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The map label for this gene is hemY [H]

Identifier: 118476674

GI number: 118476674

Start: 1092726

End: 1094147

Strand: Direct

Name: hemY [H]

Synonym: BALH_0952

Alternate gene names: 118476674

Gene position: 1092726-1094147 (Clockwise)

Preceding gene: 118476673

Following gene: 118476676

Centisome position: 20.79

GC content: 42.33

Gene sequence:

>1422_bases
TTGAGGAAAAAAGTTGTAGTCATCGGCGGTGGCATCACAGGATTAACAACGATGTATAACTTGCAAAAAGATATTCGTGA
CAAAAACTTGCCGATCGATACATTACTGATAGAAGCATCGGGTAAACTTGGCGGGAAAATTCAAACCGTTCGAAAAGATG
GATTTACAATTGAACGCGGACCGGACTCTTTCTTAGCACGAAAAGAAAGTGCAGCTACATTAGCGAAAGAATTAGGTTTT
GGCGATGAACTTGTAAATAATAAGGCCGGTCAATCATTTATCCTCGTAAACAATCGGTTACATAAAATGCCGAGCGGATC
AATGATGGGAATTCCAACGCAAATTACGCCGTTTCTATTTTCTGGGCTGTTCTCCCCAATTGGTAAACTAAGAGCTGGTT
TTGATCTATTAATGCCAAGATCAAAGCCAGTATCTGACCAATCACTCGGGCACTTTTTCAGACATCGCCTCGGAAATGAA
GTGGTTGAAAATTTAATAGAACCATTACTATCTGGTATTTATGCAGGGGATATTGATGAAATGAGCTTAATGTCAACATT
CCCGCAAATGTATCAAATTGAGCAGAAACATCGCAGTATTTCACTCGGTATGCGTACGCTCGCTCCGAAAGCAGAGAAAG
TTGAACCGAAAAAGGGAATCTTCCAAACAGTGAAAACCGGTTTAGAATCTATCGTAGAATCTCTCGAATCAAAGATGCAT
GAAGGTACGATAATAAAGGGAACTCGCATTGAAAAAGTTGCAAAACAGGGTGATGGCTATGCGATTACTCTTAGTAACGG
AAAAGAAATAGAAGCGGACGCGGTCGTAGTGGCAAGCTCACATAAAGTATTGCCGTCTATGTTTGCGCAGTACAAGCAGT
TTCGTTTTTTCCGCAACATTCCATCCACATCAGTTGCGAATGTGGCAATGGCTTTCCCGCAATCAGCCATTCAGCGCGAT
ATTGATGGTACAGGATTTGTTGTCTCTCGAAATAGTGATTACACCATTACAGCATGTACGTGGACGCATAAAAAGTGGCC
ACATACAACGCCAGAAGGAAAAATGCTTCTTCGATGTTACGTTGGACGACCTGGTGATGAAGCGGTTGTAGAACAAACAG
AAGAGGAACTCGTTCAGCTCGTACTAGAAGACTTACGAAAGACGATGGATATTACAGAGGATCCAGAGTTTACAGTCGTA
AGCCGCTGGAAAGAAGCGATGCCCCAATATACAGTAGGCCATAACGAGCGAATGAAGAAACTCACAACATTTATGGAGAA
AGAGTTGCCAGGTATATACTTGGCAGGTAGTTCCTACGCTGGTTCTGGTCTTCCGGACTGTATTGATCAAGGTGAGAAAG
CAGCAAAGCGTGTGCTAGCTCATTTGGAGAAAGTAATGGATGCGGAATTAATCGCACAATAA

Upstream 100 bases:

>100_bases
CCAGAAATGCCAAATGCATCGGACGCATTTATTGACTCTTTAACAGACGTTGTATTAAAGAAAAAAGAATCTGTAATGTA
AGAAGAAAGGGGGAGCCTGC

Downstream 100 bases:

>100_bases
AGTGAAACGCCTTCAATCACATTGAAGGCGTTTTGTTACTTATTCACCAATAAACATATATAAGTTATTTGGCTTTATAA
CGGCATCTCCTGCATAAATA

Product: protoporphyrinogen oxidase

Products: NA

Alternate protein names: PPO [H]

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MRKKVVVIGGGITGLTTMYNLQKDIRDKNLPIDTLLIEASGKLGGKIQTVRKDGFTIERGPDSFLARKESAATLAKELGF
GDELVNNKAGQSFILVNNRLHKMPSGSMMGIPTQITPFLFSGLFSPIGKLRAGFDLLMPRSKPVSDQSLGHFFRHRLGNE
VVENLIEPLLSGIYAGDIDEMSLMSTFPQMYQIEQKHRSISLGMRTLAPKAEKVEPKKGIFQTVKTGLESIVESLESKMH
EGTIIKGTRIEKVAKQGDGYAITLSNGKEIEADAVVVASSHKVLPSMFAQYKQFRFFRNIPSTSVANVAMAFPQSAIQRD
IDGTGFVVSRNSDYTITACTWTHKKWPHTTPEGKMLLRCYVGRPGDEAVVEQTEEELVQLVLEDLRKTMDITEDPEFTVV
SRWKEAMPQYTVGHNERMKKLTTFMEKELPGIYLAGSSYAGSGLPDCIDQGEKAAKRVLAHLEKVMDAELIAQ

Sequences:

>Translated_473_residues
MRKKVVVIGGGITGLTTMYNLQKDIRDKNLPIDTLLIEASGKLGGKIQTVRKDGFTIERGPDSFLARKESAATLAKELGF
GDELVNNKAGQSFILVNNRLHKMPSGSMMGIPTQITPFLFSGLFSPIGKLRAGFDLLMPRSKPVSDQSLGHFFRHRLGNE
VVENLIEPLLSGIYAGDIDEMSLMSTFPQMYQIEQKHRSISLGMRTLAPKAEKVEPKKGIFQTVKTGLESIVESLESKMH
EGTIIKGTRIEKVAKQGDGYAITLSNGKEIEADAVVVASSHKVLPSMFAQYKQFRFFRNIPSTSVANVAMAFPQSAIQRD
IDGTGFVVSRNSDYTITACTWTHKKWPHTTPEGKMLLRCYVGRPGDEAVVEQTEEELVQLVLEDLRKTMDITEDPEFTVV
SRWKEAMPQYTVGHNERMKKLTTFMEKELPGIYLAGSSYAGSGLPDCIDQGEKAAKRVLAHLEKVMDAELIAQ
>Mature_473_residues
MRKKVVVIGGGITGLTTMYNLQKDIRDKNLPIDTLLIEASGKLGGKIQTVRKDGFTIERGPDSFLARKESAATLAKELGF
GDELVNNKAGQSFILVNNRLHKMPSGSMMGIPTQITPFLFSGLFSPIGKLRAGFDLLMPRSKPVSDQSLGHFFRHRLGNE
VVENLIEPLLSGIYAGDIDEMSLMSTFPQMYQIEQKHRSISLGMRTLAPKAEKVEPKKGIFQTVKTGLESIVESLESKMH
EGTIIKGTRIEKVAKQGDGYAITLSNGKEIEADAVVVASSHKVLPSMFAQYKQFRFFRNIPSTSVANVAMAFPQSAIQRD
IDGTGFVVSRNSDYTITACTWTHKKWPHTTPEGKMLLRCYVGRPGDEAVVEQTEEELVQLVLEDLRKTMDITEDPEFTVV
SRWKEAMPQYTVGHNERMKKLTTFMEKELPGIYLAGSSYAGSGLPDCIDQGEKAAKRVLAHLEKVMDAELIAQ

Specific function: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. Also oxidizes the pathway intermediate coproporphyrinogen-III [H]

