Click here to switch to the map view.

The map label for this gene is pepA1 [H]

Identifier: 117921762

GI number: 117921762

Start: 3984769

End: 3986304

Strand: Direct

Name: pepA1 [H]

Synonym: Shewana3_3324

Alternate gene names: 117921762

Gene position: 3984769-3986304 (Clockwise)

Preceding gene: 117921761

Following gene: 117921763

Centisome position: 80.14

GC content: 51.89

Gene sequence:

>1536_bases
ATGAAAAATAAGAATAAATTTTTGTTAAGCGTTATGGCGCTGGCGTGCCTTAACTCTCTCAATGCTAACGCCGAAACCTT
TAGTTTTGACACTCGTAACTCACTCAATTCCGACACATTAGTGCTGTTCCAAAGCGCTGATTCGACAACCTATAGTCTCG
ATTTTTTACCCCAATCGACTCAAGACCAACTCAACCTTGCGGTCGCCGACAACAGTTTTGCGGGTAAACGCGGTGAAATC
TTAGAAATCCTAGTCCCAAGCGAAATCGACGCTAAGCGGGTGTTACTGGTTGGAATTGGCGATGCTAAGACCTTAACACC
GGGTGAAATCAACACTTTAGGTGGCAATATTGCCGCCAAGCTTGAAACCGTGCCTCAAGCCACAGTGCGTGTGCTGACCC
AAGGCTTAAGTAACGCGCCGCTGTTCGGTTCAGAACTGGCCCACGGCATTGAACTGCGCAGCTATCGTTACACTCAATTT
AAAGCCAGCAATCGCGCCGAGAAGAACTATCAAATCGGGGTTGATGACTTAAGCCAAAACCAAAAACACCATAAGAATCT
ACAAGCTATCGAAGCGGGTGTGTTTTTAGCGCGGGATCTCACCAATGCGCCGGCAGGGATTATGTATCCCGAAAGCTTTG
CCAACGAGGCGCGTAAACTTAAATCCCTCGGTGTAAAAGTCACAGTGCTCGAAGCCAAAGATATTGAACGTTTAAACCTC
GGCGCCTTAGCCGCGGTGGGTAAAGGCAGCGAGCGTCCACCTAAGTTGGTCGTCGCCCACTGGCCCGGTAGCAAAGAAGC
ACCTATAGCCCTAGTTGGTAAAGGCATTACCTTCGACTCTGGCGGCTACAATATCAAGGCCACAGGCACCTCTATCGCGC
GGATGAAGTCCGATATGGCGGGCGCTGCGACCGTGCTCGGCACTGTCAAGGCCATGGCCATTCAAAAGGCACCAGTAAAC
CTAGTTGCGATTATGCCGATGGCGGAAAACATGGTGTCGGGACATGCAATGATCCCAGGCGATGTGATTAAAACCGCCCA
AGGCCTCACGGTTGAAGTGCTCAACACCGACGCCGAAGGCCGTTTAGTGTTAGCCGACGGTCTCTGGTATGCCCGTGAGA
ATTACCGCCCTTCGATTATCGTCGATGTGGCGACCCTCACAGGCTCAAAAGTGGGCGCGCTGGGTAGCGTTTATGCAGGA
TTATTTACCGATTTTGAGCCACTGGTGCAGCAGCTCACCTTTGCGGGTCAACAGGTGGGTGAAAAAGTTTGGCGCTTGCC
GTTAGATCAAGCCTACGACGATGAGCTGAAATCCACCATCGCCGATTTAAAGAATACCGGTAAAGAAGGCAGCGCAGGGG
CATCGTCTGCCGCTATGTTCCTCAAACGCTTTGCGGGTGAGCAACCTTGGGCTCACCTCGATATCGCTGGCAATGCCTTA
ACTGCCACCGATACCGCCGTGGTGCCCGCAGGCGCCACTGGCTATGGCGTGCGCCTGCTCAGCACTTGGTTAACTCAGCC
TAAGGCGCAAAACTAA

Upstream 100 bases:

>100_bases
CTTGGATTTAAGATTAATCTCAGTCAAATGGCTTAAATTAGTTAACCCTAAGACTCAGCTTTGCTATGCTTCTCACTCCC
TATTGATATGAGCTGTCACC

Downstream 100 bases:

>100_bases
CGCGATATTGTGACGCTCAAGCCGAGTCTGTGGCTCGTTTGAGAAGAGAGATTAAGGGATATCGTCGATATCCCTTTTTT
ATTGCCCTGCTCTTTTACCA

Product: peptidase M17, leucyl aminopeptidase domain-containing protein

Products: NA

Alternate protein names: Leucine aminopeptidase 1; LAP 1; Leucyl aminopeptidase 1 [H]

Number of amino acids: Translated: 511; Mature: 511

Protein sequence:

>511_residues
MKNKNKFLLSVMALACLNSLNANAETFSFDTRNSLNSDTLVLFQSADSTTYSLDFLPQSTQDQLNLAVADNSFAGKRGEI
LEILVPSEIDAKRVLLVGIGDAKTLTPGEINTLGGNIAAKLETVPQATVRVLTQGLSNAPLFGSELAHGIELRSYRYTQF
KASNRAEKNYQIGVDDLSQNQKHHKNLQAIEAGVFLARDLTNAPAGIMYPESFANEARKLKSLGVKVTVLEAKDIERLNL
GALAAVGKGSERPPKLVVAHWPGSKEAPIALVGKGITFDSGGYNIKATGTSIARMKSDMAGAATVLGTVKAMAIQKAPVN
LVAIMPMAENMVSGHAMIPGDVIKTAQGLTVEVLNTDAEGRLVLADGLWYARENYRPSIIVDVATLTGSKVGALGSVYAG
LFTDFEPLVQQLTFAGQQVGEKVWRLPLDQAYDDELKSTIADLKNTGKEGSAGASSAAMFLKRFAGEQPWAHLDIAGNAL
TATDTAVVPAGATGYGVRLLSTWLTQPKAQN

Sequences:

>Translated_511_residues
MKNKNKFLLSVMALACLNSLNANAETFSFDTRNSLNSDTLVLFQSADSTTYSLDFLPQSTQDQLNLAVADNSFAGKRGEI
LEILVPSEIDAKRVLLVGIGDAKTLTPGEINTLGGNIAAKLETVPQATVRVLTQGLSNAPLFGSELAHGIELRSYRYTQF
KASNRAEKNYQIGVDDLSQNQKHHKNLQAIEAGVFLARDLTNAPAGIMYPESFANEARKLKSLGVKVTVLEAKDIERLNL
GALAAVGKGSERPPKLVVAHWPGSKEAPIALVGKGITFDSGGYNIKATGTSIARMKSDMAGAATVLGTVKAMAIQKAPVN
LVAIMPMAENMVSGHAMIPGDVIKTAQGLTVEVLNTDAEGRLVLADGLWYARENYRPSIIVDVATLTGSKVGALGSVYAG
LFTDFEPLVQQLTFAGQQVGEKVWRLPLDQAYDDELKSTIADLKNTGKEGSAGASSAAMFLKRFAGEQPWAHLDIAGNAL
TATDTAVVPAGATGYGVRLLSTWLTQPKAQN
>Mature_511_residues
MKNKNKFLLSVMALACLNSLNANAETFSFDTRNSLNSDTLVLFQSADSTTYSLDFLPQSTQDQLNLAVADNSFAGKRGEI
LEILVPSEIDAKRVLLVGIGDAKTLTPGEINTLGGNIAAKLETVPQATVRVLTQGLSNAPLFGSELAHGIELRSYRYTQF
KASNRAEKNYQIGVDDLSQNQKHHKNLQAIEAGVFLARDLTNAPAGIMYPESFANEARKLKSLGVKVTVLEAKDIERLNL
GALAAVGKGSERPPKLVVAHWPGSKEAPIALVGKGITFDSGGYNIKATGTSIARMKSDMAGAATVLGTVKAMAIQKAPVN
LVAIMPMAENMVSGHAMIPGDVIKTAQGLTVEVLNTDAEGRLVLADGLWYARENYRPSIIVDVATLTGSKVGALGSVYAG
LFTDFEPLVQQLTFAGQQVGEKVWRLPLDQAYDDELKSTIADLKNTGKEGSAGASSAAMFLKRFAGEQPWAHLDIAGNAL
TATDTAVVPAGATGYGVRLLSTWLTQPKAQN

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=351, Percent_Identity=41.025641025641, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI47155554, Length=395, Percent_Identity=34.6835443037975, Blast_Score=169, Evalue=4e-42,
Organism=Escherichia coli, GI1790710, Length=457, Percent_Identity=36.3238512035011, Blast_Score=225, Evalue=6e-60,
Organism=Escherichia coli, GI87082123, Length=366, Percent_Identity=41.5300546448087, Blast_Score=202, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17556903, Length=316, Percent_Identity=39.2405063291139, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17565172, Length=261, Percent_Identity=31.8007662835249, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21355725, Length=316, Percent_Identity=35.4430379746835, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24661038, Length=316, Percent_Identity=34.8101265822785, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI161077148, Length=352, Percent_Identity=34.375, Blast_Score=178, Evalue=6e-45,
Organism=Drosophila melanogaster, GI20130057, Length=352, Percent_Identity=34.375, Blast_Score=178, Evalue=6e-45,
Organism=Drosophila melanogaster, GI24662227, Length=379, Percent_Identity=31.9261213720317, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI20129969, Length=442, Percent_Identity=30.7692307692308, Blast_Score=172, Evalue=6e-43,
Organism=Drosophila melanogaster, GI21355645, Length=379, Percent_Identity=31.3984168865435, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24662223, Length=379, Percent_Identity=31.3984168865435, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI21357381, Length=316, Percent_Identity=36.3924050632911, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI221379063, Length=316, Percent_Identity=36.3924050632911, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI221379062, Length=316, Percent_Identity=36.3924050632911, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI20129963, Length=344, Percent_Identity=33.4302325581395, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI19922386, Length=363, Percent_Identity=30.8539944903581, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24646701, Length=223, Percent_Identity=32.2869955156951, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24646703, Length=223, Percent_Identity=32.2869955156951, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21358201, Length=223, Percent_Identity=32.2869955156951, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 54362; Mature: 54362

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNKNKFLLSVMALACLNSLNANAETFSFDTRNSLNSDTLVLFQSADSTTYSLDFLPQST
CCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEEECCCCCEEEEEECCCCC
QDQLNLAVADNSFAGKRGEILEILVPSEIDAKRVLLVGIGDAKTLTPGEINTLGGNIAAK
CCCEEEEEECCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEE
LETVPQATVRVLTQGLSNAPLFGSELAHGIELRSYRYTQFKASNRAEKNYQIGVDDLSQN
EHHHHHHHHHHHHHCCCCCCCCHHHHHCCEEEEEEEEEEEECCCCCCCCCEECCHHHHCC
QKHHKNLQAIEAGVFLARDLTNAPAGIMYPESFANEARKLKSLGVKVTVLEAKDIERLNL
HHHHHHHHHHHHHHHEEHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCC
GALAAVGKGSERPPKLVVAHWPGSKEAPIALVGKGITFDSGGYNIKATGTSIARMKSDMA
CCEEECCCCCCCCCEEEEEECCCCCCCCEEEEECCEEECCCCCEEEECCCHHHHHHHHHH
GAATVLGTVKAMAIQKAPVNLVAIMPMAENMVSGHAMIPGDVIKTAQGLTVEVLNTDAEG
HHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHCCCCCCCHHHHHCCCCCEEEEEECCCCC
RLVLADGLWYARENYRPSIIVDVATLTGSKVGALGSVYAGLFTDFEPLVQQLTFAGQQVG
CEEEECCEEEECCCCCCEEEEEEEECCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHH
EKVWRLPLDQAYDDELKSTIADLKNTGKEGSAGASSAAMFLKRFAGEQPWAHLDIAGNAL
HHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCEE
TATDTAVVPAGATGYGVRLLSTWLTQPKAQN
ECCCCEEECCCCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKNKNKFLLSVMALACLNSLNANAETFSFDTRNSLNSDTLVLFQSADSTTYSLDFLPQST
CCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEEECCCCCEEEEEECCCCC
QDQLNLAVADNSFAGKRGEILEILVPSEIDAKRVLLVGIGDAKTLTPGEINTLGGNIAAK
CCCEEEEEECCCCCCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEE
LETVPQATVRVLTQGLSNAPLFGSELAHGIELRSYRYTQFKASNRAEKNYQIGVDDLSQN
EHHHHHHHHHHHHHCCCCCCCCHHHHHCCEEEEEEEEEEEECCCCCCCCCEECCHHHHCC
QKHHKNLQAIEAGVFLARDLTNAPAGIMYPESFANEARKLKSLGVKVTVLEAKDIERLNL
HHHHHHHHHHHHHHHEEHHCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCC
GALAAVGKGSERPPKLVVAHWPGSKEAPIALVGKGITFDSGGYNIKATGTSIARMKSDMA
CCEEECCCCCCCCCEEEEEECCCCCCCCEEEEECCEEECCCCCEEEECCCHHHHHHHHHH
GAATVLGTVKAMAIQKAPVNLVAIMPMAENMVSGHAMIPGDVIKTAQGLTVEVLNTDAEG
HHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHCCCCCCCHHHHHCCCCCEEEEEECCCCC
RLVLADGLWYARENYRPSIIVDVATLTGSKVGALGSVYAGLFTDFEPLVQQLTFAGQQVG
CEEEECCEEEECCCCCCEEEEEEEECCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHH
EKVWRLPLDQAYDDELKSTIADLKNTGKEGSAGASSAAMFLKRFAGEQPWAHLDIAGNAL
HHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCEE
TATDTAVVPAGATGYGVRLLSTWLTQPKAQN
ECCCCEEECCCCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]