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The map label for this gene is ubiE [H]

Identifier: 118477066

GI number: 118477066

Start: 1508530

End: 1509372

Strand: Direct

Name: ubiE [H]

Synonym: BALH_1367

Alternate gene names: 118477066

Gene position: 1508530-1509372 (Clockwise)

Preceding gene: 118477065

Following gene: 118477067

Centisome position: 28.7

GC content: 36.3

Gene sequence:

>843_bases
ATGGATGATGAAACTTGGAAAGAAAGAAAATCAATTTTTAGAAAATCACACAGATATAAGCGAAATAAACTCTGTGTTAA
GAGATACATCGAAGACATAAGCAATTTTACATTGGAAGAAGGTACGAGCATGCAACAATCAAAAGAAGAAAGAGTACATG
ATGTATTTGAGAAAATCTCTGATAAATACGATGTGATGAATTCTGTAATTAGTTTTCAAAGACATAAAGCGTGGCGCAAA
GAGACGATGCGCATTATGGATGTAAAACCAGGTAGTAAAGCGCTTGATGTATGTTGCGGGACAGCGGACTGGACAATTGC
GCTAGCTGGAGCGGTGGGTGAACAGGGCAAGGTTGTTGGTTTAGACTTCAGTGAAAATATGTTATCTGTTGGTAAGCAAA
AGGTAGAGGCGTTACAATTAAAACAAGTAGAACTTCTACACGGGAATGCAATGGAACTTCCATTTGAAGATAACACGTTT
GATTATGTAACGATTGGATTTGGTTTACGTAATGTACCGGATTATATGCACGTATTAAAAGAAATGACGCGTGTAGTAAA
ACCAGGTGGAAAAGTAATTTGTTTAGAAACATCTCAACCAACAATGATTGGTTTTCGACAAGGTTATATTTTATACTTTA
AATATATCATGCCGTTATTTGGAAAGTTATTTGCGAAAAGTTATAAAGAATATTCATGGCTACAAGAATCTGCTAGTACA
TTCCCAGGTATGAAAGAATTGGCTAATATGTTCGAAAAAGCTGGACTTGAACGTGTGCAAGTGAAGCCATTTACTTTTGG
GGTAGCAGCGATGCATTTAGGCATGAAACCAGAATCAAAATAG

Upstream 100 bases:

>100_bases
AAGAATGTGAACTACATGTTAATAAACAACATTCACCTGTTTTTCAAGCTGTTCAAGGGATTGTGAACGATAAAGCAGAT
GCAGAAACAGTTATGAATGG

Downstream 100 bases:

>100_bases
AAAAAAGAAGTTTTAGGTTAAGGTGAACAATATGAAGTTACAACTTATGTACTCTTTTTTACGATCGGATATTAATGTGA
TAGAAAAAGAATTAAAAAAG

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MDDETWKERKSIFRKSHRYKRNKLCVKRYIEDISNFTLEEGTSMQQSKEERVHDVFEKISDKYDVMNSVISFQRHKAWRK
ETMRIMDVKPGSKALDVCCGTADWTIALAGAVGEQGKVVGLDFSENMLSVGKQKVEALQLKQVELLHGNAMELPFEDNTF
DYVTIGFGLRNVPDYMHVLKEMTRVVKPGGKVICLETSQPTMIGFRQGYILYFKYIMPLFGKLFAKSYKEYSWLQESAST
FPGMKELANMFEKAGLERVQVKPFTFGVAAMHLGMKPESK

Sequences:

>Translated_280_residues
MDDETWKERKSIFRKSHRYKRNKLCVKRYIEDISNFTLEEGTSMQQSKEERVHDVFEKISDKYDVMNSVISFQRHKAWRK
ETMRIMDVKPGSKALDVCCGTADWTIALAGAVGEQGKVVGLDFSENMLSVGKQKVEALQLKQVELLHGNAMELPFEDNTF
DYVTIGFGLRNVPDYMHVLKEMTRVVKPGGKVICLETSQPTMIGFRQGYILYFKYIMPLFGKLFAKSYKEYSWLQESAST
FPGMKELANMFEKAGLERVQVKPFTFGVAAMHLGMKPESK
>Mature_280_residues
MDDETWKERKSIFRKSHRYKRNKLCVKRYIEDISNFTLEEGTSMQQSKEERVHDVFEKISDKYDVMNSVISFQRHKAWRK
ETMRIMDVKPGSKALDVCCGTADWTIALAGAVGEQGKVVGLDFSENMLSVGKQKVEALQLKQVELLHGNAMELPFEDNTF
DYVTIGFGLRNVPDYMHVLKEMTRVVKPGGKVICLETSQPTMIGFRQGYILYFKYIMPLFGKLFAKSYKEYSWLQESAST
FPGMKELANMFEKAGLERVQVKPFTFGVAAMHLGMKPESK

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=269, Percent_Identity=33.8289962825279, Blast_Score=151, Evalue=6e-37,
Organism=Escherichia coli, GI48994983, Length=236, Percent_Identity=39.8305084745763, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1786404, Length=91, Percent_Identity=38.4615384615385, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17557039, Length=236, Percent_Identity=33.8983050847458, Blast_Score=145, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17561380, Length=183, Percent_Identity=25.1366120218579, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323526, Length=255, Percent_Identity=29.0196078431373, Blast_Score=113, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24641702, Length=249, Percent_Identity=32.9317269076305, Blast_Score=144, Evalue=9e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014122
- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 32209; Mature: 32209

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: PS01183 UBIE_1 ; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDETWKERKSIFRKSHRYKRNKLCVKRYIEDISNFTLEEGTSMQQSKEERVHDVFEKIS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHHHHHHHH
DKYDVMNSVISFQRHKAWRKETMRIMDVKPGSKALDVCCGTADWTIALAGAVGEQGKVVG
HHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHCCCCCCEEEEEECCCCCCCEEE
LDFSENMLSVGKQKVEALQLKQVELLHGNAMELPFEDNTFDYVTIGFGLRNVPDYMHVLK
ECCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCEEEECCCCCCCHHHHHHHH
EMTRVVKPGGKVICLETSQPTMIGFRQGYILYFKYIMPLFGKLFAKSYKEYSWLQESAST
HHHHHHCCCCCEEEEECCCCCEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FPGMKELANMFEKAGLERVQVKPFTFGVAAMHLGMKPESK
CCCHHHHHHHHHHCCCCEEEECCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDDETWKERKSIFRKSHRYKRNKLCVKRYIEDISNFTLEEGTSMQQSKEERVHDVFEKIS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHHHHHHHH
DKYDVMNSVISFQRHKAWRKETMRIMDVKPGSKALDVCCGTADWTIALAGAVGEQGKVVG
HHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHCCCCCCEEEEEECCCCCCCEEE
LDFSENMLSVGKQKVEALQLKQVELLHGNAMELPFEDNTFDYVTIGFGLRNVPDYMHVLK
ECCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCEEEECCCCCCCHHHHHHHH
EMTRVVKPGGKVICLETSQPTMIGFRQGYILYFKYIMPLFGKLFAKSYKEYSWLQESAST
HHHHHHCCCCCEEEEECCCCCEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FPGMKELANMFEKAGLERVQVKPFTFGVAAMHLGMKPESK
CCCHHHHHHHHHHCCCCEEEECCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA