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The map label for this gene is lmrB [H]

Identifier: 118476651

GI number: 118476651

Start: 1060434

End: 1061885

Strand: Direct

Name: lmrB [H]

Synonym: BALH_0929

Alternate gene names: 118476651

Gene position: 1060434-1061885 (Clockwise)

Preceding gene: 118476650

Following gene: 118476654

Centisome position: 20.17

GC content: 39.26

Gene sequence:

>1452_bases
ATGAATGCTCAAACAGCACCTGTTTCTTCACAGTCAAACGAGTTTGACAATGTGAAAAGACTCCCCATTTTAATATCGAT
GATCATTGGGGCGTTTTTTACCATTTTGAATGAAACATTATTGAACGTTGCTTTTCCGCAATTGATGATTGAGTTGAATG
TAACACCGTCGACTCTTCAATGGCTCTCAACAGGCTACATGCTTGTAGTTGCTGTACTCATTCCAGCTTCGGCTTTATTA
GTACAATGGTTTACAACAAGACAAGTATTCATAGGTGCTATGGTAGTCTTTACTTTCGGTACACTTGTAAGTGCAATTGC
GCCTGGATTTTCTATACTATTAATGGGGCGCTTGTTACAAGCGGCAGGTACGGGATTAATGATGCCCGTATTAATGAATA
CGATTCTTCTTCTATATCCTCCTGAAAAGAGAGGAGCGGCAATGGGGAGTATTGGGCTTGTAATCATGTTCGCTCCTGCC
ATTGGACCGACACTTTCAGGTATTATTTTGGAAACGTTGAATTGGAGATGGCTATTTTATATCGTTCTGCCATTCGCAAT
TTTTTCTATCGTTTTCGCGTTTATTTATTTAAAAAATGTCTCAGAGCCTACTAAACCAAAGGTAGATGTATTATCTATTC
TTTTATCTACAATTGGATTTGGCGGGATTGTTTATGGCTTCAGTAGCTCAGGTGAAGGTTGGGATAGTTTCCAGGTGTAT
GGAATCATTCTAATTGGTCTTGTAGCACTTCTATTTTTCGTACTACGTCAATTGAAATTGAAAGAGCCATTACTAGATCT
TAGTGCATTTAAGTATCCAATGTTTACGCTAACGACAATTTTATTGACGATCATGATGATGACGATGTTCTCGACAATGA
CGTTACTACCATTTCTATTCCAAGGTGCTTTAGGCTTAACTGTTTATGCAACTGGTCTTATCATGCTTCCAGGTAGCTTA
TTGAACGGTCTGCTTTCTCCAGTTTCAGGAAAGCTCTTTGATAAATTTGGTCCAAGAGCGCTTATTATTCCTGGTACGAT
ATTATTAGCAAGTGTGATGTGGTTCTTTACACAAGTAACGGCAGATACGTCTAAAATAACTTTCATCCTATTACATGTCA
CGATGATGGTATCCATTTCAATGATTATGATGCCGGCGCAAACGAACGGTTTGAACCAACTTCCGAAGCGATTTTATCCT
CACGGAACAGCTATTTTAAATACTCTATCACAAGTAGCTGGTGCGGTAGGAGTTGCTTTCTTTATTAGTGTTATGACTTC
CGGACAGAAGAAATATTTGGATGCATCTTCAAATCCGACTGACCCAGCTCAATTGACGGAAGCAATGGTTTCAGGCGTGC
ATAACGCATTTACAATTGGCTTTGGTTTGGCACTACTTGCAGTTGTTGTAGCTTTGTTTATAAAACGTTCGCAGACCTCG
GGAAATGAATAG

Upstream 100 bases:

>100_bases
GTTGTGCTGTATCGTTTTCAATTTGGTACGGGCGTTTCTACGTTAAATATGACTAGCAAAGGTAATAAAAATTTATAAAA
GAATACAAGGAGGTTTATGT

Downstream 100 bases:

>100_bases
AAGGACAAGGTTCTAATTCATTTCTTTTTCAACACCCCGAGACACCTTGATGATGATCAAGGTGTCTTTGTTATATGTAA
AAGAATTCACTATTATAATC

Product: permease, general substrate transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MNAQTAPVSSQSNEFDNVKRLPILISMIIGAFFTILNETLLNVAFPQLMIELNVTPSTLQWLSTGYMLVVAVLIPASALL
VQWFTTRQVFIGAMVVFTFGTLVSAIAPGFSILLMGRLLQAAGTGLMMPVLMNTILLLYPPEKRGAAMGSIGLVIMFAPA
IGPTLSGIILETLNWRWLFYIVLPFAIFSIVFAFIYLKNVSEPTKPKVDVLSILLSTIGFGGIVYGFSSSGEGWDSFQVY
GIILIGLVALLFFVLRQLKLKEPLLDLSAFKYPMFTLTTILLTIMMMTMFSTMTLLPFLFQGALGLTVYATGLIMLPGSL
LNGLLSPVSGKLFDKFGPRALIIPGTILLASVMWFFTQVTADTSKITFILLHVTMMVSISMIMMPAQTNGLNQLPKRFYP
HGTAILNTLSQVAGAVGVAFFISVMTSGQKKYLDASSNPTDPAQLTEAMVSGVHNAFTIGFGLALLAVVVALFIKRSQTS
GNE

Sequences:

