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The map label for this gene is mhpC [C]

Identifier: 118476638

GI number: 118476638

Start: 1045301

End: 1046176

Strand: Direct

Name: mhpC [C]

Synonym: BALH_0914

Alternate gene names: 118476638

Gene position: 1045301-1046176 (Clockwise)

Preceding gene: 118476637

Following gene: 118476639

Centisome position: 19.88

GC content: 41.21

Gene sequence:

>876_bases
ATGTTGAAACGGTTTAAGTTTTATTTGATTAGCGGTATTGTACTCGTTTTGCTTATCGTATGTAACTTCGTTGATAAGCC
GATTGCGAAGGTTGGAGAAGTGAAAGATACTGTTATGATGAAGCTGAATACGAAAGAGAGTATGGCGCAAATTGACGGGC
AGACGATTTATTTTAAGAAAATTGGTGAGGGGAAGCCTCCTTTACTTATGCTGCACGGGTTTGGTGGTTCTTCAGATGGT
TTTAGTGATATTTATCCGGAACTAGCGCGGGACCATACGATTATTGCGGTGGATATTTTAGGGTTTGGGCGTTCTTCTAA
GCCAGTTGATTTTGAGTATTCGTTTCCTGCGCAAGTGAATTTATATTATAAGTTAATGAAGAAGCTCGGATACGATCAGT
TTGCGGTGCTCGGTCATTCAATGGGCGGAGAGATGTCCCTCAATTTAGCGTATTTATATCCGGACGCAGTGACGCATCTC
ATTTTAGCAGACTCTACAGGAATTGAATCTTTCCAGCAAAAAGAAAGTTATGAAGTGCCGCCACTATCGACAGACTTACA
AACGGTAACAGAGATTACGGATTACAATAAAAATGAAGTGAAAAATAGTCGCGATGATAAAGGGCATTATGATCAGCTGA
CGAAAATGAGAGAGCGCCGCATTGCGATGGAAGCCGATAAAATTAAGGTGCCGACTTTAATCATATGGGGACGACACGAT
AAGAGCGTTTCTTGGAAAAATGGTGAACTGTATCATGGGCTATTTGGGAATAGCACGTTCCATATTATTGAAAAAGGATA
CCATGCACCGTTTCGCCAGGAACCAATCGAGTTTATGGAATATGTACAAGCGTTCTTCGCGAAGAATCCACAATGA

Upstream 100 bases:

>100_bases
TTTAGTATAATTGTAACTGTTGTAGTTACAATTAAAATTAATCATAAAACAACCAAAAAATGTAAAAACTTTAAATAGCA
ATAAGAGAAAGGAGACGGGA

Downstream 100 bases:

>100_bases
TAAAATTTTAAGCATAAATGTACTTCTTTCCTCATACAGTGAAACTAATAAGGCTTGTCTAAGGAAAGGAATGAAGTAGA
GTGGAAACTTTACCATGGTG

Product: alpha/beta hydrolase fold family lipase

Products: 2-oxopent-4-enoate; succinate [C]

Alternate protein names: NA

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MLKRFKFYLISGIVLVLLIVCNFVDKPIAKVGEVKDTVMMKLNTKESMAQIDGQTIYFKKIGEGKPPLLMLHGFGGSSDG
FSDIYPELARDHTIIAVDILGFGRSSKPVDFEYSFPAQVNLYYKLMKKLGYDQFAVLGHSMGGEMSLNLAYLYPDAVTHL
ILADSTGIESFQQKESYEVPPLSTDLQTVTEITDYNKNEVKNSRDDKGHYDQLTKMRERRIAMEADKIKVPTLIIWGRHD
KSVSWKNGELYHGLFGNSTFHIIEKGYHAPFRQEPIEFMEYVQAFFAKNPQ

Sequences:

>Translated_291_residues
MLKRFKFYLISGIVLVLLIVCNFVDKPIAKVGEVKDTVMMKLNTKESMAQIDGQTIYFKKIGEGKPPLLMLHGFGGSSDG
FSDIYPELARDHTIIAVDILGFGRSSKPVDFEYSFPAQVNLYYKLMKKLGYDQFAVLGHSMGGEMSLNLAYLYPDAVTHL
ILADSTGIESFQQKESYEVPPLSTDLQTVTEITDYNKNEVKNSRDDKGHYDQLTKMRERRIAMEADKIKVPTLIIWGRHD
KSVSWKNGELYHGLFGNSTFHIIEKGYHAPFRQEPIEFMEYVQAFFAKNPQ
>Mature_291_residues
MLKRFKFYLISGIVLVLLIVCNFVDKPIAKVGEVKDTVMMKLNTKESMAQIDGQTIYFKKIGEGKPPLLMLHGFGGSSDG
FSDIYPELARDHTIIAVDILGFGRSSKPVDFEYSFPAQVNLYYKLMKKLGYDQFAVLGHSMGGEMSLNLAYLYPDAVTHL
ILADSTGIESFQQKESYEVPPLSTDLQTVTEITDYNKNEVKNSRDDKGHYDQLTKMRERRIAMEADKIKVPTLIIWGRHD
KSVSWKNGELYHGLFGNSTFHIIEKGYHAPFRQEPIEFMEYVQAFFAKNPQ

Specific function: 3-hydroxyphenylpropionate degradation. [C]

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dmpD/todF/xylF esterase family [H]

Homologues:

Organism=Homo sapiens, GI50658087, Length=106, Percent_Identity=36.7924528301887, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI87081721, Length=279, Percent_Identity=24.0143369175627, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI32566936, Length=128, Percent_Identity=31.25, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17558492, Length=112, Percent_Identity=33.0357142857143, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324392, Length=119, Percent_Identity=30.2521008403361, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR000639 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: 3.7.1.- [C]

Molecular weight: Translated: 33175; Mature: 33175

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKRFKFYLISGIVLVLLIVCNFVDKPIAKVGEVKDTVMMKLNTKESMAQIDGQTIYFKK
CCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCEEEEEECCHHHHHHCCCCEEEEEE
IGEGKPPLLMLHGFGGSSDGFSDIYPELARDHTIIAVDILGFGRSSKPVDFEYSFPAQVN
CCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCEEEEEEEEECCCCCCCEEEEECCCCHHH
LYYKLMKKLGYDQFAVLGHSMGGEMSLNLAYLYPDAVTHLILADSTGIESFQQKESYEVP
HHHHHHHHCCCCCEEHHHHCCCCCEEEEEEEECHHHHHHEEEECCCCHHHHHHHCCCCCC
PLSTDLQTVTEITDYNKNEVKNSRDDKGHYDQLTKMRERRIAMEADKIKVPTLIIWGRHD
CCCCHHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEECCEEEEECCCC
KSVSWKNGELYHGLFGNSTFHIIEKGYHAPFRQEPIEFMEYVQAFFAKNPQ
CCCCCCCCCEEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLKRFKFYLISGIVLVLLIVCNFVDKPIAKVGEVKDTVMMKLNTKESMAQIDGQTIYFKK
CCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCEEEEEECCHHHHHHCCCCEEEEEE
IGEGKPPLLMLHGFGGSSDGFSDIYPELARDHTIIAVDILGFGRSSKPVDFEYSFPAQVN
CCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCEEEEEEEEECCCCCCCEEEEECCCCHHH
LYYKLMKKLGYDQFAVLGHSMGGEMSLNLAYLYPDAVTHLILADSTGIESFQQKESYEVP
HHHHHHHHCCCCCEEHHHHCCCCCEEEEEEEECHHHHHHEEEECCCCHHHHHHHCCCCCC
PLSTDLQTVTEITDYNKNEVKNSRDDKGHYDQLTKMRERRIAMEADKIKVPTLIIWGRHD
CCCCHHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCEECCEEEEECCCC
KSVSWKNGELYHGLFGNSTFHIIEKGYHAPFRQEPIEFMEYVQAFFAKNPQ
CCCCCCCCCEEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-hydroxy-6-ketononadienedicarboxylate; H2O [C]

Specific reaction: 2-hydroxy-6-ketononadienedicarboxylate + H2O = 2-oxopent-4-enoate + succinate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]