Click here to switch to the map view.

The map label for this gene is ilvC2 [H]

Identifier: 118477311

GI number: 118477311

Start: 1773220

End: 1774227

Strand: Direct

Name: ilvC2 [H]

Synonym: BALH_1626

Alternate gene names: 118477311

Gene position: 1773220-1774227 (Clockwise)

Preceding gene: 118477310

Following gene: 118477312

Centisome position: 33.73

GC content: 41.37

Gene sequence:

>1008_bases
ATGAAAACGTATTATGAGAAAGATGCAAATGTAGAGTTATTACAAGGGAAAACAGTTGCGGTAATTGGTTATGGATCTCA
AGGTCATGCACAGGCGCAAAATTTACGCGATTCTGGTGTGGAAGTGGTGGTTGGTGTTCGTCCTGGTAAGTCTTTTGAAG
TAGCAAAAGCAGATGGGTTTGAAGTAATGTCTGTTTCAGAAGCGGTTCGAACCGCGCAAGTTGTACAAATGTTATTGCCA
GATGAACAGCAAGCACATGTGTATAAAGCAGAAGTAGAAGAGAATCTCCGTGAAGGACAAATGTTACTTTTCTCACATGG
ATTTAATATTCACTTCGGACAAATTAACCCGCCAAGCTACGTAGATGTAGCAATGGTCGCGCCAAAAAGCCCGGGTCATC
TCGTTCGCCGTGTATTTCAAGAAGGAAATGGTGTTCCGGCATTGGTCGCAGTACATCAAGATGCTACGGGCACGGCATTA
CGTGTAGCACTTGCGTATGCAAAAGGTGTAGGTTGTACACGTGCAGGTGTAATTGAAACGACATTTCAAGAAGAAACGGA
GACAGATTTATTCGGAGAGCAAGCTGTACTTTGTGGCGGGGTAACGGCACTTGTGAAAGCCGGTTTTGAAACATTAACAG
AAGGCGGATATCGTCCTGAAATTGCATACTTCGAATGTTTACATGAATTAAAATTAATTGTTGATTTAATGTACGAAGGT
GGTTTAACGAATATGCGCCATTCTATTTCAGATACAGCTGAGTTCGGAGATTATGTAACAGGATCGAGAATTGTTACAGA
TGAAACGAAGAAAGAGATGAAACGAGTACTTACAGAAATTCAGCAAGGTGAATTCGCGAAGAAATGGATTTTAGAGAATC
AAGCAGGGCGTCCAACGTATAATGCGATGAAAAAAGCAGAACAAAATCATCAGTTGGAAAAAGTAGGAGAAGAGCTTCGT
GAAATGATGAGCTGGATTCATGCACCGAAAGAATTAGTGAAGAAATAG

Upstream 100 bases:

>100_bases
CAGCAGTTTGTACTGAAAATGAAGCGACATTACTTGTTAGTCAGTTGAAAAAATTAATTGATGTACTGCAAGTAAATAAA
TTATAAGGAGTGTATGGAAT

Downstream 100 bases:

>100_bases
AGTAATAGATTGCAAGTGAAAAATATGTAAGAGGGGATTTGACAAGATGAGAAGTGACATGATTAAAAAAGGTTTTGATA
AAGCGCCGCATCGTAGTTTA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase 2; Alpha-keto-beta-hydroxylacil reductoisomerase 2 [H]

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MKTYYEKDANVELLQGKTVAVIGYGSQGHAQAQNLRDSGVEVVVGVRPGKSFEVAKADGFEVMSVSEAVRTAQVVQMLLP
DEQQAHVYKAEVEENLREGQMLLFSHGFNIHFGQINPPSYVDVAMVAPKSPGHLVRRVFQEGNGVPALVAVHQDATGTAL
RVALAYAKGVGCTRAGVIETTFQEETETDLFGEQAVLCGGVTALVKAGFETLTEGGYRPEIAYFECLHELKLIVDLMYEG
GLTNMRHSISDTAEFGDYVTGSRIVTDETKKEMKRVLTEIQQGEFAKKWILENQAGRPTYNAMKKAEQNHQLEKVGEELR
EMMSWIHAPKELVKK

Sequences:

>Translated_335_residues
MKTYYEKDANVELLQGKTVAVIGYGSQGHAQAQNLRDSGVEVVVGVRPGKSFEVAKADGFEVMSVSEAVRTAQVVQMLLP
DEQQAHVYKAEVEENLREGQMLLFSHGFNIHFGQINPPSYVDVAMVAPKSPGHLVRRVFQEGNGVPALVAVHQDATGTAL
RVALAYAKGVGCTRAGVIETTFQEETETDLFGEQAVLCGGVTALVKAGFETLTEGGYRPEIAYFECLHELKLIVDLMYEG
GLTNMRHSISDTAEFGDYVTGSRIVTDETKKEMKRVLTEIQQGEFAKKWILENQAGRPTYNAMKKAEQNHQLEKVGEELR
EMMSWIHAPKELVKK
>Mature_335_residues
MKTYYEKDANVELLQGKTVAVIGYGSQGHAQAQNLRDSGVEVVVGVRPGKSFEVAKADGFEVMSVSEAVRTAQVVQMLLP
DEQQAHVYKAEVEENLREGQMLLFSHGFNIHFGQINPPSYVDVAMVAPKSPGHLVRRVFQEGNGVPALVAVHQDATGTAL
RVALAYAKGVGCTRAGVIETTFQEETETDLFGEQAVLCGGVTALVKAGFETLTEGGYRPEIAYFECLHELKLIVDLMYEG
GLTNMRHSISDTAEFGDYVTGSRIVTDETKKEMKRVLTEIQQGEFAKKWILENQAGRPTYNAMKKAEQNHQLEKVGEELR
EMMSWIHAPKELVKK

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=287, Percent_Identity=35.191637630662, Blast_Score=141, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6323387, Length=333, Percent_Identity=32.4324324324324, Blast_Score=140, Evalue=4e-34,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 37010; Mature: 37010

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTYYEKDANVELLQGKTVAVIGYGSQGHAQAQNLRDSGVEVVVGVRPGKSFEVAKADGF
CCCCCCCCCCEEEECCCEEEEEEECCCCCHHHHHHCCCCCEEEEEECCCCCEEEECCCCC
EVMSVSEAVRTAQVVQMLLPDEQQAHVYKAEVEENLREGQMLLFSHGFNIHFGQINPPSY
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCEEEECCCCCCCC
VDVAMVAPKSPGHLVRRVFQEGNGVPALVAVHQDATGTALRVALAYAKGVGCTRAGVIET
EEEEEECCCCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCEEH
TFQEETETDLFGEQAVLCGGVTALVKAGFETLTEGGYRPEIAYFECLHELKLIVDLMYEG
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCC
GLTNMRHSISDTAEFGDYVTGSRIVTDETKKEMKRVLTEIQQGEFAKKWILENQAGRPTY
CCHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHH
NAMKKAEQNHQLEKVGEELREMMSWIHAPKELVKK
HHHHHHHHCCHHHHHHHHHHHHHHHHHCHHHHHCC
>Mature Secondary Structure
MKTYYEKDANVELLQGKTVAVIGYGSQGHAQAQNLRDSGVEVVVGVRPGKSFEVAKADGF
CCCCCCCCCCEEEECCCEEEEEEECCCCCHHHHHHCCCCCEEEEEECCCCCEEEECCCCC
EVMSVSEAVRTAQVVQMLLPDEQQAHVYKAEVEENLREGQMLLFSHGFNIHFGQINPPSY
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCEEEECCCCCCCC
VDVAMVAPKSPGHLVRRVFQEGNGVPALVAVHQDATGTALRVALAYAKGVGCTRAGVIET
EEEEEECCCCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCEEH
TFQEETETDLFGEQAVLCGGVTALVKAGFETLTEGGYRPEIAYFECLHELKLIVDLMYEG
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCC
GLTNMRHSISDTAEFGDYVTGSRIVTDETKKEMKRVLTEIQQGEFAKKWILENQAGRPTY
CCHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHH
NAMKKAEQNHQLEKVGEELREMMSWIHAPKELVKK
HHHHHHHHCCHHHHHHHHHHHHHHHHHCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]