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The map label for this gene is cobA [H]

Identifier: 118476986

GI number: 118476986

Start: 1427808

End: 1428587

Strand: Direct

Name: cobA [H]

Synonym: BALH_1281

Alternate gene names: 118476986

Gene position: 1427808-1428587 (Clockwise)

Preceding gene: 118476985

Following gene: 118476987

Centisome position: 27.16

GC content: 40.26

Gene sequence:

>780_bases
ATGATGGGAAAAGTATATATCGTTGGGGCGGGCCCTGGGGATCCAGATTTAATTACTGTGAAAGGATTGAAATGTATTGA
GAAGGCAGATGTTATTTTGTACGACCGTCTTGTAAATAAAGAATTGCTTTCCTATGCAAAGCCTGAAGTGGATTTAATTT
ATTGCGGAAAACTACCAAATTATCACACGATGAAGCAAGAGACAATTAACACGTTTCTTATTAAATATGCGAAAAAAGGA
AAAATTGTAACGAGACTTAAGGGTGGGGATCCATTTGTATTTGGTAGAGGGGGAGAAGAGGCCGAAGCGTTAGCAAAGCA
AGGTGTACCATTTGAAATTGTTCCTGGTATTTCAGCTGGAATAGCTGCACCTGCTTATGCGGGTATCCCAGTGACACATC
GTGATGCAAGTGCAAGCTTTGCTATTGTGACAGGGCATCGAAAAGAAGATGCTGCAGAGGAAGTGAAATGGGAAAATTTA
GCGAAAGGTGTAGAGACTTTAGCGGTATATATGGGGGTTAGCAATTTACCCTATATATGTGAACAACTGATGAAGCATGG
AAAAGATAAAAGTACGCCTGCCGCTATTATTGAGCGGGGAACTACATCTATGCAGCGCACAGTTGTTGGGACGTTAGGGA
CAATTGTAGATGTTGCGAAAAAAGAACAAATTCAAAATCCGAGCATGATTGTAATTGGAGAAGTCGTCCGTTTTAGAGAA
AAAATCCATTGGTTTGAAAAGCAGACAGAAAGTACGTATCAAGTAAGTGGAGTGTTATAA

Upstream 100 bases:

>100_bases
TTGTTATTCATGAGTAAGGAACATTGAAATATGAAGAAATGAAAACTTCCATTCATATATAAGGATGGAAGTTTCACTTT
AATAGTAGAAATGAGGAGAG

Downstream 100 bases:

>100_bases
AATGAAAGCCATCTTATATATATGTCATGGAAGTCGCTTGAAAGCAGCTAAAGAAGAAGCGGTTGCATTTATTACGTCAT
GTATGAACCGCGTAGAGGCA

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM [H]

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MMGKVYIVGAGPGDPDLITVKGLKCIEKADVILYDRLVNKELLSYAKPEVDLIYCGKLPNYHTMKQETINTFLIKYAKKG
KIVTRLKGGDPFVFGRGGEEAEALAKQGVPFEIVPGISAGIAAPAYAGIPVTHRDASASFAIVTGHRKEDAAEEVKWENL
AKGVETLAVYMGVSNLPYICEQLMKHGKDKSTPAAIIERGTTSMQRTVVGTLGTIVDVAKKEQIQNPSMIVIGEVVRFRE
KIHWFEKQTESTYQVSGVL

Sequences:

>Translated_259_residues
MMGKVYIVGAGPGDPDLITVKGLKCIEKADVILYDRLVNKELLSYAKPEVDLIYCGKLPNYHTMKQETINTFLIKYAKKG
KIVTRLKGGDPFVFGRGGEEAEALAKQGVPFEIVPGISAGIAAPAYAGIPVTHRDASASFAIVTGHRKEDAAEEVKWENL
AKGVETLAVYMGVSNLPYICEQLMKHGKDKSTPAAIIERGTTSMQRTVVGTLGTIVDVAKKEQIQNPSMIVIGEVVRFRE
KIHWFEKQTESTYQVSGVL
>Mature_259_residues
MMGKVYIVGAGPGDPDLITVKGLKCIEKADVILYDRLVNKELLSYAKPEVDLIYCGKLPNYHTMKQETINTFLIKYAKKG
KIVTRLKGGDPFVFGRGGEEAEALAKQGVPFEIVPGISAGIAAPAYAGIPVTHRDASASFAIVTGHRKEDAAEEVKWENL
AKGVETLAVYMGVSNLPYICEQLMKHGKDKSTPAAIIERGTTSMQRTVVGTLGTIVDVAKKEQIQNPSMIVIGEVVRFRE
KIHWFEKQTESTYQVSGVL

Specific function: Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin [H]

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=246, Percent_Identity=47.1544715447154, Blast_Score=247, Evalue=6e-67,
Organism=Saccharomyces cerevisiae, GI6322922, Length=237, Percent_Identity=32.4894514767932, Blast_Score=124, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 28313; Mature: 28313

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMGKVYIVGAGPGDPDLITVKGLKCIEKADVILYDRLVNKELLSYAKPEVDLIYCGKLPN
CCCEEEEEECCCCCCCEEEECCCHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
YHTMKQETINTFLIKYAKKGKIVTRLKGGDPFVFGRGGEEAEALAKQGVPFEIVPGISAG
CCHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEECCCCCHHHHHHHCCCCEEEECCCCCC
IAAPAYAGIPVTHRDASASFAIVTGHRKEDAAEEVKWENLAKGVETLAVYMGVSNLPYIC
CCCCCCCCCCEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
EQLMKHGKDKSTPAAIIERGTTSMQRTVVGTLGTIVDVAKKEQIQNPSMIVIGEVVRFRE
HHHHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHH
KIHWFEKQTESTYQVSGVL
HHHHHHHHCCCEEEEECCC
>Mature Secondary Structure
MMGKVYIVGAGPGDPDLITVKGLKCIEKADVILYDRLVNKELLSYAKPEVDLIYCGKLPN
CCCEEEEEECCCCCCCEEEECCCHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
YHTMKQETINTFLIKYAKKGKIVTRLKGGDPFVFGRGGEEAEALAKQGVPFEIVPGISAG
CCHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEECCCCCHHHHHHHCCCCEEEECCCCCC
IAAPAYAGIPVTHRDASASFAIVTGHRKEDAAEEVKWENLAKGVETLAVYMGVSNLPYIC
CCCCCCCCCCEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
EQLMKHGKDKSTPAAIIERGTTSMQRTVVGTLGTIVDVAKKEQIQNPSMIVIGEVVRFRE
HHHHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHH
KIHWFEKQTESTYQVSGVL
HHHHHHHHCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1906874 [H]