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The map label for this gene is birA [H]

Identifier: 118477090

GI number: 118477090

Start: 1529226

End: 1530230

Strand: Direct

Name: birA [H]

Synonym: BALH_1391

Alternate gene names: 118477090

Gene position: 1529226-1530230 (Clockwise)

Preceding gene: 118477089

Following gene: 118477091

Centisome position: 29.09

GC content: 39.0

Gene sequence:

>1005_bases
GTGTATAAGGGAGTGGCTGCAAGAATGCAATCTACTATAAGAAAGCAGTTATTGCAAGTTTTTTCTGAGGCGGATGGAGA
GTTTGTATCTGGCCAAACGATTAGTGATAAACTTGGTTGCTCGAGAACCGCTGTGTGGAAACATATGGAGGACCTTCGGA
ATGAGGGCTACGAACTTGAAGCAGTGCGTCGATTAGGGTATCGAATTGCAAGTAAGCCAGACAAAGTGACTGCGAATGAA
ATACAGTTAGGGTTACAAACGAAACATATTGGTAGAACAGTGTATTTTGAAGAGTCTGTTGAATCAACGCAGCATATTGC
AGCAAAGCTTGCTTATGAAGGTGCAGAAGAAGGAACAATTGTTGTGGCAGAAGAACAAACATCGGGCAGAGGGCGTTTAA
GTAGGAAATGGTATTCACCAAAAGGAACAGGAATTTGGATGAGTATTATTTTACGTCCGTCAATCCCGGTTCATCATGCA
CCACAACTTACTTTGTTAGCCGCTGTTAGCGTTGCGCAAGCAATTGAAAAATGCACGGGTGTAAACGTAGGAATAAAATG
GCCAAATGATATTTTAATTCAAGGAAAAAAGGCTGTAGGTATATTAACAGAAATGCAGGCTGATCCTGATAAAATTAATG
CTGTCATTATGGGTATTGGTATTAATGCGAATCAAAAGCAAGAACATTTTGATGAGGAAATTCAGCATATTGCTACTTCT
TTAGCGATTGAATCTGGTAAGCCAATTGTTCGTGCAGAGCTTATGCAACAAATCTTTTTACAACTAGAAAAATTATATGA
AGAGTATTTACAAAATGGTTTCTCTGTTATTAAAATTCTTTGGGAAAGTTACGCTGTAAGCATCGGGAAAGAAATTAACG
CTCGAACGATGAGAGAGACGATTACGGGTGTAGCAAAAGGAATTACAGAGGATGGTGTATTGCTCCTAGAAGACCATGAA
GGAAAAGTACATCATATTCATTCTGCGGATATCGAAATTAAGTAA

Upstream 100 bases:

>100_bases
TATTAAACTGGGCAAATAAAAAACCAGGTCCGTGGGTTGCTGAAATGATTCAAAACATCGAGGAAGCAATCGTACAAGGA
AACGTAGTGAATGAGAAAGA

Downstream 100 bases:

>100_bases
AAGAAGTTCCTCTTTTGGAACTTCTTTTTTATTTCCATATTAATAAAATCTTTTAATATTTAAGTTTTATTTTAAAAGAT
CGTCCAGTTGAGTTTGCTTC

Product: biotin operon repressor

Products: NA

Alternate protein names: Biotin operon repressor; Biotin--[acetyl-CoA-carboxylase] synthetase; Biotin--protein ligase [H]

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MYKGVAARMQSTIRKQLLQVFSEADGEFVSGQTISDKLGCSRTAVWKHMEDLRNEGYELEAVRRLGYRIASKPDKVTANE
IQLGLQTKHIGRTVYFEESVESTQHIAAKLAYEGAEEGTIVVAEEQTSGRGRLSRKWYSPKGTGIWMSIILRPSIPVHHA
PQLTLLAAVSVAQAIEKCTGVNVGIKWPNDILIQGKKAVGILTEMQADPDKINAVIMGIGINANQKQEHFDEEIQHIATS
LAIESGKPIVRAELMQQIFLQLEKLYEEYLQNGFSVIKILWESYAVSIGKEINARTMRETITGVAKGITEDGVLLLEDHE
GKVHHIHSADIEIK

Sequences:

>Translated_334_residues
MYKGVAARMQSTIRKQLLQVFSEADGEFVSGQTISDKLGCSRTAVWKHMEDLRNEGYELEAVRRLGYRIASKPDKVTANE
IQLGLQTKHIGRTVYFEESVESTQHIAAKLAYEGAEEGTIVVAEEQTSGRGRLSRKWYSPKGTGIWMSIILRPSIPVHHA
PQLTLLAAVSVAQAIEKCTGVNVGIKWPNDILIQGKKAVGILTEMQADPDKINAVIMGIGINANQKQEHFDEEIQHIATS
LAIESGKPIVRAELMQQIFLQLEKLYEEYLQNGFSVIKILWESYAVSIGKEINARTMRETITGVAKGITEDGVLLLEDHE
GKVHHIHSADIEIK
>Mature_334_residues
MYKGVAARMQSTIRKQLLQVFSEADGEFVSGQTISDKLGCSRTAVWKHMEDLRNEGYELEAVRRLGYRIASKPDKVTANE
IQLGLQTKHIGRTVYFEESVESTQHIAAKLAYEGAEEGTIVVAEEQTSGRGRLSRKWYSPKGTGIWMSIILRPSIPVHHA
PQLTLLAAVSVAQAIEKCTGVNVGIKWPNDILIQGKKAVGILTEMQADPDKINAVIMGIGINANQKQEHFDEEIQHIATS
LAIESGKPIVRAELMQQIFLQLEKLYEEYLQNGFSVIKILWESYAVSIGKEINARTMRETITGVAKGITEDGVLLLEDHE
GKVHHIHSADIEIK

Specific function: BirA acts both as a biotin-operon repressor and as the enzyme that synthesizes the corepressor, acetyl-CoA:carbon-dioxide ligase. This protein also activates biotin to form biotinyl-5'- adenylate and transfers the biotin moiety to biotin-accepting protein

COG id: COG0340

COG function: function code H; Biotin-(acetyl-CoA carboxylase) ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biotin--protein ligase family [H]

Homologues:

Organism=Homo sapiens, GI46255045, Length=318, Percent_Identity=25.4716981132075, Blast_Score=79, Evalue=5e-15,
Organism=Escherichia coli, GI1790408, Length=312, Percent_Identity=28.2051282051282, Blast_Score=121, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24644246, Length=237, Percent_Identity=29.957805907173, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: =6.3.4.15 [H]

Molecular weight: Translated: 37154; Mature: 37154

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKGVAARMQSTIRKQLLQVFSEADGEFVSGQTISDKLGCSRTAVWKHMEDLRNEGYELE
CCCHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHCCCHHHHHHHHHHHHHCCCCHH
AVRRLGYRIASKPDKVTANEIQLGLQTKHIGRTVYFEESVESTQHIAAKLAYEGAEEGTI
HHHHHHHHHCCCCCCCCHHHHHCCEEHHHCCEEEEEHHHHHHHHHHHHHHHHCCCCCCEE
VVAEEQTSGRGRLSRKWYSPKGTGIWMSIILRPSIPVHHAPQLTLLAAVSVAQAIEKCTG
EEEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCC
VNVGIKWPNDILIQGKKAVGILTEMQADPDKINAVIMGIGINANQKQEHFDEEIQHIATS
CEEEEECCCCEEEECCHHHHHHHHCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHH
LAIESGKPIVRAELMQQIFLQLEKLYEEYLQNGFSVIKILWESYAVSIGKEINARTMRET
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
ITGVAKGITEDGVLLLEDHEGKVHHIHSADIEIK
HHHHHHCCCCCCEEEEECCCCCEEEEECCCCEEC
>Mature Secondary Structure
MYKGVAARMQSTIRKQLLQVFSEADGEFVSGQTISDKLGCSRTAVWKHMEDLRNEGYELE
CCCHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCHHHHCCCHHHHHHHHHHHHHCCCCHH
AVRRLGYRIASKPDKVTANEIQLGLQTKHIGRTVYFEESVESTQHIAAKLAYEGAEEGTI
HHHHHHHHHCCCCCCCCHHHHHCCEEHHHCCEEEEEHHHHHHHHHHHHHHHHCCCCCCEE
VVAEEQTSGRGRLSRKWYSPKGTGIWMSIILRPSIPVHHAPQLTLLAAVSVAQAIEKCTG
EEEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCC
VNVGIKWPNDILIQGKKAVGILTEMQADPDKINAVIMGIGINANQKQEHFDEEIQHIATS
CEEEEECCCCEEEECCHHHHHHHHCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHH
LAIESGKPIVRAELMQQIFLQLEKLYEEYLQNGFSVIKILWESYAVSIGKEINARTMRET
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
ITGVAKGITEDGVLLLEDHEGKVHHIHSADIEIK
HHHHHHCCCCCCEEEEECCCCCEEEEECCCCEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7730294 [H]