>Translated_483_residues
MNAQTAPVSSQSNEFDNVKRLPILISMIIGAFFTILNETLLNVAFPQLMIELNVTPSTLQWLSTGYMLVVAVLIPASALL
VQWFTTRQVFIGAMVVFTFGTLVSAIAPGFSILLMGRLLQAAGTGLMMPVLMNTILLLYPPEKRGAAMGSIGLVIMFAPA
IGPTLSGIILETLNWRWLFYIVLPFAIFSIVFAFIYLKNVSEPTKPKVDVLSILLSTIGFGGIVYGFSSSGEGWDSFQVY
GIILIGLVALLFFVLRQLKLKEPLLDLSAFKYPMFTLTTILLTIMMMTMFSTMTLLPFLFQGALGLTVYATGLIMLPGSL
LNGLLSPVSGKLFDKFGPRALIIPGTILLASVMWFFTQVTADTSKITFILLHVTMMVSISMIMMPAQTNGLNQLPKRFYP
HGTAILNTLSQVAGAVGVAFFISVMTSGQKKYLDASSNPTDPAQLTEAMVSGVHNAFTIGFGLALLAVVVALFIKRSQTS
GNE
>Mature_483_residues
MNAQTAPVSSQSNEFDNVKRLPILISMIIGAFFTILNETLLNVAFPQLMIELNVTPSTLQWLSTGYMLVVAVLIPASALL
VQWFTTRQVFIGAMVVFTFGTLVSAIAPGFSILLMGRLLQAAGTGLMMPVLMNTILLLYPPEKRGAAMGSIGLVIMFAPA
IGPTLSGIILETLNWRWLFYIVLPFAIFSIVFAFIYLKNVSEPTKPKVDVLSILLSTIGFGGIVYGFSSSGEGWDSFQVY
GIILIGLVALLFFVLRQLKLKEPLLDLSAFKYPMFTLTTILLTIMMMTMFSTMTLLPFLFQGALGLTVYATGLIMLPGSL
LNGLLSPVSGKLFDKFGPRALIIPGTILLASVMWFFTQVTADTSKITFILLHVTMMVSISMIMMPAQTNGLNQLPKRFYP
HGTAILNTLSQVAGAVGVAFFISVMTSGQKKYLDASSNPTDPAQLTEAMVSGVHNAFTIGFGLALLAVVVALFIKRSQTS
GNE

Specific function: Proton-dependent transporter. May mediate the efflux of lincomycin [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI87081983, Length=417, Percent_Identity=24.9400479616307, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1789042, Length=455, Percent_Identity=23.7362637362637, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1788710, Length=420, Percent_Identity=25, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1790195, Length=423, Percent_Identity=26.0047281323877, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1788392, Length=394, Percent_Identity=27.6649746192893, Blast_Score=99, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6325455, Length=247, Percent_Identity=25.5060728744939, Blast_Score=74, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 52388; Mature: 52388

Theoretical pI: Translated: 9.84; Mature: 9.84

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAQTAPVSSQSNEFDNVKRLPILISMIIGAFFTILNETLLNVAFPQLMIELNVTPSTLQ
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHH
WLSTGYMLVVAVLIPASALLVQWFTTRQVFIGAMVVFTFGTLVSAIAPGFSILLMGRLLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
AAGTGLMMPVLMNTILLLYPPEKRGAAMGSIGLVIMFAPAIGPTLSGIILETLNWRWLFY
HHCCCHHHHHHHHHHEEEECCCHHCCCCCCHHHHHEECCCCCCHHHHHHHHHCCHHHHHH
IVLPFAIFSIVFAFIYLKNVSEPTKPKVDVLSILLSTIGFGGIVYGFSSSGEGWDSFQVY
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHH
GIILIGLVALLFFVLRQLKLKEPLLDLSAFKYPMFTLTTILLTIMMMTMFSTMTLLPFLF
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGALGLTVYATGLIMLPGSLLNGLLSPVSGKLFDKFGPRALIIPGTILLASVMWFFTQVT
HHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHCCCCEEEECHHHHHHHHHHHHHHHH
ADTSKITFILLHVTMMVSISMIMMPAQTNGLNQLPKRFYPHGTAILNTLSQVAGAVGVAF
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
FISVMTSGQKKYLDASSNPTDPAQLTEAMVSGVHNAFTIGFGLALLAVVVALFIKRSQTS
HHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GNE
CCC
>Mature Secondary Structure
MNAQTAPVSSQSNEFDNVKRLPILISMIIGAFFTILNETLLNVAFPQLMIELNVTPSTLQ
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHH
WLSTGYMLVVAVLIPASALLVQWFTTRQVFIGAMVVFTFGTLVSAIAPGFSILLMGRLLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
AAGTGLMMPVLMNTILLLYPPEKRGAAMGSIGLVIMFAPAIGPTLSGIILETLNWRWLFY
HHCCCHHHHHHHHHHEEEECCCHHCCCCCCHHHHHEECCCCCCHHHHHHHHHCCHHHHHH
IVLPFAIFSIVFAFIYLKNVSEPTKPKVDVLSILLSTIGFGGIVYGFSSSGEGWDSFQVY
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHH
GIILIGLVALLFFVLRQLKLKEPLLDLSAFKYPMFTLTTILLTIMMMTMFSTMTLLPFLF
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QGALGLTVYATGLIMLPGSLLNGLLSPVSGKLFDKFGPRALIIPGTILLASVMWFFTQVT
HHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHCCCCEEEECHHHHHHHHHHHHHHHH
ADTSKITFILLHVTMMVSISMIMMPAQTNGLNQLPKRFYPHGTAILNTLSQVAGAVGVAF
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
FISVMTSGQKKYLDASSNPTDPAQLTEAMVSGVHNAFTIGFGLALLAVVVALFIKRSQTS
HHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GNE
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9274031; 9384377 [H]