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The map label for this gene is flp [H]

Identifier: 118477666

GI number: 118477666

Start: 2146403

End: 2147875

Strand: Reverse

Name: flp [H]

Synonym: BALH_1998

Alternate gene names: 118477666

Gene position: 2147875-2146403 (Counterclockwise)

Preceding gene: 118477673

Following gene: 118477665

Centisome position: 40.86

GC content: 37.14

Gene sequence:

>1473_bases
TTGGAGGTTAGAAGTATGTCTAAAATTGAAACCCCTGTTATGGCTTCTTTACAAACAACGGTTGAAAAAATGATGAAGGA
TTTAAACGTTCCGGGAGCTGCTGTAGCTGTTATAAAAGACGGTGAAATGATTATTTCAGAAGGTTTCGGCTATCGTAATT
TAGAGACAAAAGCCCCTGTTACACCGCGTACTTTGTTCGCAATCGGTTCCTCAACGAAAGCTTTTGGCACACTTTCATTA
AGCTTATTAGCGCAGCAAAAAAAGTTTAATTGGGATGCTCCTGTCCAATCTTATATACCAAACTTCTCTTTATCTGAACT
ACTTGCTAGCTCACAAGTTACCGGACGAGATTTAGCTTCTCATCGAACTGGCGTAAGCCGCCATGAGGCTCTTTGGTATA
GCTCTTCCTTATCTCGAAAAGATCTCGTTGAAAAAATAAAACATTTACCACTTGATGCACCGTTTCGGACTTCATTTCTA
TATAACAACTTAATGTATGCGACAATTAGCTATATTGTAGAGAACATCACAAATCAAACGTGGGAGCAATACGCTACAGA
ACATATTTTAGAACCTTTAAATATGAGACATACAAACTTCTCTGTTACCGATTCACAAACGACAGAAGACTATGCTTTAC
CTTACATTGAAAATGATGGGGAAATAAAAGAAGTTCCATTCCGCAACATCGATACCGTTGGCGCTGCTGGGTGTATTAAT
TCTACAATTGAAGATATGGCAAATTGGGTACTTCTTCACTTAAACAATGGAAAATTTGGAGATCATGAATTAATCTCCTC
TGAATTATTCCAACAAATGTATACACCACACAATTCAATTCCAGATCAACCAGTTTTATCACTTCCTGAATCTCCATTAA
ATAGTTACGGCCTTGGTTGGTTTATTAGCGCTTATCGTGGTAATAAGGTGATTCATCATGGTGGTAATATTGATGGATTT
TCAGCGCTTGTTTCTTTCATACCAACAGAAAACATCGGCCTTGTCATTTTAACGAATGCTGGAGGCACATTACTGCCTAC
TTATCTCGCTAATCAAATTTATGACGAACTGCTTGAATTAGAATCCATTGATTGGCATAAACGTGCTGTAGAAGATACCG
AAAAAATGAAGGAAATGATGAAAGAAGCGACTGAATCCGTTCCAGAACAAATAAAAGGAACTACACCTTCTCATAAATTA
GAAGATTATACTGGTACTTTCGAACATCCGGCATACGGAACATTACAAGTATACAAGCGAGATGATTCGTTAGTTGTACA
ATTTATGGAGATGGACATTCAATTAGGGCATCATCATTATGACATCTTCTCTGCAAAAGTTGACTTATTCCAAATGAAGA
TGAATCTATTATTTGCATATGAAATGAATGTGAACGGTGACTTCCCATCCCTTCAGTTACATGTACCAGCAATGTTAAGT
ACTCAGCCGCTTGCATTTAAGAAAATTAAATAA

Upstream 100 bases:

>100_bases
ATAATTTCATTCATCCTTACAAAATTATTAACTTTCCATAATTAAAAAGGTTTTCATTTTCTATTACCGAAAGTATAGTG
CGGTAGAACAAAAATTATAT

Downstream 100 bases:

>100_bases
AGTTTTAATAGAGGGATGATAACACGTCCCTCTATTTTTCATTACAATCCCCATCTAAATAAAGGATTTTAAGCATTGAA
TAAAGAATCCTTTTATTTAA

Product: penicillin-binding protein

Products: A Substituted Beta- Amino Acid. [C]

Alternate protein names: FmtA-like protein [H]

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MEVRSMSKIETPVMASLQTTVEKMMKDLNVPGAAVAVIKDGEMIISEGFGYRNLETKAPVTPRTLFAIGSSTKAFGTLSL
SLLAQQKKFNWDAPVQSYIPNFSLSELLASSQVTGRDLASHRTGVSRHEALWYSSSLSRKDLVEKIKHLPLDAPFRTSFL
YNNLMYATISYIVENITNQTWEQYATEHILEPLNMRHTNFSVTDSQTTEDYALPYIENDGEIKEVPFRNIDTVGAAGCIN
STIEDMANWVLLHLNNGKFGDHELISSELFQQMYTPHNSIPDQPVLSLPESPLNSYGLGWFISAYRGNKVIHHGGNIDGF
SALVSFIPTENIGLVILTNAGGTLLPTYLANQIYDELLELESIDWHKRAVEDTEKMKEMMKEATESVPEQIKGTTPSHKL
EDYTGTFEHPAYGTLQVYKRDDSLVVQFMEMDIQLGHHHYDIFSAKVDLFQMKMNLLFAYEMNVNGDFPSLQLHVPAMLS
TQPLAFKKIK

Sequences:

>Translated_490_residues
MEVRSMSKIETPVMASLQTTVEKMMKDLNVPGAAVAVIKDGEMIISEGFGYRNLETKAPVTPRTLFAIGSSTKAFGTLSL
SLLAQQKKFNWDAPVQSYIPNFSLSELLASSQVTGRDLASHRTGVSRHEALWYSSSLSRKDLVEKIKHLPLDAPFRTSFL
YNNLMYATISYIVENITNQTWEQYATEHILEPLNMRHTNFSVTDSQTTEDYALPYIENDGEIKEVPFRNIDTVGAAGCIN
STIEDMANWVLLHLNNGKFGDHELISSELFQQMYTPHNSIPDQPVLSLPESPLNSYGLGWFISAYRGNKVIHHGGNIDGF
SALVSFIPTENIGLVILTNAGGTLLPTYLANQIYDELLELESIDWHKRAVEDTEKMKEMMKEATESVPEQIKGTTPSHKL
EDYTGTFEHPAYGTLQVYKRDDSLVVQFMEMDIQLGHHHYDIFSAKVDLFQMKMNLLFAYEMNVNGDFPSLQLHVPAMLS
TQPLAFKKIK
>Mature_490_residues
MEVRSMSKIETPVMASLQTTVEKMMKDLNVPGAAVAVIKDGEMIISEGFGYRNLETKAPVTPRTLFAIGSSTKAFGTLSL
SLLAQQKKFNWDAPVQSYIPNFSLSELLASSQVTGRDLASHRTGVSRHEALWYSSSLSRKDLVEKIKHLPLDAPFRTSFL
YNNLMYATISYIVENITNQTWEQYATEHILEPLNMRHTNFSVTDSQTTEDYALPYIENDGEIKEVPFRNIDTVGAAGCIN
STIEDMANWVLLHLNNGKFGDHELISSELFQQMYTPHNSIPDQPVLSLPESPLNSYGLGWFISAYRGNKVIHHGGNIDGF
SALVSFIPTENIGLVILTNAGGTLLPTYLANQIYDELLELESIDWHKRAVEDTEKMKEMMKEATESVPEQIKGTTPSHKL
EDYTGTFEHPAYGTLQVYKRDDSLVVQFMEMDIQLGHHHYDIFSAKVDLFQMKMNLLFAYEMNVNGDFPSLQLHVPAMLS
TQPLAFKKIK