COG id: COG1232

COG function: function code H; Protoporphyrinogen oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protoporphyrinogen oxidase family [H]

Homologues:

Organism=Homo sapiens, GI170650615, Length=493, Percent_Identity=28.3975659229209, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI4506001, Length=493, Percent_Identity=28.3975659229209, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24649745, Length=447, Percent_Identity=25.503355704698, Blast_Score=85, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002937
- InterPro:   IPR016040
- InterPro:   IPR004572 [H]

Pfam domain/function: PF01593 Amino_oxidase [H]

EC number: =1.3.3.4 [H]

Molecular weight: Translated: 52435; Mature: 52435

Theoretical pI: Translated: 8.70; Mature: 8.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKKVVVIGGGITGLTTMYNLQKDIRDKNLPIDTLLIEASGKLGGKIQTVRKDGFTIERG
CCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCEEEEEECCCEEEECC
PDSFLARKESAATLAKELGFGDELVNNKAGQSFILVNNRLHKMPSGSMMGIPTQITPFLF
CHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCEEEEECCHHHCCCCCCCCCCCHHHHHHHH
SGLFSPIGKLRAGFDLLMPRSKPVSDQSLGHFFRHRLGNEVVENLIEPLLSGIYAGDIDE
HHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
MSLMSTFPQMYQIEQKHRSISLGMRTLAPKAEKVEPKKGIFQTVKTGLESIVESLESKMH
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EGTIIKGTRIEKVAKQGDGYAITLSNGKEIEADAVVVASSHKVLPSMFAQYKQFRFFRNI
CCCEECCHHHHHHHHCCCCEEEEECCCCEECCCEEEEECCCCHHHHHHHHHHHHHHHHCC
PSTSVANVAMAFPQSAIQRDIDGTGFVVSRNSDYTITACTWTHKKWPHTTPEGKMLLRCY
CCHHHHHHHHHCCHHHHHHCCCCCCEEEECCCCEEEEEEEEECCCCCCCCCCCCEEEEEE
VGRPGDEAVVEQTEEELVQLVLEDLRKTMDITEDPEFTVVSRWKEAMPQYTVGHNERMKK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHH
LTTFMEKELPGIYLAGSSYAGSGLPDCIDQGEKAAKRVLAHLEKVMDAELIAQ
HHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRKKVVVIGGGITGLTTMYNLQKDIRDKNLPIDTLLIEASGKLGGKIQTVRKDGFTIERG
CCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCEEEEEECCCEEEECC
PDSFLARKESAATLAKELGFGDELVNNKAGQSFILVNNRLHKMPSGSMMGIPTQITPFLF
CHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCEEEEECCHHHCCCCCCCCCCCHHHHHHHH
SGLFSPIGKLRAGFDLLMPRSKPVSDQSLGHFFRHRLGNEVVENLIEPLLSGIYAGDIDE
HHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
MSLMSTFPQMYQIEQKHRSISLGMRTLAPKAEKVEPKKGIFQTVKTGLESIVESLESKMH
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EGTIIKGTRIEKVAKQGDGYAITLSNGKEIEADAVVVASSHKVLPSMFAQYKQFRFFRNI
CCCEECCHHHHHHHHCCCCEEEEECCCCEECCCEEEEECCCCHHHHHHHHHHHHHHHHCC
PSTSVANVAMAFPQSAIQRDIDGTGFVVSRNSDYTITACTWTHKKWPHTTPEGKMLLRCY
CCHHHHHHHHHCCHHHHHHCCCCCCEEEECCCCEEEEEEEEECCCCCCCCCCCCEEEEEE
VGRPGDEAVVEQTEEELVQLVLEDLRKTMDITEDPEFTVVSRWKEAMPQYTVGHNERMKK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHH
LTTFMEKELPGIYLAGSSYAGSGLPDCIDQGEKAAKRVLAHLEKVMDAELIAQ
HHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1459957; 9579061; 9384377; 8288631 [H]