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The map label for this gene is mdtG [H]

Identifier: 118477317

GI number: 118477317

Start: 1780664

End: 1781884

Strand: Direct

Name: mdtG [H]

Synonym: BALH_1634

Alternate gene names: 118477317

Gene position: 1780664-1781884 (Clockwise)

Preceding gene: 118477316

Following gene: 118477319

Centisome position: 33.87

GC content: 37.92

Gene sequence:

>1221_bases
GTGAAAATGGCCAGCTGGAAACGAAATTTAATGATTTGTTGGCTAGGTTGTTTTACCACTGCAGCCGGTATGAGTTTAGT
AATTCCTTTTTTATCTTTTTATATTGAGGAATTAGGAGTAACTGGCACTTCAAGTATTGCACAGTGGTCGGGGCTTGCAT
TTGGTATTACATTTTTAATGGGTGCGATTGTATCACCAATATGGGGAAAACTTGGTGATATACATGGACGGAAATTGATG
CTAATTCGTGCGAGCCTAGGTATGGCGATTATTATGACGCTTATGGGATTTGTAACGGATGTGTATCAACTAGTCGCACT
AAGATTTTTAATGGGAGCAGTATCTGGTTTCCTTTCAACGGCGATGACATTTATTGCGGCAGAAACTCCAAAAGAGCATT
CAGGCTGGGCAATTTCTACAATTTCAACTGGTGGAGTGAGCGGTTCTTTACTTGGTCCATTACTTGGAGGATATTTGTCT
GAGTTAATTGGAATGCGCCATGTTTTTCTTGTTACAGGAGCTTTTTTATTCCTTTCTTTTCTCATCGTTTTTTTCTTCCT
ACATGAAGAGAATCACTCCGCTCAAGCAAAAAAAGTACAACCGAAAAAAGTATGGACGATGGTTCCAGCGAAGCATTTAA
TTGTTAGTTTGTTTGTCACAACATTTATTATTCAACTTGCTAATATGTCTGTTCAACCAATTGTTACATTGTACGTAAAA
AATTTAGTAGGTCCTCAAACTGCACATATTGAAACAATTGCGGGCGCCGTTATGTCAGCGACAGGGTTAGCAGTTATTTT
GGCAGCACCAAGACTCGGACGATTATCAGATCAAATTGGTCCTCAAAAAACGTTAGTTGTAGCGTTGTTTGCTGCAGGAA
TTATTTTTATCCCGCAAGCATTTGTAACCTCAGCTTGGCAACTATTAATTCTTCGATTTTTATTAGGTATCGCACAAGCA
GGATTATTACCTTCCGTACAAACTCTACTAAAACAACATACACCAACTCATGTAACGGGACGAATATTTGGGTATAATCA
ATCGTTTCAGTTTTTAGGAAATATGATTGGACCAGTACTTGGTGGACAAATTGCAGCACATGCAGGATTCCAATATGTTT
TCTTCTCTACATCATCACTATTATTTATTGCGTGTATTTGGGTTTATTTTCACAATAAGAACGAAGAAGTATCAGAGAAA
CGACATTTGGAAGTTAGTTAA

Upstream 100 bases:

>100_bases
ACTAGAAAATAGCGGGTTTTGTAGTAAATCTTACAAACAAAGCAAATTACTAAACTTTTTACAAGAAAGGGTGTAGAATG
GGTATCTAAAGAAAGAAGGT

Downstream 100 bases:

>100_bases
CTAGGTGAATAAAAAAGGAAAGGATGAAGCAATGATTGCTTCATCCTTTTTATTTAAAATTGGAGGCAAAGATAACTTAA
CGTACCAAGCTCGTAACTGC

Product: multidrug resistance protein B

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MKMASWKRNLMICWLGCFTTAAGMSLVIPFLSFYIEELGVTGTSSIAQWSGLAFGITFLMGAIVSPIWGKLGDIHGRKLM
LIRASLGMAIIMTLMGFVTDVYQLVALRFLMGAVSGFLSTAMTFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLS
ELIGMRHVFLVTGAFLFLSFLIVFFFLHEENHSAQAKKVQPKKVWTMVPAKHLIVSLFVTTFIIQLANMSVQPIVTLYVK
NLVGPQTAHIETIAGAVMSATGLAVILAAPRLGRLSDQIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQA
GLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYFHNKNEEVSEK
RHLEVS

Sequences:

>Translated_406_residues
MKMASWKRNLMICWLGCFTTAAGMSLVIPFLSFYIEELGVTGTSSIAQWSGLAFGITFLMGAIVSPIWGKLGDIHGRKLM
LIRASLGMAIIMTLMGFVTDVYQLVALRFLMGAVSGFLSTAMTFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLS
ELIGMRHVFLVTGAFLFLSFLIVFFFLHEENHSAQAKKVQPKKVWTMVPAKHLIVSLFVTTFIIQLANMSVQPIVTLYVK
NLVGPQTAHIETIAGAVMSATGLAVILAAPRLGRLSDQIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQA
GLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYFHNKNEEVSEK
RHLEVS
>Mature_406_residues
MKMASWKRNLMICWLGCFTTAAGMSLVIPFLSFYIEELGVTGTSSIAQWSGLAFGITFLMGAIVSPIWGKLGDIHGRKLM
LIRASLGMAIIMTLMGFVTDVYQLVALRFLMGAVSGFLSTAMTFIAAETPKEHSGWAISTISTGGVSGSLLGPLLGGYLS
ELIGMRHVFLVTGAFLFLSFLIVFFFLHEENHSAQAKKVQPKKVWTMVPAKHLIVSLFVTTFIIQLANMSVQPIVTLYVK
NLVGPQTAHIETIAGAVMSATGLAVILAAPRLGRLSDQIGPQKTLVVALFAAGIIFIPQAFVTSAWQLLILRFLLGIAQA
GLLPSVQTLLKQHTPTHVTGRIFGYNQSFQFLGNMIGPVLGGQIAAHAGFQYVFFSTSSLLFIACIWVYFHNKNEEVSEK
RHLEVS

Specific function: Confers resistance to fosfomycin and deoxycholate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily [H]

Homologues:

Organism=Homo sapiens, GI217416366, Length=243, Percent_Identity=27.5720164609054, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1787291, Length=396, Percent_Identity=45.959595959596, Blast_Score=359, Evalue=1e-100,
Organism=Escherichia coli, GI87082404, Length=374, Percent_Identity=24.5989304812834, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319871, Length=152, Percent_Identity=26.3157894736842, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44122; Mature: 44122

Theoretical pI: Translated: 10.11; Mature: 10.11

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCHHHHHCCEEEEEECHHHHHHHHHHHHHHCCCCHHHHHHHCCCCC
>Mature Secondary Structure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CCHHHHHCCEEEEEECHHHHHHHHHHHHHHCCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA