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The map label for this gene is pyrC [H]

Identifier: 117921701

GI number: 117921701

Start: 3905284

End: 3906327

Strand: Direct

Name: pyrC [H]

Synonym: Shewana3_3263

Alternate gene names: 117921701

Gene position: 3905284-3906327 (Clockwise)

Preceding gene: 117921690

Following gene: 117921702

Centisome position: 78.54

GC content: 50.96

Gene sequence:

>1044_bases
ATGAATCGCCCTATGACAACACTCACTATTACTCGTCCTGACGACTGGCACATTCACCTAAGAGACGGCGCACAATTAAA
AGACACGGTTCGCGATATCAGCCGCTATATGGGCCGCGCTATCGTGATGCCTAACCTGGTTCCTCCCGCTATCGATACCG
AAACCGCCTTGGCTTATTACGATCGTATCAAGGCACAAGTGCCAGCCGGCTCGCAATTTGAACCCTTAATGGTGTTGTAT
CTCACCGACAAAACCAGCCCAGAAGAAATCCGTAAAGCCAAAGCCTCGGGTAAAATCGTTGCCGCTAAACTCTACCCAGC
AGGCGCGACCACTAACTCGGATTCTGGCGTGACCGATTTGAAGAACATCTACCCCGCCCTCGAAGCGATGCAGGAAGTGG
GCATGTTGTTCCTAGTGCATGGTGAAGTGACTGATTCATCGATTGATATTTTCGACCGCGAACGGGTGTTTATTGAGAAT
ATCCTCAGCAAGATCGTGGCTGATTTCCCTAAGCTTAAAATCGTTCTCGAGCATATCACCACTAAGGATGCGGTCGATTT
CGTGACTCAAGCCTCTGACAATGTGGCTGCCACGATCACCGCGCATCACTTGCTCTATAACCGCAACCATATGTTGGCTG
GCGGTATTCGTCCGCACTTCTATTGCCTGCCGATTTTAAAGCGCAATACCCACCAGCAAGCGCTGTTAGGCGCAGCGGCC
AGTGGCAATAAGAAGTTCTTCCTCGGTACCGACTCTGCGCCACACGCTAAAGATCGTAAAGAAGCCGCATGTGGCTGCGC
GGGTTCTTATACAGCCCATGCCGCCATTGAGCTTTACGCCGAAGCCTTTGAATCGGTCAATGCGCTGGATAAATTAGAAG
CCTTTGCCAGCTTCAACGGCCCAGATTTTTACAATCTGCCCCGCAACAGCGATACCATCACCCTAGTGAAAAAATCTTGG
GATGTGCCCGTCAGTTACCCACTTGGTGACAACAACGTTGTGCCAATTCGCGCCGGCGAACAAATCGATTGGCAGGTCGA
ATAA

Upstream 100 bases:

>100_bases
GCGTTAACACTTTTATTGGTGAAATGGCTGAGTTTCCCTTTACAGCTAAATCCTTGCCACATAAGATCCTGCCACCCTCG
CAGCAGAAACATTCAACAAG

Downstream 100 bases:

>100_bases
ACAGGCCTTTTGACGCGATAAACGGCTATCTAAACCTGCCGTTTATCAAGCTTGAAACCGTTAAGAGTCGCCTTAAGGCG
ACTTTTTTATAACCAGTAAA

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MNRPMTTLTITRPDDWHIHLRDGAQLKDTVRDISRYMGRAIVMPNLVPPAIDTETALAYYDRIKAQVPAGSQFEPLMVLY
LTDKTSPEEIRKAKASGKIVAAKLYPAGATTNSDSGVTDLKNIYPALEAMQEVGMLFLVHGEVTDSSIDIFDRERVFIEN
ILSKIVADFPKLKIVLEHITTKDAVDFVTQASDNVAATITAHHLLYNRNHMLAGGIRPHFYCLPILKRNTHQQALLGAAA
SGNKKFFLGTDSAPHAKDRKEAACGCAGSYTAHAAIELYAEAFESVNALDKLEAFASFNGPDFYNLPRNSDTITLVKKSW
DVPVSYPLGDNNVVPIRAGEQIDWQVE

Sequences:

>Translated_347_residues
MNRPMTTLTITRPDDWHIHLRDGAQLKDTVRDISRYMGRAIVMPNLVPPAIDTETALAYYDRIKAQVPAGSQFEPLMVLY
LTDKTSPEEIRKAKASGKIVAAKLYPAGATTNSDSGVTDLKNIYPALEAMQEVGMLFLVHGEVTDSSIDIFDRERVFIEN
ILSKIVADFPKLKIVLEHITTKDAVDFVTQASDNVAATITAHHLLYNRNHMLAGGIRPHFYCLPILKRNTHQQALLGAAA
SGNKKFFLGTDSAPHAKDRKEAACGCAGSYTAHAAIELYAEAFESVNALDKLEAFASFNGPDFYNLPRNSDTITLVKKSW
DVPVSYPLGDNNVVPIRAGEQIDWQVE
>Mature_347_residues
MNRPMTTLTITRPDDWHIHLRDGAQLKDTVRDISRYMGRAIVMPNLVPPAIDTETALAYYDRIKAQVPAGSQFEPLMVLY
LTDKTSPEEIRKAKASGKIVAAKLYPAGATTNSDSGVTDLKNIYPALEAMQEVGMLFLVHGEVTDSSIDIFDRERVFIEN
ILSKIVADFPKLKIVLEHITTKDAVDFVTQASDNVAATITAHHLLYNRNHMLAGGIRPHFYCLPILKRNTHQQALLGAAA
SGNKKFFLGTDSAPHAKDRKEAACGCAGSYTAHAAIELYAEAFESVNALDKLEAFASFNGPDFYNLPRNSDTITLVKKSW
DVPVSYPLGDNNVVPIRAGEQIDWQVE

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787301, Length=347, Percent_Identity=55.043227665706, Blast_Score=393, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6323452, Length=356, Percent_Identity=35.9550561797753, Blast_Score=180, Evalue=3e-46,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004721
- InterPro:   IPR002195 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 38315; Mature: 38315

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRPMTTLTITRPDDWHIHLRDGAQLKDTVRDISRYMGRAIVMPNLVPPAIDTETALAYY
CCCCCEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHCCEEECCCCCCCCCCCHHHHHHH
DRIKAQVPAGSQFEPLMVLYLTDKTSPEEIRKAKASGKIVAAKLYPAGATTNSDSGVTDL
HHHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHH
KNIYPALEAMQEVGMLFLVHGEVTDSSIDIFDRERVFIENILSKIVADFPKLKIVLEHIT
HHHHHHHHHHHHCCEEEEEECCCCCCCCCHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHC
TKDAVDFVTQASDNVAATITAHHLLYNRNHMLAGGIRPHFYCLPILKRNTHQQALLGAAA
CHHHHHHHHHCCCCEEEEEEEEEHEECCCCEEECCCCCCEEEEEHHHCCCHHHHHHHHCC
SGNKKFFLGTDSAPHAKDRKEAACGCAGSYTAHAAIELYAEAFESVNALDKLEAFASFNG
CCCEEEEEECCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PDFYNLPRNSDTITLVKKSWDVPVSYPLGDNNVVPIRAGEQIDWQVE
CCCCCCCCCCCEEEEEEECCCCEEEECCCCCCEEEEECCCCEEEEEC
>Mature Secondary Structure
MNRPMTTLTITRPDDWHIHLRDGAQLKDTVRDISRYMGRAIVMPNLVPPAIDTETALAYY
CCCCCEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHCCEEECCCCCCCCCCCHHHHHHH
DRIKAQVPAGSQFEPLMVLYLTDKTSPEEIRKAKASGKIVAAKLYPAGATTNSDSGVTDL
HHHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHH
KNIYPALEAMQEVGMLFLVHGEVTDSSIDIFDRERVFIENILSKIVADFPKLKIVLEHIT
HHHHHHHHHHHHCCEEEEEECCCCCCCCCHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHC
TKDAVDFVTQASDNVAATITAHHLLYNRNHMLAGGIRPHFYCLPILKRNTHQQALLGAAA
CHHHHHHHHHCCCCEEEEEEEEEHEECCCCEEECCCCCCEEEEEHHHCCCHHHHHHHHCC
SGNKKFFLGTDSAPHAKDRKEAACGCAGSYTAHAAIELYAEAFESVNALDKLEAFASFNG
CCCEEEEEECCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PDFYNLPRNSDTITLVKKSWDVPVSYPLGDNNVVPIRAGEQIDWQVE
CCCCCCCCCCCEEEEEEECCCCEEEECCCCCCEEEEECCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA