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The map label for this gene is nhaC [H]

Identifier: 118476089

GI number: 118476089

Start: 382891

End: 384312

Strand: Reverse

Name: nhaC [H]

Synonym: BALH_0332

Alternate gene names: 118476089

Gene position: 384312-382891 (Counterclockwise)

Preceding gene: 118476092

Following gene: 118476087

Centisome position: 7.31

GC content: 37.13

Gene sequence:

>1422_bases
ATGAAAAAAGAAATACCTTTTGGTGTAGCAATGATCCCTATTATCATTACAGTTGCAGTTATGATGGTTACAATTGTTGT
ATTAAAACAAAGCCCTCACGTCCCACTTATTATCGGTACAACTGTTGCTTCTATCGTCGCTTGGCGTTACGGTTACAAAT
GGAACGACATTGAAGAAGCAATGTATAAAGGCATTCGCCTCGCATTACCGGCTATCGTTATCATTATTCTAGTAGGTTTA
ACGATCGGTGCCTGGATTGGTGGTGGAATTGTCGCAACAATGATTTATTACGGTTTAAATCTTTTAACACCATCACTATT
TTTAGTTTCAATTACAATTATTTGTTCTATTGTTGCATTAGCTATTGGTAGCTCTTGGTCTACAATGGGAACAATTGGTG
TTGCAGGAATGGGTATTGGCCTAAGTATGGGAATCCCAGCTCCGATGGTTGCCGGTGCTATCATTTCCGGTTCTTATTTC
GGCGATAAAATGTCACCGCTTTCAGACACAACAAACTTAGCCGCAGGATTAACAAATACAGATTTATTCACACATATTCG
TCATATGTTATTTACTACAATTCCAGGTTTAATTATTACTCTTATCGTTTATGCCTTCTTAGGAAGAAGCTTCGGTGCTA
ACAATATTGATGCAAAAAGTATCGAGCAAACATTACAAGTATTGCAACAAAACTTTGTTATCTCACCTTTCCTATTAATC
ATACCTGTAGTCGTTATGGTATTGGTTGCTAAAAAAGTTCCTGCTATACCAGCTATTCTTGTAGGTATTATTTTAGGGTT
TTTATCACAAGTCTTTATTCAAGGTGGTTCTGTCTCAGCATCTGTCGGTGCACTCCAAGCTGGATTTGTTATAGACACTG
GAAACAAACTAGTAGACGAGCTATTTAACCGTGGTGGCTTAGATTCGATGATGAATACAGTCTCTATGACAATTGTCGCC
ATGACTTTCGGAGGAGTATTAGAACATACAGGTATTCTTCGTTCCATTGTAAATCAAATTTTAAAGTTAGCGAAATCAGC
AAAGGGACTTATCGCTTCTACTATTGCTTCATGTTTTGCAACAAACCTTACTTGCTCTGAACAATATATTTCGATTGTTG
TTCCTTCAAGAATGTACGCGAATGCATACACAGAAAAAGGACTACATTCTAAAAATTTATCCAGAGCATTAGAAGATGGC
GGAACATTAACTTCTGTTTTCGTACCTTGGAATACATGTGGCGTATTTATACTCGCAACACTCGGCGTAGGTGCATTCGA
ATATGCTCCTTATGCTATATTGAATTTCATCGTACCTATTATCTCGATCATTTACGGTATAACTGGTCTCACAATTACGA
AACTATCTGACATTGAAAAAGCGGAACTACTAAAAAAACAAAACGCTCAATTAGAAGCTTAA

Upstream 100 bases:

>100_bases
TATTGACGCTTGTATCGTTTTTTAGTTATTATAACTTAATAGCGTCTATTTTACGACAATTCTAAAAATACAAACAAACA
TACATAACAGGAGGAAATTT

Downstream 100 bases:

>100_bases
AGATAACGGTAAATTCAGTTCATATATTGCGCGAGGACGCCCTTGTTGATAAGGCATTTCCTCGCCGCAAATATGAACAT
ACCCATAATCAACTAGTTTC

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: Sodium/hydrogen antiporter; Sodium/proton antiporter [H]

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MKKEIPFGVAMIPIIITVAVMMVTIVVLKQSPHVPLIIGTTVASIVAWRYGYKWNDIEEAMYKGIRLALPAIVIIILVGL
TIGAWIGGGIVATMIYYGLNLLTPSLFLVSITIICSIVALAIGSSWSTMGTIGVAGMGIGLSMGIPAPMVAGAIISGSYF
GDKMSPLSDTTNLAAGLTNTDLFTHIRHMLFTTIPGLIITLIVYAFLGRSFGANNIDAKSIEQTLQVLQQNFVISPFLLI
IPVVVMVLVAKKVPAIPAILVGIILGFLSQVFIQGGSVSASVGALQAGFVIDTGNKLVDELFNRGGLDSMMNTVSMTIVA
MTFGGVLEHTGILRSIVNQILKLAKSAKGLIASTIASCFATNLTCSEQYISIVVPSRMYANAYTEKGLHSKNLSRALEDG
GTLTSVFVPWNTCGVFILATLGVGAFEYAPYAILNFIVPIISIIYGITGLTITKLSDIEKAELLKKQNAQLEA

Sequences:

>Translated_473_residues
MKKEIPFGVAMIPIIITVAVMMVTIVVLKQSPHVPLIIGTTVASIVAWRYGYKWNDIEEAMYKGIRLALPAIVIIILVGL
TIGAWIGGGIVATMIYYGLNLLTPSLFLVSITIICSIVALAIGSSWSTMGTIGVAGMGIGLSMGIPAPMVAGAIISGSYF
GDKMSPLSDTTNLAAGLTNTDLFTHIRHMLFTTIPGLIITLIVYAFLGRSFGANNIDAKSIEQTLQVLQQNFVISPFLLI
IPVVVMVLVAKKVPAIPAILVGIILGFLSQVFIQGGSVSASVGALQAGFVIDTGNKLVDELFNRGGLDSMMNTVSMTIVA
MTFGGVLEHTGILRSIVNQILKLAKSAKGLIASTIASCFATNLTCSEQYISIVVPSRMYANAYTEKGLHSKNLSRALEDG
GTLTSVFVPWNTCGVFILATLGVGAFEYAPYAILNFIVPIISIIYGITGLTITKLSDIEKAELLKKQNAQLEA
>Mature_473_residues
MKKEIPFGVAMIPIIITVAVMMVTIVVLKQSPHVPLIIGTTVASIVAWRYGYKWNDIEEAMYKGIRLALPAIVIIILVGL
TIGAWIGGGIVATMIYYGLNLLTPSLFLVSITIICSIVALAIGSSWSTMGTIGVAGMGIGLSMGIPAPMVAGAIISGSYF
GDKMSPLSDTTNLAAGLTNTDLFTHIRHMLFTTIPGLIITLIVYAFLGRSFGANNIDAKSIEQTLQVLQQNFVISPFLLI
IPVVVMVLVAKKVPAIPAILVGIILGFLSQVFIQGGSVSASVGALQAGFVIDTGNKLVDELFNRGGLDSMMNTVSMTIVA
MTFGGVLEHTGILRSIVNQILKLAKSAKGLIASTIASCFATNLTCSEQYISIVVPSRMYANAYTEKGLHSKNLSRALEDG
GTLTSVFVPWNTCGVFILATLGVGAFEYAPYAILNFIVPIISIIYGITGLTITKLSDIEKAELLKKQNAQLEA

Specific function: Na(+)/H(+) antiporter. Involved in pH homeostasis and sodium extrusion [H]

COG id: COG1757

COG function: function code C; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaC Na(+)/H(+) antiporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004770
- InterPro:   IPR018461 [H]

Pfam domain/function: PF03553 Na_H_antiporter [H]

EC number: NA

Molecular weight: Translated: 50183; Mature: 50183

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure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HCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1660475; 9190799 [H]