Specific function: Its precise function is unknown. Has no penicillin- binding activity and is not involved in methicillin resistance [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI239747261, Length=381, Percent_Identity=24.1469816272966, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI239752721, Length=381, Percent_Identity=24.1469816272966, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI239741085, Length=381, Percent_Identity=24.1469816272966, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI26051231, Length=125, Percent_Identity=31.2, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI26051233, Length=125, Percent_Identity=31.2, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1790593, Length=343, Percent_Identity=26.8221574344023, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87082101, Length=314, Percent_Identity=23.8853503184713, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17550934, Length=334, Percent_Identity=23.6526946107784, Blast_Score=89, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI115533026, Length=358, Percent_Identity=24.8603351955307, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: 3.5.2.6 [C]

Molecular weight: Translated: 55165; Mature: 55165

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVRSMSKIETPVMASLQTTVEKMMKDLNVPGAAVAVIKDGEMIISEGFGYRNLETKAPV
CCCCCCHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEECCCCCCCCCCCCCC
TPRTLFAIGSSTKAFGTLSLSLLAQQKKFNWDAPVQSYIPNFSLSELLASSQVTGRDLAS
CCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHHCCCCHHHHHH
HRTGVSRHEALWYSSSLSRKDLVEKIKHLPLDAPFRTSFLYNNLMYATISYIVENITNQT
HHCCCCHHHHHEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
WEQYATEHILEPLNMRHTNFSVTDSQTTEDYALPYIENDGEIKEVPFRNIDTVGAAGCIN
HHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCEECCCCCEEECCCCCCCCCCCHHHHH
STIEDMANWVLLHLNNGKFGDHELISSELFQQMYTPHNSIPDQPVLSLPESPLNSYGLGW
HHHHHHHCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCCHH
FISAYRGNKVIHHGGNIDGFSALVSFIPTENIGLVILTNAGGTLLPTYLANQIYDELLEL
EEEEECCCEEEECCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
ESIDWHKRAVEDTEKMKEMMKEATESVPEQIKGTTPSHKLEDYTGTFEHPAYGTLQVYKR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEEC
DDSLVVQFMEMDIQLGHHHYDIFSAKVDLFQMKMNLLFAYEMNVNGDFPSLQLHVPAMLS
CHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHEEEEEEEEECCCCCCCCEEEECCHHHC
TQPLAFKKIK
CCCCHHCCCC
>Mature Secondary Structure
MEVRSMSKIETPVMASLQTTVEKMMKDLNVPGAAVAVIKDGEMIISEGFGYRNLETKAPV
CCCCCCHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEECCCCCCCCCCCCCC
TPRTLFAIGSSTKAFGTLSLSLLAQQKKFNWDAPVQSYIPNFSLSELLASSQVTGRDLAS
CCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHHCCCCHHHHHH
HRTGVSRHEALWYSSSLSRKDLVEKIKHLPLDAPFRTSFLYNNLMYATISYIVENITNQT
HHCCCCHHHHHEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
WEQYATEHILEPLNMRHTNFSVTDSQTTEDYALPYIENDGEIKEVPFRNIDTVGAAGCIN
HHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCEECCCCCEEECCCCCCCCCCCHHHHH
STIEDMANWVLLHLNNGKFGDHELISSELFQQMYTPHNSIPDQPVLSLPESPLNSYGLGW
HHHHHHHCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCCHH
FISAYRGNKVIHHGGNIDGFSALVSFIPTENIGLVILTNAGGTLLPTYLANQIYDELLEL
EEEEECCCEEEECCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
ESIDWHKRAVEDTEKMKEMMKEATESVPEQIKGTTPSHKLEDYTGTFEHPAYGTLQVYKR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEEC
DDSLVVQFMEMDIQLGHHHYDIFSAKVDLFQMKMNLLFAYEMNVNGDFPSLQLHVPAMLS
CHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHEEEEEEEEECCCCCCCCEEEECCHHHC
TQPLAFKKIK
CCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Beta-Lactam; H2O [C]

Specific reaction: A Beta-Lactam + H2O = A Substituted Beta- Amino Acid. [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA