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The map label for this gene is ndk [H]

Identifier: 118477068

GI number: 118477068

Start: 1510410

End: 1510937

Strand: Direct

Name: ndk [H]

Synonym: BALH_1369

Alternate gene names: 118477068

Gene position: 1510410-1510937 (Clockwise)

Preceding gene: 118477067

Following gene: 118477069

Centisome position: 28.73

GC content: 37.88

Gene sequence:

>528_bases
TTGCACAATTGTGATAAGGGTGTTAATATGTGTGTGGGGATATACAATTACATACATAATTCAGAAGTGGAGAGATTTTT
TATGGAAAAAACATTTCTAATGGTTAAACCAGACGGTGTACAACGTGCCTTCATTGGGGAAATTGTAGCTCGTTTTGAGA
AGAAGGGCTTTCAATTAGTTGGTGCAAAATTAATGCAAGTCACTCCAGAAATCGCTGGACAACACTATGCTGAGCACACA
GAAAAACCTTTCTTTGGTGAATTAGTAGACTTTATTACATCTGGTCCTGTATTCGCAATGGTATGGCAAGGTGAAGGTGT
AGTAGATACAGCTCGTAACATGATGGGTAAAACAAGACCACATGAAGCAGCTCCTGGAACAATTCGTGGAGATTTCGGTG
TAACTGTTGCGAAAAACATTATCCATGGTTCTGATTCGTTAGAAAGTGCAGAGCGCGAGATTGGTATTTTCTTTAAGGAA
GAAGAATTAGTTGACTACTCAAAATTAATGAATGAATGGATTTACTAA

Upstream 100 bases:

>100_bases
CAAGCGAAGTATGCATTACAAAATGTAGCAAAGTATATTGGAAAACGAAAATTTTAGTGTTTTTTCTAAAAAATAAAATA
ATCTCTCTATTTCAAAACTA

Downstream 100 bases:

>100_bases
TTATTTTGAAATAATTTGTAAACGCTTTAATCACTGTGATAATAGTAGAAAGTGCAAGGAGAATAGGGGTATTCTTCTTG
CACTTTTTTTATTTCTATTA

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 175; Mature: 175

Protein sequence:

>175_residues
MHNCDKGVNMCVGIYNYIHNSEVERFFMEKTFLMVKPDGVQRAFIGEIVARFEKKGFQLVGAKLMQVTPEIAGQHYAEHT
EKPFFGELVDFITSGPVFAMVWQGEGVVDTARNMMGKTRPHEAAPGTIRGDFGVTVAKNIIHGSDSLESAEREIGIFFKE
EELVDYSKLMNEWIY

Sequences:

>Translated_175_residues
MHNCDKGVNMCVGIYNYIHNSEVERFFMEKTFLMVKPDGVQRAFIGEIVARFEKKGFQLVGAKLMQVTPEIAGQHYAEHT
EKPFFGELVDFITSGPVFAMVWQGEGVVDTARNMMGKTRPHEAAPGTIRGDFGVTVAKNIIHGSDSLESAEREIGIFFKE
EELVDYSKLMNEWIY
>Mature_175_residues
MHNCDKGVNMCVGIYNYIHNSEVERFFMEKTFLMVKPDGVQRAFIGEIVARFEKKGFQLVGAKLMQVTPEIAGQHYAEHT
EKPFFGELVDFITSGPVFAMVWQGEGVVDTARNMMGKTRPHEAAPGTIRGDFGVTVAKNIIHGSDSLESAEREIGIFFKE
EELVDYSKLMNEWIY

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI38045913, Length=147, Percent_Identity=56.4625850340136, Blast_Score=187, Evalue=5e-48,
Organism=Homo sapiens, GI4557797, Length=147, Percent_Identity=56.4625850340136, Blast_Score=187, Evalue=5e-48,
Organism=Homo sapiens, GI37693993, Length=147, Percent_Identity=57.1428571428571, Blast_Score=186, Evalue=1e-47,
Organism=Homo sapiens, GI66392227, Length=148, Percent_Identity=54.0540540540541, Blast_Score=181, Evalue=2e-46,
Organism=Homo sapiens, GI66392205, Length=148, Percent_Identity=54.0540540540541, Blast_Score=181, Evalue=2e-46,
Organism=Homo sapiens, GI4505409, Length=148, Percent_Identity=54.0540540540541, Blast_Score=181, Evalue=2e-46,
Organism=Homo sapiens, GI66392192, Length=148, Percent_Identity=54.0540540540541, Blast_Score=181, Evalue=2e-46,
Organism=Homo sapiens, GI66392203, Length=148, Percent_Identity=54.0540540540541, Blast_Score=181, Evalue=3e-46,
Organism=Homo sapiens, GI4826862, Length=149, Percent_Identity=47.6510067114094, Blast_Score=162, Evalue=2e-40,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=35.3383458646617, Blast_Score=88, Evalue=4e-18,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=35.3383458646617, Blast_Score=88, Evalue=5e-18,
Organism=Homo sapiens, GI5031951, Length=137, Percent_Identity=35.7664233576642, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI148839372, Length=147, Percent_Identity=32.6530612244898, Blast_Score=78, Evalue=5e-15,
Organism=Homo sapiens, GI4505413, Length=140, Percent_Identity=30, Blast_Score=74, Evalue=5e-14,
Organism=Escherichia coli, GI1788866, Length=141, Percent_Identity=46.0992907801418, Blast_Score=135, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17506807, Length=148, Percent_Identity=50, Blast_Score=166, Evalue=8e-42,
Organism=Saccharomyces cerevisiae, GI6322783, Length=147, Percent_Identity=53.7414965986395, Blast_Score=181, Evalue=4e-47,
Organism=Drosophila melanogaster, GI45549037, Length=147, Percent_Identity=53.0612244897959, Blast_Score=178, Evalue=2e-45,
Organism=Drosophila melanogaster, GI18860097, Length=136, Percent_Identity=33.0882352941176, Blast_Score=91, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 19804; Mature: 19804

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNCDKGVNMCVGIYNYIHNSEVERFFMEKTFLMVKPDGVQRAFIGEIVARFEKKGFQLV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHCCHHHH
GAKLMQVTPEIAGQHYAEHTEKPFFGELVDFITSGPVFAMVWQGEGVVDTARNMMGKTRP
HHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCC
HEAAPGTIRGDFGVTVAKNIIHGSDSLESAEREIGIFFKEEELVDYSKLMNEWIY
CCCCCCCEECCCCHHHHHHHHCCCCHHHHHHHHHCEEECHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHNCDKGVNMCVGIYNYIHNSEVERFFMEKTFLMVKPDGVQRAFIGEIVARFEKKGFQLV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHCCHHHH
GAKLMQVTPEIAGQHYAEHTEKPFFGELVDFITSGPVFAMVWQGEGVVDTARNMMGKTRP
HHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCC
HEAAPGTIRGDFGVTVAKNIIHGSDSLESAEREIGIFFKEEELVDYSKLMNEWIY
CCCCCCCEECCCCHHHHHHHHCCCCHHHHHHHHHCEEECHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]