGCTTTCCATAATCTAGTATCATATGAACTATTTGAAAATA
CCATAACGGCCTATACTTCAGATTTACAACCTATTTATTTACCAGATGGTGCTACAATTATTGATTTTACTTTCTCTGCA
TTTCCGAAAATTGCACATAACATGAAAAATGCAAAAGTAAATGGTATACCTGTTCCACTTAAAACAAAGGTATCCCATTT
TGACGTCATAGAAATCTATTTTGGTTTAAAACAAAACTTGGTATTAGAGTGGCTCAATTATGCCAATACCGCTAAAGCAC
AATTAATTATTCAGCAAAAACTATCTTAA

Upstream 100 bases:

>100_bases
CTCAACACTTTTATTTATTTCATAATTAAAATAATTTAAAAGGGTATTTATTCTATTATATAGAATTATTATTAAAAATA
ATTTTAAGGGATGGATTTAT

Downstream 100 bases:

>100_bases
ATAACAGACCAATGCTTCTTATAAAAAGTATTGGTCTGTTATTTAAGATACAAAATACAACCCATATTCTTTATGGAATA
AGCGAATTTAATACGATACC

Product: GTP pyrophosphokinase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MSEVLLQKANYLQSNELKLLKKAIQFAERAHDGQYRQTGEPYIIHPFAIAEILINYKADITTLIAALLHDVVEDTEHSLE
EIESHFGTTIRYIVNGLTKRKKQQNQNKIIYEAINFKKLLLSSQHDIRVGIIKVIDRLHNIKTLNVKKPAKQVAYANETL
TLFAPLAKRLGLYTIQYELENLAFQYLHKERYNKVLEFLTGYVPHLQKNITDLRRGIHSFYDTNLSFEISYEFPPIYTAY
SQLQEVQNVSGISQICITTTSVLDCYKILGIIHQLYKPTINYFEDNIALENSPFNSNLKTKIKMNDTEQTIIIQTKFAKR
LKNNGIFSLLNNETVDIQSLSYKIMNDTILNNNLLTTDPIAFHNLVSYELFENTITAYTSDLQPIYLPDGATIIDFTFSA
FPKIAHNMKNAKVNGIPVPLKTKVSHFDVIEIYFGLKQNLVLEWLNYANTAKAQLIIQQKLS

Sequences:

>Translated_462_residues
MSEVLLQKANYLQSNELKLLKKAIQFAERAHDGQYRQTGEPYIIHPFAIAEILINYKADITTLIAALLHDVVEDTEHSLE
EIESHFGTTIRYIVNGLTKRKKQQNQNKIIYEAINFKKLLLSSQHDIRVGIIKVIDRLHNIKTLNVKKPAKQVAYANETL
TLFAPLAKRLGLYTIQYELENLAFQYLHKERYNKVLEFLTGYVPHLQKNITDLRRGIHSFYDTNLSFEISYEFPPIYTAY
SQLQEVQNVSGISQICITTTSVLDCYKILGIIHQLYKPTINYFEDNIALENSPFNSNLKTKIKMNDTEQTIIIQTKFAKR
LKNNGIFSLLNNETVDIQSLSYKIMNDTILNNNLLTTDPIAFHNLVSYELFENTITAYTSDLQPIYLPDGATIIDFTFSA
FPKIAHNMKNAKVNGIPVPLKTKVSHFDVIEIYFGLKQNLVLEWLNYANTAKAQLIIQQKLS
>Mature_461_residues
SEVLLQKANYLQSNELKLLKKAIQFAERAHDGQYRQTGEPYIIHPFAIAEILINYKADITTLIAALLHDVVEDTEHSLEE
IESHFGTTIRYIVNGLTKRKKQQNQNKIIYEAINFKKLLLSSQHDIRVGIIKVIDRLHNIKTLNVKKPAKQVAYANETLT
LFAPLAKRLGLYTIQYELENLAFQYLHKERYNKVLEFLTGYVPHLQKNITDLRRGIHSFYDTNLSFEISYEFPPIYTAYS
QLQEVQNVSGISQICITTTSVLDCYKILGIIHQLYKPTINYFEDNIALENSPFNSNLKTKIKMNDTEQTIIIQTKFAKRL
KNNGIFSLLNNETVDIQSLSYKIMNDTILNNNLLTTDPIAFHNLVSYELFENTITAYTSDLQPIYLPDGATIIDFTFSAF
PKIAHNMKNAKVNGIPVPLKTKVSHFDVIEIYFGLKQNLVLEWLNYANTAKAQLIIQQKLS

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=145, Percent_Identity=35.1724137931034, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1790082, Length=461, Percent_Identity=30.3687635574837, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1789147, Length=441, Percent_Identity=22.2222222222222, Blast_Score=108, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI25143118, Length=134, Percent_Identity=35.0746268656716, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 53148; Mature: 53017

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEVLLQKANYLQSNELKLLKKAIQFAERAHDGQYRQTGEPYIIHPFAIAEILINYKADI
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECHHHHHHHHHHCCCHH
TTLIAALLHDVVEDTEHSLEEIESHFGTTIRYIVNGLTKRKKQQNQNKIIYEAINFKKLL
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHH
LSSQHDIRVGIIKVIDRLHNIKTLNVKKPAKQVAYANETLTLFAPLAKRLGLYTIQYELE
HCCCCCHHHHHHHHHHHHHCCEEECCCCHHHHHHHCCCHHHHHHHHHHHHCEEEEEEHHH
NLAFQYLHKERYNKVLEFLTGYVPHLQKNITDLRRGIHSFYDTNLSFEISYEFPPIYTAY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHH
SQLQEVQNVSGISQICITTTSVLDCYKILGIIHQLYKPTINYFEDNIALENSPFNSNLKT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCEE
KIKMNDTEQTIIIQTKFAKRLKNNGIFSLLNNETVDIQSLSYKIMNDTILNNNLLTTDPI
EEEECCCCCEEEEEEHHHHHHCCCCCEEEECCCEEEHHHHHHHHHCCEEECCCCCCCCCH
AFHNLVSYELFENTITAYTSDLQPIYLPDGATIIDFTFSAFPKIAHNMKNAKVNGIPVPL
HHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEEEHHHHHHHHHHCCCCCCCCCCCCCC
KTKVSHFDVIEIYFGLKQNLVLEWLNYANTAKAQLIIQQKLS
CCCCCCCHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SEVLLQKANYLQSNELKLLKKAIQFAERAHDGQYRQTGEPYIIHPFAIAEILINYKADI
CHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECHHHHHHHHHHCCCHH
TTLIAALLHDVVEDTEHSLEEIESHFGTTIRYIVNGLTKRKKQQNQNKIIYEAINFKKLL
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHH
LSSQHDIRVGIIKVIDRLHNIKTLNVKKPAKQVAYANETLTLFAPLAKRLGLYTIQYELE
HCCCCCHHHHHHHHHHHHHCCEEECCCCHHHHHHHCCCHHHHHHHHHHHHCEEEEEEHHH
NLAFQYLHKERYNKVLEFLTGYVPHLQKNITDLRRGIHSFYDTNLSFEISYEFPPIYTAY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHH
SQLQEVQNVSGISQICITTTSVLDCYKILGIIHQLYKPTINYFEDNIALENSPFNSNLKT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCEE
KIKMNDTEQTIIIQTKFAKRLKNNGIFSLLNNETVDIQSLSYKIMNDTILNNNLLTTDPI
EEEECCCCCEEEEEEHHHHHHCCCCCEEEECCCEEEHHHHHHHHHCCEEECCCCCCCCCH
AFHNLVSYELFENTITAYTSDLQPIYLPDGATIIDFTFSAFPKIAHNMKNAKVNGIPVPL
HHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEEEHHHHHHHHHHCCCCCCCCCCCCCC
KTKVSHFDVIEIYFGLKQNLVLEWLNYANTAKAQLIIQQKLS
CCCCCCCHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]