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The map label for this gene is hisG [H]

Identifier: 118476966

GI number: 118476966

Start: 1409841

End: 1410518

Strand: Direct

Name: hisG [H]

Synonym: BALH_1260

Alternate gene names: 118476966

Gene position: 1409841-1410518 (Clockwise)

Preceding gene: 118476965

Following gene: 118476967

Centisome position: 26.82

GC content: 33.48

Gene sequence:

>678_bases
GTGGAAAGAGAAATGGGTCGTCCAGAAAGAAGGGGAAACTTCATGCGTAACATTCAAATTGCGTTAACGAAAGGGAGATT
AGAAAAACATGTGATTCCGCTCTTTGAGCAGATTGGAATTGATTGTTCAGAGCTCAAAAATAAAGGAAGAAAACTTGTCT
TTCAAAGTAAAAATACGGATATCTCATTTATTTTAGTGAAAGCAGTAGATGTTGCTACTTATGTAGAACATGGAGTAGCG
GATATCGGAGTCGTTGGAAAAGATATTTTAATGGAAAACGAGAAAGATATTTATGAAATGTTAGATTTAGGAGTAGGCGT
GTGTAAGTTTTGTGTCGCTTCTATTCCTACGTATAATCCGAAGAGCTACCGGAAGAAATGTATTGCGACGAAATATCCAC
ATATTACTTCTAACTATTTTCATAATAAAGGAGAGGATGTAGAAATTATTAAAATAGAAGGTTCTGTAGAAATTGCTCCT
ATTCTTGGATTGGCAGATGCAATTGTTGATATTGTTGAAACAGGAAAAACATTACAAGAAAATGGACTCATTGTATTTGA
GGAAATGTATTCTATATCTGCTCGAATGATTGTAAATAAGGCTGCCTTAAAAACTAAAAAAGACGAAATATTCAGTATTA
TAAATATGATGGAGCAAGAAATTTTGTCAGGAAAATAG

Upstream 100 bases:

>100_bases
TGTCTTTATTCTCTAATTTAAATGATACTTTTCAATTTGCTAGAAAAAATCAAATCGTAACGGTCGTTGAGGCAAAGAGC
GAATCATTAGTGGAATATGT

Downstream 100 bases:

>100_bases
GGGGACTTGTAATGGAGATAGTTTGTGAGGATTTTCAAAAGGCGTTAACGAAAATAAAACTGTTACGAGAAAACGCTAAT
ATAATAGAAGAAACTGTTCA

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MEREMGRPERRGNFMRNIQIALTKGRLEKHVIPLFEQIGIDCSELKNKGRKLVFQSKNTDISFILVKAVDVATYVEHGVA
DIGVVGKDILMENEKDIYEMLDLGVGVCKFCVASIPTYNPKSYRKKCIATKYPHITSNYFHNKGEDVEIIKIEGSVEIAP
ILGLADAIVDIVETGKTLQENGLIVFEEMYSISARMIVNKAALKTKKDEIFSIINMMEQEILSGK

Sequences:

>Translated_225_residues
MEREMGRPERRGNFMRNIQIALTKGRLEKHVIPLFEQIGIDCSELKNKGRKLVFQSKNTDISFILVKAVDVATYVEHGVA
DIGVVGKDILMENEKDIYEMLDLGVGVCKFCVASIPTYNPKSYRKKCIATKYPHITSNYFHNKGEDVEIIKIEGSVEIAP
ILGLADAIVDIVETGKTLQENGLIVFEEMYSISARMIVNKAALKTKKDEIFSIINMMEQEILSGK
>Mature_225_residues
MEREMGRPERRGNFMRNIQIALTKGRLEKHVIPLFEQIGIDCSELKNKGRKLVFQSKNTDISFILVKAVDVATYVEHGVA
DIGVVGKDILMENEKDIYEMLDLGVGVCKFCVASIPTYNPKSYRKKCIATKYPHITSNYFHNKGEDVEIIKIEGSVEIAP
ILGLADAIVDIVETGKTLQENGLIVFEEMYSISARMIVNKAALKTKKDEIFSIINMMEQEILSGK

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=207, Percent_Identity=30.9178743961353, Blast_Score=95, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6320896, Length=205, Percent_Identity=30.7317073170732, Blast_Score=79, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 25332; Mature: 25332

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEREMGRPERRGNFMRNIQIALTKGRLEKHVIPLFEQIGIDCSELKNKGRKLVFQSKNTD
CCCCCCCCHHHCCHHHHEEEEEECCHHHHHHHHHHHHHCCCHHHHHCCCCEEEEECCCCC
ISFILVKAVDVATYVEHGVADIGVVGKDILMENEKDIYEMLDLGVGVCKFCVASIPTYNP
EEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
KSYRKKCIATKYPHITSNYFHNKGEDVEIIKIEGSVEIAPILGLADAIVDIVETGKTLQE
HHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCEEEHHHHHHHHHHHHHHHCCCCHHH
NGLIVFEEMYSISARMIVNKAALKTKKDEIFSIINMMEQEILSGK
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEREMGRPERRGNFMRNIQIALTKGRLEKHVIPLFEQIGIDCSELKNKGRKLVFQSKNTD
CCCCCCCCHHHCCHHHHEEEEEECCHHHHHHHHHHHHHCCCHHHHHCCCCEEEEECCCCC
ISFILVKAVDVATYVEHGVADIGVVGKDILMENEKDIYEMLDLGVGVCKFCVASIPTYNP
EEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
KSYRKKCIATKYPHITSNYFHNKGEDVEIIKIEGSVEIAPILGLADAIVDIVETGKTLQE
HHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCEEEHHHHHHHHHHHHHHHCCCCHHH
NGLIVFEEMYSISARMIVNKAALKTKKDEIFSIINMMEQEILSGK
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA