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The map label for this gene is hmuU [H]

Identifier: 117921678

GI number: 117921678

Start: 3884808

End: 3885824

Strand: Direct

Name: hmuU [H]

Synonym: Shewana3_3240

Alternate gene names: 117921678

Gene position: 3884808-3885824 (Clockwise)

Preceding gene: 117921677

Following gene: 117921679

Centisome position: 78.13

GC content: 53.0

Gene sequence:

>1017_bases
ATGTTACAACATCGCTGGCTATGGCCCACCATGGCAACGCTGCTTATCCTCAGCAGTTTACTTTCCGTCAGTGTCGGGCC
AGTGAATATCAGCCTTATCGACTCCCTCAGCGCGGTGTTTAACTGGGCCACGGAGCAAAATATTGGCAATCTTGCTCCCC
ACGAGCAACTGGTTGTCAGCAATGTCCGCTTGCCTCGTACCTTACTCGCCCTTGCCGTTGGGGCCATGTTGGCCCAATGC
GGTGCTGTGATGCAGGGGTTGTTTCGTAACCCCTTGGCAGATCCTGGGATTATTGGCGTGTCATCCGGCGCGGCATTAGG
CGCAGCAATCTGCATAGTGCAGTTCCCTCACGCCGAATCTGTCATGATTTCTGTCAGTGCTTTTTCCTCTGGCTTAATCA
CTACCCTTATTGTCTATCGCCTTGCCAGCAGCGCTTTAGGTACATCGGTCGTGTTATTGCTGTTATCTGGCGTCGCCGTT
GCCGCACTCGCCGGAGCTGGAATTGGCGTGCTGACCTATTTAGCCAATGATATGGCGCTTAGGGACTTAACCCTATGGCA
AATGGGCAGTATTGCTGGCGCACAATGGCAATATGTGGGCTTGTGTTTAGTGGTGTTAGCACTGCTGAGTTGGCAATTTA
ATCGTGATGCTAAGGCGCTTAATGCCCTGCTACTCGGTGAGGCCGAGGCCAGGCATTTAGGGATTGATGTTGATTCACTC
AAGCTGAGACTCATCCTGCTCTGCGCCTTAGGGGTCGGCGTCAGTGTTGCAGCAACAGGCATTATCGGTTTTATTGGCTT
AGTGGTGCCCCATTTAGTGCGTATGTTGCTGGGGCCAGATCATCAACGCCTCCTCCCTATGAGCGCCCTGCTAGGTGCGG
CCTTGTTGGCACTTGCCGATATCGGCGCGCGCGCCTTTTTACCCCCAGCGGAACTCCCCGTTGGCTTAGTGACAGCGCTC
ATTGGTGCACCATTCTTTATCTTTTTACTCCTGCAACAACGCAGCAAATTAATCTAA

Upstream 100 bases:

>100_bases
GGCCTTACTCGGCGGGTTAGGTATTAGCGCTATCGGTGCGGCTGAAACCTTGGCAGCCACTTTGCTCAAGCAAGATCAAT
AAGTTGTGGGGCTGATGAGT

Downstream 100 bases:

>100_bases
GCGAGAACCCCATGGCTATGAGCTTATCGGCTGCGCCCGTCGCTAAACAACATTTTGAACGTGCTCAACTAAGCGTGGAT
AGACTCAGCTACGCTATCGG

Product: transport system permease

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MLQHRWLWPTMATLLILSSLLSVSVGPVNISLIDSLSAVFNWATEQNIGNLAPHEQLVVSNVRLPRTLLALAVGAMLAQC
GAVMQGLFRNPLADPGIIGVSSGAALGAAICIVQFPHAESVMISVSAFSSGLITTLIVYRLASSALGTSVVLLLLSGVAV
AALAGAGIGVLTYLANDMALRDLTLWQMGSIAGAQWQYVGLCLVVLALLSWQFNRDAKALNALLLGEAEARHLGIDVDSL
KLRLILLCALGVGVSVAATGIIGFIGLVVPHLVRMLLGPDHQRLLPMSALLGAALLALADIGARAFLPPAELPVGLVTAL
IGAPFFIFLLLQQRSKLI

Sequences:

>Translated_338_residues
MLQHRWLWPTMATLLILSSLLSVSVGPVNISLIDSLSAVFNWATEQNIGNLAPHEQLVVSNVRLPRTLLALAVGAMLAQC
GAVMQGLFRNPLADPGIIGVSSGAALGAAICIVQFPHAESVMISVSAFSSGLITTLIVYRLASSALGTSVVLLLLSGVAV
AALAGAGIGVLTYLANDMALRDLTLWQMGSIAGAQWQYVGLCLVVLALLSWQFNRDAKALNALLLGEAEARHLGIDVDSL
KLRLILLCALGVGVSVAATGIIGFIGLVVPHLVRMLLGPDHQRLLPMSALLGAALLALADIGARAFLPPAELPVGLVTAL
IGAPFFIFLLLQQRSKLI
>Mature_338_residues
MLQHRWLWPTMATLLILSSLLSVSVGPVNISLIDSLSAVFNWATEQNIGNLAPHEQLVVSNVRLPRTLLALAVGAMLAQC
GAVMQGLFRNPLADPGIIGVSSGAALGAAICIVQFPHAESVMISVSAFSSGLITTLIVYRLASSALGTSVVLLLLSGVAV
AALAGAGIGVLTYLANDMALRDLTLWQMGSIAGAQWQYVGLCLVVLALLSWQFNRDAKALNALLLGEAEARHLGIDVDSL
KLRLILLCALGVGVSVAATGIIGFIGLVVPHLVRMLLGPDHQRLLPMSALLGAALLALADIGARAFLPPAELPVGLVTAL
IGAPFFIFLLLQQRSKLI

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=295, Percent_Identity=44.7457627118644, Blast_Score=167, Evalue=9e-43,
Organism=Escherichia coli, GI1790740, Length=285, Percent_Identity=40.7017543859649, Blast_Score=160, Evalue=8e-41,
Organism=Escherichia coli, GI1790741, Length=281, Percent_Identity=36.6548042704626, Blast_Score=131, Evalue=8e-32,
Organism=Escherichia coli, GI1786805, Length=291, Percent_Identity=37.1134020618557, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1786347, Length=300, Percent_Identity=31.6666666666667, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1786804, Length=299, Percent_Identity=31.7725752508361, Blast_Score=102, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 35319; Mature: 35319

Theoretical pI: Translated: 8.00; Mature: 8.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQHRWLWPTMATLLILSSLLSVSVGPVNISLIDSLSAVFNWATEQNIGNLAPHEQLVVS
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
NVRLPRTLLALAVGAMLAQCGAVMQGLFRNPLADPGIIGVSSGAALGAAICIVQFPHAES
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCHHHHHHHHEEECCCCCC
VMISVSAFSSGLITTLIVYRLASSALGTSVVLLLLSGVAVAALAGAGIGVLTYLANDMAL
EEEEHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
RDLTLWQMGSIAGAQWQYVGLCLVVLALLSWQFNRDAKALNALLLGEAEARHLGIDVDSL
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHCCCCHHHH
KLRLILLCALGVGVSVAATGIIGFIGLVVPHLVRMLLGPDHQRLLPMSALLGAALLALAD
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
IGARAFLPPAELPVGLVTALIGAPFFIFLLLQQRSKLI
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLQHRWLWPTMATLLILSSLLSVSVGPVNISLIDSLSAVFNWATEQNIGNLAPHEQLVVS
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
NVRLPRTLLALAVGAMLAQCGAVMQGLFRNPLADPGIIGVSSGAALGAAICIVQFPHAES
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCHHHHHHHHEEECCCCCC
VMISVSAFSSGLITTLIVYRLASSALGTSVVLLLLSGVAVAALAGAGIGVLTYLANDMAL
EEEEHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
RDLTLWQMGSIAGAQWQYVGLCLVVLALLSWQFNRDAKALNALLLGEAEARHLGIDVDSL
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHCCCCHHHH
KLRLILLCALGVGVSVAATGIIGFIGLVVPHLVRMLLGPDHQRLLPMSALLGAALLALAD
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
IGARAFLPPAELPVGLVTALIGAPFFIFLLLQQRSKLI
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]