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The map label for this gene is mepA [H]

Identifier: 118477150

GI number: 118477150

Start: 1605068

End: 1606423

Strand: Direct

Name: mepA [H]

Synonym: BALH_1454

Alternate gene names: 118477150

Gene position: 1605068-1606423 (Clockwise)

Preceding gene: 118477148

Following gene: 118477152

Centisome position: 30.53

GC content: 34.96

Gene sequence:

>1356_bases
ATGGAAGTAACAGAAAAATTAAGAGAAAAACCAATTAAAAGTTTATTTATTACTTATTTAATACCAGCCGTTCTCGGAAT
GGTATTAATGTCAGTTAATATTGTGATTGACGCGGTTATGATTAGTAGGGGAGTTGGAGCGAACGGATTAGCAGGAGTAA
ACGTGGCTATTCCAGCGTTTTCAATTTTCTTCTCTATTTCATTATGGATTGGAATGGGCGGGGCAACGTTATATTCCATT
GCATTAGGTGAAAATAAAATAGAAAGAGCAAGGTCTATTTTTACTCAATCCATGACAGTGGCAGTCATTATCGTAGGTAT
TTTAGCAGCGATTTGCTTATGGAGAATAGAAGATTTAGCGTATTTATTCGGTGCAAATGAAGTGATTTTACCGTATGCGT
TAGATTATTTACACGTGTTATTAACATTTGGAATGATATACGTGTTAGAAAATATTTTAAGTACATTTATACGAAATGAT
GGAAATCCTAATTTAGCAATGGCAGGTCTTGTTGTAACAGCTGTATTAAACATAGTGTTTGACTATATCTTTATTTTTAT
TTTTGGATGGGGCGTAACGGGTGCTGCTTCAGCGACTATTCTTTCGGCAGCAATTGGTTTCCTTGTATTATTAACGCATT
TCTTTAGAAAAAATAGTATTTTAAAGTGGACGAAATTCCATTTTGAATGGGATACGATTAAACAAATTATGATAATAGGT
TTTCCGAGCTTTATAACAGAAAGTACAGTGGCAATCGTAACGATTGGTTTTAATATAGCATTCGTTCAATATGCAGGAGA
AGTAGGAGTAGCTTCCTATGCGATGGTAAACAGCATTCATGCGATGACATTACTATTATTCTTCGGTGTAGGTGCTGCAT
TGCAACCAATTGCTAGTTTCCATTACGGTGCGAATTTATCAGAAAGATTGCGTGAAGGATTACAGTTTGCTGTGAAAATT
GCAGTTGTACTTGGAGGCGTTGCGATAATTGTCGGATTATTCTTCGGGAAATATATTATTGGTCTATTTGATGTCCAATC
TCCACAATTATTGGAGTTAACATTAACAGGTATTAGTTTGTTCTTTATCCAATACGTATTTTTAGGCTATAACATTGTGT
ATGGAGAGTACTTCCAATCAGTGCGACAAACGAAGAAATCAGTCCTGATTATAATGAGCCGAGGGTTACTATTTATTATT
CCATTATTATGGATTATGCCAAAGTTATTTGGGATAAATGGAATTTGGCTCGTTATGCCAGTAGCTGAAGTATTGACAGC
GATTATCGTATTTACGATGAATCGTATGAAACATCCTGTACCAATAAACATGGCAGGCGAGAAAGAAGTAATATAA

Upstream 100 bases:

>100_bases
TAATATAATTCAGTTACCTATTTTTTAATTCTCTCTTGACCTTCAAGTTACTTGAAGGTTTAAAATGTGAACAGAGCGTT
GAAAAAAGGAGCAAAATAGT

Downstream 100 bases:

>100_bases
TGGAGAAAATCCCCTTGAGCAAGTAAGGGGATTTTCTATTTTTTTAAACTAATAGCAAAAGAACCATCTGTTTCTTGAAC
AGACGCGAAAGCAACGTTTT

Product: Na+ driven multidrug efflux pump

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MEVTEKLREKPIKSLFITYLIPAVLGMVLMSVNIVIDAVMISRGVGANGLAGVNVAIPAFSIFFSISLWIGMGGATLYSI
ALGENKIERARSIFTQSMTVAVIIVGILAAICLWRIEDLAYLFGANEVILPYALDYLHVLLTFGMIYVLENILSTFIRND
GNPNLAMAGLVVTAVLNIVFDYIFIFIFGWGVTGAASATILSAAIGFLVLLTHFFRKNSILKWTKFHFEWDTIKQIMIIG
FPSFITESTVAIVTIGFNIAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHYGANLSERLREGLQFAVKI
AVVLGGVAIIVGLFFGKYIIGLFDVQSPQLLELTLTGISLFFIQYVFLGYNIVYGEYFQSVRQTKKSVLIIMSRGLLFII
PLLWIMPKLFGINGIWLVMPVAEVLTAIIVFTMNRMKHPVPINMAGEKEVI

Sequences:

>Translated_451_residues
MEVTEKLREKPIKSLFITYLIPAVLGMVLMSVNIVIDAVMISRGVGANGLAGVNVAIPAFSIFFSISLWIGMGGATLYSI
ALGENKIERARSIFTQSMTVAVIIVGILAAICLWRIEDLAYLFGANEVILPYALDYLHVLLTFGMIYVLENILSTFIRND
GNPNLAMAGLVVTAVLNIVFDYIFIFIFGWGVTGAASATILSAAIGFLVLLTHFFRKNSILKWTKFHFEWDTIKQIMIIG
FPSFITESTVAIVTIGFNIAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHYGANLSERLREGLQFAVKI
AVVLGGVAIIVGLFFGKYIIGLFDVQSPQLLELTLTGISLFFIQYVFLGYNIVYGEYFQSVRQTKKSVLIIMSRGLLFII
PLLWIMPKLFGINGIWLVMPVAEVLTAIIVFTMNRMKHPVPINMAGEKEVI
>Mature_451_residues
MEVTEKLREKPIKSLFITYLIPAVLGMVLMSVNIVIDAVMISRGVGANGLAGVNVAIPAFSIFFSISLWIGMGGATLYSI
ALGENKIERARSIFTQSMTVAVIIVGILAAICLWRIEDLAYLFGANEVILPYALDYLHVLLTFGMIYVLENILSTFIRND
GNPNLAMAGLVVTAVLNIVFDYIFIFIFGWGVTGAASATILSAAIGFLVLLTHFFRKNSILKWTKFHFEWDTIKQIMIIG
FPSFITESTVAIVTIGFNIAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHYGANLSERLREGLQFAVKI
AVVLGGVAIIVGLFFGKYIIGLFDVQSPQLLELTLTGISLFFIQYVFLGYNIVYGEYFQSVRQTKKSVLIIMSRGLLFII
PLLWIMPKLFGINGIWLVMPVAEVLTAIIVFTMNRMKHPVPINMAGEKEVI

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49665; Mature: 49665

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVTEKLREKPIKSLFITYLIPAVLGMVLMSVNIVIDAVMISRGVGANGLAGVNVAIPAF
CCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
SIFFSISLWIGMGGATLYSIALGENKIERARSIFTQSMTVAVIIVGILAAICLWRIEDLA
HHHHHHHHHHCCCCHHHEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLFGANEVILPYALDYLHVLLTFGMIYVLENILSTFIRNDGNPNLAMAGLVVTAVLNIVF
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
DYIFIFIFGWGVTGAASATILSAAIGFLVLLTHFFRKNSILKWTKFHFEWDTIKQIMIIG
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHEEEEEHHHHHHHHHHC
FPSFITESTVAIVTIGFNIAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASF
CHHHHHCCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
HYGANLSERLREGLQFAVKIAVVLGGVAIIVGLFFGKYIIGLFDVQSPQLLELTLTGISL
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHH
FFIQYVFLGYNIVYGEYFQSVRQTKKSVLIIMSRGLLFIIPLLWIMPKLFGINGIWLVMP
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHH
VAEVLTAIIVFTMNRMKHPVPINMAGEKEVI
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEVTEKLREKPIKSLFITYLIPAVLGMVLMSVNIVIDAVMISRGVGANGLAGVNVAIPAF
CCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
SIFFSISLWIGMGGATLYSIALGENKIERARSIFTQSMTVAVIIVGILAAICLWRIEDLA
HHHHHHHHHHCCCCHHHEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLFGANEVILPYALDYLHVLLTFGMIYVLENILSTFIRNDGNPNLAMAGLVVTAVLNIVF
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
DYIFIFIFGWGVTGAASATILSAAIGFLVLLTHFFRKNSILKWTKFHFEWDTIKQIMIIG
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHEEEEEHHHHHHHHHHC
FPSFITESTVAIVTIGFNIAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASF
CHHHHHCCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
HYGANLSERLREGLQFAVKIAVVLGGVAIIVGLFFGKYIIGLFDVQSPQLLELTLTGISL
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHH
FFIQYVFLGYNIVYGEYFQSVRQTKKSVLIIMSRGLLFIIPLLWIMPKLFGINGIWLVMP
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHH
VAEVLTAIIVFTMNRMKHPVPINMAGEKEVI
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA