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The map label for this gene is nth [H]

Identifier: 118477098

GI number: 118477098

Start: 1539123

End: 1539770

Strand: Direct

Name: nth [H]

Synonym: BALH_1399

Alternate gene names: 118477098

Gene position: 1539123-1539770 (Clockwise)

Preceding gene: 118477097

Following gene: 118477099

Centisome position: 29.28

GC content: 36.73

Gene sequence:

>648_bases
ATGTTAAATAAAACGCAAATTCGCTATTGTTTAGATACAATGGCGGATATGTACCCAGAAGCACATTGTGAATTAATTCA
TGATAATCCATTTGAACTAGTAATCGCGGTAGCATTATCTGCACAATGTACAGATGCACTTGTAAATAAAGTGACGAAAA
ATTTATTTCAAAAATATAAAACACCAGAAGATTATTTAAGTGTTTCTCTAGAAGAATTACAACAAGACATACGTTCTATT
GGATTGTATAGAAATAAAGCAAAAAATATTCAAAAATTGTGCAGAATGTTATTAGATGATTACAATGGGGAAGTGCCGAA
AGATCGAGATGAGCTTACGAAGTTACCAGGTGTAGGTCGGAAAACAGCAAACGTAGTTGTTTCGGTAGCGTTTGATATTC
CGGCAATTGCTGTTGATACGCATGTAGAGAGAGTGAGTAAACGGTTAGCGATTTGTAGATGGAAAGATTCAGTGTTAGAA
GTAGAAAAGACATTGATGAAGAAAATTCCGATGGATGAATGGAGCGTTACACATCACCGTATGATTTTCTTTGGACGTTA
TCACTGCAAGGCACAGCGACCACAATGCGAAGAGTGCCCGTTACTAGAAGTATGCCGAGAAGGAAAGAAGCGAATGAAGG
GGAAATAA

Upstream 100 bases:

>100_bases
AAATCAACAACGAACGCAGCAAACGACAAAACAAGAGACGAAATTTACTGGAAAAGTGCCTTTTTATAATTGGTTGGAGC
AGTAGTGTAGGAGGAAGTAT

Downstream 100 bases:

>100_bases
AGGATGGAGCGAGTTATAGAAATACCGAAAGAATTTCGGTGCTTACCATTTTTTAAAGAAAGTGTAAATTCGATTGCGTA
TTATGCAGAACAGTCTTTCG

Product: endonuclease III / DNA-(apurinic or apyrimidinic site) lyase

Products: NA

Alternate protein names: DNA-(apurinic or apyrimidinic site) lyase [H]

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MLNKTQIRYCLDTMADMYPEAHCELIHDNPFELVIAVALSAQCTDALVNKVTKNLFQKYKTPEDYLSVSLEELQQDIRSI
GLYRNKAKNIQKLCRMLLDDYNGEVPKDRDELTKLPGVGRKTANVVVSVAFDIPAIAVDTHVERVSKRLAICRWKDSVLE
VEKTLMKKIPMDEWSVTHHRMIFFGRYHCKAQRPQCEECPLLEVCREGKKRMKGK

Sequences:

>Translated_215_residues
MLNKTQIRYCLDTMADMYPEAHCELIHDNPFELVIAVALSAQCTDALVNKVTKNLFQKYKTPEDYLSVSLEELQQDIRSI
GLYRNKAKNIQKLCRMLLDDYNGEVPKDRDELTKLPGVGRKTANVVVSVAFDIPAIAVDTHVERVSKRLAICRWKDSVLE
VEKTLMKKIPMDEWSVTHHRMIFFGRYHCKAQRPQCEECPLLEVCREGKKRMKGK
>Mature_215_residues
MLNKTQIRYCLDTMADMYPEAHCELIHDNPFELVIAVALSAQCTDALVNKVTKNLFQKYKTPEDYLSVSLEELQQDIRSI
GLYRNKAKNIQKLCRMLLDDYNGEVPKDRDELTKLPGVGRKTANVVVSVAFDIPAIAVDTHVERVSKRLAICRWKDSVLE
VEKTLMKKIPMDEWSVTHHRMIFFGRYHCKAQRPQCEECPLLEVCREGKKRMKGK

Specific function: Has Both An Apurinic And/Or Apyrimidinic Endonuclease Activity And A DNA N-Glycosylase Activity. Incises Damaged DNA At Cytosines, Thymines And Guanines. Acts On A Damaged Strand, 5' From The Damaged Site. Required For The Repair Of Both Oxidative DNA Da

COG id: COG0177

COG function: function code L; Predicted EndoIII-related endonuclease

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI4505471, Length=208, Percent_Identity=28.3653846153846, Blast_Score=91, Evalue=5e-19,
Organism=Homo sapiens, GI6912520, Length=189, Percent_Identity=26.984126984127, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI190358497, Length=189, Percent_Identity=26.984126984127, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI115298648, Length=189, Percent_Identity=26.984126984127, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI115298654, Length=189, Percent_Identity=26.984126984127, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI115298652, Length=189, Percent_Identity=26.984126984127, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI115298650, Length=189, Percent_Identity=26.984126984127, Blast_Score=76, Evalue=2e-14,
Organism=Escherichia coli, GI1787920, Length=209, Percent_Identity=44.9760765550239, Blast_Score=174, Evalue=3e-45,
Organism=Escherichia coli, GI1789331, Length=193, Percent_Identity=24.8704663212435, Blast_Score=65, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17554540, Length=172, Percent_Identity=35.4651162790698, Blast_Score=107, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6319304, Length=180, Percent_Identity=27.2222222222222, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324530, Length=190, Percent_Identity=25.2631578947368, Blast_Score=67, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45550361, Length=190, Percent_Identity=31.5789473684211, Blast_Score=99, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR005759
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170 [H]

Pfam domain/function: PF00633 HHH; PF00730 HhH-GPD [H]

EC number: =4.2.99.18 [H]

Molecular weight: Translated: 24873; Mature: 24873

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
7.9 %Cys+Met (Translated Protein)
4.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
7.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNKTQIRYCLDTMADMYPEAHCELIHDNPFELVIAVALSAQCTDALVNKVTKNLFQKYK
CCCHHHHHHHHHHHHHHCCHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TPEDYLSVSLEELQQDIRSIGLYRNKAKNIQKLCRMLLDDYNGEVPKDRDELTKLPGVGR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCC
KTANVVVSVAFDIPAIAVDTHVERVSKRLAICRWKDSVLEVEKTLMKKIPMDEWSVTHHR
HHHHHHEEHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
MIFFGRYHCKAQRPQCEECPLLEVCREGKKRMKGK
HHEEEHHHCCCCCCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLNKTQIRYCLDTMADMYPEAHCELIHDNPFELVIAVALSAQCTDALVNKVTKNLFQKYK
CCCHHHHHHHHHHHHHHCCHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TPEDYLSVSLEELQQDIRSIGLYRNKAKNIQKLCRMLLDDYNGEVPKDRDELTKLPGVGR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCC
KTANVVVSVAFDIPAIAVDTHVERVSKRLAICRWKDSVLEVEKTLMKKIPMDEWSVTHHR
HHHHHHEEHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
MIFFGRYHCKAQRPQCEECPLLEVCREGKKRMKGK
HHEEEHHHCCCCCCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7704260; 8760912; 9384377 [H]