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The map label for this gene is serA [C]

Identifier: 118476976

GI number: 118476976

Start: 1416600

End: 1417646

Strand: Direct

Name: serA [C]

Synonym: BALH_1270

Alternate gene names: 118476976

Gene position: 1416600-1417646 (Clockwise)

Preceding gene: 118476974

Following gene: 118476979

Centisome position: 26.95

GC content: 36.2

Gene sequence:

>1047_bases
TTGGTTTTTATATGTGGATTTCTTACAATGAAAGATAAGAGATATCCTATTTTGTATAGAAGAGGTGTTAGTATAGTGGC
AAAAATATTAGTAGCAGGAAAAATTCCCGAAATCGGATTAGAACTATTAAAAGGTCATGATGTGGAAATGTATGATAAAG
AGGAGTTAATTTCTTTAGATGAATTAACAGAGCGTGTAAAAGATAAAGATGCATTGCTAAGTCTACTTTCTACAAAGGTG
ACAAAAGAAGTGATTGATGCGGCATCTAATTTGAAGATTGTTGCAAACTACGGTGCTGGTTACGATAATATTGATTACAC
GTATGCTGGAGAAAAAGGGATTGCGGTAACGAATACACCGAAAGTATCAACGGAAGCGACAGCAGAATTAACATTTGCAC
TTCTTTTAGCAGCTGCACGTAGAATTCCTGAAGGTGATACGCTATGCCGTACAACGGGATTTAACGGATGGGCACCGTTA
TTTTTCTTAGGCCGAGAAGTACATGGTAAAACAATTGGAATTATTGGCCTTGGAGAAATCGGAAAGGCAGTTGCAAAACG
TGCGAAAGCATTTGGAATGAATATTTTATATACAGGACCAAATCGAAAACCTGAAGCTGAAAGTGAACTGGAAGCAACAT
ATGTAACATTGGAAGAATTATTACAAACAGCAGACTTTATTACAATTAACTGTGCGTATAATCCGAAATTGCATCATATG
ATTGATGAAGAACAGTTTAAAATGATGAAGAAAACAGCGTATATTGTAAATGCTTCACGTGGACCAATCATGCATGAAGC
GGCACTTGCTCATGCGTTAAAAACGAATGAAATTGAAGGAGCAGCTCTTGACGTGTTCGAATTTGAGCCAAAAATTACTG
AAGAGTTAAAAGGATTAAAGAATGTAGTACTTGCTCCTCACGTAGGAAATGCAACATTTGAAACGCGTGATGCGATGGCT
GAAATGGCAGTAAGAAATATTTTAGCTGTATTAAATGGTGAAGAACCTGTAACACCTGTAAATCAAAAAGTATTCGTTAC
AAAATAA

Upstream 100 bases:

>100_bases
TTGGTTCAACTAATAATCAGTGGGGGATGAAGAAAACCCCCACTGATTAAAGTTTCACTTTATGGAAAAGTGTCGATTTT
CAAAACTATAATCAAATTCC

Downstream 100 bases:

>100_bases
AAAGAAACCTTCCGGAACCGGAAGGTTTCTTTTTATTTTTCTTTATTTGCTCTTTTTGATGGTCTTTGTCTAAGGAATTG
AGATAGCATGTACAAAATAT

Product: 2-hydroxyacid dehydrogenase family protein

Products: 3-phosphohydroxypyruvate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MVFICGFLTMKDKRYPILYRRGVSIVAKILVAGKIPEIGLELLKGHDVEMYDKEELISLDELTERVKDKDALLSLLSTKV
TKEVIDAASNLKIVANYGAGYDNIDYTYAGEKGIAVTNTPKVSTEATAELTFALLLAAARRIPEGDTLCRTTGFNGWAPL
FFLGREVHGKTIGIIGLGEIGKAVAKRAKAFGMNILYTGPNRKPEAESELEATYVTLEELLQTADFITINCAYNPKLHHM
IDEEQFKMMKKTAYIVNASRGPIMHEAALAHALKTNEIEGAALDVFEFEPKITEELKGLKNVVLAPHVGNATFETRDAMA
EMAVRNILAVLNGEEPVTPVNQKVFVTK

Sequences:

>Translated_348_residues
MVFICGFLTMKDKRYPILYRRGVSIVAKILVAGKIPEIGLELLKGHDVEMYDKEELISLDELTERVKDKDALLSLLSTKV
TKEVIDAASNLKIVANYGAGYDNIDYTYAGEKGIAVTNTPKVSTEATAELTFALLLAAARRIPEGDTLCRTTGFNGWAPL
FFLGREVHGKTIGIIGLGEIGKAVAKRAKAFGMNILYTGPNRKPEAESELEATYVTLEELLQTADFITINCAYNPKLHHM
IDEEQFKMMKKTAYIVNASRGPIMHEAALAHALKTNEIEGAALDVFEFEPKITEELKGLKNVVLAPHVGNATFETRDAMA
EMAVRNILAVLNGEEPVTPVNQKVFVTK
>Mature_348_residues
MVFICGFLTMKDKRYPILYRRGVSIVAKILVAGKIPEIGLELLKGHDVEMYDKEELISLDELTERVKDKDALLSLLSTKV
TKEVIDAASNLKIVANYGAGYDNIDYTYAGEKGIAVTNTPKVSTEATAELTFALLLAAARRIPEGDTLCRTTGFNGWAPL
FFLGREVHGKTIGIIGLGEIGKAVAKRAKAFGMNILYTGPNRKPEAESELEATYVTLEELLQTADFITINCAYNPKLHHM
IDEEQFKMMKKTAYIVNASRGPIMHEAALAHALKTNEIEGAALDVFEFEPKITEELKGLKNVVLAPHVGNATFETRDAMA
EMAVRNILAVLNGEEPVTPVNQKVFVTK

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=313, Percent_Identity=39.6166134185303, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI23308577, Length=320, Percent_Identity=33.125, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI4557497, Length=319, Percent_Identity=35.1097178683386, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI61743967, Length=319, Percent_Identity=35.1097178683386, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI145580578, Length=305, Percent_Identity=34.0983606557377, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI4557499, Length=305, Percent_Identity=34.0983606557377, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI145580575, Length=361, Percent_Identity=32.6869806094183, Blast_Score=152, Evalue=6e-37,
Organism=Escherichia coli, GI87082289, Length=268, Percent_Identity=38.0597014925373, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1789279, Length=265, Percent_Identity=32.0754716981132, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1787645, Length=259, Percent_Identity=30.8880308880309, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1788660, Length=257, Percent_Identity=29.1828793774319, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=319, Percent_Identity=33.2288401253918, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI25147481, Length=317, Percent_Identity=30.5993690851735, Blast_Score=122, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6320925, Length=316, Percent_Identity=32.2784810126582, Blast_Score=160, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6324055, Length=246, Percent_Identity=36.9918699186992, Blast_Score=159, Evalue=7e-40,
Organism=Saccharomyces cerevisiae, GI6322116, Length=298, Percent_Identity=32.8859060402685, Blast_Score=159, Evalue=8e-40,
Organism=Saccharomyces cerevisiae, GI6321253, Length=293, Percent_Identity=25.5972696245734, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6324964, Length=322, Percent_Identity=27.0186335403727, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28571528, Length=306, Percent_Identity=39.8692810457516, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI28574286, Length=318, Percent_Identity=35.2201257861635, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI45552429, Length=318, Percent_Identity=34.2767295597484, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI45551003, Length=318, Percent_Identity=34.2767295597484, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24585514, Length=318, Percent_Identity=34.2767295597484, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI28574282, Length=318, Percent_Identity=34.2767295597484, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI28574284, Length=318, Percent_Identity=34.2767295597484, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI19921140, Length=317, Percent_Identity=34.384858044164, Blast_Score=158, Evalue=6e-39,
Organism=Drosophila melanogaster, GI24646446, Length=318, Percent_Identity=33.9622641509434, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24646448, Length=318, Percent_Identity=33.9622641509434, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24646452, Length=318, Percent_Identity=33.9622641509434, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24646450, Length=318, Percent_Identity=33.9622641509434, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI62472511, Length=318, Percent_Identity=33.9622641509434, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24585516, Length=317, Percent_Identity=29.3375394321767, Blast_Score=139, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: 1.1.1.95

Molecular weight: Translated: 38292; Mature: 38292

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVFICGFLTMKDKRYPILYRRGVSIVAKILVAGKIPEIGLELLKGHDVEMYDKEELISLD
CEEEEEEEEECCCCCCCHHHCCHHHHHHHHHHCCCCHHHHHHHCCCCCCEECHHHHHHHH
ELTERVKDKDALLSLLSTKVTKEVIDAASNLKIVANYGAGYDNIDYTYAGEKGIAVTNTP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEECCCCEEEECCC
KVSTEATAELTFALLLAAARRIPEGDTLCRTTGFNGWAPLFFLGREVHGKTIGIIGLGEI
CCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHCCCCCCCCEEEEEECHHH
GKAVAKRAKAFGMNILYTGPNRKPEAESELEATYVTLEELLQTADFITINCAYNPKLHHM
HHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEEECCCHHHH
IDEEQFKMMKKTAYIVNASRGPIMHEAALAHALKTNEIEGAALDVFEFEPKITEELKGLK
CCHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHH
NVVLAPHVGNATFETRDAMAEMAVRNILAVLNGEEPVTPVNQKVFVTK
HEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEC
>Mature Secondary Structure
MVFICGFLTMKDKRYPILYRRGVSIVAKILVAGKIPEIGLELLKGHDVEMYDKEELISLD
CEEEEEEEEECCCCCCCHHHCCHHHHHHHHHHCCCCHHHHHHHCCCCCCEECHHHHHHHH
ELTERVKDKDALLSLLSTKVTKEVIDAASNLKIVANYGAGYDNIDYTYAGEKGIAVTNTP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEECCCCEEEECCC
KVSTEATAELTFALLLAAARRIPEGDTLCRTTGFNGWAPLFFLGREVHGKTIGIIGLGEI
CCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHCCCCCCCCEEEEEECHHH
GKAVAKRAKAFGMNILYTGPNRKPEAESELEATYVTLEELLQTADFITINCAYNPKLHHM
HHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEEECCCHHHH
IDEEQFKMMKKTAYIVNASRGPIMHEAALAHALKTNEIEGAALDVFEFEPKITEELKGLK
CCHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHH
NVVLAPHVGNATFETRDAMAEMAVRNILAVLNGEEPVTPVNQKVFVTK
HEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-phosphoglycerate; NAD+

Specific reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA